KR900700598A - 프로우로키나제의 저분자량 유도체 및 이를 함유하는 약제학적 조성물 - Google Patents

프로우로키나제의 저분자량 유도체 및 이를 함유하는 약제학적 조성물

Info

Publication number
KR900700598A
KR900700598A KR1019890702374A KR890702374A KR900700598A KR 900700598 A KR900700598 A KR 900700598A KR 1019890702374 A KR1019890702374 A KR 1019890702374A KR 890702374 A KR890702374 A KR 890702374A KR 900700598 A KR900700598 A KR 900700598A
Authority
KR
South Korea
Prior art keywords
prourokinase
molecular weight
low molecular
pharmaceutical composition
composition containing
Prior art date
Application number
KR1019890702374A
Other languages
English (en)
Inventor
브란다자 안나
란센 야퀄린
마쭈이 귀
사르미엔토스 파올로
Original Assignee
파미탈리아 카를로 데르바 에스. 알. 엘
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 파미탈리아 카를로 데르바 에스. 알. 엘 filed Critical 파미탈리아 카를로 데르바 에스. 알. 엘
Publication of KR900700598A publication Critical patent/KR900700598A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1019890702374A 1988-04-18 1989-12-18 프로우로키나제의 저분자량 유도체 및 이를 함유하는 약제학적 조성물 KR900700598A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888809093A GB8809093D0 (en) 1988-04-18 1988-04-18 Low molecular weight derivatives of prourokinase
PCT/EP1989/000394 WO1989010402A1 (en) 1988-04-18 1989-04-13 Low molecular weight derivatives of prourokinase and pharmaceutical compositions containing the same

Publications (1)

Publication Number Publication Date
KR900700598A true KR900700598A (ko) 1990-08-16

Family

ID=10635366

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890702374A KR900700598A (ko) 1988-04-18 1989-12-18 프로우로키나제의 저분자량 유도체 및 이를 함유하는 약제학적 조성물

Country Status (18)

Country Link
EP (1) EP0338409B1 (ko)
JP (1) JPH03500125A (ko)
KR (1) KR900700598A (ko)
CN (1) CN1037360A (ko)
AT (1) ATE118033T1 (ko)
AU (1) AU617459B2 (ko)
DE (1) DE68920900D1 (ko)
FI (1) FI896003A0 (ko)
GB (1) GB8809093D0 (ko)
HU (1) HUT52558A (ko)
IL (1) IL90011A (ko)
MY (1) MY105110A (ko)
NZ (1) NZ228791A (ko)
PH (1) PH27586A (ko)
PT (1) PT90298B (ko)
WO (1) WO1989010402A1 (ko)
YU (1) YU79189A (ko)
ZA (1) ZA892829B (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4101736A1 (de) * 1991-01-22 1992-07-23 Gruenenthal Gmbh Neue als plasminogenaktivatoren einsetzbare polypeptide, dafuer codierende plasmide und verfahren zu deren herstellung und deren verwendung
DE4440892A1 (de) * 1994-11-17 1996-05-23 Gruenenthal Gmbh Proteine mit fibrinolytischen und gerinnungshemmenden Eigenschaften
EP1060255A2 (en) * 1998-03-06 2000-12-20 Abbott Laboratories Highly crystalline urokinase
CN100420485C (zh) * 2004-08-06 2008-09-24 上海天士力药业有限公司 含活性尿激酶原的组合物、其冻干方法及冻干制剂
CN110339349A (zh) * 2018-04-04 2019-10-18 天士力生物医药股份有限公司 一种重组人尿激酶原组合物及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8601240A (nl) * 1986-05-15 1987-12-01 Leuven Res & Dev Vzw Plasminogeenactivator en trombolytisch geneesmiddel.
JPH0761266B2 (ja) * 1986-07-03 1995-07-05 株式会社ミドリ十字 変異ヒトプロウロキナ−ゼ
JPH02438A (ja) * 1987-10-09 1990-01-05 Collaborative Res Inc 修飾した低分子量プラスミノーゲン活性化因子およびその製造方法

Also Published As

Publication number Publication date
WO1989010402A1 (en) 1989-11-02
PT90298A (pt) 1989-11-10
PT90298B (pt) 1994-09-30
AU617459B2 (en) 1991-11-28
ATE118033T1 (de) 1995-02-15
EP0338409A1 (en) 1989-10-25
DE68920900D1 (de) 1995-03-16
FI896003A0 (fi) 1989-12-15
JPH03500125A (ja) 1991-01-17
CN1037360A (zh) 1989-11-22
IL90011A (en) 1994-10-21
EP0338409B1 (en) 1995-02-01
MY105110A (en) 1994-08-30
AU3414989A (en) 1989-11-24
IL90011A0 (en) 1989-12-15
HU892527D0 (en) 1990-05-28
PH27586A (en) 1993-08-18
GB8809093D0 (en) 1988-05-18
HUT52558A (en) 1990-07-28
NZ228791A (en) 1991-04-26
ZA892829B (en) 1990-01-31
YU79189A (sh) 1992-07-20

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Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E601 Decision to refuse application