PE20081176A1 - Derivados de acido vinilogo inhibidores de quimasa - Google Patents
Derivados de acido vinilogo inhibidores de quimasaInfo
- Publication number
- PE20081176A1 PE20081176A1 PE2007001382A PE2007001382A PE20081176A1 PE 20081176 A1 PE20081176 A1 PE 20081176A1 PE 2007001382 A PE2007001382 A PE 2007001382A PE 2007001382 A PE2007001382 A PE 2007001382A PE 20081176 A1 PE20081176 A1 PE 20081176A1
- Authority
- PE
- Peru
- Prior art keywords
- methyl
- phenyl
- halogen
- cyclobut
- indol
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 229920002554 vinyl polymer Polymers 0.000 title abstract 2
- ORGHESHFQPYLAO-UHFFFAOYSA-N vinyl radical Chemical class C=[CH] ORGHESHFQPYLAO-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 229910052736 halogen Inorganic materials 0.000 abstract 5
- 150000002367 halogens Chemical class 0.000 abstract 5
- -1 AMINO Chemical class 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010002388 Angina unstable Diseases 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 102000012479 Serine Proteases Human genes 0.000 abstract 1
- 108010022999 Serine Proteases Proteins 0.000 abstract 1
- 208000007814 Unstable Angina Diseases 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 201000004332 intermediate coronary syndrome Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
REFERIDA A UN DERIVADO DE ACIDO VINILOGO DE FORMULA (I), DONDE A ES FENILO, UN ANILLO HETEROARILO DE 5 O 6 MIEMBROS QUE CONTIENE HETEROATOMOS SELECCIONADOS DE N, O Y S, O UN ANILLO HETEROCICLILO DE 5 O 6 MIEMBROS QUE CONTIENE HETEROATOMOS SELECCIONADOS DE N Y S(O)n; R1 ES H, HALOGENO, NITRO, CIANO, ENTRE OTROS; R2, R2' Y R2'' SON H, HALOGENO, AMINO, OH, ENTRE OTROS; R3 ES H, HALOGENO, AMINO, ALQUILO C1-C6, ENTRE OTROS; R4 ES H, HALOGENO, AMINO, CIANO, ENTRE OTROS; R5 ES H, HALOGENO O ALQUILO C1-C6. SON COMPUESTOS PREFERIDOS: N-(2-[(2-HIDROXI-3-METIL-4-OXO-3-FENIL-CICLOBUT-1-ENIL)-FENIL-METIL]-6-METIL-1H-INDOL-3-IL}-1,1-DIMETIL-ETIL)-ACETAMIDA, 3-HIDROXI-4-METIL-2-[(3-METIL-1H-INDOL-2-IL)-FENIL-METIL]-4-FENIL-CICLOBUT-2-ENONA, 2-[(3,5-DIMETIL-1H-INDOL-2-IL)-FENIL-METIL]-3-HIDROXI-4-.METIL-4-FENIL-CICLOBUT-2-ENONA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA Y A UN PROCESO DE PREPARACION. DICHOS COMPUESTOS SON INHIDORES DE LA SERINA-PROTEINASA QUIMASA Y SON UTILES EN EL TRATAMIENTO DE ALERGIAS, ASMA, ANGINA INESTABLE, ENTRE OTRAS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06122239 | 2006-10-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20081176A1 true PE20081176A1 (es) | 2008-09-17 |
Family
ID=38728675
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2007001382A PE20081176A1 (es) | 2006-10-13 | 2007-10-12 | Derivados de acido vinilogo inhibidores de quimasa |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US7705034B2 (es) |
| EP (1) | EP2074090A1 (es) |
| JP (1) | JP4976499B2 (es) |
| KR (1) | KR101122989B1 (es) |
| CN (1) | CN101522615A (es) |
| AR (1) | AR063269A1 (es) |
| AU (1) | AU2007306399B2 (es) |
| BR (1) | BRPI0719785A2 (es) |
| CA (1) | CA2665046A1 (es) |
| CL (1) | CL2007002922A1 (es) |
| CR (1) | CR10678A (es) |
| IL (1) | IL197764A0 (es) |
| MA (1) | MA30882B1 (es) |
| MX (1) | MX2009003640A (es) |
| NO (1) | NO20091255L (es) |
| NZ (1) | NZ575741A (es) |
| PE (1) | PE20081176A1 (es) |
| RU (1) | RU2451013C2 (es) |
| TW (1) | TWI337864B (es) |
| UA (1) | UA96610C2 (es) |
| WO (1) | WO2008043698A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2012131747A (ru) | 2009-12-25 | 2014-01-27 | Дайити Санке Компани, Лимитед | Семичленное циклическое соединение и его фармацевтическое применение |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1982000032A1 (en) | 1980-06-25 | 1982-02-07 | Tsuchiya M | Process for preparing indoles |
| US4443615A (en) * | 1981-11-10 | 1984-04-17 | Tanabe Seiyaku Co., Ltd. | Process for preparing indoles |
| AU7855787A (en) | 1986-08-08 | 1988-02-24 | Upjohn Company, The | Asymmetric synthesis of enantiomerically pure monocyclic beta-lactam intermediates |
| JPH0578250A (ja) | 1991-09-18 | 1993-03-30 | Fujisawa Pharmaceut Co Ltd | 肝炎または膵炎の予防・治療剤 |
| ATE195530T1 (de) | 1992-05-20 | 2000-09-15 | Merck & Co Inc | 17-ether und thioether von 4-aza-steroiden |
| CA2135173A1 (en) | 1992-05-20 | 1993-11-25 | Bruce E. Witzel | Ester derivatives of 4-aza-steroids |
| GB9418762D0 (en) | 1994-09-16 | 1994-11-02 | Bayer Ag | Use of substituted cyclopentane-DI-and-triones |
| US5814631A (en) * | 1995-09-28 | 1998-09-29 | Suntory Limited | Quinazoline derivatives and applications thereof |
| AU723234B2 (en) * | 1996-09-06 | 2000-08-24 | Nippon Kayaku Kabushiki Kaisha | Novel acetamide derivatives and protease inhibitors |
| ATE232521T1 (de) | 1998-03-27 | 2003-02-15 | Janssen Pharmaceutica Nv | Hiv hemmende pyrimidin derivate |
| EP1099690A4 (en) | 1998-07-23 | 2001-10-17 | Shionogi & Co | MONOCYCLIC BETA LACTAM COMPOUNDS AND CHYMASE INHIBITORS THAT CONTAIN THEM |
| EP1136488A4 (en) | 1998-12-01 | 2002-06-12 | Meiji Seika Kaisha | SF2809-I, II, III. VI, V AND VI COMPOUNDS WITH CHYMASE INHIBITING EFFECT |
| IL142768A0 (en) | 1998-12-18 | 2002-03-10 | Du Pont Pharm Co | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
| WO2001053272A1 (fr) * | 2000-01-17 | 2001-07-26 | Teijin Limited | Inhibiteurs de chymase humaine |
| US7205318B2 (en) | 2003-03-18 | 2007-04-17 | Bristol-Myers Squibb Company | Lactam-containing cyclic diamines and derivatives as a factor Xa inhibitors |
-
2007
- 2007-09-24 US US11/903,579 patent/US7705034B2/en not_active Expired - Fee Related
- 2007-10-04 JP JP2009531810A patent/JP4976499B2/ja not_active Expired - Fee Related
- 2007-10-04 AU AU2007306399A patent/AU2007306399B2/en not_active Expired - Fee Related
- 2007-10-04 MX MX2009003640A patent/MX2009003640A/es active IP Right Grant
- 2007-10-04 WO PCT/EP2007/060528 patent/WO2008043698A1/en active Application Filing
- 2007-10-04 KR KR1020097007357A patent/KR101122989B1/ko not_active IP Right Cessation
- 2007-10-04 NZ NZ575741A patent/NZ575741A/en not_active IP Right Cessation
- 2007-10-04 CA CA002665046A patent/CA2665046A1/en not_active Abandoned
- 2007-10-04 EP EP07820905A patent/EP2074090A1/en not_active Withdrawn
- 2007-10-04 CN CNA2007800376817A patent/CN101522615A/zh active Pending
- 2007-10-04 BR BRPI0719785-3A2A patent/BRPI0719785A2/pt not_active IP Right Cessation
- 2007-10-04 UA UAA200904015A patent/UA96610C2/ru unknown
- 2007-10-04 RU RU2009117707/04A patent/RU2451013C2/ru not_active IP Right Cessation
- 2007-10-09 TW TW096137881A patent/TWI337864B/zh not_active IP Right Cessation
- 2007-10-11 CL CL200702922A patent/CL2007002922A1/es unknown
- 2007-10-12 AR ARP070104527A patent/AR063269A1/es unknown
- 2007-10-12 PE PE2007001382A patent/PE20081176A1/es not_active Application Discontinuation
-
2009
- 2009-03-20 CR CR10678A patent/CR10678A/es not_active Application Discontinuation
- 2009-03-23 IL IL197764A patent/IL197764A0/en unknown
- 2009-03-26 NO NO20091255A patent/NO20091255L/no not_active Application Discontinuation
- 2009-05-11 MA MA31862A patent/MA30882B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101522615A (zh) | 2009-09-02 |
| CA2665046A1 (en) | 2008-04-17 |
| NZ575741A (en) | 2011-12-22 |
| MA30882B1 (fr) | 2009-11-02 |
| MX2009003640A (es) | 2009-04-22 |
| RU2009117707A (ru) | 2010-11-20 |
| JP4976499B2 (ja) | 2012-07-18 |
| WO2008043698A1 (en) | 2008-04-17 |
| AR063269A1 (es) | 2009-01-14 |
| CL2007002922A1 (es) | 2008-05-30 |
| TW200824685A (en) | 2008-06-16 |
| JP2010505900A (ja) | 2010-02-25 |
| US7705034B2 (en) | 2010-04-27 |
| AU2007306399A1 (en) | 2008-04-17 |
| RU2451013C2 (ru) | 2012-05-20 |
| AU2007306399B2 (en) | 2012-05-17 |
| KR20090067165A (ko) | 2009-06-24 |
| KR101122989B1 (ko) | 2012-03-13 |
| TWI337864B (en) | 2011-03-01 |
| NO20091255L (no) | 2009-04-27 |
| UA96610C2 (ru) | 2011-11-25 |
| CR10678A (es) | 2009-06-25 |
| IL197764A0 (en) | 2009-12-24 |
| US20080096953A1 (en) | 2008-04-24 |
| EP2074090A1 (en) | 2009-07-01 |
| BRPI0719785A2 (pt) | 2014-11-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |