PE20090141A1 - Compuestos derivados de isoquinolina proceso de preparacion y composicion farmaceutica - Google Patents
Compuestos derivados de isoquinolina proceso de preparacion y composicion farmaceuticaInfo
- Publication number
- PE20090141A1 PE20090141A1 PE2008000613A PE2008000613A PE20090141A1 PE 20090141 A1 PE20090141 A1 PE 20090141A1 PE 2008000613 A PE2008000613 A PE 2008000613A PE 2008000613 A PE2008000613 A PE 2008000613A PE 20090141 A1 PE20090141 A1 PE 20090141A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- alcoxy
- halo
- compounds derived
- pharmaceutical composition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91023507P | 2007-04-05 | 2007-04-05 | |
| US97952307P | 2007-10-12 | 2007-10-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20090141A1 true PE20090141A1 (es) | 2009-04-30 |
Family
ID=39560895
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008000613A PE20090141A1 (es) | 2007-04-05 | 2008-04-04 | Compuestos derivados de isoquinolina proceso de preparacion y composicion farmaceutica |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8012979B2 (ru) |
| EP (1) | EP2144881B1 (ru) |
| JP (1) | JP5400759B2 (ru) |
| KR (1) | KR20100016218A (ru) |
| CN (1) | CN101679275B (ru) |
| AR (1) | AR065965A1 (ru) |
| AU (1) | AU2008235359B2 (ru) |
| BR (1) | BRPI0810047A2 (ru) |
| CA (1) | CA2681221A1 (ru) |
| CL (1) | CL2008000973A1 (ru) |
| CO (1) | CO6230983A2 (ru) |
| EC (1) | ECSP099679A (ru) |
| IL (1) | IL201015A0 (ru) |
| MX (1) | MX2009010225A (ru) |
| PE (1) | PE20090141A1 (ru) |
| RU (1) | RU2472781C2 (ru) |
| TW (1) | TW200845988A (ru) |
| UY (1) | UY31005A1 (ru) |
| WO (1) | WO2008122765A1 (ru) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR073711A1 (es) * | 2008-10-01 | 2010-11-24 | Astrazeneca Ab | Derivados de isoquinolina |
| AR092742A1 (es) * | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| CN103864684A (zh) * | 2012-12-07 | 2014-06-18 | 天津科技大学 | 一种新颖的3,4-二氢-1(2h)异喹啉类衍生物的合成与抗肿瘤药物的应用 |
| CA2927830A1 (en) | 2013-10-23 | 2015-04-30 | Chugai Seiyaku Kabushiki Kaisha | Quinazolinone and isoquinolinone derivative |
| FR3017868A1 (fr) * | 2014-02-21 | 2015-08-28 | Servier Lab | Derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CN106674254B (zh) * | 2016-12-21 | 2019-03-15 | 广东省中医院 | 一类喹诺酮羧酸化合物及其中间体、制备方法以及应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU176214B (en) * | 1977-05-18 | 1981-01-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing new 5,6-dihydro-imidazo-square bracket-5,1-a-square bracket closed-isoquinolin derivatives |
| JP4619545B2 (ja) | 1999-03-17 | 2011-01-26 | アストラゼネカ アクチボラグ | アミド誘導体 |
| AU2003211931A1 (en) * | 2002-02-13 | 2003-09-04 | Takeda Chemical Industries, Ltd. | Jnk inhibitor |
| ATE420847T1 (de) * | 2002-02-21 | 2009-01-15 | Asahi Kasei Pharma Corp | Substituiertes phenylalkansäurederivat und dessen verwendung |
| US6867320B2 (en) * | 2002-02-21 | 2005-03-15 | Asahi Kasei Pharma Corporation | Substituted phenylalkanoic acid derivatives and use thereof |
| KR101175371B1 (ko) | 2003-08-06 | 2012-08-20 | 바스프 에스이 | 하나 이상의 유기 화합물의 연속 불균일 촉매적 기체상부분 산화 수행 방법 |
| CA2535665A1 (en) | 2003-08-14 | 2005-02-24 | Asahi Kasei Pharma Corporation | Substituted arylalkanoic acid derivative and use thereof |
| JP2007008816A (ja) | 2003-10-15 | 2007-01-18 | Ube Ind Ltd | 新規イソキノリン誘導体 |
| US20070054916A1 (en) * | 2004-10-01 | 2007-03-08 | Amgen Inc. | Aryl nitrogen-containing bicyclic compounds and methods of use |
| BRPI0519287A2 (pt) | 2004-12-24 | 2009-01-06 | Astrazeneca Ab | derivados de amida |
| TW200728277A (en) * | 2005-06-29 | 2007-08-01 | Palau Pharma Sa | Bicyclic derivatives as P38 inhibitors |
| BRPI0614063A2 (pt) | 2005-07-26 | 2011-03-09 | Sanofi Aventis | derivados de cicloexilamina isoquinolona |
-
2008
- 2008-04-03 CL CL2008000973A patent/CL2008000973A1/es unknown
- 2008-04-03 TW TW097112152A patent/TW200845988A/zh unknown
- 2008-04-04 MX MX2009010225A patent/MX2009010225A/es not_active Application Discontinuation
- 2008-04-04 US US12/062,718 patent/US8012979B2/en not_active Expired - Fee Related
- 2008-04-04 UY UY31005A patent/UY31005A1/es unknown
- 2008-04-04 KR KR1020097023057A patent/KR20100016218A/ko not_active Application Discontinuation
- 2008-04-04 EP EP08718978A patent/EP2144881B1/en active Active
- 2008-04-04 AU AU2008235359A patent/AU2008235359B2/en not_active Ceased
- 2008-04-04 WO PCT/GB2008/001171 patent/WO2008122765A1/en active Application Filing
- 2008-04-04 BR BRPI0810047-0A2A patent/BRPI0810047A2/pt not_active IP Right Cessation
- 2008-04-04 CA CA002681221A patent/CA2681221A1/en not_active Abandoned
- 2008-04-04 AR ARP080101429A patent/AR065965A1/es unknown
- 2008-04-04 JP JP2010501584A patent/JP5400759B2/ja not_active Expired - Fee Related
- 2008-04-04 RU RU2009136246/04A patent/RU2472781C2/ru not_active IP Right Cessation
- 2008-04-04 CN CN2008800191868A patent/CN101679275B/zh not_active Expired - Fee Related
- 2008-04-04 PE PE2008000613A patent/PE20090141A1/es not_active Application Discontinuation
-
2009
- 2009-09-17 IL IL201015A patent/IL201015A0/en unknown
- 2009-09-22 CO CO09103185A patent/CO6230983A2/es not_active Application Discontinuation
- 2009-10-07 EC EC2009009679A patent/ECSP099679A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP5400759B2 (ja) | 2014-01-29 |
| JP2010523533A (ja) | 2010-07-15 |
| KR20100016218A (ko) | 2010-02-12 |
| CN101679275A (zh) | 2010-03-24 |
| UY31005A1 (es) | 2008-11-28 |
| WO2008122765A1 (en) | 2008-10-16 |
| AR065965A1 (es) | 2009-07-15 |
| AU2008235359A1 (en) | 2008-10-16 |
| CN101679275B (zh) | 2013-07-31 |
| MX2009010225A (es) | 2009-12-14 |
| RU2472781C2 (ru) | 2013-01-20 |
| EP2144881A1 (en) | 2010-01-20 |
| IL201015A0 (en) | 2010-05-17 |
| ECSP099679A (es) | 2009-11-30 |
| AU2008235359B2 (en) | 2011-12-15 |
| CO6230983A2 (es) | 2010-12-20 |
| EP2144881B1 (en) | 2012-06-20 |
| CA2681221A1 (en) | 2008-10-16 |
| CL2008000973A1 (es) | 2009-01-02 |
| US8012979B2 (en) | 2011-09-06 |
| RU2009136246A (ru) | 2011-05-10 |
| BRPI0810047A2 (pt) | 2014-10-21 |
| US20090023746A1 (en) | 2009-01-22 |
| TW200845988A (en) | 2008-12-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE602005008558D1 (de) | Kondensierte heterocyclische verbindungen und deren verwendung als antagonisten des metabotropen reznkungen | |
| PE20090141A1 (es) | Compuestos derivados de isoquinolina proceso de preparacion y composicion farmaceutica | |
| EA200601266A1 (ru) | Соединения триазола и их применение в качестве антагонистов метаботропного рецептора глутамата | |
| CY1110952T1 (el) | Παραγωγα κινουκλιδινης και η χρηση αυτων ως μουσκαρινικοι ανταγωνιστες υποδοχεων μ3 | |
| BG108650A (en) | Azabicyclic-substituted fused-heteroaryl compounds for the treatment of disease | |
| TW200635585A (en) | Monocyclic substituted methanones | |
| ATE464304T1 (de) | Carboxamid-spirolactam-cgrp-rezeptor-antagonist n | |
| PE20140609A1 (es) | Diazacarbazoles y metodos de uso | |
| PE20080768A1 (es) | Compuestos de isoindolina 5-sustituidos | |
| ATE440834T1 (de) | Substituierte arylaminderivate und verwendungsverfahren | |
| MX2011011764A (es) | Compuestos de carboxamida y su uso como inhibidores de calpaina. | |
| ATE427932T1 (de) | 11beta-hsd1-inhibitoren | |
| NO20063470L (no) | Tetrazolforbindelser og deres anvendelse av metabotrofe glutamatreseptorantagonister | |
| EA201001682A1 (ru) | Производные фенил- и бензодиоксинилзамещенных индазолов | |
| EA200900658A1 (ru) | Производные индазолилэфиров или -амидов для лечения расстройств, опосредованных глюкокортиодными рецепторами | |
| ATE503755T1 (de) | Cgrp-rezeptorantagonisten | |
| ATE466860T1 (de) | Cgrp-rezeptorantagonisten | |
| MX2009010083A (es) | Compuestos biarilo y biheteroarilo de utilidad en el tratamiento de trastornos de hierro. | |
| SE0403171D0 (sv) | New compounds | |
| ATE517861T1 (de) | Benzylether und benzylaminoverbindungen als inhibitoren von beta-secretase zur behandlung von alzheimer-krankheit | |
| PE20070619A1 (es) | TIENO(2,3-b)PIRIDIN-5-CARBONITRILOS COMO INHIBIDORES DE PROTEINAS QUINASA | |
| MY157116A (en) | Novel seh inhibitors and their use | |
| SE0301446D0 (sv) | New Compounds | |
| EA200501595A1 (ru) | Азабициклические производные в качестве антагонистов мускаринового рецептора | |
| ATE466853T1 (de) | Cgrp-rezeptorantagonisten |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |