PE20140883A1 - Proceso para preparar una composicion de vacuna - Google Patents
Proceso para preparar una composicion de vacunaInfo
- Publication number
- PE20140883A1 PE20140883A1 PE2013002365A PE2013002365A PE20140883A1 PE 20140883 A1 PE20140883 A1 PE 20140883A1 PE 2013002365 A PE2013002365 A PE 2013002365A PE 2013002365 A PE2013002365 A PE 2013002365A PE 20140883 A1 PE20140883 A1 PE 20140883A1
- Authority
- PE
- Peru
- Prior art keywords
- pollen
- solution
- modified
- composition
- filtration
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 6
- 229960005486 vaccine Drugs 0.000 title 1
- 239000000427 antigen Substances 0.000 abstract 4
- 102000036639 antigens Human genes 0.000 abstract 4
- 108091007433 antigens Proteins 0.000 abstract 4
- 238000001914 filtration Methods 0.000 abstract 4
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical group O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 abstract 3
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 3
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 abstract 3
- 239000002156 adsorbate Substances 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 239000011260 aqueous acid Substances 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 238000009413 insulation Methods 0.000 abstract 1
- 238000002156 mixing Methods 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 230000003472 neutralizing effect Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
- 230000000717 retained effect Effects 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 238000011146 sterile filtration Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
- A61K39/36—Allergens from pollen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
- A61K2039/622—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier non-covalent binding
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
SE REFIERE A UNA COMPOSICION ESTERIL QUE COMPRENDE UN ANTIGENO DE POLEN MODIFICADO CON GLUTARALDEHIDO ADSORBIDO EN UN AMINOACIDO TAL COMO TIROSINA. TAMBIEN SE REFIERE A UN METODO DE PREPARACION DE DICHA COMPOSICION QUE COMPRENDE: A) LA EXTRACCION DEL ANTIGENO DE POLEN EN UNA SOLUCION PARA FORMAR UNA SOLUCION DE EXTRACTO DE POLEN; B) LA FILTRACION DE LA SOLUCION DE EXTRACTO DE POLEN PARA ELIMINAR LOS SOLIDOS; C) APLICACION DE FILTRACION TANGENCIAL Y AISLAMIENTO DEL RETENIDO QUE COMPRENDE EL ANTIGENO DE POLEN; D) MODIFICACION DEL ANTIGENO DE POLEN CON GLUTARALDEHIDO; E) ELIMINACION DEL EXCEDENTE DE GLUTARALDEHIDO UTILIZANDO FILTRACION TANGENCIAL PARA FORMAR UNA SOLUCION DE POLEN MODIFICADO; F) FILTRACION ESTERIL DE LA SOLUCION DE POLEN MODIFICADO; G) MEZCLAR LA SOLUCION DE POLEN MODIFICADO CON UNA SOLUCION DE TIROSINA EN UN ACIDO ACUOSO A LA VEZ DE NEUTRALIZAR LA MEZCLA DE LAS SOLUCIONES PARA FORMAR UN ADSORBATO QUE COMPRENDE EL POLEN MODIFICADO Y LA TIROSINA; H) SEPARACION DEL ADSORBATO EN UN TAMPON MEDIANTE FILTRACION TANGENCIAL PARA FORMAR LA COMPOSICION; E I) RECUPERACION DE LA COMPOSICION
