ATE118033T1 - Prourokinasederivate mit niedrigem molekulargewicht und sie enthaltende pharmazeutische zusammensetzungen. - Google Patents

Prourokinasederivate mit niedrigem molekulargewicht und sie enthaltende pharmazeutische zusammensetzungen.

Info

Publication number
ATE118033T1
ATE118033T1 AT89106549T AT89106549T ATE118033T1 AT E118033 T1 ATE118033 T1 AT E118033T1 AT 89106549 T AT89106549 T AT 89106549T AT 89106549 T AT89106549 T AT 89106549T AT E118033 T1 ATE118033 T1 AT E118033T1
Authority
AT
Austria
Prior art keywords
molecular weight
low molecular
derivatives
prourokinase
pharmaceutical compositions
Prior art date
Application number
AT89106549T
Other languages
English (en)
Inventor
Anna Brandazza
Jacqueline Lansen
Guy Mazue
Paolo Sarmientos
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Application granted granted Critical
Publication of ATE118033T1 publication Critical patent/ATE118033T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT89106549T 1988-04-18 1989-04-13 Prourokinasederivate mit niedrigem molekulargewicht und sie enthaltende pharmazeutische zusammensetzungen. ATE118033T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888809093A GB8809093D0 (en) 1988-04-18 1988-04-18 Low molecular weight derivatives of prourokinase

Publications (1)

Publication Number Publication Date
ATE118033T1 true ATE118033T1 (de) 1995-02-15

Family

ID=10635366

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89106549T ATE118033T1 (de) 1988-04-18 1989-04-13 Prourokinasederivate mit niedrigem molekulargewicht und sie enthaltende pharmazeutische zusammensetzungen.

Country Status (18)

Country Link
EP (1) EP0338409B1 (de)
JP (1) JPH03500125A (de)
KR (1) KR900700598A (de)
CN (1) CN1037360A (de)
AT (1) ATE118033T1 (de)
AU (1) AU617459B2 (de)
DE (1) DE68920900D1 (de)
FI (1) FI896003A0 (de)
GB (1) GB8809093D0 (de)
HU (1) HUT52558A (de)
IL (1) IL90011A (de)
MY (1) MY105110A (de)
NZ (1) NZ228791A (de)
PH (1) PH27586A (de)
PT (1) PT90298B (de)
WO (1) WO1989010402A1 (de)
YU (1) YU79189A (de)
ZA (1) ZA892829B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4101736A1 (de) * 1991-01-22 1992-07-23 Gruenenthal Gmbh Neue als plasminogenaktivatoren einsetzbare polypeptide, dafuer codierende plasmide und verfahren zu deren herstellung und deren verwendung
DE4440892A1 (de) * 1994-11-17 1996-05-23 Gruenenthal Gmbh Proteine mit fibrinolytischen und gerinnungshemmenden Eigenschaften
JP2003521222A (ja) * 1998-03-06 2003-07-15 アボット・ラボラトリーズ 高度結晶性ウロキナーゼ
CN100420485C (zh) * 2004-08-06 2008-09-24 上海天士力药业有限公司 含活性尿激酶原的组合物、其冻干方法及冻干制剂
CN110339349A (zh) * 2018-04-04 2019-10-18 天士力生物医药股份有限公司 一种重组人尿激酶原组合物及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8601240A (nl) * 1986-05-15 1987-12-01 Leuven Res & Dev Vzw Plasminogeenactivator en trombolytisch geneesmiddel.
JPH0761266B2 (ja) * 1986-07-03 1995-07-05 株式会社ミドリ十字 変異ヒトプロウロキナ−ゼ
EP0316068A1 (de) * 1987-10-09 1989-05-17 Collaborative Research Inc. Modifizierter Plasminogenaktivator mit niedrigem Molekulargewicht und Verfahren zu seiner Herstellung

Also Published As

Publication number Publication date
FI896003A0 (fi) 1989-12-15
EP0338409B1 (de) 1995-02-01
HUT52558A (en) 1990-07-28
GB8809093D0 (en) 1988-05-18
YU79189A (sh) 1992-07-20
MY105110A (en) 1994-08-30
HU892527D0 (en) 1990-05-28
IL90011A0 (en) 1989-12-15
PH27586A (en) 1993-08-18
AU617459B2 (en) 1991-11-28
NZ228791A (en) 1991-04-26
PT90298A (pt) 1989-11-10
JPH03500125A (ja) 1991-01-17
ZA892829B (en) 1990-01-31
DE68920900D1 (de) 1995-03-16
AU3414989A (en) 1989-11-24
PT90298B (pt) 1994-09-30
IL90011A (en) 1994-10-21
KR900700598A (ko) 1990-08-16
CN1037360A (zh) 1989-11-22
WO1989010402A1 (en) 1989-11-02
EP0338409A1 (de) 1989-10-25

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee