PE20100086A1 - Metodos para preparar compuestos biciclicos de imidazol - Google Patents

Metodos para preparar compuestos biciclicos de imidazol

Info

Publication number
PE20100086A1
PE20100086A1 PE2009000872A PE2009000872A PE20100086A1 PE 20100086 A1 PE20100086 A1 PE 20100086A1 PE 2009000872 A PE2009000872 A PE 2009000872A PE 2009000872 A PE2009000872 A PE 2009000872A PE 20100086 A1 PE20100086 A1 PE 20100086A1
Authority
PE
Peru
Prior art keywords
formula
isoxazol
dihydro
metoxide
compound
Prior art date
Application number
PE2009000872A
Other languages
English (en)
Inventor
Jason Guohua Chen
Weifeng Hu
Renmao Liu
Yuelie Lu
Wenxue Wu
Xiaogen Yang
Original Assignee
Lexicon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41402541&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20100086(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lexicon Pharmaceuticals Inc filed Critical Lexicon Pharmaceuticals Inc
Publication of PE20100086A1 publication Critical patent/PE20100086A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A UN PROCEDIMIENTO PARA PREPARAR UN COMPUESTO DE FORMULA (I) DONDE A ES DIHIDRO-IMIDAZOL, DIHIDRO-PIRAZOL, DIHIDRO-TIAZOL, ENTRE OTROS; R1 ES H, OH, ALQUILO OPCIONALMENTE SUSTITUIDO, ARILO, ARILALQUILO, ENTRE OTROS, QUE COMPRENDE: PONER EN CONTACTO UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), EN PRESENCIA DE UN SOLVENTE TAL COMO METANOL, ISOPROPANOL, TETRAHIDROFURANO, ENTRE OTROS, Y DE UNA BASE TAL COMO METOXIDO DE SODIO, ETOXIDO DE SODIO, T-BUTOXIDO DE POTASIO, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION DEL (1R,2S,3R)-1-(2-(ISOXAZOL-3-IL)-1H-IMIDAZOL-5-IL)BUTANO-1,2,3,4-TETRAOL QUE COMPRENDE: A) COMBINAR ISOXAZOL-3-CARBONITRILO CON METANOL Y UNA PRIMERA BASE TAL COMO METOXIDO PARA PROPORCIONAR UNA PRIMERA MEZCLA DE REACCION; B) COMBINAR DICHA PRIMERA MEZCLA CON FRUCTOSAMINA Y METOXIDO PARA OBTENER UNA SEGUNDA MEZCLA DE REACCION; Y C) AISLAR EL (1R,2S,3R)-1-(2-(ISOXAZOL-3-IL)-1H-IMIDAZOL-5-IL)BUTANO-1,2,3,4-TETRAOL DE LA SEGUNDA MEZCLA DE REACCION. LOS COMPUESTOS DE FORMULA (I) SON INHIBIDORES DE LA S1P LIASA SIENDO UTILES EN EL TRATAMIENTO DE ARTRITIS REUMATOIDE
PE2009000872A 2008-06-18 2009-06-16 Metodos para preparar compuestos biciclicos de imidazol PE20100086A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7339908P 2008-06-18 2008-06-18

Publications (1)

Publication Number Publication Date
PE20100086A1 true PE20100086A1 (es) 2010-02-08

Family

ID=41402541

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2009000872A PE20100086A1 (es) 2008-06-18 2009-06-16 Metodos para preparar compuestos biciclicos de imidazol

Country Status (19)

Country Link
US (1) US7968726B2 (es)
EP (1) EP2318380B1 (es)
JP (1) JP2011524916A (es)
KR (1) KR20110019433A (es)
CN (1) CN102066344A (es)
AR (1) AR072152A1 (es)
AU (1) AU2009271409B2 (es)
BR (1) BRPI0914260A2 (es)
CA (1) CA2728097C (es)
CL (1) CL2009001437A1 (es)
CO (1) CO6341619A2 (es)
ES (1) ES2604313T3 (es)
IL (1) IL209817A0 (es)
MX (1) MX2010013817A (es)
PE (1) PE20100086A1 (es)
RU (1) RU2011101593A (es)
TW (1) TW201002698A (es)
UY (1) UY31899A (es)
WO (1) WO2010008734A2 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009271408A1 (en) * 2008-06-18 2010-01-21 Lexicon Pharmaceuticals, Inc. Solid forms of (1R,2S,3R)-1-(2-(isoxazol-3-yl) -1H-imidazol-4-yl)butane-1,2,3,4-tetraol and methods of their use
WO2013049272A2 (en) 2011-09-29 2013-04-04 Theraceutix, Llc Composition and method for treatment of symptoms associated with various skin conditions

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4567194A (en) * 1983-03-10 1986-01-28 The Coca-Cola Company 2-Acylimidazole compounds, their synthesis and use as medicinal agents
US4587194A (en) * 1984-11-20 1986-05-06 The Mead Corporation Photosensitive material employing microcapsules having different photographic speeds
AU2881797A (en) 1996-05-31 1998-01-05 University Of Wollongong, The Acetyl derivatives of thiazoles and analogues
JP2008546839A (ja) * 2005-06-28 2008-12-25 メルク エンド カムパニー インコーポレーテッド 非ヌクレオシド逆転写酵素阻害剤
US7649098B2 (en) 2006-02-24 2010-01-19 Lexicon Pharmaceuticals, Inc. Imidazole-based compounds, compositions comprising them and methods of their use
TW200848029A (en) * 2007-03-01 2008-12-16 Lexicon Pharmaceuticals Inc Heterocyclic compounds, compositions comprising them and methods of their use
AR065980A1 (es) 2007-04-12 2009-07-15 Lexicon Pharmaceuticals Inc Metodos para preparar compuestos basados en imidazol
AU2009271408A1 (en) 2008-06-18 2010-01-21 Lexicon Pharmaceuticals, Inc. Solid forms of (1R,2S,3R)-1-(2-(isoxazol-3-yl) -1H-imidazol-4-yl)butane-1,2,3,4-tetraol and methods of their use

Also Published As

Publication number Publication date
WO2010008734A3 (en) 2010-03-11
KR20110019433A (ko) 2011-02-25
MX2010013817A (es) 2011-02-24
JP2011524916A (ja) 2011-09-08
CO6341619A2 (es) 2011-11-21
BRPI0914260A2 (pt) 2015-11-03
US20090318705A1 (en) 2009-12-24
ES2604313T3 (es) 2017-03-06
WO2010008734A2 (en) 2010-01-21
EP2318380A2 (en) 2011-05-11
AR072152A1 (es) 2010-08-11
US7968726B2 (en) 2011-06-28
RU2011101593A (ru) 2012-07-27
AU2009271409B2 (en) 2014-01-30
EP2318380B1 (en) 2016-08-24
IL209817A0 (en) 2011-02-28
AU2009271409A1 (en) 2010-01-21
TW201002698A (en) 2010-01-16
CA2728097A1 (en) 2010-01-21
UY31899A (es) 2010-01-29
CL2009001437A1 (es) 2010-08-20
CN102066344A (zh) 2011-05-18
CA2728097C (en) 2017-01-03

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