PH12021552674A1 - Strains and methods for production of heme-containing proteins - Google Patents
Strains and methods for production of heme-containing proteinsInfo
- Publication number
- PH12021552674A1 PH12021552674A1 PH1/2021/552674A PH12021552674A PH12021552674A1 PH 12021552674 A1 PH12021552674 A1 PH 12021552674A1 PH 12021552674 A PH12021552674 A PH 12021552674A PH 12021552674 A1 PH12021552674 A1 PH 12021552674A1
- Authority
- PH
- Philippines
- Prior art keywords
- heme
- production
- methods
- nucleic acid
- nucleotide sequence
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y203/00—Acyltransferases (2.3)
- C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- C12Y203/01037—5-Aminolevulinate synthase (2.3.1.37)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962838770P | 2019-04-25 | 2019-04-25 | |
| PCT/US2020/029946 WO2020219972A1 (en) | 2019-04-25 | 2020-04-24 | Strains and methods for production of heme-containing proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH12021552674A1 true PH12021552674A1 (en) | 2022-07-04 |
Family
ID=70740761
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH1/2021/552674A PH12021552674A1 (en) | 2019-04-25 | 2020-04-24 | Strains and methods for production of heme-containing proteins |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11965167B2 (https=) |
| EP (1) | EP3959311A1 (https=) |
| JP (2) | JP7700046B2 (https=) |
| KR (1) | KR20220004090A (https=) |
| CN (1) | CN114341351A (https=) |
| AU (1) | AU2020263580A1 (https=) |
| BR (1) | BR112021021154A2 (https=) |
| CA (1) | CA3137581A1 (https=) |
| IL (1) | IL287418A (https=) |
| MX (2) | MX2021012851A (https=) |
| PH (1) | PH12021552674A1 (https=) |
| SG (1) | SG11202111693YA (https=) |
| WO (1) | WO2020219972A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3294762T (pt) | 2015-05-11 | 2022-03-21 | Impossible Foods Inc | Constructos de expressão e métodos de modificar geneticamente levedura metilotrófica |
| AU2020257270B2 (en) | 2019-04-17 | 2026-01-15 | Impossible Foods Inc. | Materials and methods for protein production |
| EP3959311A1 (en) | 2019-04-25 | 2022-03-02 | Impossible Foods Inc. | Strains and methods for production of heme-containing proteins |
| US10947552B1 (en) | 2020-09-30 | 2021-03-16 | Alpine Roads, Inc. | Recombinant fusion proteins for producing milk proteins in plants |
| AU2021353004A1 (en) | 2020-09-30 | 2023-04-13 | Nobell Foods, Inc. | Recombinant milk proteins and food compositions comprising the same |
| US20240200088A1 (en) * | 2021-04-13 | 2024-06-20 | Kyomei Ltd. | Transgenic Plants Comprising Myoglobin and Methods for Producing Myoglobin in Transgenic Plants |
| CN116940688A (zh) * | 2021-05-10 | 2023-10-24 | 韩国科学技术院 | 具有改善的风味、营养和色泽的食品及其制备方法 |
| AU2022369299A1 (en) | 2021-10-19 | 2024-03-14 | Eat Scifi Inc. | Plant base/animal cell hybrid meat substitute |
| KR20240118861A (ko) * | 2021-12-16 | 2024-08-05 | 임파서블 푸즈 인크. | 재조합 단백질의 발현을 증가시키는 유전 인자 |
| CN120302886A (zh) * | 2022-10-06 | 2025-07-11 | 米克罗食品配料有限公司 | 多形汉逊酵母来源的组合物及应用 |
| CN116790395B (zh) * | 2023-06-28 | 2024-07-19 | 江南大学 | 一种合成高活性血红素类蛋白毕赤酵母底盘菌株的构建及应用 |
| KR20250004435A (ko) | 2023-06-29 | 2025-01-08 | 인테이크 주식회사 | 헴 생합성 경로의 미토콘드리아 구획화를 통한 헴 고생산 시스템 및 이의 용도 |
| WO2025183375A1 (ko) * | 2024-02-28 | 2025-09-04 | 서울과학기술대학교 산학협력단 | 재조합 플라스미드 벡터를 이용하여 형질전환된 재조합 균주와 이로부터 생성된 heme containing globin 재조합 단백질 및 이의 제조방법 |
| WO2026003081A1 (en) * | 2024-06-25 | 2026-01-02 | Danmarks Tekniske Universitet | Cells and methods for production of heme |
Family Cites Families (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3013863A (en) | 1959-01-29 | 1961-12-19 | American Potash & Chem Corp | Method for the preparation of diborane |
| US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| DK162399C (da) | 1986-01-28 | 1992-03-23 | Danisco | Fremgangsmaade til ekspression af gener i baelgplanteceller, dna-fragment, rekombineret dna-fragment samt plasmid til brug ved udoevelsen af fremgangsmaaden |
| US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| US6946587B1 (en) | 1990-01-22 | 2005-09-20 | Dekalb Genetics Corporation | Method for preparing fertile transgenic corn plants |
| US5484956A (en) | 1990-01-22 | 1996-01-16 | Dekalb Genetics Corporation | Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin |
| US5204253A (en) | 1990-05-29 | 1993-04-20 | E. I. Du Pont De Nemours And Company | Method and apparatus for introducing biological substances into living cells |
| US5753465A (en) | 1994-08-30 | 1998-05-19 | Carnegie Mellon University | Unmodified recombinant human adult hemoglobin production |
| FR2736930B1 (fr) | 1995-07-17 | 1997-09-19 | Biocem | Procede de production, par des cellules vegetales, de proteines heminiques, proteines ainsi obtenues et produits contenant ces proteines |
| US5824511A (en) * | 1995-08-01 | 1998-10-20 | University Technology Corporation | Method for enhancing the production of hemoproteins |
| JP3462218B2 (ja) | 1996-06-10 | 2003-11-05 | ノボザイムス バイオテック，インコーポレイティド | 糸状菌におけるヘムタンパク質生産を増加せしめるための方法 |
| JP3794760B2 (ja) | 1996-07-30 | 2006-07-12 | 三井化学株式会社 | フィターゼ生産酵母 |
| US5959187A (en) | 1996-09-26 | 1999-09-28 | Bailey; James E. | Expression of oxygen-binding proteins in plants |
| JPH10117776A (ja) | 1996-10-22 | 1998-05-12 | Japan Tobacco Inc | インディカイネの形質転換方法 |
| US6784340B1 (en) | 1998-01-28 | 2004-08-31 | The Rockefeller University | Chemical inducible promoter used to obtain transgenic plants with a silent marker |
| CA2331772C (en) | 1998-06-26 | 2009-08-04 | The University Of Manitoba | Hemoglobins to maintain cell energy status |
| US7803765B2 (en) | 1999-05-05 | 2010-09-28 | Phylogica Limited | Methods of constructing biodiverse gene fragment libraries and biological modulators isolated therefrom |
| US7304208B2 (en) | 2000-05-02 | 2007-12-04 | Ventria Bioscience | Expression of human serum albumin (HSA) in monocot seeds |
| WO2001098480A2 (en) | 2000-06-23 | 2001-12-27 | Syngenta Participations Ag | Promoters for regulation of plant gene expression |
| US7495148B2 (en) | 2000-07-14 | 2009-02-24 | Unicrop Ltd | Double recoverable block of function |
| EP1356060B1 (en) | 2000-09-18 | 2005-12-14 | Genencor International, Inc. | Twin-arginine translocation in bacillus |
| ATE530654T1 (de) | 2001-07-06 | 2011-11-15 | Monsanto Technology Llc | Verfahren zur förderung der aufspaltung von transgenen bei pflanzen und zusammensetzungen dafür |
| US8021695B2 (en) | 2002-02-15 | 2011-09-20 | Arch Personal Care Products, L.P. | Personal care composition containing leghemoglobin |
| AU2002253458A1 (en) * | 2002-04-09 | 2003-10-20 | Universitat Basel | Enhancer sequence of the 5-aminolevulinic synthase gene |
| US7683238B2 (en) | 2002-11-12 | 2010-03-23 | iBio, Inc. and Fraunhofer USA, Inc. | Production of pharmaceutically active proteins in sprouted seedlings |
| AU2003296714A1 (en) | 2002-12-23 | 2004-07-22 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften Ev | Method for altering the content of reserve substances in plants |
| WO2004099405A1 (en) | 2003-04-11 | 2004-11-18 | Ventria Bioscience | Human blood proteins expressed in monocot seeds |
| US20060041961A1 (en) | 2004-03-25 | 2006-02-23 | Abad Mark S | Genes and uses for pant improvement |
| JP4520219B2 (ja) | 2004-05-28 | 2010-08-04 | 協和発酵バイオ株式会社 | ５−アミノレブリン酸の製造法 |
| US20080193969A1 (en) | 2005-01-12 | 2008-08-14 | Rob Te Biesebeke | Hemoglobin Overexpression in Fungal Fermentations |
| EP2479254A1 (en) | 2005-08-24 | 2012-07-25 | The Scripps Research Institute | Translation enhancer-element dependent vector systems |
| US20100064384A1 (en) | 2006-04-13 | 2010-03-11 | Max Planck Institut fur molekulare | Method for modifying the atp/adp ratio in cells |
| CN101484582A (zh) | 2006-07-07 | 2009-07-15 | 拜耳生物科学股份有限公司 | 表达靶向内腔蛋白质的转质体植物 |
| JP2008017733A (ja) | 2006-07-11 | 2008-01-31 | Tokyo Univ Of Agriculture | 異種タンパク質の発現方法及び異種タンパク質の発現方法により得られたタンパク質 |
| JP2008017774A (ja) | 2006-07-13 | 2008-01-31 | Nipro Corp | ピキア酵母を用いた組換えヒトヘモグロビンの製造 |
| CN1974758B (zh) * | 2006-12-15 | 2012-03-21 | 湖南省植物保护研究所 | 一种高产5-氨基乙酰丙酸的工程菌的培养方法 |
| US8143023B2 (en) | 2007-01-26 | 2012-03-27 | Novozymes A/S | Method for methanol independent induction from methanol inducible promoters in Pichia |
| WO2009009142A2 (en) | 2007-07-10 | 2009-01-15 | Monsanto Technology, Llc | Transgenic plants with enhanced agronomic traits |
| EP2058398A1 (en) | 2007-11-09 | 2009-05-13 | Nipro Corporation | Production of recombinant human hemoglobin using pichia yeast |
| CN102105589A (zh) | 2008-07-11 | 2011-06-22 | 诺维信公司 | 巴斯德毕赤酵母(Pichia pastoris) DAS启动子变体 |
| AU2009324228A1 (en) | 2008-12-04 | 2011-06-23 | Sanofi-Aventis | Methods and uses involving Heme binding protein 1 |
| US9085766B2 (en) | 2010-05-21 | 2015-07-21 | Cornell University | Methods of producing recombinant heme-binding proteins and uses thereof |
| WO2012083424A1 (en) | 2010-12-21 | 2012-06-28 | The University Of Western Ontario | Novel amino acid linker sequences for ligand immobilization |
| EP2669375B1 (en) | 2011-01-27 | 2018-10-17 | Kaneka Corporation | Yeast of the genus pichia modified to express high levels of a mpp1 homolog and process for producing protein |
| CN105724726A (zh) | 2011-07-12 | 2016-07-06 | 非凡食品有限公司 | 用于消费品的方法和组合物 |
| CN102757976B (zh) | 2012-07-12 | 2014-10-08 | 华东理工大学 | 消除甲醇诱导型启动子单一甲醇碳源依赖性的方法 |
| CN104812405A (zh) | 2012-09-19 | 2015-07-29 | 国立大学法人大阪大学 | 含有肺炎球菌表面蛋白a的肺炎球菌疫苗 |
| US20160340411A1 (en) | 2013-01-11 | 2016-11-24 | Impossible Foods Inc. | Secretion of heme-containing polypeptides |
