PE20140883A1 - Proceso para preparar una composicion de vacuna - Google Patents
Proceso para preparar una composicion de vacunaInfo
- Publication number
- PE20140883A1 PE20140883A1 PE2013002365A PE2013002365A PE20140883A1 PE 20140883 A1 PE20140883 A1 PE 20140883A1 PE 2013002365 A PE2013002365 A PE 2013002365A PE 2013002365 A PE2013002365 A PE 2013002365A PE 20140883 A1 PE20140883 A1 PE 20140883A1
- Authority
- PE
- Peru
- Prior art keywords
- pollen
- solution
- modified
- composition
- filtration
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 6
- 229960005486 vaccine Drugs 0.000 title 1
- 239000000427 antigen Substances 0.000 abstract 4
- 102000036639 antigens Human genes 0.000 abstract 4
- 108091007433 antigens Proteins 0.000 abstract 4
- 238000001914 filtration Methods 0.000 abstract 4
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical group O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 abstract 3
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 3
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 abstract 3
- 239000002156 adsorbate Substances 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 239000011260 aqueous acid Substances 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 238000009413 insulation Methods 0.000 abstract 1
- 238000002156 mixing Methods 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 230000003472 neutralizing effect Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
- 230000000717 retained effect Effects 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 238000011146 sterile filtration Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
- A61K39/36—Allergens from pollen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
- A61K2039/622—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier non-covalent binding
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
SE REFIERE A UNA COMPOSICION ESTERIL QUE COMPRENDE UN ANTIGENO DE POLEN MODIFICADO CON GLUTARALDEHIDO ADSORBIDO EN UN AMINOACIDO TAL COMO TIROSINA. TAMBIEN SE REFIERE A UN METODO DE PREPARACION DE DICHA COMPOSICION QUE COMPRENDE: A) LA EXTRACCION DEL ANTIGENO DE POLEN EN UNA SOLUCION PARA FORMAR UNA SOLUCION DE EXTRACTO DE POLEN; B) LA FILTRACION DE LA SOLUCION DE EXTRACTO DE POLEN PARA ELIMINAR LOS SOLIDOS; C) APLICACION DE FILTRACION TANGENCIAL Y AISLAMIENTO DEL RETENIDO QUE COMPRENDE EL ANTIGENO DE POLEN; D) MODIFICACION DEL ANTIGENO DE POLEN CON GLUTARALDEHIDO; E) ELIMINACION DEL EXCEDENTE DE GLUTARALDEHIDO UTILIZANDO FILTRACION TANGENCIAL PARA FORMAR UNA SOLUCION DE POLEN MODIFICADO; F) FILTRACION ESTERIL DE LA SOLUCION DE POLEN MODIFICADO; G) MEZCLAR LA SOLUCION DE POLEN MODIFICADO CON UNA SOLUCION DE TIROSINA EN UN ACIDO ACUOSO A LA VEZ DE NEUTRALIZAR LA MEZCLA DE LAS SOLUCIONES PARA FORMAR UN ADSORBATO QUE COMPRENDE EL POLEN MODIFICADO Y LA TIROSINA; H) SEPARACION DEL ADSORBATO EN UN TAMPON MEDIANTE FILTRACION TANGENCIAL PARA FORMAR LA COMPOSICION; E I) RECUPERACION DE LA COMPOSICION
