PE20070019A1 - Forma polimorfica de dexcetoprofeno trometamol, su preparacion y composiciones que lo contienen - Google Patents

Forma polimorfica de dexcetoprofeno trometamol, su preparacion y composiciones que lo contienen

Info

Publication number
PE20070019A1
PE20070019A1 PE2006000666A PE2006000666A PE20070019A1 PE 20070019 A1 PE20070019 A1 PE 20070019A1 PE 2006000666 A PE2006000666 A PE 2006000666A PE 2006000666 A PE2006000666 A PE 2006000666A PE 20070019 A1 PE20070019 A1 PE 20070019A1
Authority
PE
Peru
Prior art keywords
polymorph
trometamol
polymorphic form
dexketoprophene
refers
Prior art date
Application number
PE2006000666A
Other languages
English (en)
Inventor
Fondevila Margarita Bosch
Serena Mannucci
Vasco Ester Torras
Roberto Falorni
Bosch Jose Maria Gonzalez
Original Assignee
Menarini Lab Sa
Menarini Int Operations Lu Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35229901&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20070019(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Menarini Lab Sa, Menarini Int Operations Lu Sa filed Critical Menarini Lab Sa
Publication of PE20070019A1 publication Critical patent/PE20070019A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A UNA FORMA POLIMORFICA DE DEXKETOPROFENO TROMETAMOL DENOMINADA FORMA A, CARACTERIZADA POR UN PATRON DE DIFRACCION DE POLVO DE RAYOS X QUE COMPRENDE PICOS EXPRESADOS EN GRADOS 2* DE 5.14±0.02, 8.02±0.02, 19.58±0.02, 21.47±0.02, 26.86±0.02. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA CARACTERIZADA PORQUE EL POLIMORFO A ES SUBSTANCIALMENTE PURO DEL POLIMORFO B, Y UN PROCEDIMIENTO DE PREPARACION DE LA FORMA A, QUE COMPRENDE: A) DISOLVER EL ACIDO DE DEXKETOPROFENO EN ETANOL; B) ANADIR TROMETAMINA A LA SOLUCION OBTENIDA EN (A); C) CALENTAR LA MEZCLA PARA OBTENER UNA SOLUCION CLARA; D) AGREGAR XILENO A LA SOLUCION OBTENIDA EN (C) Y CALENTAR HASTA OBTENER UNA SOLUCION COMPLETA; E) ENFRIAR A 40ºC A 46ºC Y DESPUES ENFRIAR ADICIONALMENTE A 18ºC A 22ºC DURANTE 4 A 6 HORAS; F) ENFRIAMIENTO ADICIONAL A UNA TEMPERATURA DE 0ºC A 5ºC POR UN TIEMPO DE 6 A 15 HORAS ADICIONALES; G) RECUPERAR EL POLIMORFO A CRISTALIZADO Y SECAR BAJO VACIO; DICHA COMPOSICION ES UTIL COMO ANALGESICO Y ANTIINFLAMATORIO
PE2006000666A 2005-06-15 2006-06-14 Forma polimorfica de dexcetoprofeno trometamol, su preparacion y composiciones que lo contienen PE20070019A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05012919A EP1739072A1 (en) 2005-06-15 2005-06-15 Polymorphic forms of dexketoprofen trometamol, preparation and pharmaceutical compositions thereof

Publications (1)

Publication Number Publication Date
PE20070019A1 true PE20070019A1 (es) 2007-01-31

Family

ID=35229901

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000666A PE20070019A1 (es) 2005-06-15 2006-06-14 Forma polimorfica de dexcetoprofeno trometamol, su preparacion y composiciones que lo contienen

Country Status (8)

Country Link
EP (1) EP1739072A1 (es)
CN (1) CN1880294B (es)
AR (1) AR055217A1 (es)
BR (1) BRPI0602206B8 (es)
CO (1) CO5780134A1 (es)
MX (1) MXPA06006731A (es)
PE (1) PE20070019A1 (es)
TW (1) TWI385148B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011001213A1 (en) * 2009-06-30 2011-01-06 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi A process for preparing dexketoprofen trometamol form a and form b crystals
WO2013100877A1 (en) * 2011-12-27 2013-07-04 Mahmut Bilgic Dexketoprofen formulations
ES2501415T3 (es) 2012-06-06 2016-02-22 Galenicum Health S.L. Composiciones farmacéuticas estables de acción rápida
EP2759293A1 (en) * 2013-01-25 2014-07-30 Laboratorios Lesvi, S.L. Pharmaceutical compositions of (+)-(s)-2-(3-benzoylphenyl)propionic acid tromethamine salt
ITMI20130210A1 (it) 2013-02-14 2014-08-15 Menarini Lab Composizioni farmaceutiche contenenti dexketoprofene e tramadolo

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2058024B1 (es) * 1992-11-10 1995-05-01 Menarini Lab Nuevo derivado arilpropionico, procedimiento de fabricacion del mismo y su utilizacion como analgesico.
FR2721316B1 (fr) 1994-06-21 1996-09-13 Thomson Csf Procédé d'obtention de matériaux composites à base de polymère réticulé et de molécules fluides, comprenant une étape de séchage en phase supercritique.

Also Published As

Publication number Publication date
TW200716537A (en) 2007-05-01
CN1880294A (zh) 2006-12-20
BRPI0602206A (pt) 2007-08-14
BRPI0602206B8 (pt) 2021-05-25
BRPI0602206B1 (pt) 2021-01-19
MXPA06006731A (es) 2007-01-19
CN1880294B (zh) 2011-09-21
EP1739072A1 (en) 2007-01-03
CO5780134A1 (es) 2007-07-31
AR055217A1 (es) 2007-08-15
TWI385148B (zh) 2013-02-11

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