PE20070019A1 - Forma polimorfica de dexcetoprofeno trometamol, su preparacion y composiciones que lo contienen - Google Patents
Forma polimorfica de dexcetoprofeno trometamol, su preparacion y composiciones que lo contienenInfo
- Publication number
- PE20070019A1 PE20070019A1 PE2006000666A PE2006000666A PE20070019A1 PE 20070019 A1 PE20070019 A1 PE 20070019A1 PE 2006000666 A PE2006000666 A PE 2006000666A PE 2006000666 A PE2006000666 A PE 2006000666A PE 20070019 A1 PE20070019 A1 PE 20070019A1
- Authority
- PE
- Peru
- Prior art keywords
- polymorph
- trometamol
- polymorphic form
- dexketoprophene
- refers
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
- C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIERE A UNA FORMA POLIMORFICA DE DEXKETOPROFENO TROMETAMOL DENOMINADA FORMA A, CARACTERIZADA POR UN PATRON DE DIFRACCION DE POLVO DE RAYOS X QUE COMPRENDE PICOS EXPRESADOS EN GRADOS 2* DE 5.14±0.02, 8.02±0.02, 19.58±0.02, 21.47±0.02, 26.86±0.02. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA CARACTERIZADA PORQUE EL POLIMORFO A ES SUBSTANCIALMENTE PURO DEL POLIMORFO B, Y UN PROCEDIMIENTO DE PREPARACION DE LA FORMA A, QUE COMPRENDE: A) DISOLVER EL ACIDO DE DEXKETOPROFENO EN ETANOL; B) ANADIR TROMETAMINA A LA SOLUCION OBTENIDA EN (A); C) CALENTAR LA MEZCLA PARA OBTENER UNA SOLUCION CLARA; D) AGREGAR XILENO A LA SOLUCION OBTENIDA EN (C) Y CALENTAR HASTA OBTENER UNA SOLUCION COMPLETA; E) ENFRIAR A 40ºC A 46ºC Y DESPUES ENFRIAR ADICIONALMENTE A 18ºC A 22ºC DURANTE 4 A 6 HORAS; F) ENFRIAMIENTO ADICIONAL A UNA TEMPERATURA DE 0ºC A 5ºC POR UN TIEMPO DE 6 A 15 HORAS ADICIONALES; G) RECUPERAR EL POLIMORFO A CRISTALIZADO Y SECAR BAJO VACIO; DICHA COMPOSICION ES UTIL COMO ANALGESICO Y ANTIINFLAMATORIO
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05012919A EP1739072A1 (en) | 2005-06-15 | 2005-06-15 | Polymorphic forms of dexketoprofen trometamol, preparation and pharmaceutical compositions thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20070019A1 true PE20070019A1 (es) | 2007-01-31 |
Family
ID=35229901
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2006000666A PE20070019A1 (es) | 2005-06-15 | 2006-06-14 | Forma polimorfica de dexcetoprofeno trometamol, su preparacion y composiciones que lo contienen |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP1739072A1 (es) |
CN (1) | CN1880294B (es) |
AR (1) | AR055217A1 (es) |
BR (1) | BRPI0602206B8 (es) |
CO (1) | CO5780134A1 (es) |
MX (1) | MXPA06006731A (es) |
PE (1) | PE20070019A1 (es) |
TW (1) | TWI385148B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011001213A1 (en) * | 2009-06-30 | 2011-01-06 | Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi | A process for preparing dexketoprofen trometamol form a and form b crystals |
WO2013100877A1 (en) * | 2011-12-27 | 2013-07-04 | Mahmut Bilgic | Dexketoprofen formulations |
ES2501415T3 (es) | 2012-06-06 | 2016-02-22 | Galenicum Health S.L. | Composiciones farmacéuticas estables de acción rápida |
EP2759293A1 (en) * | 2013-01-25 | 2014-07-30 | Laboratorios Lesvi, S.L. | Pharmaceutical compositions of (+)-(s)-2-(3-benzoylphenyl)propionic acid tromethamine salt |
ITMI20130210A1 (it) | 2013-02-14 | 2014-08-15 | Menarini Lab | Composizioni farmaceutiche contenenti dexketoprofene e tramadolo |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2058024B1 (es) * | 1992-11-10 | 1995-05-01 | Menarini Lab | Nuevo derivado arilpropionico, procedimiento de fabricacion del mismo y su utilizacion como analgesico. |
FR2721316B1 (fr) | 1994-06-21 | 1996-09-13 | Thomson Csf | Procédé d'obtention de matériaux composites à base de polymère réticulé et de molécules fluides, comprenant une étape de séchage en phase supercritique. |
-
2005
- 2005-06-15 EP EP05012919A patent/EP1739072A1/en not_active Ceased
- 2005-06-17 AR ARP050102513A patent/AR055217A1/es unknown
-
2006
- 2006-06-14 BR BRPI0602206A patent/BRPI0602206B8/pt active IP Right Grant
- 2006-06-14 CO CO06057932A patent/CO5780134A1/es not_active Application Discontinuation
- 2006-06-14 TW TW095121118A patent/TWI385148B/zh active
- 2006-06-14 MX MXPA06006731A patent/MXPA06006731A/es active IP Right Grant
- 2006-06-14 CN CN2006100918930A patent/CN1880294B/zh active Active
- 2006-06-14 PE PE2006000666A patent/PE20070019A1/es active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
TW200716537A (en) | 2007-05-01 |
CN1880294A (zh) | 2006-12-20 |
BRPI0602206A (pt) | 2007-08-14 |
BRPI0602206B8 (pt) | 2021-05-25 |
BRPI0602206B1 (pt) | 2021-01-19 |
MXPA06006731A (es) | 2007-01-19 |
CN1880294B (zh) | 2011-09-21 |
EP1739072A1 (en) | 2007-01-03 |
CO5780134A1 (es) | 2007-07-31 |
AR055217A1 (es) | 2007-08-15 |
TWI385148B (zh) | 2013-02-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration |