MX2019001321A - Moduladores del receptor nmda espiro-lactam y uso de los mismos. - Google Patents
Moduladores del receptor nmda espiro-lactam y uso de los mismos.Info
- Publication number
- MX2019001321A MX2019001321A MX2019001321A MX2019001321A MX2019001321A MX 2019001321 A MX2019001321 A MX 2019001321A MX 2019001321 A MX2019001321 A MX 2019001321A MX 2019001321 A MX2019001321 A MX 2019001321A MX 2019001321 A MX2019001321 A MX 2019001321A
- Authority
- MX
- Mexico
- Prior art keywords
- nmda receptor
- spiro
- receptor modulators
- compounds
- lactam nmda
- Prior art date
Links
- 102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 title abstract 2
- 108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 238000009472 formulation Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 238000001990 intravenous administration Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/499—Spiro-condensed pyrazines or piperazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Se describen los compuestos que tienen potencia en la modulación de la actividad del receptor de NMDA. Tales compuestos pueden ser usados en el tratamiento de afecciones tal como depresión y trastornos relacionados. También se describen formulaciones administradas por vía oral y otras formas de administración farmacéuticamente aceptables de los compuestos, incluidas las formulaciones intravenosas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662369456P | 2016-08-01 | 2016-08-01 | |
PCT/US2017/044841 WO2018026782A1 (en) | 2016-08-01 | 2017-08-01 | Spiro-lactam nmda receptor modulators and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019001321A true MX2019001321A (es) | 2019-07-04 |
Family
ID=59593191
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019001321A MX2019001321A (es) | 2016-08-01 | 2017-08-01 | Moduladores del receptor nmda espiro-lactam y uso de los mismos. |
Country Status (17)
Country | Link |
---|---|
US (3) | US10918637B2 (es) |
EP (1) | EP3490993B1 (es) |
JP (1) | JP7032378B2 (es) |
KR (1) | KR102465757B1 (es) |
CN (1) | CN109890825B (es) |
AU (1) | AU2017305240B2 (es) |
CA (1) | CA3031539C (es) |
CL (1) | CL2019000247A1 (es) |
CO (1) | CO2019000943A2 (es) |
EA (1) | EA201990428A1 (es) |
ES (1) | ES2973283T3 (es) |
IL (2) | IL286107B1 (es) |
MX (1) | MX2019001321A (es) |
PE (1) | PE20190504A1 (es) |
PH (1) | PH12019500206A1 (es) |
SG (1) | SG11201900551WA (es) |
WO (1) | WO2018026782A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2011003015A (es) | 2008-09-18 | 2011-11-18 | Univ Northwestern | Moduladores del receptor de n-metil-d-aspartato, y usos de los mismos. |
ES2935352T3 (es) | 2013-01-29 | 2023-03-06 | Aptinyx Inc | Moduladores de receptores NMDA de espiro-lactama y sus usos |
KR101518972B1 (ko) | 2014-08-01 | 2015-05-18 | 제이더블유크레아젠 주식회사 | 수지상세포의 제조방법, 이에 의해 제조된 수지상세포 및 그 용도 |
AU2017306164B2 (en) | 2016-08-01 | 2021-10-21 | Aptinyx Inc. | Spiro-lactam NMDA modulators and methods of using same |
CA3031534C (en) | 2016-08-01 | 2023-10-17 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
CN109661398B (zh) | 2016-08-01 | 2022-07-05 | 阿普廷伊克斯股份有限公司 | 螺-内酰胺和二-螺-内酰胺nmda受体调节剂及其用途 |
BR112019001768A2 (pt) | 2016-08-01 | 2019-06-11 | Aptinyx Inc | moduladores do receptor de spiro-lactamas nmda e usos dos mesmos |
ES2973283T3 (es) | 2016-08-01 | 2024-06-19 | Tenacia Biotechnology Hong Kong Co Ltd | Moduladores de receptores de NMDA espirolactámicos y usos de los mismos |
WO2019152687A1 (en) | 2018-01-31 | 2019-08-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
US12012413B2 (en) | 2019-11-11 | 2024-06-18 | Tenacia Biotechnology (Hong Kong) Co., Limited | Methods of treating painful diabetic peripheral neuropathy |
CA3184348A1 (en) | 2020-06-03 | 2021-12-09 | Aptinyx Inc. | Spiro-lactam compounds and methods of treating viral infections using the same |
