CL2009001437A1 - Metodo para la preparacion de (1r, 2s, 3r)-1-(2-(isoxazol-3-il)-1h-imidazol-5-il)butano-1,2,3,4-tetraol utilizando isoxazol-3-carbonitrilo; y uno de los compuestos intermediarios considerados en la preparacion del isoxazol-3-carbonitrilo. - Google Patents

Metodo para la preparacion de (1r, 2s, 3r)-1-(2-(isoxazol-3-il)-1h-imidazol-5-il)butano-1,2,3,4-tetraol utilizando isoxazol-3-carbonitrilo; y uno de los compuestos intermediarios considerados en la preparacion del isoxazol-3-carbonitrilo.

Info

Publication number
CL2009001437A1
CL2009001437A1 CL2009001437A CL2009001437A CL2009001437A1 CL 2009001437 A1 CL2009001437 A1 CL 2009001437A1 CL 2009001437 A CL2009001437 A CL 2009001437A CL 2009001437 A CL2009001437 A CL 2009001437A CL 2009001437 A1 CL2009001437 A1 CL 2009001437A1
Authority
CL
Chile
Prior art keywords
isoxazol
carbonitrile
preparation
tetraol
isoxazole
Prior art date
Application number
CL2009001437A
Other languages
English (en)
Inventor
Wu Wenxue
Guohua Chen Jason
Hu Weifeng
Liu Renmao
Lu Yuelie
Yang Xiaogen
Original Assignee
Lexicon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41402541&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2009001437(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lexicon Pharmaceuticals Inc filed Critical Lexicon Pharmaceuticals Inc
Publication of CL2009001437A1 publication Critical patent/CL2009001437A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Método para preparar un compuesto derivado de 1-(2-heteroaril-1h-imidazol)-hidroxialquil de formula i, a partir de ciano-heteroarilo y 1-amino-3-hidroxialquil-2-ona, en condiciones suficientes para la formación del compuesto de formula i; compuesto intermediario.
CL2009001437A 2008-06-18 2009-06-17 Metodo para la preparacion de (1r, 2s, 3r)-1-(2-(isoxazol-3-il)-1h-imidazol-5-il)butano-1,2,3,4-tetraol utilizando isoxazol-3-carbonitrilo; y uno de los compuestos intermediarios considerados en la preparacion del isoxazol-3-carbonitrilo. CL2009001437A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7339908P 2008-06-18 2008-06-18

Publications (1)

Publication Number Publication Date
CL2009001437A1 true CL2009001437A1 (es) 2010-08-20

Family

ID=41402541

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2009001437A CL2009001437A1 (es) 2008-06-18 2009-06-17 Metodo para la preparacion de (1r, 2s, 3r)-1-(2-(isoxazol-3-il)-1h-imidazol-5-il)butano-1,2,3,4-tetraol utilizando isoxazol-3-carbonitrilo; y uno de los compuestos intermediarios considerados en la preparacion del isoxazol-3-carbonitrilo.

Country Status (19)

Country Link
US (1) US7968726B2 (es)
EP (1) EP2318380B1 (es)
JP (1) JP2011524916A (es)
KR (1) KR20110019433A (es)
CN (1) CN102066344A (es)
AR (1) AR072152A1 (es)
AU (1) AU2009271409B2 (es)
BR (1) BRPI0914260A2 (es)
CA (1) CA2728097C (es)
CL (1) CL2009001437A1 (es)
CO (1) CO6341619A2 (es)
ES (1) ES2604313T3 (es)
IL (1) IL209817A0 (es)
MX (1) MX2010013817A (es)
PE (1) PE20100086A1 (es)
RU (1) RU2011101593A (es)
TW (1) TW201002698A (es)
UY (1) UY31899A (es)
WO (1) WO2010008734A2 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2401555T3 (es) * 2008-06-18 2013-04-22 Lexicon Pharmaceuticals, Inc. Formas sólidas de (1R,2S,3R)-1-(2-(isoxazol-3-il)-1H-imidazol-4-il)butano-1,2,3,4-tetraol y métodos de utilización de las mismas
WO2013049272A2 (en) 2011-09-29 2013-04-04 Theraceutix, Llc Composition and method for treatment of symptoms associated with various skin conditions

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4567194A (en) * 1983-03-10 1986-01-28 The Coca-Cola Company 2-Acylimidazole compounds, their synthesis and use as medicinal agents
US4587194A (en) * 1984-11-20 1986-05-06 The Mead Corporation Photosensitive material employing microcapsules having different photographic speeds
ZA974811B (en) 1996-05-31 1997-12-30 Univ Wollongong Novel therapeutic compounds.
WO2007002458A2 (en) * 2005-06-28 2007-01-04 Merck & Co., Inc. Non-nucleoside reverse transcriptase inhibitors
US7649098B2 (en) 2006-02-24 2010-01-19 Lexicon Pharmaceuticals, Inc. Imidazole-based compounds, compositions comprising them and methods of their use
TW200848029A (en) * 2007-03-01 2008-12-16 Lexicon Pharmaceuticals Inc Heterocyclic compounds, compositions comprising them and methods of their use
UY31013A1 (es) 2007-04-12 2008-09-02 Lexicon Pharmaceuticals Inc Metodos para prepar compuestos basados en imidazol
ES2401555T3 (es) 2008-06-18 2013-04-22 Lexicon Pharmaceuticals, Inc. Formas sólidas de (1R,2S,3R)-1-(2-(isoxazol-3-il)-1H-imidazol-4-il)butano-1,2,3,4-tetraol y métodos de utilización de las mismas

Also Published As

Publication number Publication date
EP2318380B1 (en) 2016-08-24
CO6341619A2 (es) 2011-11-21
MX2010013817A (es) 2011-02-24
KR20110019433A (ko) 2011-02-25
WO2010008734A3 (en) 2010-03-11
EP2318380A2 (en) 2011-05-11
BRPI0914260A2 (pt) 2015-11-03
IL209817A0 (en) 2011-02-28
AU2009271409A1 (en) 2010-01-21
WO2010008734A2 (en) 2010-01-21
US20090318705A1 (en) 2009-12-24
TW201002698A (en) 2010-01-16
PE20100086A1 (es) 2010-02-08
CA2728097A1 (en) 2010-01-21
AR072152A1 (es) 2010-08-11
JP2011524916A (ja) 2011-09-08
AU2009271409B2 (en) 2014-01-30
ES2604313T3 (es) 2017-03-06
CA2728097C (en) 2017-01-03
RU2011101593A (ru) 2012-07-27
US7968726B2 (en) 2011-06-28
UY31899A (es) 2010-01-29
CN102066344A (zh) 2011-05-18

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