PE20190504A1 - Moduladores del receptor nmda espiro-lactam y uso de los mismos - Google Patents
Moduladores del receptor nmda espiro-lactam y uso de los mismosInfo
- Publication number
- PE20190504A1 PE20190504A1 PE2019000297A PE2019000297A PE20190504A1 PE 20190504 A1 PE20190504 A1 PE 20190504A1 PE 2019000297 A PE2019000297 A PE 2019000297A PE 2019000297 A PE2019000297 A PE 2019000297A PE 20190504 A1 PE20190504 A1 PE 20190504A1
- Authority
- PE
- Peru
- Prior art keywords
- nmda
- independently selected
- espiro
- lactam
- same
- Prior art date
Links
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 238000002648 combination therapy Methods 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/499—Spiro-condensed pyrazines or piperazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662369456P | 2016-08-01 | 2016-08-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20190504A1 true PE20190504A1 (es) | 2019-04-10 |
Family
ID=59593191
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2019000297A PE20190504A1 (es) | 2016-08-01 | 2017-08-01 | Moduladores del receptor nmda espiro-lactam y uso de los mismos |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US10918637B2 (enExample) |
| EP (1) | EP3490993B1 (enExample) |
| JP (1) | JP7032378B2 (enExample) |
| KR (1) | KR102465757B1 (enExample) |
| CN (1) | CN109890825B (enExample) |
| AU (1) | AU2017305240B2 (enExample) |
| CA (1) | CA3031539C (enExample) |
| CL (1) | CL2019000247A1 (enExample) |
| CO (1) | CO2019000943A2 (enExample) |
| EA (1) | EA201990428A1 (enExample) |
| ES (1) | ES2973283T3 (enExample) |
| IL (2) | IL286107B2 (enExample) |
| MX (1) | MX386938B (enExample) |
| PE (1) | PE20190504A1 (enExample) |
| PH (1) | PH12019500206A1 (enExample) |
| SG (1) | SG11201900551WA (enExample) |
| WO (1) | WO2018026782A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010033757A1 (en) | 2008-09-18 | 2010-03-25 | Naurex, Inc. | Nmda receptor modulators and uses thereof |
| ES2935352T3 (es) | 2013-01-29 | 2023-03-06 | Aptinyx Inc | Moduladores de receptores NMDA de espiro-lactama y sus usos |
| KR101518972B1 (ko) | 2014-08-01 | 2015-05-18 | 제이더블유크레아젠 주식회사 | 수지상세포의 제조방법, 이에 의해 제조된 수지상세포 및 그 용도 |
| JP2019527235A (ja) | 2016-08-01 | 2019-09-26 | アプティニックス インコーポレイテッド | スピロ−ラクタム及びビス−スピロ−ラクタムｎｍｄａ受容体修飾因子及びその使用 |
| KR102503590B1 (ko) | 2016-08-01 | 2023-02-24 | 앱티닉스 인크. | 스피로-락탐 nmda 수용체 조정제 및 그의 용도 |
| SG11201900551WA (en) | 2016-08-01 | 2019-02-27 | Aptinyx Inc | Spiro-lactam nmda receptor modulators and uses thereof |
| CA3031563C (en) | 2016-08-01 | 2023-12-05 | Aptinyx Inc. | Spiro-lactam nmda modulators and methods of using same |
| EA201990424A1 (ru) | 2016-08-01 | 2019-08-30 | Аптиникс Инк. | Спиролактамовые модуляторы nmda-рецептора и их применение |
| SG11202007256PA (en) | 2018-01-31 | 2020-08-28 | Aptinyx Inc | Spiro-lactam nmda receptor modulators and uses thereof |
| US12012413B2 (en) | 2019-11-11 | 2024-06-18 | Tenacia Biotechnology (Hong Kong) Co., Limited | Methods of treating painful diabetic peripheral neuropathy |
| MX2022015168A (es) | 2020-06-03 | 2023-01-16 | Aptinyx Inc | Compuestos de espirolactama y metodos para tratar infecciones virales usando los mismos. |
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| BR112012020142A2 (pt) | 2010-02-11 | 2020-08-18 | Northwestern University | moduladores do receptor de nmda com estrutura secundária estabilizada e usos dos mesmos. |
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| ES2935352T3 (es) | 2013-01-29 | 2023-03-06 | Aptinyx Inc | Moduladores de receptores NMDA de espiro-lactama y sus usos |
| MX375286B (es) | 2013-01-29 | 2025-03-06 | Aptinyx Inc | Moduladores de receptores nmda de espiro-lactama y sus usos. |
| BR112015018094A2 (pt) * | 2013-01-29 | 2017-07-18 | Naurex Inc | moduladores de receptor nmda de espiro-lactama e usos dos mesmos |
