PE20080702A1 - PROLINAMIDAS SUSTITUIDAS COMO INHIBIDORES DEL FACTOR Xa - Google Patents
PROLINAMIDAS SUSTITUIDAS COMO INHIBIDORES DEL FACTOR XaInfo
- Publication number
- PE20080702A1 PE20080702A1 PE2007000580A PE2007000580A PE20080702A1 PE 20080702 A1 PE20080702 A1 PE 20080702A1 PE 2007000580 A PE2007000580 A PE 2007000580A PE 2007000580 A PE2007000580 A PE 2007000580A PE 20080702 A1 PE20080702 A1 PE 20080702A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- amide
- inhibitors
- phenyl
- factor
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 108010074860 Factor Xa Proteins 0.000 title abstract 2
- GEAXLHPORCRESC-UHFFFAOYSA-N chlorocyclohexatriene Chemical class ClC1=CC=C=C[CH]1 GEAXLHPORCRESC-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- KYXSVGVQGFPNRQ-UHFFFAOYSA-N 2-methyl-3,4-dihydro-1h-isoquinoline Chemical compound C1=CC=C2CN(C)CCC2=C1 KYXSVGVQGFPNRQ-UHFFFAOYSA-N 0.000 abstract 1
- 108010022999 Serine Proteases Proteins 0.000 abstract 1
- 102000012479 Serine Proteases Human genes 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001732 thrombotic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06113977 | 2006-05-16 | ||
| EP07102566 | 2007-02-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20080702A1 true PE20080702A1 (es) | 2008-07-10 |
Family
ID=38646563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2007000580A PE20080702A1 (es) | 2006-05-16 | 2007-05-14 | PROLINAMIDAS SUSTITUIDAS COMO INHIBIDORES DEL FACTOR Xa |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7807693B2 (https=) |
| EP (1) | EP2051975B1 (https=) |
| JP (1) | JP5263686B2 (https=) |
| KR (1) | KR101422456B1 (https=) |
| AR (1) | AR060945A1 (https=) |
| AU (1) | AU2007251614B2 (https=) |
| BR (1) | BRPI0711648A2 (https=) |
| CA (1) | CA2653753C (https=) |
| CL (1) | CL2007001391A1 (https=) |
| DK (1) | DK2051975T3 (https=) |
| EA (1) | EA200802210A1 (https=) |
| EC (1) | ECSP088824A (https=) |
| ES (1) | ES2395538T3 (https=) |
| IL (1) | IL195245A (https=) |
| MX (1) | MX2008014499A (https=) |
| MY (1) | MY146623A (https=) |
| NO (1) | NO20084530L (https=) |
| NZ (1) | NZ573573A (https=) |
| PE (1) | PE20080702A1 (https=) |
| PL (1) | PL2051975T3 (https=) |
| TW (1) | TW200813047A (https=) |
| UY (1) | UY30352A1 (https=) |
| WO (1) | WO2007131982A2 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1975165A1 (de) | 2007-03-27 | 2008-10-01 | Boehringer Ingelheim Pharma GmbH & Co. KG | Substituierte Pyrrolidinamide, deren Herstellung und deren Verwendung als Arzneimittel |
| EP2220079A2 (en) | 2007-11-15 | 2010-08-25 | Boehringer Ingelheim International GmbH | Substituted amides, manufacturing and use thereof as medicaments |
| CN102046624A (zh) * | 2008-03-31 | 2011-05-04 | 埃沃特克股份有限公司 | 作为组胺h3受体拮抗剂的四氢萘啶及其氮杂衍生物 |
| GB201209138D0 (en) * | 2012-05-24 | 2012-07-04 | Ono Pharmaceutical Co | Compounds |
| JP6052527B2 (ja) | 2013-02-21 | 2016-12-27 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ジヒドロプテリジノンｉ |
| JP6337750B2 (ja) * | 2013-11-22 | 2018-06-06 | 小野薬品工業株式会社 | 化合物 |
| AU2015210833B2 (en) | 2014-02-03 | 2019-01-03 | Vitae Pharmaceuticals, Llc | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| KR102736869B1 (ko) * | 2014-03-07 | 2024-12-02 | 바이오크리스트파마슈티컬즈,인코포레이티드 | 인간 혈장 칼리크레인 저해제 |
| JP6564029B2 (ja) | 2014-10-14 | 2019-08-21 | ヴァイティー ファーマシューティカルズ，エルエルシー | Ｒｏｒ−ガンマのジヒドロピロロピリジン阻害剤 |
| US9663515B2 (en) | 2014-11-05 | 2017-05-30 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| US9845308B2 (en) | 2014-11-05 | 2017-12-19 | Vitae Pharmaceuticals, Inc. | Isoindoline inhibitors of ROR-gamma |
| EP3078378B1 (en) | 2015-04-08 | 2020-06-24 | Vaiomer | Use of factor xa inhibitors for regulating glycemia |
| DK3331876T3 (da) | 2015-08-05 | 2021-01-11 | Vitae Pharmaceuticals Llc | Modulators of ror-gamma |
| MA53943A (fr) | 2015-11-20 | 2021-08-25 | Vitae Pharmaceuticals Llc | Modulateurs de ror-gamma |
| TWI757266B (zh) | 2016-01-29 | 2022-03-11 | 美商維它藥物有限責任公司 | ＲＯＲ－γ調節劑 |
| US9481674B1 (en) | 2016-06-10 | 2016-11-01 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| WO2019018975A1 (en) | 2017-07-24 | 2019-01-31 | Vitae Pharmaceuticals, Inc. | INHIBITORS OF ROR GAMMA |
| CN115650976A (zh) | 2017-07-24 | 2023-01-31 | 生命医药有限责任公司 | RORγ的抑制剂 |
| CN114646701B (zh) * | 2022-03-01 | 2023-09-29 | 浙江国邦药业有限公司 | 一种l-脯氨酰胺中有关物质的hplc测试方法 |
| EP4695226A1 (en) * | 2023-04-14 | 2026-02-18 | Pfizer Inc. | Glucose-dependent insulinotropic polypeptide receptor antagonists and uses thereof |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7030141B2 (en) * | 2001-11-29 | 2006-04-18 | Christopher Franklin Bigge | Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade |
| JP3975254B2 (ja) * | 2002-07-25 | 2007-09-12 | 日野自動車株式会社 | チャイルドシート用アンカの取付構造 |
| PL377633A1 (pl) | 2003-04-03 | 2006-02-06 | Merck Patent Gmbh | Związki karbonylowe |
| DE10329457A1 (de) | 2003-04-03 | 2005-01-20 | Merck Patent Gmbh | Ethinylprolinderivate |
| AU2004246766B2 (en) | 2003-06-18 | 2009-09-17 | Merck Patent Gmbh | Pyrrolidin-1, 2- dicarboxylic acid- 1- [(4- ethinyl- phenyl) - amid]- 2- [(phenyl)- amid] derivative as inhibitors of coagulation factor Xa and VIIa for the treatment of thrombosis |
| ES2223277B1 (es) | 2003-06-19 | 2006-03-01 | Fernando Bouffard Fita | Composicion anestesica para administracion topica. |
| DE10358814A1 (de) | 2003-12-16 | 2005-07-21 | Merck Patent Gmbh | Prolinylarylacetamide |
| DE102004014945A1 (de) | 2004-03-26 | 2005-10-13 | Merck Patent Gmbh | Prolinylderivate |
| US7453002B2 (en) * | 2004-06-15 | 2008-11-18 | Bristol-Myers Squibb Company | Five-membered heterocycles useful as serine protease inhibitors |
| DE102004045796A1 (de) | 2004-09-22 | 2006-03-23 | Merck Patent Gmbh | Arzneimittel enthaltend Carbonylverbindungen sowie deren Verwendung |
| US20090099231A1 (en) | 2005-04-11 | 2009-04-16 | John David Harling | 3-Sulfonylamino-Pyrrolidine-2-One Derivatives as Factor Xa Inhibitors |
| WO2007009883A1 (en) * | 2005-07-15 | 2007-01-25 | F. Hoffmann-La Roche Ag | Novel heteroaryl fused cyclic amines |
-
2007
- 2007-05-14 EP EP07729083A patent/EP2051975B1/de active Active
- 2007-05-14 ES ES07729083T patent/ES2395538T3/es active Active
- 2007-05-14 WO PCT/EP2007/054631 patent/WO2007131982A2/de not_active Ceased
- 2007-05-14 JP JP2009510435A patent/JP5263686B2/ja not_active Expired - Fee Related
- 2007-05-14 MY MYPI20084581A patent/MY146623A/en unknown
- 2007-05-14 MX MX2008014499A patent/MX2008014499A/es active IP Right Grant
- 2007-05-14 BR BRPI0711648-9A patent/BRPI0711648A2/pt not_active IP Right Cessation
- 2007-05-14 EA EA200802210A patent/EA200802210A1/ru unknown
- 2007-05-14 KR KR1020087027907A patent/KR101422456B1/ko not_active Expired - Fee Related
- 2007-05-14 CA CA2653753A patent/CA2653753C/en not_active Expired - Fee Related
- 2007-05-14 AU AU2007251614A patent/AU2007251614B2/en not_active Ceased
- 2007-05-14 DK DK07729083.1T patent/DK2051975T3/da active
- 2007-05-14 PE PE2007000580A patent/PE20080702A1/es not_active Application Discontinuation
- 2007-05-14 PL PL07729083T patent/PL2051975T3/pl unknown
- 2007-05-14 NZ NZ573573A patent/NZ573573A/en not_active IP Right Cessation
- 2007-05-15 TW TW096117145A patent/TW200813047A/zh unknown
- 2007-05-15 UY UY30352A patent/UY30352A1/es not_active Application Discontinuation
- 2007-05-15 CL CL2007001391A patent/CL2007001391A1/es unknown
- 2007-05-16 US US11/749,204 patent/US7807693B2/en active Active
- 2007-05-16 AR ARP070102101A patent/AR060945A1/es unknown
-
2008
- 2008-10-15 EC EC2008008824A patent/ECSP088824A/es unknown