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1106802.0A GB201106802D0 (en) | 2011-04-21 | 2011-04-21 | Process for preparing vaccine composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20140883A1 true PE20140883A1 (es) | 2014-08-01 |
Family
ID=44147385
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2013002365A PE20140883A1 (es) | 2011-04-21 | 2012-04-20 | Proceso para preparar una composicion de vacuna |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US9731004B2 (es) |
| EP (1) | EP2699255B1 (es) |
| JP (1) | JP6175051B2 (es) |
| KR (1) | KR101945265B1 (es) |
| CN (1) | CN103608034B (es) |
| AU (1) | AU2012246087B2 (es) |
| BR (1) | BR112013026759B1 (es) |
| CA (1) | CA2833319C (es) |
| CL (1) | CL2013003033A1 (es) |
| CO (1) | CO6910162A2 (es) |
| DK (1) | DK2699255T3 (es) |
| ES (1) | ES2613089T3 (es) |
| GB (2) | GB201106802D0 (es) |
| HU (1) | HUE030623T2 (es) |
| MX (1) | MX345947B (es) |
| PE (1) | PE20140883A1 (es) |
| PL (1) | PL2699255T3 (es) |
| PT (1) | PT2699255T (es) |
| WO (1) | WO2012143732A1 (es) |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4070455A (en) | 1974-02-16 | 1978-01-24 | Beecham Group Limited | Process for preparing injectable desensitizing compositions and products thereof in microparticle form |
| US4234569A (en) * | 1978-10-04 | 1980-11-18 | The Johns Hopkins University | Production of aldehyde-treated allergen-containing substances |
| US4987237A (en) | 1983-08-26 | 1991-01-22 | Ribi Immunochem Research, Inc. | Derivatives of monophosphoryl lipid A |
| EP0192321A3 (en) | 1985-01-19 | 1987-09-02 | Beecham Group Plc | Enteric coated allergen pharmaceutical composition |
| GB8501400D0 (en) * | 1985-01-19 | 1985-02-20 | Beecham Group Plc | Compositions |
| JPS63159324A (ja) | 1986-12-22 | 1988-07-02 | Lion Corp | スギ花粉症用経口ワクチン |
| US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
| ES2013359A6 (es) * | 1988-11-04 | 1990-05-01 | Corporacion Biolog Farmaceutic | Procedimiento para la fabricacion de alergenos inmunogenicos polimerizados. |
| US5480972A (en) * | 1992-10-30 | 1996-01-02 | The University Of Melbourne | Allergenic proteins from Johnson grass pollen |
| JPH06329553A (ja) | 1993-05-25 | 1994-11-29 | Hitachi Chem Co Ltd | 花粉内容物の抽出方法 |
| GB9508785D0 (en) * | 1995-04-29 | 1995-06-21 | Smithkline Beecham Plc | Novel compositions |
| GB9706957D0 (en) * | 1997-04-05 | 1997-05-21 | Smithkline Beecham Plc | Formulation |
| GB9820525D0 (en) * | 1998-09-21 | 1998-11-11 | Allergy Therapeutics Ltd | Formulation |
| US7695627B2 (en) | 2002-06-19 | 2010-04-13 | Northwest Biotherapeutics, Inc. | Tangential flow filtration devices and methods for leukocyte enrichment |
| CA2497723A1 (en) | 2002-09-11 | 2004-03-25 | Tanabe Seiyaku Co., Ltd. | Method for preparation of microspheres and apparatus therefor |
| US7790039B2 (en) * | 2003-11-24 | 2010-09-07 | Northwest Biotherapeutics, Inc. | Tangential flow filtration devices and methods for stem cell enrichment |
| AU2005242409A1 (en) | 2004-05-19 | 2005-11-24 | Alza Corporation | Method and formulation for transdermal delivery of immunologically active agents |
| JP5061099B2 (ja) | 2005-05-24 | 2012-10-31 | ネオヴァク | ＴＮＦαと担体タンパク質との抗原性ヘテロ複合体を含む安定な免疫原性生成物の製造方法 |
| FR2888582B1 (fr) * | 2005-07-15 | 2010-08-20 | Solvay | Procede de preparation d'un polymere halogene et dispositif pour sa mise en oeuvre |
| JP2010029109A (ja) | 2008-07-29 | 2010-02-12 | Ihi Corp | サンプリング装置およびこれを用いたサンプリング方法 |
| GB0917003D0 (en) | 2009-09-28 | 2009-11-11 | Novartis Vaccines Inst For Global Health Srl | Purification of bacterial vesicles |
| CN101972472A (zh) | 2010-10-26 | 2011-02-16 | 北京新华联协和药业有限责任公司 | 一种变应原疫苗纯化及其制备的方法 |
-
2011
- 2011-04-21 GB GBGB1106802.0A patent/GB201106802D0/en not_active Ceased
-
2012
- 2012-04-20 ES ES12719034.6T patent/ES2613089T3/es active Active
- 2012-04-20 KR KR1020137030934A patent/KR101945265B1/ko active IP Right Grant
- 2012-04-20 AU AU2012246087A patent/AU2012246087B2/en active Active
- 2012-04-20 CA CA2833319A patent/CA2833319C/en active Active
- 2012-04-20 WO PCT/GB2012/050883 patent/WO2012143732A1/en active Application Filing
- 2012-04-20 BR BR112013026759-3A patent/BR112013026759B1/pt active IP Right Grant
- 2012-04-20 HU HUE12719034A patent/HUE030623T2/en unknown
- 2012-04-20 US US14/112,544 patent/US9731004B2/en active Active
- 2012-04-20 PE PE2013002365A patent/PE20140883A1/es active IP Right Grant
- 2012-04-20 JP JP2014505725A patent/JP6175051B2/ja active Active
- 2012-04-20 GB GB1320508.3A patent/GB2504444B/en active Active
- 2012-04-20 PT PT127190346T patent/PT2699255T/pt unknown
- 2012-04-20 CN CN201280030190.0A patent/CN103608034B/zh active Active
- 2012-04-20 DK DK12719034.6T patent/DK2699255T3/en active
- 2012-04-20 MX MX2013012207A patent/MX345947B/es active IP Right Grant
- 2012-04-20 PL PL12719034T patent/PL2699255T3/pl unknown
- 2012-04-20 EP EP12719034.6A patent/EP2699255B1/en active Active
-
2013
- 2013-10-18 CL CL2013003033A patent/CL2013003033A1/es unknown
- 2013-10-28 CO CO13255473A patent/CO6910162A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK2699255T3 (en) | 2017-02-13 |
| PT2699255T (pt) | 2017-01-17 |
| EP2699255B1 (en) | 2016-11-02 |
| MX345947B (es) | 2017-02-27 |
| MX2013012207A (es) | 2014-07-09 |
| BR112013026759A8 (pt) | 2018-02-14 |
| CL2013003033A1 (es) | 2014-07-25 |
| GB2504444A (en) | 2014-01-29 |
| US20140106455A1 (en) | 2014-04-17 |
| JP2014517824A (ja) | 2014-07-24 |
| GB201320508D0 (en) | 2014-01-01 |
| CO6910162A2 (es) | 2014-03-31 |
| EP2699255A1 (en) | 2014-02-26 |
| US9731004B2 (en) | 2017-08-15 |
| GB2504444B (en) | 2014-12-10 |
| KR101945265B1 (ko) | 2019-02-07 |
| JP6175051B2 (ja) | 2017-08-02 |
| ES2613089T3 (es) | 2017-05-22 |
| KR20140048123A (ko) | 2014-04-23 |
| CA2833319A1 (en) | 2012-10-26 |
| CA2833319C (en) | 2021-05-18 |
| CN103608034B (zh) | 2017-10-10 |
| HUE030623T2 (en) | 2017-05-29 |
| GB201106802D0 (en) | 2011-06-01 |
| CN103608034A (zh) | 2014-02-26 |
| AU2012246087A1 (en) | 2013-10-24 |
| PL2699255T3 (pl) | 2017-05-31 |
| NZ616268A (en) | 2015-12-24 |
| WO2012143732A1 (en) | 2012-10-26 |
| BR112013026759B1 (pt) | 2021-12-21 |
| AU2012246087B2 (en) | 2017-05-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |