PE20191206A1 - Composiciones de aminoacidos y metodos para el tratamiento de enfermedades y trastornos musculares - Google Patents
Composiciones de aminoacidos y metodos para el tratamiento de enfermedades y trastornos muscularesInfo
- Publication number
- PE20191206A1 PE20191206A1 PE2019001282A PE2019001282A PE20191206A1 PE 20191206 A1 PE20191206 A1 PE 20191206A1 PE 2019001282 A PE2019001282 A PE 2019001282A PE 2019001282 A PE2019001282 A PE 2019001282A PE 20191206 A1 PE20191206 A1 PE 20191206A1
- Authority
- PE
- Peru
- Prior art keywords
- amino acid
- entity
- disorders
- treatment
- methods
- Prior art date
Links
- 150000001413 amino acids Chemical class 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 2
- 208000037765 diseases and disorders Diseases 0.000 title 1
- 210000003205 muscle Anatomy 0.000 title 1
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 abstract 2
- 229960004308 acetylcysteine Drugs 0.000 abstract 2
- 239000004475 Arginine Substances 0.000 abstract 1
- 150000008575 L-amino acids Chemical class 0.000 abstract 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 235000020776 essential amino acid Nutrition 0.000 abstract 1
- 239000003797 essential amino acid Substances 0.000 abstract 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 abstract 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 1
- 230000003387 muscular Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4172—Imidazole-alkanecarboxylic acids, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/06—Anabolic agents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/316—Foods, ingredients or supplements having a functional effect on health having an effect on regeneration or building of ligaments or muscles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662436073P | 2016-12-19 | 2016-12-19 | |
| US201762443205P | 2017-01-06 | 2017-01-06 | |
| US201762491776P | 2017-04-28 | 2017-04-28 | |
| US201762545358P | 2017-08-14 | 2017-08-14 | |
| US201762576321P | 2017-10-24 | 2017-10-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20191206A1 true PE20191206A1 (es) | 2019-09-10 |
Family
ID=61025047
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2019001282A PE20191206A1 (es) | 2016-12-19 | 2017-12-19 | Composiciones de aminoacidos y metodos para el tratamiento de enfermedades y trastornos musculares |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US20180207119A1 (enExample) |
| EP (1) | EP3554493A1 (enExample) |
| JP (1) | JP2020502183A (enExample) |
| KR (1) | KR20190099243A (enExample) |
| CN (1) | CN110267655A (enExample) |
| AU (1) | AU2017379825A1 (enExample) |
| BR (1) | BR112019012476A2 (enExample) |
| CA (1) | CA3046558A1 (enExample) |
| CL (1) | CL2019001685A1 (enExample) |
| CO (1) | CO2019006292A2 (enExample) |
| CU (1) | CU20190057A7 (enExample) |
| EC (1) | ECSP19043725A (enExample) |
| IL (1) | IL267210A (enExample) |
| JO (1) | JOP20190147A1 (enExample) |
| MA (1) | MA50763A (enExample) |
| MX (1) | MX2019007352A (enExample) |
| PE (1) | PE20191206A1 (enExample) |
| PH (1) | PH12019501339A1 (enExample) |
| TW (1) | TWI780096B (enExample) |
| WO (1) | WO2018118957A1 (enExample) |
| ZA (1) | ZA201903581B (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JOP20190146A1 (ar) | 2016-12-19 | 2019-06-18 | Axcella Health Inc | تركيبات حمض أميني وطرق لمعالجة أمراض الكبد |
| US11617731B2 (en) | 2017-04-28 | 2023-04-04 | Axcella Health, Inc. | Amino acid compositions and their use for the treatment of traumatic brain injury |
| WO2019036442A1 (en) * | 2017-08-14 | 2019-02-21 | Axcella Health Inc. | AMINO ACIDS BRANCHED FOR THE TREATMENT OF NEURONAL INJURY |
| MA49906A (fr) | 2017-08-14 | 2020-06-24 | Axcella Health Inc | Acides aminés à chaîne ramifiée pour le traitement d'une maladie du foie |
| KR20210023846A (ko) | 2018-06-20 | 2021-03-04 | 악셀라 헬스 인크. | 아미노산 조성물을 제조하는 방법 |
| CN112839712A (zh) * | 2018-06-20 | 2021-05-25 | 胺细拉健康公司 | 用于减少或治疗发炎的组合物和方法 |
| CU20200106A7 (es) | 2018-06-20 | 2021-08-06 | Axcella Health Inc | Composiciones y métodos para el tratamiento de hemoglobinopatías y talasemias |
| EP3810123A1 (en) | 2018-06-20 | 2021-04-28 | Axcella Health Inc. | Compositions and methods for the treatment of fat infiltration in muscle |
| CN112752575A (zh) * | 2018-09-27 | 2021-05-04 | 雀巢产品有限公司 | 组氨酸、甘氨酸和其它氨基酸用于预防胰岛素抗性和/或糖尿病的用途 |
| BR112021021537A2 (pt) * | 2019-06-07 | 2022-04-19 | Nestle Sa | Composições e métodos que usam um ou mais aminoácidos indutores de autofagia para potencializar o efeito músculo-esquelético de um ou mais aminoácidos anabólicos |
| US20220184015A1 (en) * | 2019-06-20 | 2022-06-16 | Societe Des Produits Nestle S.A. | Compositions and methods to potentiate musculoskeletal effect of one or more anabolic amino acids on bone health |
| KR102456270B1 (ko) * | 2019-09-24 | 2022-10-19 | 마이오텍사이언스 주식회사 | 비천연 아미노산 유도체를 함유하는 근감소증의 예방 또는 치료용 약학적 조성물 |
| KR102338447B1 (ko) * | 2019-09-24 | 2021-12-14 | 마이오텍사이언스 주식회사 | 비천연 아미노산을 함유하는 근감소증의 예방 또는 치료용 약학적 조성물 |
| US20220331290A1 (en) * | 2019-09-24 | 2022-10-20 | Myo-Tec-Sci | Pharmaceutical composition for preventing or treating sarcopenia, containing unnatural amino acid |
| CN110801007A (zh) * | 2019-12-17 | 2020-02-18 | 苟春虎 | 老年肌少症营养肽 |
| US20230089723A1 (en) * | 2020-03-06 | 2023-03-23 | Axcella Health Inc. | Amino acid compositions and methods for muscle and myotube modulation |
| US20230390234A1 (en) * | 2021-02-26 | 2023-12-07 | Ex Healthcare Inc. | Composition inhibiting muscle loss or promoting muscle formation through skin-derived exosomes |
| CN113288890B (zh) * | 2021-06-21 | 2022-02-22 | 南方医科大学南方医院 | N-乙酰-l-半胱氨酸在制备预防和/或治疗运动损伤的药物中的应用 |
| WO2024026307A1 (en) | 2022-07-25 | 2024-02-01 | Axcella Health Inc. | Biomarker for long covid and fatigue |
| WO2024030909A1 (en) | 2022-08-01 | 2024-02-08 | Axcella Health Inc. | Biomarkers of amino acid composition treatment response in long covid |
| WO2025167857A1 (zh) * | 2024-02-06 | 2025-08-14 | 南京纽邦生物科技有限公司 | 用于增强或改善肌肉功能和/或提高运动表现和/或预防或缓解疲劳的方法和组合物 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA02007466A (es) * | 2000-02-01 | 2004-02-26 | Muscletech Res And Dev Inc | Suplemento alimenticio a base de acido alfa-lipoico para incrementar la masa muscular escas y la fuerza. |
| US20040087490A1 (en) * | 2002-09-20 | 2004-05-06 | Troup John P. | Nutritional compositions |
| WO2006009975A2 (en) * | 2004-06-22 | 2006-01-26 | Maxim Pharmaceuticals, Inc. | Histamine to treat disorders affecting muscle function |
