EA200802210A1 - Замещенные пролинамиды, их получение и их применение в качестве лекарственных средств - Google Patents
Замещенные пролинамиды, их получение и их применение в качестве лекарственных средствInfo
- Publication number
- EA200802210A1 EA200802210A1 EA200802210A EA200802210A EA200802210A1 EA 200802210 A1 EA200802210 A1 EA 200802210A1 EA 200802210 A EA200802210 A EA 200802210A EA 200802210 A EA200802210 A EA 200802210A EA 200802210 A1 EA200802210 A1 EA 200802210A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- substituted
- medicines
- receiving
- prolinamides
- salts
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06113977 | 2006-05-16 | ||
| EP07102566 | 2007-02-16 | ||
| PCT/EP2007/054631 WO2007131982A2 (de) | 2006-05-16 | 2007-05-14 | Substituierte prolinamide, deren herstellung und deren verwendung als arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA200802210A1 true EA200802210A1 (ru) | 2009-06-30 |
Family
ID=38646563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200802210A EA200802210A1 (ru) | 2006-05-16 | 2007-05-14 | Замещенные пролинамиды, их получение и их применение в качестве лекарственных средств |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7807693B2 (https=) |
| EP (1) | EP2051975B1 (https=) |
| JP (1) | JP5263686B2 (https=) |
| KR (1) | KR101422456B1 (https=) |
| AR (1) | AR060945A1 (https=) |
| AU (1) | AU2007251614B2 (https=) |
| BR (1) | BRPI0711648A2 (https=) |
| CA (1) | CA2653753C (https=) |
| CL (1) | CL2007001391A1 (https=) |
| DK (1) | DK2051975T3 (https=) |
| EA (1) | EA200802210A1 (https=) |
| EC (1) | ECSP088824A (https=) |
| ES (1) | ES2395538T3 (https=) |
| IL (1) | IL195245A (https=) |
| MX (1) | MX2008014499A (https=) |
| MY (1) | MY146623A (https=) |
| NO (1) | NO20084530L (https=) |
| NZ (1) | NZ573573A (https=) |
| PE (1) | PE20080702A1 (https=) |
| PL (1) | PL2051975T3 (https=) |
| TW (1) | TW200813047A (https=) |
| UY (1) | UY30352A1 (https=) |
| WO (1) | WO2007131982A2 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2636050C2 (ru) * | 2012-05-24 | 2017-11-20 | Оно Фармасьютикал Ко., Лтд. | Замещенные пирролидины в качестве ингибиторов фактора xia для лечения тромбоэмболических заболеваний |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1975165A1 (de) | 2007-03-27 | 2008-10-01 | Boehringer Ingelheim Pharma GmbH & Co. KG | Substituierte Pyrrolidinamide, deren Herstellung und deren Verwendung als Arzneimittel |
| EP2220079A2 (en) | 2007-11-15 | 2010-08-25 | Boehringer Ingelheim International GmbH | Substituted amides, manufacturing and use thereof as medicaments |
| CN102046624A (zh) * | 2008-03-31 | 2011-05-04 | 埃沃特克股份有限公司 | 作为组胺h3受体拮抗剂的四氢萘啶及其氮杂衍生物 |
| JP6052527B2 (ja) | 2013-02-21 | 2016-12-27 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ジヒドロプテリジノンｉ |
| JP6337750B2 (ja) * | 2013-11-22 | 2018-06-06 | 小野薬品工業株式会社 | 化合物 |
| AU2015210833B2 (en) | 2014-02-03 | 2019-01-03 | Vitae Pharmaceuticals, Llc | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| KR102736869B1 (ko) * | 2014-03-07 | 2024-12-02 | 바이오크리스트파마슈티컬즈,인코포레이티드 | 인간 혈장 칼리크레인 저해제 |
| JP6564029B2 (ja) | 2014-10-14 | 2019-08-21 | ヴァイティー ファーマシューティカルズ，エルエルシー | Ｒｏｒ−ガンマのジヒドロピロロピリジン阻害剤 |
| US9663515B2 (en) | 2014-11-05 | 2017-05-30 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| US9845308B2 (en) | 2014-11-05 | 2017-12-19 | Vitae Pharmaceuticals, Inc. | Isoindoline inhibitors of ROR-gamma |
| EP3078378B1 (en) | 2015-04-08 | 2020-06-24 | Vaiomer | Use of factor xa inhibitors for regulating glycemia |
| DK3331876T3 (da) | 2015-08-05 | 2021-01-11 | Vitae Pharmaceuticals Llc | Modulators of ror-gamma |
| MA53943A (fr) | 2015-11-20 | 2021-08-25 | Vitae Pharmaceuticals Llc | Modulateurs de ror-gamma |
| TWI757266B (zh) | 2016-01-29 | 2022-03-11 | 美商維它藥物有限責任公司 | ＲＯＲ－γ調節劑 |
| US9481674B1 (en) | 2016-06-10 | 2016-11-01 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| WO2019018975A1 (en) | 2017-07-24 | 2019-01-31 | Vitae Pharmaceuticals, Inc. | INHIBITORS OF ROR GAMMA |
| CN115650976A (zh) | 2017-07-24 | 2023-01-31 | 生命医药有限责任公司 | RORγ的抑制剂 |
| CN114646701B (zh) * | 2022-03-01 | 2023-09-29 | 浙江国邦药业有限公司 | 一种l-脯氨酰胺中有关物质的hplc测试方法 |
| EP4695226A1 (en) * | 2023-04-14 | 2026-02-18 | Pfizer Inc. | Glucose-dependent insulinotropic polypeptide receptor antagonists and uses thereof |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7030141B2 (en) * | 2001-11-29 | 2006-04-18 | Christopher Franklin Bigge | Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade |
| JP3975254B2 (ja) * | 2002-07-25 | 2007-09-12 | 日野自動車株式会社 | チャイルドシート用アンカの取付構造 |
| PL377633A1 (pl) | 2003-04-03 | 2006-02-06 | Merck Patent Gmbh | Związki karbonylowe |
| DE10329457A1 (de) | 2003-04-03 | 2005-01-20 | Merck Patent Gmbh | Ethinylprolinderivate |
| AU2004246766B2 (en) | 2003-06-18 | 2009-09-17 | Merck Patent Gmbh | Pyrrolidin-1, 2- dicarboxylic acid- 1- [(4- ethinyl- phenyl) - amid]- 2- [(phenyl)- amid] derivative as inhibitors of coagulation factor Xa and VIIa for the treatment of thrombosis |
| ES2223277B1 (es) | 2003-06-19 | 2006-03-01 | Fernando Bouffard Fita | Composicion anestesica para administracion topica. |
| DE10358814A1 (de) | 2003-12-16 | 2005-07-21 | Merck Patent Gmbh | Prolinylarylacetamide |
| DE102004014945A1 (de) | 2004-03-26 | 2005-10-13 | Merck Patent Gmbh | Prolinylderivate |
| US7453002B2 (en) * | 2004-06-15 | 2008-11-18 | Bristol-Myers Squibb Company | Five-membered heterocycles useful as serine protease inhibitors |
| DE102004045796A1 (de) | 2004-09-22 | 2006-03-23 | Merck Patent Gmbh | Arzneimittel enthaltend Carbonylverbindungen sowie deren Verwendung |
| US20090099231A1 (en) | 2005-04-11 | 2009-04-16 | John David Harling | 3-Sulfonylamino-Pyrrolidine-2-One Derivatives as Factor Xa Inhibitors |
| WO2007009883A1 (en) * | 2005-07-15 | 2007-01-25 | F. Hoffmann-La Roche Ag | Novel heteroaryl fused cyclic amines |
-
2007
- 2007-05-14 EP EP07729083A patent/EP2051975B1/de active Active
- 2007-05-14 ES ES07729083T patent/ES2395538T3/es active Active
- 2007-05-14 WO PCT/EP2007/054631 patent/WO2007131982A2/de not_active Ceased
- 2007-05-14 JP JP2009510435A patent/JP5263686B2/ja not_active Expired - Fee Related
- 2007-05-14 MY MYPI20084581A patent/MY146623A/en unknown
- 2007-05-14 MX MX2008014499A patent/MX2008014499A/es active IP Right Grant
- 2007-05-14 BR BRPI0711648-9A patent/BRPI0711648A2/pt not_active IP Right Cessation
- 2007-05-14 EA EA200802210A patent/EA200802210A1/ru unknown
- 2007-05-14 KR KR1020087027907A patent/KR101422456B1/ko not_active Expired - Fee Related
- 2007-05-14 CA CA2653753A patent/CA2653753C/en not_active Expired - Fee Related
- 2007-05-14 AU AU2007251614A patent/AU2007251614B2/en not_active Ceased
- 2007-05-14 DK DK07729083.1T patent/DK2051975T3/da active
- 2007-05-14 PE PE2007000580A patent/PE20080702A1/es not_active Application Discontinuation
- 2007-05-14 PL PL07729083T patent/PL2051975T3/pl unknown
- 2007-05-14 NZ NZ573573A patent/NZ573573A/en not_active IP Right Cessation
- 2007-05-15 TW TW096117145A patent/TW200813047A/zh unknown
- 2007-05-15 UY UY30352A patent/UY30352A1/es not_active Application Discontinuation
- 2007-05-15 CL CL2007001391A patent/CL2007001391A1/es unknown
- 2007-05-16 US US11/749,204 patent/US7807693B2/en active Active
- 2007-05-16 AR ARP070102101A patent/AR060945A1/es unknown
-
2008
- 2008-10-15 EC EC2008008824A patent/ECSP088824A/es unknown
- 2008-10-28 NO NO20084530A patent/NO20084530L/no not_active Application Discontinuation
- 2008-11-12 IL IL195245A patent/IL195245A/en not_active IP Right Cessation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2636050C2 (ru) * | 2012-05-24 | 2017-11-20 | Оно Фармасьютикал Ко., Лтд. | Замещенные пирролидины в качестве ингибиторов фактора xia для лечения тромбоэмболических заболеваний |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2653753A1 (en) | 2007-11-22 |
| NO20084530L (no) | 2008-12-12 |
| JP2009537483A (ja) | 2009-10-29 |
| BRPI0711648A2 (pt) | 2011-11-29 |
| EP2051975B1 (de) | 2012-09-12 |
| PE20080702A1 (es) | 2008-07-10 |
| UY30352A1 (es) | 2008-01-02 |
| US7807693B2 (en) | 2010-10-05 |
| WO2007131982A3 (de) | 2008-01-10 |
| PL2051975T3 (pl) | 2013-01-31 |
| AU2007251614A1 (en) | 2007-11-22 |
| EP2051975A2 (de) | 2009-04-29 |
| CA2653753C (en) | 2013-09-24 |
| WO2007131982A2 (de) | 2007-11-22 |
| AR060945A1 (es) | 2008-07-23 |
| CL2007001391A1 (es) | 2008-01-18 |
| IL195245A (en) | 2012-09-24 |
| NZ573573A (en) | 2011-10-28 |
| TW200813047A (en) | 2008-03-16 |
| KR101422456B1 (ko) | 2014-07-23 |
| DK2051975T3 (da) | 2012-10-15 |
| JP5263686B2 (ja) | 2013-08-14 |
| US20080139605A1 (en) | 2008-06-12 |
| KR20090017523A (ko) | 2009-02-18 |
| ES2395538T3 (es) | 2013-02-13 |
| IL195245A0 (en) | 2009-09-22 |
| HK1131140A1 (en) | 2010-01-15 |
| ECSP088824A (es) | 2008-11-27 |
| MX2008014499A (es) | 2008-11-27 |
| AU2007251614B2 (en) | 2013-01-17 |
| MY146623A (en) | 2012-09-14 |
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