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1106802.0A GB201106802D0 (en) | 2011-04-21 | 2011-04-21 | Process for preparing vaccine composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20140883A1 true PE20140883A1 (es) | 2014-08-01 |
Family
ID=44147385
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2013002365A PE20140883A1 (es) | 2011-04-21 | 2012-04-20 | Proceso para preparar una composicion de vacuna |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US9731004B2 (es) |
| EP (1) | EP2699255B1 (es) |
| JP (1) | JP6175051B2 (es) |
| KR (1) | KR101945265B1 (es) |
| CN (1) | CN103608034B (es) |
| AU (1) | AU2012246087B2 (es) |
| BR (1) | BR112013026759B1 (es) |
| CA (1) | CA2833319C (es) |
| CL (1) | CL2013003033A1 (es) |
| CO (1) | CO6910162A2 (es) |
| DK (1) | DK2699255T3 (es) |
| ES (1) | ES2613089T3 (es) |
| GB (2) | GB201106802D0 (es) |
| HU (1) | HUE030623T2 (es) |
| MX (1) | MX345947B (es) |
| PE (1) | PE20140883A1 (es) |
| PL (1) | PL2699255T3 (es) |
| PT (1) | PT2699255T (es) |
| WO (1) | WO2012143732A1 (es) |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4070455A (en) | 1974-02-16 | 1978-01-24 | Beecham Group Limited | Process for preparing injectable desensitizing compositions and products thereof in microparticle form |
| US4234569A (en) | 1978-10-04 | 1980-11-18 | The Johns Hopkins University | Production of aldehyde-treated allergen-containing substances |
| US4987237A (en) | 1983-08-26 | 1991-01-22 | Ribi Immunochem Research, Inc. | Derivatives of monophosphoryl lipid A |
| EP0192321A3 (en) | 1985-01-19 | 1987-09-02 | Beecham Group Plc | Enteric coated allergen pharmaceutical composition |
| GB8501400D0 (en) * | 1985-01-19 | 1985-02-20 | Beecham Group Plc | Compositions |
| JPS63159324A (ja) | 1986-12-22 | 1988-07-02 | Lion Corp | スギ花粉症用経口ワクチン |
| US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
| ES2013359A6 (es) * | 1988-11-04 | 1990-05-01 | Corporacion Biolog Farmaceutic | Procedimiento para la fabricacion de alergenos inmunogenicos polimerizados. |
| US5480972A (en) * | 1992-10-30 | 1996-01-02 | The University Of Melbourne | Allergenic proteins from Johnson grass pollen |
| JPH06329553A (ja) | 1993-05-25 | 1994-11-29 | Hitachi Chem Co Ltd | 花粉内容物の抽出方法 |
| GB9508785D0 (en) * | 1995-04-29 | 1995-06-21 | Smithkline Beecham Plc | Novel compositions |
| GB9706957D0 (en) * | 1997-04-05 | 1997-05-21 | Smithkline Beecham Plc | Formulation |
| GB9820525D0 (en) * | 1998-09-21 | 1998-11-11 | Allergy Therapeutics Ltd | Formulation |
| US7695627B2 (en) | 2002-06-19 | 2010-04-13 | Northwest Biotherapeutics, Inc. | Tangential flow filtration devices and methods for leukocyte enrichment |
| US20050271731A1 (en) | 2002-09-11 | 2005-12-08 | Akira Suzuki | Process for the production of microspheres and unit therefor |
| US7790039B2 (en) | 2003-11-24 | 2010-09-07 | Northwest Biotherapeutics, Inc. | Tangential flow filtration devices and methods for stem cell enrichment |
| CA2566759A1 (en) | 2004-05-19 | 2005-11-24 | Alza Corporation | Method and formulation for transdermal delivery of immunologically active agents |
| WO2007022813A2 (en) | 2005-05-24 | 2007-03-01 | Neovacs | A METHOD FOR PREPARING A STABLE IMMUNOGENIC PRODUCT COMPRISING ANTIGENIC HETEROCOMPLEXES OF TNFα AND A CARRIER PROTEIN |
| FR2888582B1 (fr) * | 2005-07-15 | 2010-08-20 | Solvay | Procede de preparation d'un polymere halogene et dispositif pour sa mise en oeuvre |
| JP2010029109A (ja) | 2008-07-29 | 2010-02-12 | Ihi Corp | サンプリング装置およびこれを用いたサンプリング方法 |
| GB0917003D0 (en) | 2009-09-28 | 2009-11-11 | Novartis Vaccines Inst For Global Health Srl | Purification of bacterial vesicles |
| CN101972472A (zh) * | 2010-10-26 | 2011-02-16 | 北京新华联协和药业有限责任公司 | 一种变应原疫苗纯化及其制备的方法 |
-
2011
- 2011-04-21 GB GBGB1106802.0A patent/GB201106802D0/en not_active Ceased
-
2012
- 2012-04-20 US US14/112,544 patent/US9731004B2/en active Active
- 2012-04-20 CA CA2833319A patent/CA2833319C/en active Active
- 2012-04-20 MX MX2013012207A patent/MX345947B/es active IP Right Grant
- 2012-04-20 PL PL12719034T patent/PL2699255T3/pl unknown
- 2012-04-20 PT PT127190346T patent/PT2699255T/pt unknown
- 2012-04-20 KR KR1020137030934A patent/KR101945265B1/ko active IP Right Grant
- 2012-04-20 HU HUE12719034A patent/HUE030623T2/en unknown
- 2012-04-20 ES ES12719034.6T patent/ES2613089T3/es active Active
- 2012-04-20 JP JP2014505725A patent/JP6175051B2/ja active Active
- 2012-04-20 CN CN201280030190.0A patent/CN103608034B/zh active Active
- 2012-04-20 EP EP12719034.6A patent/EP2699255B1/en active Active
- 2012-04-20 GB GB1320508.3A patent/GB2504444B/en active Active
- 2012-04-20 PE PE2013002365A patent/PE20140883A1/es active IP Right Grant
- 2012-04-20 AU AU2012246087A patent/AU2012246087B2/en active Active
- 2012-04-20 WO PCT/GB2012/050883 patent/WO2012143732A1/en active Application Filing
- 2012-04-20 DK DK12719034.6T patent/DK2699255T3/en active
- 2012-04-20 BR BR112013026759-3A patent/BR112013026759B1/pt active IP Right Grant
-
2013
- 2013-10-18 CL CL2013003033A patent/CL2013003033A1/es unknown
- 2013-10-28 CO CO13255473A patent/CO6910162A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US9731004B2 (en) | 2017-08-15 |
| CA2833319C (en) | 2021-05-18 |
| PT2699255T (pt) | 2017-01-17 |
| DK2699255T3 (en) | 2017-02-13 |
| MX2013012207A (es) | 2014-07-09 |
| HUE030623T2 (en) | 2017-05-29 |
| GB201320508D0 (en) | 2014-01-01 |
| GB2504444B (en) | 2014-12-10 |
| PL2699255T3 (pl) | 2017-05-31 |
| WO2012143732A1 (en) | 2012-10-26 |
| CA2833319A1 (en) | 2012-10-26 |
| CN103608034A (zh) | 2014-02-26 |
| KR101945265B1 (ko) | 2019-02-07 |
| JP2014517824A (ja) | 2014-07-24 |
| EP2699255A1 (en) | 2014-02-26 |
| CN103608034B (zh) | 2017-10-10 |
| ES2613089T3 (es) | 2017-05-22 |
| AU2012246087B2 (en) | 2017-05-18 |
| BR112013026759B1 (pt) | 2021-12-21 |
| GB2504444A (en) | 2014-01-29 |
| JP6175051B2 (ja) | 2017-08-02 |
| US20140106455A1 (en) | 2014-04-17 |
| CL2013003033A1 (es) | 2014-07-25 |
| NZ616268A (en) | 2015-12-24 |
| CO6910162A2 (es) | 2014-03-31 |
| GB201106802D0 (en) | 2011-06-01 |
| MX345947B (es) | 2017-02-27 |
| AU2012246087A1 (en) | 2013-10-24 |
| BR112013026759A8 (pt) | 2018-02-14 |
| KR20140048123A (ko) | 2014-04-23 |
| EP2699255B1 (en) | 2016-11-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |