PE20200600A1 - Composiciones y metodos para promover el crecimiento del cabello con inhibidores de mpc - Google Patents

Composiciones y metodos para promover el crecimiento del cabello con inhibidores de mpc

Info

Publication number
PE20200600A1
PE20200600A1 PE2019001733A PE2019001733A PE20200600A1 PE 20200600 A1 PE20200600 A1 PE 20200600A1 PE 2019001733 A PE2019001733 A PE 2019001733A PE 2019001733 A PE2019001733 A PE 2019001733A PE 20200600 A1 PE20200600 A1 PE 20200600A1
Authority
PE
Peru
Prior art keywords
hair growth
mpc
inhibitors
compositions
methods
Prior art date
Application number
PE2019001733A
Other languages
English (en)
Inventor
William E Lowry
Heather Christofk
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Priority claimed from PCT/US2017/048701 external-priority patent/WO2018039612A1/en
Publication of PE20200600A1 publication Critical patent/PE20200600A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
    • A61K8/492—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid having condensed rings, e.g. indol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

Referido a un metodo para acelerar, promover o restaurar el crecimiento del cabello, que comprende administrar a un sujeto que lo necesite, una cantidad efectiva de un compuesto de formula (I) o una sal farmaceuticamente aceptable del mismo. Dicho metodo se aplica para el tratamiento de la alopecia, perdida de cabello, afinamiento del cabello y calvicie. Tambien se refiere a una composicion farmaceutica que contiene dicho compuesto de formula (I).
PE2019001733A 2017-02-24 2017-08-25 Composiciones y metodos para promover el crecimiento del cabello con inhibidores de mpc PE20200600A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762463232P 2017-02-24 2017-02-24
PCT/US2017/048701 WO2018039612A1 (en) 2016-08-26 2017-08-25 Compositions and methods for promoting hair growth with mpc1 inhibitors

Publications (1)

Publication Number Publication Date
PE20200600A1 true PE20200600A1 (es) 2020-03-10

Family

ID=67297690

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2019001733A PE20200600A1 (es) 2017-02-24 2017-08-25 Composiciones y metodos para promover el crecimiento del cabello con inhibidores de mpc

Country Status (13)

Country Link
US (1) US11213513B2 (es)
EP (1) EP3585381A4 (es)
JP (1) JP7046086B2 (es)
KR (1) KR102440809B1 (es)
CN (1) CN110300583A (es)
AU (1) AU2017314833A1 (es)
BR (1) BR112019015552A2 (es)
CA (1) CA3050635A1 (es)
EA (1) EA038943B1 (es)
IL (1) IL268345B (es)
MX (1) MX2019010101A (es)
PE (1) PE20200600A1 (es)
SG (1) SG11201906807VA (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102440809B1 (ko) 2017-02-24 2022-09-05 더 리전트 오브 더 유니버시티 오브 캘리포니아 Mpc 저해제를 사용하여 모발 성장을 촉진하는 조성물 및 방법
WO2019005724A1 (en) 2017-06-26 2019-01-03 Virtue Labs, LLC FUNGICIDE COMPOSITIONS AND METHODS OF USE
US11312714B2 (en) 2017-06-30 2022-04-26 The Regents Of The University Of California Compositions and methods for modulating hair growth
KR20240007905A (ko) * 2021-04-14 2024-01-17 버츄 랩스 엘엘씨 모발 처리 조성물 및 사용 방법
AU2022327765A1 (en) * 2021-08-13 2024-03-28 Mpc Therapeutics Sa [1,2,4]triazolo[4,3-a]pyrimidin-7(8h)-one as mitochondrial pyruvate carrier inhibitors for use in the treatment of cancer

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9014221D0 (en) 1990-06-26 1990-08-15 Janssen Pharmaceutica Nv Method of treating alopecia
GB9023585D0 (en) 1990-10-30 1990-12-12 Beecham Group Plc Novel compounds
FR2796274B1 (fr) * 1999-07-16 2001-09-21 Oreal Utilisation de l'acide 4,6-dimethoxy-indole 2-carboxylique ou de ses derives pour stimuler ou induire la pousse des cheveux et/ou stopper leur chute
WO2001062237A2 (en) 2000-02-23 2001-08-30 Orentreich Foundation For The Advancement Of Science, Inc. Compositions for the treatment of alopecia and other disorders of the pilosebaceous apparatus
EP1605967A1 (en) 2003-03-13 2005-12-21 Novo Nordisk A/S Novel nph insulin preparations
CA2581237C (en) * 2004-09-24 2018-11-06 Angioblast Systems, Inc. Method of enhancing proliferation and/or survival of mesenchymal precursor cells (mpc)
EP1919449A2 (en) 2005-06-07 2008-05-14 Foamix Ltd. Antibiotic kit and composition and uses thereof
JP2007191473A (ja) 2005-12-21 2007-08-02 Daiichi Sankyo Healthcare Co Ltd 新規な育毛用組成物
US8563500B2 (en) 2007-09-05 2013-10-22 Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts Methods and compounds for treating diseases caused by reactive oxygen species
CA2860187C (en) 2011-12-22 2020-11-10 Connexios Life Sciences Pvt. Ltd. Cyclic amide derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase and uses thereof
JP5956242B2 (ja) 2012-05-09 2016-07-27 富士産業株式会社 まつ毛・眉毛用の育毛用組成物
EP2847356A4 (en) * 2012-05-10 2015-08-05 Univ Utah Res Found COMPOSITIONS AND METHODS FOR MODULATING THE ACTIVITY OF A MITOCHONDRIAL PYRUVATE CARRIER
WO2014207213A1 (en) 2013-06-28 2014-12-31 Medizinische Universität Innsbruck Novel inhibitors of protein kinase c epsilon signaling
EP3052133A2 (en) 2013-10-03 2016-08-10 INSERM - Institut National de la Santé et de la Recherche Médicale Methods and pharmaceutical compositions for modulating autophagy in a subject in need thereof
US9636340B2 (en) 2013-11-12 2017-05-02 Ayyappan K. Rajasekaran Kinase inhibitors
WO2018039612A1 (en) 2016-08-26 2018-03-01 The Regents Of The University Of California Compositions and methods for promoting hair growth with mpc1 inhibitors
KR102440809B1 (ko) 2017-02-24 2022-09-05 더 리전트 오브 더 유니버시티 오브 캘리포니아 Mpc 저해제를 사용하여 모발 성장을 촉진하는 조성물 및 방법
CN106880693A (zh) 2017-03-22 2017-06-23 广州国草夏方生物科技有限公司 一种治疗脂溢性脱发的生发液组合物及其制备方法
US11312714B2 (en) 2017-06-30 2022-04-26 The Regents Of The University Of California Compositions and methods for modulating hair growth
AU2018339064A1 (en) 2017-09-29 2020-02-27 The Regents Of The University Of California Compositions and methods for modulating hair growth
JP2022516136A (ja) 2019-01-02 2022-02-24 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 毛髪の成長を調節するための組成物及び方法

Also Published As

Publication number Publication date
KR102440809B1 (ko) 2022-09-05
CN110300583A (zh) 2019-10-01
US11213513B2 (en) 2022-01-04
IL268345A (en) 2019-09-26
BR112019015552A2 (pt) 2020-03-17
JP2020524127A (ja) 2020-08-13
EA038943B1 (ru) 2021-11-12
CA3050635A1 (en) 2018-03-01
JP7046086B2 (ja) 2022-04-01
EP3585381A4 (en) 2020-08-19
MX2019010101A (es) 2019-10-15
KR20190119118A (ko) 2019-10-21
EA201991988A1 (ru) 2020-01-24
EP3585381A1 (en) 2020-01-01
AU2017314833A1 (en) 2019-07-25
IL268345B (en) 2022-08-01
US20200030289A1 (en) 2020-01-30
SG11201906807VA (en) 2019-08-27

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