TWI780096B - 胺基酸組合物及肌肉疾病與病症之治療方法 - Google Patents
胺基酸組合物及肌肉疾病與病症之治療方法 Download PDFInfo
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| WO2018201024A1 (en) | 2017-04-28 | 2018-11-01 | Axcella Health Inc. | Amino acid compositions and their use for the treatment of traumatic brain injury |
| US20190046486A1 (en) * | 2017-08-14 | 2019-02-14 | Axcella Health Inc. | Compositions and methods for the treatment of neuronal injury |
| WO2019036471A1 (en) | 2017-08-14 | 2019-02-21 | Axcella Health Inc. | AMINO ACIDS BRANCHED FOR THE TREATMENT OF LIVER DISEASE |
| US20210260010A1 (en) * | 2018-06-20 | 2021-08-26 | Axcella Health Inc. | Compositions and methods for the reduction or treatment of inflammation |
| CU20200106A7 (es) | 2018-06-20 | 2021-08-06 | Axcella Health Inc | Composiciones y métodos para el tratamiento de hemoglobinopatías y talasemias |
| EP3810123A1 (en) | 2018-06-20 | 2021-04-28 | Axcella Health Inc. | Compositions and methods for the treatment of fat infiltration in muscle |
| BR112020025831A2 (pt) | 2018-06-20 | 2021-03-23 | Axcella Health Inc. | métodos de fabricação de composições de aminoácidos |
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| EP3980002A1 (en) | 2019-06-07 | 2022-04-13 | Société des Produits Nestlé S.A. | Compositions and methods using one or more autophagy-inducing amino acids to potentiate musculoskeletal effect of one or more anabolic amino acids |
| US20220184015A1 (en) * | 2019-06-20 | 2022-06-16 | Societe Des Produits Nestle S.A. | Compositions and methods to potentiate musculoskeletal effect of one or more anabolic amino acids on bone health |
| IT201900010437A1 (it) | 2019-06-28 | 2020-12-28 | Dompe Farm Spa | Composizione per il trattamento del deperimento muscolare |
| WO2021060880A1 (ko) * | 2019-09-24 | 2021-04-01 | 마이오텍사이언스 주식회사 | 비천연 아미노산을 함유하는 근감소증의 예방 또는 치료용 약학적 조성물 |
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| CN110801007A (zh) * | 2019-12-17 | 2020-02-18 | 苟春虎 | 老年肌少症营养肽 |
| US20230089723A1 (en) * | 2020-03-06 | 2023-03-23 | Axcella Health Inc. | Amino acid compositions and methods for muscle and myotube modulation |
| US20230390234A1 (en) * | 2021-02-26 | 2023-12-07 | Ex Healthcare Inc. | Composition inhibiting muscle loss or promoting muscle formation through skin-derived exosomes |
| CN113288890B (zh) * | 2021-06-21 | 2022-02-22 | 南方医科大学南方医院 | N-乙酰-l-半胱氨酸在制备预防和/或治疗运动损伤的药物中的应用 |
| WO2024026307A1 (en) | 2022-07-25 | 2024-02-01 | Axcella Health Inc. | Biomarker for long covid and fatigue |
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| WO2025167857A1 (zh) * | 2024-02-06 | 2025-08-14 | 南京纽邦生物科技有限公司 | 用于增强或改善肌肉功能和/或提高运动表现和/或预防或缓解疲劳的方法和组合物 |
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| WO2015061607A1 (en) * | 2013-10-23 | 2015-04-30 | Whitehead Institute For Biomedical Research | Mtorc1 modulation by amino acids and uses thereof |
Non-Patent Citations (3)
| Title |
|---|
| 期刊 Lambertucci AC, et al. "Glutamine Supplementation Stimulates Protein-Synthetic and Inhibits Protein-Degradative Signaling Pathways in Skeletal Muscle of Diabetic Rats" PLOS ONE 7(12): 2012; e50390; * |
| 期刊 Medved I, et al. "N-acetylcysteine enhances muscle cysteine and glutathione availability and attenuates fatigue during prolonged exercise in endurance-trained individuals" J Appl Physiol 97: 2004; 1477–1485; * |
| 期刊 Moberg M, et al. "Activation of mTORC1 by leucine is potentiated by ranched-chain amino acids and even more so by essential amino acids following resistance exercise" Am J Physiol Cell Physiol 310: First published April 6, 2016 C874–C884. * |
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| EP3554493A1 (en) | 2019-10-23 |
| JP2020502183A (ja) | 2020-01-23 |
| CU20190057A7 (es) | 2020-02-04 |
| KR20190099243A (ko) | 2019-08-26 |
| PH12019501339A1 (en) | 2019-09-30 |
| CA3046558A1 (en) | 2018-06-28 |
| US20180207119A1 (en) | 2018-07-26 |
| CN110267655A (zh) | 2019-09-20 |
| ZA201903581B (en) | 2020-12-23 |
| CO2019006292A2 (es) | 2019-06-28 |
| BR112019012476A2 (pt) | 2020-04-14 |
| US20180169046A1 (en) | 2018-06-21 |
| WO2018118957A1 (en) | 2018-06-28 |
| US20180169047A1 (en) | 2018-06-21 |
| ECSP19043725A (es) | 2019-07-31 |
| TW201827068A (zh) | 2018-08-01 |
| JOP20190147A1 (ar) | 2019-06-18 |
| IL267210A (en) | 2019-08-29 |
| CL2019001685A1 (es) | 2019-08-30 |
| MA50763A (fr) | 2019-10-23 |
| AU2017379825A1 (en) | 2019-06-13 |
| MX2019007352A (es) | 2019-09-05 |
| PE20191206A1 (es) | 2019-09-10 |
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