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| WO2017201285A1 (en) | 2016-05-19 | 2017-11-23 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
| KR102128675B1 (ko) | 2016-05-19 | 2020-06-30 | 앱티닉스 인크. | 스피로-락탐 nmda 수용체 조정제 및 그의 용도 |
| CA3031563C (en) | 2016-08-01 | 2023-12-05 | Aptinyx Inc. | Spiro-lactam nmda modulators and methods of using same |
| KR102503590B1 (ko) | 2016-08-01 | 2023-02-24 | 앱티닉스 인크. | 스피로-락탐 nmda 수용체 조정제 및 그의 용도 |
| SG11201900551WA (en) | 2016-08-01 | 2019-02-27 | Aptinyx Inc | Spiro-lactam nmda receptor modulators and uses thereof |
| EA201990424A1 (ru) | 2016-08-01 | 2019-08-30 | Аптиникс Инк. | Спиролактамовые модуляторы nmda-рецептора и их применение |
| JP2019527235A (ja) | 2016-08-01 | 2019-09-26 | アプティニックス インコーポレイテッド | スピロ−ラクタム及びビス−スピロ−ラクタムｎｍｄａ受容体修飾因子及びその使用 |
| PE20211455A1 (es) | 2018-01-31 | 2021-08-05 | Aptinyx Inc | Moduladores del receptor nmda espiro-lactama y usos de los mismos |
| SG11202007256PA (en) | 2018-01-31 | 2020-08-28 | Aptinyx Inc | Spiro-lactam nmda receptor modulators and uses thereof |
| US12012413B2 (en) | 2019-11-11 | 2024-06-18 | Tenacia Biotechnology (Hong Kong) Co., Limited | Methods of treating painful diabetic peripheral neuropathy |
-
2017
- 2017-08-01 SG SG11201900551WA patent/SG11201900551WA/en unknown
- 2017-08-01 EA EA201990428A patent/EA201990428A1/ru unknown
- 2017-08-01 PE PE2019000297A patent/PE20190504A1/es unknown
- 2017-08-01 IL IL286107A patent/IL286107B2/en unknown
- 2017-08-01 US US16/321,903 patent/US10918637B2/en active Active
- 2017-08-01 WO PCT/US2017/044841 patent/WO2018026782A1/en not_active Ceased
- 2017-08-01 CN CN201780048070.6A patent/CN109890825B/zh active Active
- 2017-08-01 CA CA3031539A patent/CA3031539C/en active Active
- 2017-08-01 AU AU2017305240A patent/AU2017305240B2/en not_active Ceased
- 2017-08-01 MX MX2019001321A patent/MX386938B/es unknown
- 2017-08-01 JP JP2019505249A patent/JP7032378B2/ja active Active
- 2017-08-01 EP EP17751913.9A patent/EP3490993B1/en active Active
- 2017-08-01 ES ES17751913T patent/ES2973283T3/es active Active
- 2017-08-01 KR KR1020197005662A patent/KR102465757B1/ko active Active
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2019
- 2019-01-27 IL IL264495A patent/IL264495B/en unknown
- 2019-01-28 PH PH12019500206A patent/PH12019500206A1/en unknown
- 2019-01-30 CL CL2019000247A patent/CL2019000247A1/es unknown
- 2019-01-30 CO CONC2019/0000943A patent/CO2019000943A2/es unknown
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2020
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2022
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Also Published As
| Publication number | Publication date |
|---|---|
| EA201990428A1 (ru) | 2019-08-30 |
| AU2017305240B2 (en) | 2021-12-09 |
| JP7032378B2 (ja) | 2022-03-08 |
| CN109890825B (zh) | 2022-03-11 |
| IL264495B (en) | 2021-09-30 |
| IL286107A (en) | 2021-10-31 |
| KR20190033594A (ko) | 2019-03-29 |
| CA3031539C (en) | 2023-11-28 |
| JP2019527234A (ja) | 2019-09-26 |
| US20230131402A1 (en) | 2023-04-27 |
| WO2018026782A1 (en) | 2018-02-08 |
| US20210322406A1 (en) | 2021-10-21 |
| AU2017305240A1 (en) | 2019-02-28 |
| EP3490993A1 (en) | 2019-06-05 |
| CA3031539A1 (en) | 2018-02-08 |
| ES2973283T3 (es) | 2024-06-19 |
| US10918637B2 (en) | 2021-02-16 |
| KR102465757B1 (ko) | 2022-11-09 |
| SG11201900551WA (en) | 2019-02-27 |
| EP3490993B1 (en) | 2023-12-06 |
| US20190175588A1 (en) | 2019-06-13 |
| CO2019000943A2 (es) | 2019-02-08 |
| US11376250B2 (en) | 2022-07-05 |
| EP3490993C0 (en) | 2023-12-06 |
| MX386938B (es) | 2025-03-19 |
| IL286107B1 (en) | 2024-05-01 |
| MX2019001321A (es) | 2019-07-04 |
| PH12019500206A1 (en) | 2019-06-17 |
| CL2019000247A1 (es) | 2019-06-21 |
| CN109890825A (zh) | 2019-06-14 |
| IL286107B2 (en) | 2024-09-01 |
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