JP7032378B2 - スピロ－ラクタムｎｍｄａ受容体修飾因子及びその使用 - Google Patents

スピロ－ラクタムｎｍｄａ受容体修飾因子及びその使用 Download PDF

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JP7032378B2
JP7032378B2 JP2019505249A JP2019505249A JP7032378B2 JP 7032378 B2 JP7032378 B2 JP 7032378B2 JP 2019505249 A JP2019505249 A JP 2019505249A JP 2019505249 A JP2019505249 A JP 2019505249A JP 7032378 B2 JP7032378 B2 JP 7032378B2
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JP2019527234A5 (enExample
JP2019527234A (ja
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カーン，エム．，アミン
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アプティニックス インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/499—Spiro-condensed pyrazines or piperazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2019505249A 2016-08-01 2017-08-01 スピロ－ラクタムｎｍｄａ受容体修飾因子及びその使用 Active JP7032378B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662369456P 2016-08-01 2016-08-01
US62/369,456 2016-08-01
PCT/US2017/044841 WO2018026782A1 (en) 2016-08-01 2017-08-01 Spiro-lactam nmda receptor modulators and uses thereof

Publications (3)

Publication Number Publication Date
JP2019527234A JP2019527234A (ja) 2019-09-26
JP2019527234A5 JP2019527234A5 (enExample) 2020-09-17
JP7032378B2 true JP7032378B2 (ja) 2022-03-08

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JP2019505249A Active JP7032378B2 (ja) 2016-08-01 2017-08-01 スピロ－ラクタムｎｍｄａ受容体修飾因子及びその使用

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US (3) US10918637B2 (enExample)
EP (1) EP3490993B1 (enExample)
JP (1) JP7032378B2 (enExample)
KR (1) KR102465757B1 (enExample)
CN (1) CN109890825B (enExample)
AU (1) AU2017305240B2 (enExample)
CA (1) CA3031539C (enExample)
CL (1) CL2019000247A1 (enExample)
CO (1) CO2019000943A2 (enExample)
EA (1) EA201990428A1 (enExample)
ES (1) ES2973283T3 (enExample)
IL (2) IL286107B2 (enExample)
MX (1) MX386938B (enExample)
PE (1) PE20190504A1 (enExample)
PH (1) PH12019500206A1 (enExample)
SG (1) SG11201900551WA (enExample)
WO (1) WO2018026782A1 (enExample)

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CA2898861C (en) 2013-01-29 2021-07-20 Naurex, Inc. Spiro-lactam nmda receptor modulators and uses thereof
KR101518972B1 (ko) 2014-08-01 2015-05-18 제이더블유크레아젠 주식회사 수지상세포의 제조방법, 이에 의해 제조된 수지상세포 및 그 용도
CA3031534C (en) 2016-08-01 2023-10-17 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
JP2019527235A (ja) 2016-08-01 2019-09-26 アプティニックス インコーポレイテッド スピロ−ラクタム及びビス−スピロ−ラクタムｎｍｄａ受容体修飾因子及びその使用
PE20190501A1 (es) 2016-08-01 2019-04-10 Aptinyx Inc Moduladores nmda espiro-lactam y metodos de uso de los mismos
CN109890825B (zh) 2016-08-01 2022-03-11 阿普廷伊克斯股份有限公司 螺-内酰胺nmda受体调节剂及其用途
EP3490992B1 (en) 2016-08-01 2023-03-22 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
PE20210455A1 (es) 2018-01-31 2021-03-08 Aptinyx Inc Moduladores del receptor nmda espiro-lactama y usos de los mismos
US12012413B2 (en) 2019-11-11 2024-06-18 Tenacia Biotechnology (Hong Kong) Co., Limited Methods of treating painful diabetic peripheral neuropathy
IL298343A (en) 2020-06-03 2023-01-01 Aptinyx Inc Spiro-lactam compounds and methods for treating viral infections

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IL286107B2 (en) 2024-09-01
EP3490993A1 (en) 2019-06-05
WO2018026782A1 (en) 2018-02-08
IL286107B1 (en) 2024-05-01
US11376250B2 (en) 2022-07-05
US10918637B2 (en) 2021-02-16
SG11201900551WA (en) 2019-02-27
MX2019001321A (es) 2019-07-04
EP3490993C0 (en) 2023-12-06
CN109890825A (zh) 2019-06-14
US20230131402A1 (en) 2023-04-27
KR20190033594A (ko) 2019-03-29
AU2017305240A1 (en) 2019-02-28
IL264495B (en) 2021-09-30
CA3031539A1 (en) 2018-02-08
CL2019000247A1 (es) 2019-06-21
PH12019500206A1 (en) 2019-06-17
CA3031539C (en) 2023-11-28
EP3490993B1 (en) 2023-12-06
CN109890825B (zh) 2022-03-11
PE20190504A1 (es) 2019-04-10
CO2019000943A2 (es) 2019-02-08
KR102465757B1 (ko) 2022-11-09
ES2973283T3 (es) 2024-06-19
MX386938B (es) 2025-03-19
US20210322406A1 (en) 2021-10-21
US20190175588A1 (en) 2019-06-13
IL286107A (en) 2021-10-31
AU2017305240B2 (en) 2021-12-09
JP2019527234A (ja) 2019-09-26
EA201990428A1 (ru) 2019-08-30

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