PE20080708A1 - Compuestos 2-pirrolidincarboxamida sustituidos como inhibidores de la proteasa que activa el canal respiratorio - Google Patents
Compuestos 2-pirrolidincarboxamida sustituidos como inhibidores de la proteasa que activa el canal respiratorioInfo
- Publication number
- PE20080708A1 PE20080708A1 PE2007000642A PE2007000642A PE20080708A1 PE 20080708 A1 PE20080708 A1 PE 20080708A1 PE 2007000642 A PE2007000642 A PE 2007000642A PE 2007000642 A PE2007000642 A PE 2007000642A PE 20080708 A1 PE20080708 A1 PE 20080708A1
- Authority
- PE
- Peru
- Prior art keywords
- pyrrolidinecarboxamide
- protease
- activates
- alkyl
- inhibitors
- Prior art date
Links
- 108091005804 Peptidases Proteins 0.000 title abstract 2
- 239000004365 Protease Substances 0.000 title abstract 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 title abstract 2
- VLJNHYLEOZPXFW-UHFFFAOYSA-N pyrrolidine-2-carboxamide Chemical class NC(=O)C1CCCN1 VLJNHYLEOZPXFW-UHFFFAOYSA-N 0.000 title abstract 2
- 230000000241 respiratory effect Effects 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 101000798702 Homo sapiens Transmembrane protease serine 4 Proteins 0.000 abstract 2
- 102100032471 Transmembrane protease serine 4 Human genes 0.000 abstract 2
- 206010006458 Bronchitis chronic Diseases 0.000 abstract 1
- 206010011732 Cyst Diseases 0.000 abstract 1
- 206010016654 Fibrosis Diseases 0.000 abstract 1
- 101000897856 Homo sapiens Adenylyl cyclase-associated protein 2 Proteins 0.000 abstract 1
- 101000836079 Homo sapiens Serpin B8 Proteins 0.000 abstract 1
- 101000798707 Homo sapiens Transmembrane protease serine 13 Proteins 0.000 abstract 1
- 101000638154 Homo sapiens Transmembrane protease serine 2 Proteins 0.000 abstract 1
- 101000798700 Homo sapiens Transmembrane protease serine 3 Proteins 0.000 abstract 1
- 101000848014 Homo sapiens Trypsin-2 Proteins 0.000 abstract 1
- 102100032467 Transmembrane protease serine 13 Human genes 0.000 abstract 1
- 102100031989 Transmembrane protease serine 2 Human genes 0.000 abstract 1
- 102100034392 Trypsin-2 Human genes 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 206010006451 bronchitis Diseases 0.000 abstract 1
- 208000007451 chronic bronchitis Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000031513 cyst Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000004761 fibrosis Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Communicable Diseases (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80298306P | 2006-05-23 | 2006-05-23 | |
| US86060406P | 2006-11-22 | 2006-11-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20080708A1 true PE20080708A1 (es) | 2008-07-30 |
Family
ID=38565503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2007000642A PE20080708A1 (es) | 2006-05-23 | 2007-05-23 | Compuestos 2-pirrolidincarboxamida sustituidos como inhibidores de la proteasa que activa el canal respiratorio |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7951823B2 (enExample) |
| EP (1) | EP2027143A2 (enExample) |
| JP (1) | JP2009538327A (enExample) |
| KR (1) | KR101069051B1 (enExample) |
| AR (1) | AR061109A1 (enExample) |
| AU (1) | AU2007253819B2 (enExample) |
| BR (1) | BRPI0712021A2 (enExample) |
| CA (1) | CA2651762A1 (enExample) |
| CL (1) | CL2007001481A1 (enExample) |
| MX (1) | MX2008014839A (enExample) |
| PE (1) | PE20080708A1 (enExample) |
| RU (1) | RU2419626C2 (enExample) |
| TW (1) | TW200813094A (enExample) |
| WO (1) | WO2007137080A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0507577D0 (en) * | 2005-04-14 | 2005-05-18 | Novartis Ag | Organic compounds |
| AU2007253819B2 (en) * | 2006-05-23 | 2011-02-17 | Irm Llc | Compounds and compositions as channel activating protease inhibitors |
| RU2419625C2 (ru) * | 2006-05-23 | 2011-05-27 | Айрм Ллк | Соединения и композиции в качестве ингибиторов протеазы, активирующей каналы |
| JP2010518097A (ja) * | 2007-02-09 | 2010-05-27 | アイアールエム・リミテッド・ライアビリティ・カンパニー | チャネル活性化プロテアーゼ阻害剤としての化合物および組成物 |
| US8293915B2 (en) | 2007-02-09 | 2012-10-23 | Irm Llc | Compounds and compositions as channel activating protease inhibitors |
| IE20070935A1 (en) * | 2007-12-21 | 2009-06-24 | Trinity College Dublin | Guanidine based compounds and their use in the treatment of mental and neurological disorders. |
| SI2421826T1 (sl) * | 2009-04-20 | 2014-02-28 | F. Hoffmann-La Roche Ag | Derivati prolina kot inhibitorji katepsina |
| CN102811989A (zh) * | 2010-02-03 | 2012-12-05 | Meh联合公司 | 作为具有选择性和生物活性的等排物的多取代氟甲烷 |
| RU2014123784A (ru) * | 2011-11-25 | 2015-12-27 | Ф. Хоффманн-Ля Рош Аг | Новые производные пирролидина в качестве ингибиторов катепсина |
| KR20170068521A (ko) | 2014-10-06 | 2017-06-19 | 코텍자임, 인코포레이티드 | 리신 진지페인의 억제제 |
| CN105001131A (zh) * | 2015-07-31 | 2015-10-28 | 吉尔生化（上海）有限公司 | 一种医药中间体nα-z-s-苄基-l-半胱氨酸-4-硝基苯酯的合成方法 |
| CA3004095A1 (en) | 2015-11-09 | 2017-05-18 | Cortexyme, Inc. | Inhibitors of arginine gingipain |
| WO2018053353A1 (en) | 2016-09-16 | 2018-03-22 | Cortexyme, Inc. | Ketone inhibitors of lysine gingipain |
| CN110483437B (zh) * | 2018-05-14 | 2022-12-06 | 嘉兴维眸生物科技有限公司 | 一种含五元环的化合物及其制备和应用 |
| US20220354833A1 (en) | 2019-09-17 | 2022-11-10 | Mereo Biopharma 4 Limited | Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease |
| ES2962498T3 (es) | 2020-04-16 | 2024-03-19 | Mereo Biopharma 4 Ltd | Métodos que implican el inhibidor de elastasa de neutrófilos alvelestat para el tratamiento de enfermedades respiratorias mediadas por deficiencia de alfa-1 antitripsina |
| US20240382472A1 (en) | 2021-10-20 | 2024-11-21 | Mereo Biopharma 4 Limited | Neutrophil elastase inhibitors for use in the treatment of fibrosis |
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| GB8809316D0 (en) * | 1987-05-11 | 1988-05-25 | Ici America Inc | Heterocyclic ketones |
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| US5726159A (en) * | 1994-03-04 | 1998-03-10 | Eli Lilly And Company | Antithrombotic agents |
| ZA951618B (en) | 1994-03-04 | 1996-08-27 | Lilly Co Eli | Antithrombotic agents |
| US5705487A (en) * | 1994-03-04 | 1998-01-06 | Eli Lilly And Company | Antithrombotic agents |
| ZA951617B (en) | 1994-03-04 | 1997-02-27 | Lilly Co Eli | Antithrombotic agents. |
| US5707966A (en) * | 1994-03-04 | 1998-01-13 | Eli Lilly And Company | Antithrombotic agents |
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| JPH0820597A (ja) | 1994-07-07 | 1996-01-23 | Meiji Seika Kaisha Ltd | トロンビン阻害作用を有する複素環カルボニル化合物 |
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| EP1363631A4 (en) | 2001-03-02 | 2005-11-16 | Bristol Myers Squibb Co | "COMPOUNDS SUITED AS MODULATORS OF MELANOCORTIN RECEPTORS AND THESE PHARMACEUTICAL COMPOSITIONS CONTAINING THEREOF" |
| KR100926244B1 (ko) | 2001-07-11 | 2009-11-12 | 버텍스 파마슈티칼스 인코포레이티드 | 브릿지된 바이사이클릭 세린 프로테아제 억제제 |
| WO2003013571A1 (en) | 2001-08-10 | 2003-02-20 | Palatin Technologies, Inc. | Peptidomimetics of biologically active metallopeptides |
| EP1480999A2 (en) | 2002-02-08 | 2004-12-01 | Idun Pharmaceuticals | (substituted)acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases |
| US7019019B2 (en) * | 2002-12-23 | 2006-03-28 | Dendreon Corporation | Matriptase inhibitors and methods of use |
| US7205384B2 (en) * | 2003-08-05 | 2007-04-17 | Ortho-Mcneil Pharmaceutical Inc. | Process for preparing peptidyl heterocyclic ketone derivatives |
| PE20050374A1 (es) | 2003-09-05 | 2005-05-30 | Vertex Pharma | Inhibidores de proteasas de serina, en particular proteasa ns3-ns4a del vhc |
| NZ546663A (en) | 2003-10-10 | 2010-01-29 | Vertex Pharma | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease |
| RU2006124594A (ru) | 2003-12-11 | 2008-01-27 | Шеринг Корпорейшн (US) | Ингибиторы сериновой протеазы ns3/ns4а вируса гепатита с |
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| WO2005087721A2 (en) | 2004-02-27 | 2005-09-22 | Schering Corporation | Compounds as inhibitors of hepatitis c virus ns3 serine protease |
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| EP1773868B1 (en) | 2004-05-20 | 2009-07-15 | Schering Corporation | Substituted prolines as inhibitors of hepatitis c virus ns3 serine protease |
| JPWO2006006644A1 (ja) | 2004-07-14 | 2008-05-01 | 協和醗酵工業株式会社 | 複素環式化合物 |
| GB0507577D0 (en) | 2005-04-14 | 2005-05-18 | Novartis Ag | Organic compounds |
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| RU2419625C2 (ru) | 2006-05-23 | 2011-05-27 | Айрм Ллк | Соединения и композиции в качестве ингибиторов протеазы, активирующей каналы |
| AU2007253819B2 (en) * | 2006-05-23 | 2011-02-17 | Irm Llc | Compounds and compositions as channel activating protease inhibitors |
| NZ577939A (en) | 2007-01-10 | 2011-03-31 | Irm Llc | Compounds and compositions as channel activating protease inhibitors |
| US8293915B2 (en) | 2007-02-09 | 2012-10-23 | Irm Llc | Compounds and compositions as channel activating protease inhibitors |
| JP2010518097A (ja) | 2007-02-09 | 2010-05-27 | アイアールエム・リミテッド・ライアビリティ・カンパニー | チャネル活性化プロテアーゼ阻害剤としての化合物および組成物 |
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2007
- 2007-05-16 AU AU2007253819A patent/AU2007253819B2/en not_active Ceased
- 2007-05-16 MX MX2008014839A patent/MX2008014839A/es active IP Right Grant
- 2007-05-16 WO PCT/US2007/069059 patent/WO2007137080A2/en not_active Ceased
- 2007-05-16 CA CA002651762A patent/CA2651762A1/en not_active Abandoned
- 2007-05-16 RU RU2008150615/04A patent/RU2419626C2/ru not_active IP Right Cessation
- 2007-05-16 KR KR1020087031129A patent/KR101069051B1/ko not_active Expired - Fee Related
- 2007-05-16 US US11/749,430 patent/US7951823B2/en not_active Expired - Fee Related
- 2007-05-16 JP JP2009512222A patent/JP2009538327A/ja active Pending
- 2007-05-16 EP EP07783835A patent/EP2027143A2/en not_active Withdrawn
- 2007-05-16 BR BRPI0712021-4A patent/BRPI0712021A2/pt not_active IP Right Cessation
- 2007-05-23 TW TW096118422A patent/TW200813094A/zh unknown
- 2007-05-23 PE PE2007000642A patent/PE20080708A1/es not_active Application Discontinuation
- 2007-05-23 AR ARP070102231A patent/AR061109A1/es not_active Application Discontinuation
- 2007-05-23 CL CL200701481A patent/CL2007001481A1/es unknown
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2011
- 2011-04-19 US US13/089,973 patent/US8338469B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2007253819B2 (en) | 2011-02-17 |
| US7951823B2 (en) | 2011-05-31 |
| AU2007253819A1 (en) | 2007-11-29 |
| WO2007137080A3 (en) | 2008-01-24 |
| RU2419626C2 (ru) | 2011-05-27 |
| RU2008150615A (ru) | 2010-06-27 |
| BRPI0712021A2 (pt) | 2012-01-03 |
| EP2027143A2 (en) | 2009-02-25 |
| US20070275906A1 (en) | 2007-11-29 |
| TW200813094A (en) | 2008-03-16 |
| AR061109A1 (es) | 2008-08-06 |
| KR20090014217A (ko) | 2009-02-06 |
| CA2651762A1 (en) | 2007-11-29 |
| CL2007001481A1 (es) | 2008-05-09 |
| MX2008014839A (es) | 2008-12-05 |
| KR101069051B1 (ko) | 2011-09-29 |
| US8338469B2 (en) | 2012-12-25 |
| WO2007137080A2 (en) | 2007-11-29 |
| US20110257077A1 (en) | 2011-10-20 |
| JP2009538327A (ja) | 2009-11-05 |
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