- 2008-10-28 NO NO20084530A patent/NO20084530L/no not_active Application Discontinuation
- 2008-11-12 IL IL195245A patent/IL195245A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2653753A1 (en) | 2007-11-22 |
| NO20084530L (no) | 2008-12-12 |
| EA200802210A1 (ru) | 2009-06-30 |
| JP2009537483A (ja) | 2009-10-29 |
| BRPI0711648A2 (pt) | 2011-11-29 |
| EP2051975B1 (de) | 2012-09-12 |
| UY30352A1 (es) | 2008-01-02 |
| US7807693B2 (en) | 2010-10-05 |
| WO2007131982A3 (de) | 2008-01-10 |
| PL2051975T3 (pl) | 2013-01-31 |
| AU2007251614A1 (en) | 2007-11-22 |
| EP2051975A2 (de) | 2009-04-29 |
| CA2653753C (en) | 2013-09-24 |
| WO2007131982A2 (de) | 2007-11-22 |
| AR060945A1 (es) | 2008-07-23 |
| CL2007001391A1 (es) | 2008-01-18 |
| IL195245A (en) | 2012-09-24 |
| NZ573573A (en) | 2011-10-28 |
| TW200813047A (en) | 2008-03-16 |
| KR101422456B1 (ko) | 2014-07-23 |
| DK2051975T3 (da) | 2012-10-15 |
| JP5263686B2 (ja) | 2013-08-14 |
| US20080139605A1 (en) | 2008-06-12 |
| KR20090017523A (ko) | 2009-02-18 |
| ES2395538T3 (es) | 2013-02-13 |
| IL195245A0 (en) | 2009-09-22 |
| HK1131140A1 (en) | 2010-01-15 |
| ECSP088824A (es) | 2008-11-27 |
| MX2008014499A (es) | 2008-11-27 |
| AU2007251614B2 (en) | 2013-01-17 |
| MY146623A (en) | 2012-09-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20080702A1 (es) | PROLINAMIDAS SUSTITUIDAS COMO INHIBIDORES DEL FACTOR Xa | |
| PE20090226A1 (es) | PIRROLIDINAMIDAS SUSTITUIDAS COMO INHIBIDORES DEL FACTOR Xa Y SU PREPARACION | |
| PE20091843A1 (es) | Inhibidores de catepsina c | |
| ECSP088765A (es) | Aminotetrahidropiranos como inhibidores de dipeptidil peptidasa-iv para el tratamiento o prevención de diabetes | |
| PE20130311A1 (es) | Composiciones y metodos para modular la via de senalizacion de wnt | |
| PE20120911A1 (es) | Derivados de prolina como inhibidores de catepsina | |
| NI201100081A (es) | Aminotetrahidropiranos como inhibidores de dipeptidil peptidasa - iv para el tratamiento o prevención de diabetes. | |
| PE20070811A1 (es) | Analogos de arilpropionamida, arilacrilamida, arilpropinamida, o arilmetilurea como inhibidores del factor xia | |
| EA201070442A1 (ru) | НОВЫЕ ИНГИБИТОРЫ sEH И ИХ ПРИМЕНЕНИЕ | |
| PE20130281A1 (es) | Derivados de acido 5-alquinil-3-amida-2-tiofeno-carboxilico como inhibidores del virus flaviviridae | |
| UY32547A (es) | Piperidinas sustituidas como antagonistas de ccr3 | |
| PE20161218A1 (es) | (2s)-n-[(1s)-1-ciano-2-feniletil]-1,4-oxazepan-2-carboxamidas como inhibidores de dipeptidil peptidasa 1 | |
| PE20091841A1 (es) | Inhibidores del virus de hepatitis c | |
| ATE554085T1 (de) | Neue inhibitoren von glutaminylcyclase | |
| PE20110367A1 (es) | DERIVADOS DE 4-CIANO-4-FENIL-PIRROLIDIN-2-CARBOXAMIDAS SUSTITUIDAS COMO INHIBIDORES DE LA INTERACCION p53-MDM2 | |
| EA201100311A1 (ru) | Амидные производные гетероарилов и их применение в качестве активаторов глюкокиназы | |
| PE20040925A1 (es) | DERIVADOS DE PIRAZOL COMO INHIBIDORES DEL FACTOR Xa | |
| PE20120355A1 (es) | DERIVADOS DE PIRAZOL COMO INHIBIDORES DE LA ENZIMA 11ßHSD1 | |
| PE20071326A1 (es) | Inhibidores de la polimerasa viral | |
| PE20140966A1 (es) | Quinazolincarboxamida azetidinas | |
| EA200900605A1 (ru) | Новые производные фенилсульфамоил бензамидов в качестве антагонистов брадикининовых рецепторов | |
| PE20090548A1 (es) | Compuestos aza-biciclohexano como inhibidores de trombina | |
| PE20061099A1 (es) | Compuestos de piridil acido acetico como inhibidores de peptidasa | |
| PE20090880A1 (es) | Compuestos heterociclicos como inhibidores de fosfatidilinositol 3-cinasa | |
| TW200716531A (en) | Cyclohexanesulfonyl derivatives as GLYT1 inhibitors to treat schizophrenia |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |