IL90011A - History of low molecular weight prourokinase and pharmaceutical preparations containing them - Google Patents

History of low molecular weight prourokinase and pharmaceutical preparations containing them

Info

Publication number
IL90011A
IL90011A IL9001189A IL9001189A IL90011A IL 90011 A IL90011 A IL 90011A IL 9001189 A IL9001189 A IL 9001189A IL 9001189 A IL9001189 A IL 9001189A IL 90011 A IL90011 A IL 90011A
Authority
IL
Israel
Prior art keywords
urokinase
molecular weight
derivatives
prourokinase
human
Prior art date
Application number
IL9001189A
Other languages
English (en)
Hebrew (he)
Other versions
IL90011A0 (en
Original Assignee
Farmitalia Carlo Erba S L R
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba S L R filed Critical Farmitalia Carlo Erba S L R
Publication of IL90011A0 publication Critical patent/IL90011A0/xx
Publication of IL90011A publication Critical patent/IL90011A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL9001189A 1988-04-18 1989-04-18 History of low molecular weight prourokinase and pharmaceutical preparations containing them IL90011A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888809093A GB8809093D0 (en) 1988-04-18 1988-04-18 Low molecular weight derivatives of prourokinase

Publications (2)

Publication Number Publication Date
IL90011A0 IL90011A0 (en) 1989-12-15
IL90011A true IL90011A (en) 1994-10-21

Family

ID=10635366

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9001189A IL90011A (en) 1988-04-18 1989-04-18 History of low molecular weight prourokinase and pharmaceutical preparations containing them

Country Status (18)

Country Link
EP (1) EP0338409B1 (de)
JP (1) JPH03500125A (de)
KR (1) KR900700598A (de)
CN (1) CN1037360A (de)
AT (1) ATE118033T1 (de)
AU (1) AU617459B2 (de)
DE (1) DE68920900D1 (de)
FI (1) FI896003A0 (de)
GB (1) GB8809093D0 (de)
HU (1) HUT52558A (de)
IL (1) IL90011A (de)
MY (1) MY105110A (de)
NZ (1) NZ228791A (de)
PH (1) PH27586A (de)
PT (1) PT90298B (de)
WO (1) WO1989010402A1 (de)
YU (1) YU79189A (de)
ZA (1) ZA892829B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4101736A1 (de) * 1991-01-22 1992-07-23 Gruenenthal Gmbh Neue als plasminogenaktivatoren einsetzbare polypeptide, dafuer codierende plasmide und verfahren zu deren herstellung und deren verwendung
DE4440892A1 (de) * 1994-11-17 1996-05-23 Gruenenthal Gmbh Proteine mit fibrinolytischen und gerinnungshemmenden Eigenschaften
JP2003521222A (ja) * 1998-03-06 2003-07-15 アボット・ラボラトリーズ 高度結晶性ウロキナーゼ
CN100420485C (zh) * 2004-08-06 2008-09-24 上海天士力药业有限公司 含活性尿激酶原的组合物、其冻干方法及冻干制剂
CN110339349A (zh) * 2018-04-04 2019-10-18 天士力生物医药股份有限公司 一种重组人尿激酶原组合物及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8601240A (nl) * 1986-05-15 1987-12-01 Leuven Res & Dev Vzw Plasminogeenactivator en trombolytisch geneesmiddel.
JPH0761266B2 (ja) * 1986-07-03 1995-07-05 株式会社ミドリ十字 変異ヒトプロウロキナ−ゼ
EP0316068A1 (de) * 1987-10-09 1989-05-17 Collaborative Research Inc. Modifizierter Plasminogenaktivator mit niedrigem Molekulargewicht und Verfahren zu seiner Herstellung

Also Published As

Publication number Publication date
YU79189A (sh) 1992-07-20
PH27586A (en) 1993-08-18
GB8809093D0 (en) 1988-05-18
EP0338409A1 (de) 1989-10-25
FI896003A0 (fi) 1989-12-15
ZA892829B (en) 1990-01-31
JPH03500125A (ja) 1991-01-17
EP0338409B1 (de) 1995-02-01
HUT52558A (en) 1990-07-28
PT90298B (pt) 1994-09-30
AU617459B2 (en) 1991-11-28
ATE118033T1 (de) 1995-02-15
MY105110A (en) 1994-08-30
WO1989010402A1 (en) 1989-11-02
IL90011A0 (en) 1989-12-15
DE68920900D1 (de) 1995-03-16
NZ228791A (en) 1991-04-26
AU3414989A (en) 1989-11-24
PT90298A (pt) 1989-11-10
KR900700598A (ko) 1990-08-16
CN1037360A (zh) 1989-11-22
HU892527D0 (en) 1990-05-28

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