PE20240362A1 - Compuestos moduladores del glp-ir carboxibenzimidazolicos - Google Patents

Compuestos moduladores del glp-ir carboxibenzimidazolicos

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PE20240362A1
PE20240362A1 PE2023002895A PE2023002895A PE20240362A1 PE 20240362 A1 PE20240362 A1 PE 20240362A1 PE 2023002895 A PE2023002895 A PE 2023002895A PE 2023002895 A PE2023002895 A PE 2023002895A PE 20240362 A1 PE20240362 A1 PE 20240362A1
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Peru
Prior art keywords
alkyl
haloalkyl
alkoxyalkyl
alkoxy
substituted
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PE2023002895A
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English (en)
Inventor
Megan K Armstrong
James S Cassidy
Elbert Chin
Chienhung Chou
Jeromy J Cottell
Chao-I Hung
Kavoos Kolahdouzan
David W Lin
Michael L Mitchell
Ezra Roberts
Scott D Schroeder
Nathan D Shapiro
James G Taylor
Rhiannon Thomas-Tran
Nathan E Wright
Zheng-Yu Yang
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Gilead Sciences Inc
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Publication of PE20240362A1 publication Critical patent/PE20240362A1/es

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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Referida a un compuesto de formula (I), donde R1 es arilo C6-10 o heteroarilo de 6 miembros, cada uno de los cuales se sustituye opcionalmente con uno a cuatro R4, entre otros; el anillo A es pirdina, bencilo, pirimidina, entre otros, que se sustituyen con RA; RA es alquilo C1-6, haloalquilo C1-6, alcoxi C1-6, entre otros; el anillo B es arilo C6-10 o heteroarilo, que se sustituye cada uno opcionalmente con uno a cuatro RB; RB es alquilo C1-9, haloalquilo C1-8, haloalcoxi C1- 6, alcoxialquilo C2-6, entre otros; V es -C(R11a) (R11b)-; X1 , X2 , y X3 son -C(H)=, o -C(R8 )=; R2 es cicloalquilo C3-10 o heterociclilo, en donde el cicloalquilo o heterociclilo se sustituye con Z1, en donde cada Z1 es alquilo C1- 6, alcoxi C1-6, hidroxialquilo C1-6, alcoxialquilo C2-6, entre otros; R3 es -C(O)OR3a , en donde R3a es H, alquilo C1-4-N(R9a)(R9b), -alquilo C1-4- N(R9a)C(O)-O-alquilo C1-4-OP(O)(OR9c)2, alquilo C1-4-, entre otros; R4 es alquilo C1-6, haloalquilo C1-8, haloalcoxi C1-6, alcoxialquilo C2-6, entre otros; R8 es alquilo C1-9, alcoxi C1-6, alcoxialquilo C2-6, haloalquilo C1-8, alquenilo C2-6, alquinilo C2-6, entre otros; R9a y R9b son H, alquilo C1-6, haloalquilo C1-6, entre otros; R11a y R11b son H, alquilo C1-6, oxo o halogeno. Dichos compuestos se unen y actuan como agonistas o moduladores del receptor del peptido similar al glucagon 1 (GLP1R) y actuan como agonistas o moduladores del GLP-1R. Son utiles en el tratamiento de enfermedades metabolicas y enfermedades relacionadas tales como obesidad y diabetes tipo 2, entre otras.
PE2023002895A 2021-04-21 2022-04-19 Compuestos moduladores del glp-ir carboxibenzimidazolicos PE20240362A1 (es)

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US11851419B2 (en) 2020-11-20 2023-12-26 Gilead Sciences, Inc. GLP-1R modulating compounds
WO2023111144A1 (en) 2021-12-16 2023-06-22 Astrazeneca Ab Certain 3-azabicyclo[3.1.0]hexanes as glp-1 receptor modulators
WO2023111145A1 (en) 2021-12-16 2023-06-22 Astrazeneca Ab Certain 3-azabicyclo[3.1.0]hexanes as glp-1 receptor modulators
WO2024102625A1 (en) 2022-11-11 2024-05-16 Eli Lilly And Company Glucagon-like peptide 1 receptor agonists
WO2024107781A1 (en) 2022-11-16 2024-05-23 Eli Lilly And Company Glucagon-like peptide 1 receptor agonists

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