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ES2935352T3 (es) * | 2013-01-29 | 2023-03-06 | Aptinyx Inc | Moduladores de receptores NMDA de espiro-lactama y sus usos |
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BR112019001768A2 (pt) | 2016-08-01 | 2019-06-11 | Aptinyx Inc | moduladores do receptor de spiro-lactamas nmda e usos dos mesmos |
CA3031534C (en) | 2016-08-01 | 2023-10-17 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
ES2973283T3 (es) * | 2016-08-01 | 2024-06-19 | Tenacia Biotechnology Hong Kong Co Ltd | Moduladores de receptores de NMDA espirolactámicos y usos de los mismos |
CN109661398B (zh) | 2016-08-01 | 2022-07-05 | 阿普廷伊克斯股份有限公司 | 螺-内酰胺和二-螺-内酰胺nmda受体调节剂及其用途 |
AU2017306164B2 (en) | 2016-08-01 | 2021-10-21 | Aptinyx Inc. | Spiro-lactam NMDA modulators and methods of using same |
WO2019152687A1 (en) | 2018-01-31 | 2019-08-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
SG11202007251XA (en) | 2018-01-31 | 2020-08-28 | Aptinyx Inc | Spiro-lactam nmda receptor modulators and uses thereof |
US12012413B2 (en) | 2019-11-11 | 2024-06-18 | Tenacia Biotechnology (Hong Kong) Co., Limited | Methods of treating painful diabetic peripheral neuropathy |
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2017
- 2017-08-01 ES ES17751913T patent/ES2973283T3/es active Active
- 2017-08-01 PE PE2019000297A patent/PE20190504A1/es unknown
- 2017-08-01 US US16/321,903 patent/US10918637B2/en active Active
- 2017-08-01 IL IL286107A patent/IL286107B1/en unknown
- 2017-08-01 JP JP2019505249A patent/JP7032378B2/ja active Active
- 2017-08-01 CN CN201780048070.6A patent/CN109890825B/zh active Active
- 2017-08-01 CA CA3031539A patent/CA3031539C/en active Active
- 2017-08-01 SG SG11201900551WA patent/SG11201900551WA/en unknown
- 2017-08-01 MX MX2019001321A patent/MX2019001321A/es unknown
- 2017-08-01 EP EP17751913.9A patent/EP3490993B1/en active Active
- 2017-08-01 EA EA201990428A patent/EA201990428A1/ru unknown
- 2017-08-01 WO PCT/US2017/044841 patent/WO2018026782A1/en unknown
- 2017-08-01 KR KR1020197005662A patent/KR102465757B1/ko active IP Right Grant
- 2017-08-01 AU AU2017305240A patent/AU2017305240B2/en not_active Ceased
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2019
- 2019-01-27 IL IL264495A patent/IL264495B/en unknown
- 2019-01-28 PH PH12019500206A patent/PH12019500206A1/en unknown
- 2019-01-30 CL CL2019000247A patent/CL2019000247A1/es unknown
- 2019-01-30 CO CONC2019/0000943A patent/CO2019000943A2/es unknown
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2020
- 2020-12-01 US US17/108,199 patent/US11376250B2/en active Active
-
2022
- 2022-06-03 US US17/831,544 patent/US20230131402A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20230131402A1 (en) | 2023-04-27 |
PE20190504A1 (es) | 2019-04-10 |
IL286107B1 (en) | 2024-05-01 |
EP3490993B1 (en) | 2023-12-06 |
JP7032378B2 (ja) | 2022-03-08 |
CN109890825B (zh) | 2022-03-11 |
KR20190033594A (ko) | 2019-03-29 |
EA201990428A1 (ru) | 2019-08-30 |
CA3031539A1 (en) | 2018-02-08 |
CL2019000247A1 (es) | 2019-06-21 |
IL286107A (en) | 2021-10-31 |
AU2017305240A1 (en) | 2019-02-28 |
SG11201900551WA (en) | 2019-02-27 |
EP3490993A1 (en) | 2019-06-05 |
WO2018026782A1 (en) | 2018-02-08 |
ES2973283T3 (es) | 2024-06-19 |
US20190175588A1 (en) | 2019-06-13 |
PH12019500206A1 (en) | 2019-06-17 |
CO2019000943A2 (es) | 2019-02-08 |
AU2017305240B2 (en) | 2021-12-09 |
KR102465757B1 (ko) | 2022-11-09 |
US10918637B2 (en) | 2021-02-16 |
US20210322406A1 (en) | 2021-10-21 |
US11376250B2 (en) | 2022-07-05 |
CA3031539C (en) | 2023-11-28 |
EP3490993C0 (en) | 2023-12-06 |
IL264495B (en) | 2021-09-30 |
CN109890825A (zh) | 2019-06-14 |
JP2019527234A (ja) | 2019-09-26 |
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