| PT2943078T (pt) | 2013-01-11 | 2021-06-16 | Impossible Foods Inc | Métodos e composições para consumíveis |
| GB201309866D0 (en) | 2013-06-03 | 2013-07-17 | Vib Vzw | Means and methods for yield performance in plants |
| SI3044320T1 (sl) | 2013-09-11 | 2020-07-31 | Impossible Foods Inc. | Sekrecija polipeptidov, ki vsebujejo hem |
| JP6759103B2 (ja) | 2014-03-31 | 2020-09-23 | インポッシブル フーズ インコーポレイテッド | ひき肉レプリカ |
| HRP20211551T1 (hr) | 2014-10-01 | 2021-12-24 | Impossible Foods Inc. | Postupci ekstrakcije i pročišćavanja denaturiranih bjelančevina |
| PT3294762T (pt) | 2015-05-11 | 2022-03-21 | Impossible Foods Inc | Constructos de expressão e métodos de modificar geneticamente levedura metilotrófica |
| CN105483146B (zh) * | 2016-01-22 | 2019-03-26 | 吉林大学 | 一种与致病力相关的灰霉病菌基因BcAls1及其应用 |
| US20190292217A1 (en) | 2016-12-02 | 2019-09-26 | Impossible Foods Inc. | Transgenic plants with upregulated heme biosynthesis |
| US20190292555A1 (en) | 2016-12-02 | 2019-09-26 | Impossible Foods Inc. | Producing recombinant products in contained systems |
| CN108517327B (zh) * | 2018-04-20 | 2020-10-30 | 中国科学院天津工业生物技术研究所 | 5-氨基乙酰丙酸高产菌株及其制备方法和应用 |
| AU2020257270B2 (en) | 2019-04-17 | 2026-01-15 | Impossible Foods Inc. | Materials and methods for protein production |
| EP3959311A1 (en) | 2019-04-25 | 2022-03-02 | Impossible Foods Inc. | Strains and methods for production of heme-containing proteins |
-
2020
- 2020-04-24 EP EP20726602.4A patent/EP3959311A1/en active Pending
- 2020-04-24 CN CN202080040385.8A patent/CN114341351A/zh active Pending
- 2020-04-24 SG SG11202111693YA patent/SG11202111693YA/en unknown
- 2020-04-24 JP JP2021563177A patent/JP7700046B2/ja active Active
- 2020-04-24 US US16/858,443 patent/US11965167B2/en active Active
- 2020-04-24 KR KR1020217037341A patent/KR20220004090A/ko not_active Ceased
- 2020-04-24 BR BR112021021154A patent/BR112021021154A2/pt unknown
- 2020-04-24 PH PH1/2021/552674A patent/PH12021552674A1/en unknown
- 2020-04-24 AU AU2020263580A patent/AU2020263580A1/en active Pending
- 2020-04-24 WO PCT/US2020/029946 patent/WO2020219972A1/en not_active Ceased
- 2020-04-24 MX MX2021012851A patent/MX2021012851A/es unknown
- 2020-04-24 CA CA3137581A patent/CA3137581A1/en active Pending
-
2021
- 2021-10-20 MX MX2025006371A patent/MX2025006371A/es unknown
- 2021-10-20 IL IL287418A patent/IL287418A/en unknown
-
2024
- 2024-03-19 US US18/609,276 patent/US12509695B2/en active Active
-
2025
- 2025-03-05 JP JP2025034487A patent/JP2025102779A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| MX2025006371A (es) | 2025-07-01 |
| JP2025102779A (ja) | 2025-07-08 |
| US20200340000A1 (en) | 2020-10-29 |
| CN114341351A (zh) | 2022-04-12 |
| BR112021021154A2 (pt) | 2021-12-14 |
| EP3959311A1 (en) | 2022-03-02 |
| CA3137581A1 (en) | 2020-10-29 |
| MX2021012851A (es) | 2022-02-10 |
| US11965167B2 (en) | 2024-04-23 |
| JP7700046B2 (ja) | 2025-06-30 |
| WO2020219972A1 (en) | 2020-10-29 |
| US20240218378A1 (en) | 2024-07-04 |
| SG11202111693YA (en) | 2021-11-29 |
| KR20220004090A (ko) | 2022-01-11 |
| JP2022531140A (ja) | 2022-07-06 |
| AU2020263580A1 (en) | 2021-11-18 |
| IL287418A (en) | 2021-12-01 |
| US12509695B2 (en) | 2025-12-30 |
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