| JP5545424B2 (ja) * | 2005-03-29 | 2014-07-09 | 味の素株式会社 | 高齢者の骨格筋量減少を防止又は改善するためのアミノ酸含有組成物 |
| JP2007023921A (ja) * | 2005-07-19 | 2007-02-01 | Toyota Motor Corp | 内燃機関の制御装置 |
| US20070286909A1 (en) * | 2006-06-07 | 2007-12-13 | Daniel S. Smith | Amino acid compositions |
| CN100518815C (zh) * | 2007-02-15 | 2009-07-29 | 北京苏里曼医药科技有限公司 | 一种氨基酸组合物 |
| AU2012299126B2 (en) * | 2011-08-19 | 2016-05-26 | Musclepharm Corporation | Compositions and methods for use in promoting lean body mass |
| WO2015061607A1 (en) * | 2013-10-23 | 2015-04-30 | Whitehead Institute For Biomedical Research | Mtorc1 modulation by amino acids and uses thereof |
-
2017
- 2017-06-16 JO JOP/2019/0147A patent/JOP20190147A1/ar unknown
- 2017-12-19 BR BR112019012476A patent/BR112019012476A2/pt not_active IP Right Cessation
- 2017-12-19 TW TW106144666A patent/TWI780096B/zh not_active IP Right Cessation
- 2017-12-19 JP JP2019532941A patent/JP2020502183A/ja active Pending
- 2017-12-19 WO PCT/US2017/067368 patent/WO2018118957A1/en not_active Ceased
- 2017-12-19 AU AU2017379825A patent/AU2017379825A1/en not_active Abandoned
- 2017-12-19 US US15/847,343 patent/US20180207119A1/en not_active Abandoned
- 2017-12-19 CN CN201780078594.XA patent/CN110267655A/zh active Pending
- 2017-12-19 MX MX2019007352A patent/MX2019007352A/es unknown
- 2017-12-19 CA CA3046558A patent/CA3046558A1/en active Pending
- 2017-12-19 PE PE2019001282A patent/PE20191206A1/es unknown
- 2017-12-19 EP EP17835529.3A patent/EP3554493A1/en not_active Withdrawn
- 2017-12-19 CU CU2019000057A patent/CU20190057A7/es unknown
- 2017-12-19 KR KR1020197020658A patent/KR20190099243A/ko not_active Ceased
- 2017-12-19 MA MA050763A patent/MA50763A/fr unknown
- 2017-12-29 US US15/858,475 patent/US20180169046A1/en not_active Abandoned
- 2017-12-29 US US15/858,605 patent/US20180169047A1/en not_active Abandoned
-
2019
- 2019-06-04 ZA ZA2019/03581A patent/ZA201903581B/en unknown
- 2019-06-10 IL IL267210A patent/IL267210A/en unknown
- 2019-06-13 PH PH12019501339A patent/PH12019501339A1/en unknown
- 2019-06-17 CO CONC2019/0006292A patent/CO2019006292A2/es unknown
- 2019-06-19 EC ECSENADI201943725A patent/ECSP19043725A/es unknown
- 2019-06-19 CL CL2019001685A patent/CL2019001685A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN110267655A (zh) | 2019-09-20 |
| JP2020502183A (ja) | 2020-01-23 |
| BR112019012476A2 (pt) | 2020-04-14 |
| ZA201903581B (en) | 2020-12-23 |
| CL2019001685A1 (es) | 2019-08-30 |
| IL267210A (en) | 2019-08-29 |
| US20180207119A1 (en) | 2018-07-26 |
| CU20190057A7 (es) | 2020-02-04 |
| WO2018118957A1 (en) | 2018-06-28 |
| AU2017379825A1 (en) | 2019-06-13 |
| US20180169047A1 (en) | 2018-06-21 |
| TWI780096B (zh) | 2022-10-11 |
| CA3046558A1 (en) | 2018-06-28 |
| MA50763A (fr) | 2019-10-23 |
| TW201827068A (zh) | 2018-08-01 |
| PH12019501339A1 (en) | 2019-09-30 |
| MX2019007352A (es) | 2019-09-05 |
| JOP20190147A1 (ar) | 2019-06-18 |
| CO2019006292A2 (es) | 2019-06-28 |
| KR20190099243A (ko) | 2019-08-26 |
| ECSP19043725A (es) | 2019-07-31 |
| EP3554493A1 (en) | 2019-10-23 |
| US20180169046A1 (en) | 2018-06-21 |
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