CO5780134A1 - Forma polimorfica de descetoprofeno trometamol, su preparacion y composiciones que lo contienen - Google Patents

Forma polimorfica de descetoprofeno trometamol, su preparacion y composiciones que lo contienen

Info

Publication number
CO5780134A1
CO5780134A1 CO06057932A CO06057932A CO5780134A1 CO 5780134 A1 CO5780134 A1 CO 5780134A1 CO 06057932 A CO06057932 A CO 06057932A CO 06057932 A CO06057932 A CO 06057932A CO 5780134 A1 CO5780134 A1 CO 5780134A1
Authority
CO
Colombia
Prior art keywords
trometamol
dexcetoprofen
polymorph
preparation
solution
Prior art date
Application number
CO06057932A
Other languages
English (en)
Inventor
Margarita Bosch
Ester Torras
Josep Ma Gonzalez
Serena Mannucci
Roberto Falorni
Original Assignee
Menarini Lab
Menarini Int Operations Lux Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35229901&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO5780134(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Menarini Lab, Menarini Int Operations Lux Sa filed Critical Menarini Lab
Publication of CO5780134A1 publication Critical patent/CO5780134A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

? Forma A de dexcetoprofeno trometamol caracterizada por un patrón de difracción de polvo de rayos X que comprende picos en 5.14±0.02, 8.02±0.02, 9.83±0.02, 10.06±0.02, 10.37±0.02, 16.06±0.02, 16.69±0.02, 17.50±0.02, 19.58±0.02, 21.47±0.02, 26.86±0.02 grados en 2-theta. Un procedimiento para la preparación de la forma A de dexcetoprofeno trometamol que comprende: a) disolver el ácido de dexcetoprofeno en etanol; b) añadir trometamina a la solución obtenida en a); c) calentar la mezcla para proporcionar una solución clara; d) agregar xileno a la solución obtenida en c) y calentar hasta que se obtenga una solución completa; e) enfriar a 40-46°C y después enfriar adicionalmente a 18-22°C durante 4 a 6 horas; f) completar la cristalización del polimorfo A mediante enfriamiento adicional a una temperatura de 0-5°C que se mantiene por 6-15 horas adicionales; g) recuperar el polimorfo A cristalizado y secar bajo vacío. Composiciones farmacéuticas que comprenden como el ingrediente activo el compuesto que se define en la reivindicación 1, el polimorfo A de dexcetoprofeno trometamol, y portadores y/o excipientes adecuados. <EMI FILE="06057932_1" ID="1" IMF=JPEG HE=50 WI=50 >
CO06057932A 2005-06-15 2006-06-14 Forma polimorfica de descetoprofeno trometamol, su preparacion y composiciones que lo contienen CO5780134A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05012919A EP1739072A1 (en) 2005-06-15 2005-06-15 Polymorphic forms of dexketoprofen trometamol, preparation and pharmaceutical compositions thereof

Publications (1)

Publication Number Publication Date
CO5780134A1 true CO5780134A1 (es) 2007-07-31

Family

ID=35229901

Family Applications (1)

Application Number Title Priority Date Filing Date
CO06057932A CO5780134A1 (es) 2005-06-15 2006-06-14 Forma polimorfica de descetoprofeno trometamol, su preparacion y composiciones que lo contienen

Country Status (8)

Country Link
EP (1) EP1739072A1 (es)
CN (1) CN1880294B (es)
AR (1) AR055217A1 (es)
BR (1) BRPI0602206B8 (es)
CO (1) CO5780134A1 (es)
MX (1) MXPA06006731A (es)
PE (1) PE20070019A1 (es)
TW (1) TWI385148B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2475636A1 (en) * 2009-06-30 2012-07-18 Abdi Ibrahim Ilac Sanayi ve Ticaret Anonim Sirketi A process for preparing dexketoprofen trometamol form a and form b crystals
WO2013100877A1 (en) * 2011-12-27 2013-07-04 Mahmut Bilgic Dexketoprofen formulations
EP2671569B1 (en) 2012-06-06 2015-09-16 Galenicum Health S.L. Stable pharmaceutical compositions with fast onset
EP2759293A1 (en) 2013-01-25 2014-07-30 Laboratorios Lesvi, S.L. Pharmaceutical compositions of (+)-(s)-2-(3-benzoylphenyl)propionic acid tromethamine salt
ITMI20130210A1 (it) 2013-02-14 2014-08-15 Menarini Lab Composizioni farmaceutiche contenenti dexketoprofene e tramadolo

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2058024B1 (es) * 1992-11-10 1995-05-01 Menarini Lab Nuevo derivado arilpropionico, procedimiento de fabricacion del mismo y su utilizacion como analgesico.
FR2721316B1 (fr) 1994-06-21 1996-09-13 Thomson Csf Procédé d'obtention de matériaux composites à base de polymère réticulé et de molécules fluides, comprenant une étape de séchage en phase supercritique.

Also Published As

Publication number Publication date
BRPI0602206B1 (pt) 2021-01-19
CN1880294A (zh) 2006-12-20
TW200716537A (en) 2007-05-01
AR055217A1 (es) 2007-08-15
TWI385148B (zh) 2013-02-11
BRPI0602206B8 (pt) 2021-05-25
MXPA06006731A (es) 2007-01-19
CN1880294B (zh) 2011-09-21
EP1739072A1 (en) 2007-01-03
PE20070019A1 (es) 2007-01-31
BRPI0602206A (pt) 2007-08-14

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