PE20212330A1 - Procedimiento de obtencion de heparinas de bajo peso molecular por filtracion de flujo tangencial - Google Patents

Procedimiento de obtencion de heparinas de bajo peso molecular por filtracion de flujo tangencial

Info

Publication number
PE20212330A1
PE20212330A1 PE2021001650A PE2021001650A PE20212330A1 PE 20212330 A1 PE20212330 A1 PE 20212330A1 PE 2021001650 A PE2021001650 A PE 2021001650A PE 2021001650 A PE2021001650 A PE 2021001650A PE 20212330 A1 PE20212330 A1 PE 20212330A1
Authority
PE
Peru
Prior art keywords
approximately
molecular weight
low molecular
flow filtration
tangential flow
Prior art date
Application number
PE2021001650A
Other languages
English (en)
Inventor
Rodriguez Guillermo Franco
Aduriz Ibon Gutierro
Original Assignee
Farm Rovi Lab Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farm Rovi Lab Sa filed Critical Farm Rovi Lab Sa
Publication of PE20212330A1 publication Critical patent/PE20212330A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/145—Ultrafiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/16—Feed pretreatment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/02—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/10—Heparin; Derivatives thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/04—Specific process operations in the feed stream; Feed pretreatment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/26—Further operations combined with membrane separation processes
    • B01D2311/2649—Filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/10—Cross-flow filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/16—Diafiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2325/00—Details relating to properties of membranes
    • B01D2325/20—Specific permeability or cut-off range

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Water Supply & Treatment (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Referido a un procedimiento de obtencion de heparinas de bajo peso molecular (HBPM) con una distribucion de peso molecular medio de entre aproximadamente 3,0 y aproximadamente 5,0 KDa que comprende las siguientes etapas: a) proporcionar una solucion de heparina despolimerizada cruda con un rango de distribucion de cadenas oligosacaridicas de entre aproximadamente 0,6 a aproximadamente 10 KDa y una concentracion de heparina de hasta aproximadamente 4% p/v, y b) realizar al menos una etapa de concentracion mediante filtracion de flujo tangencial (TFF) en fase acuosa utilizando una membrana de menor o igual a 1 KDa de corte nominal hasta conseguir una concentracion de la heparina de hasta aproximadamente 25% p/v, proporcionando asi dicha HBPM; el procedimiento puede englobar otras etapas como la diafiltracion o el tratamiento con peroxido de hidrogeno.
PE2021001650A 2019-04-26 2020-04-24 Procedimiento de obtencion de heparinas de bajo peso molecular por filtracion de flujo tangencial PE20212330A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ES201930373 2019-04-26
CN202010078241 2020-01-23
PCT/ES2020/070263 WO2020216981A1 (es) 2019-04-26 2020-04-24 Procedimiento de obtención de heparinas de bajo peso molecular por filtración de flujo tangencial

Publications (1)

Publication Number Publication Date
PE20212330A1 true PE20212330A1 (es) 2021-12-14

Family

ID=72941056

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2021001650A PE20212330A1 (es) 2019-04-26 2020-04-24 Procedimiento de obtencion de heparinas de bajo peso molecular por filtracion de flujo tangencial

Country Status (18)

Country Link
US (1) US20220112315A1 (es)
EP (1) EP3943513A4 (es)
JP (1) JP2022530321A (es)
KR (1) KR20220005441A (es)
AU (1) AU2020263142A1 (es)
BR (1) BR112021020048A2 (es)
CA (1) CA3134458C (es)
CL (1) CL2021002647A1 (es)
CO (1) CO2021013320A2 (es)
ES (1) ES2888148B2 (es)
GE (1) GEP20247598B (es)
IL (1) IL286931A (es)
MA (1) MA55388A (es)
MX (1) MX2021011671A (es)
PE (1) PE20212330A1 (es)
SG (1) SG11202111009WA (es)
WO (1) WO2020216981A1 (es)
ZA (1) ZA202109022B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024518174A (ja) * 2021-05-12 2024-04-25 ネクシオス ダイアグノスティックス、インク． 高分子量ヘパリン化合物の製造方法
CN116284499B (zh) * 2022-07-28 2024-07-23 河北常山生化药业股份有限公司 一种羊源低分子肝素钠的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2059321T3 (es) 1986-05-16 1994-11-16 Italfarmaco Spa Heparinas, fracciones y fragmentos de heparinas libres de edta, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
US5767269A (en) 1996-10-01 1998-06-16 Hamilton Civic Hospitals Research Development Inc. Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
ES2161615B1 (es) 1999-07-23 2003-03-16 Rovi Lab Farmaceut Sa Composiciones de heparinas de muy bajo peso molecular.
GB0509433D0 (en) 2005-05-09 2005-06-15 Uni For Milj Og Biovitenskap Method
JP5286089B2 (ja) 2006-01-13 2013-09-11 バクスター・インターナショナル・インコーポレイテッド ポリサッカライドを精製する方法
WO2010111710A1 (en) 2009-03-27 2010-09-30 Solazyme, Inc. Microalgal polysaccharide compositions
CN102050888B (zh) 2010-12-13 2011-12-07 河北常山生化药业股份有限公司 一种依诺肝素钠的制备方法
CN102731683A (zh) * 2012-07-17 2012-10-17 湖北亿诺瑞生物制药有限公司 一种从肝素废液中分离天然低分子肝素的方法
CN103342761B (zh) 2013-07-15 2016-01-06 河北常山生化药业股份有限公司 一种膜分离制备依诺肝素钠工艺
CN103936889A (zh) * 2014-03-19 2014-07-23 苏州英诺凯生物医药科技有限公司 一种使用切向流过滤纯化依诺肝素的方法

Also Published As

Publication number Publication date
EP3943513A4 (en) 2022-12-21
ES2888148A1 (es) 2021-12-30
JP2022530321A (ja) 2022-06-29
KR20220005441A (ko) 2022-01-13
CA3134458C (en) 2023-11-21
BR112021020048A2 (pt) 2021-12-07
US20220112315A1 (en) 2022-04-14
ZA202109022B (en) 2023-10-25
CL2021002647A1 (es) 2022-05-13
IL286931A (en) 2021-10-31
MX2021011671A (es) 2021-10-22
CO2021013320A2 (es) 2022-03-18
ES2888148B2 (es) 2022-11-14
CA3134458A1 (en) 2020-10-29
EP3943513A1 (en) 2022-01-26
SG11202111009WA (en) 2021-11-29
WO2020216981A1 (es) 2020-10-29
AU2020263142A1 (en) 2021-10-28
GEP20247598B (en) 2024-02-26
MA55388A (fr) 2022-01-26

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