AR041679A1 - Compuestos polimorfos de mesilato de imatinib - Google Patents

Compuestos polimorfos de mesilato de imatinib

Info

Publication number
AR041679A1
AR041679A1 ARP030103826A ARP030103826A AR041679A1 AR 041679 A1 AR041679 A1 AR 041679A1 AR P030103826 A ARP030103826 A AR P030103826A AR P030103826 A ARP030103826 A AR P030103826A AR 041679 A1 AR041679 A1 AR 041679A1
Authority
AR
Argentina
Prior art keywords
imatinib mesylate
compounds
polymorphous
mixture
suitable solvent
Prior art date
Application number
ARP030103826A
Other languages
English (en)
Inventor
Reddy Bandi Parthasaradhi
Reddy Kura Rathnakar
Reddy Rapolu Raji
Reddy Dasari Muralidhara
Chander Reddy Kesireddy Subash
Original Assignee
Hetero Drugs Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hetero Drugs Ltd filed Critical Hetero Drugs Ltd
Publication of AR041679A1 publication Critical patent/AR041679A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente se refiere a compuestos de mesilato de imatinib, procedimientos para la preparación de los mismos y composiciones farmacéuticas que los contienen. Reivindicación 1: Un mesilato de imatinib cristalino forma H1, caracterizado por un espectro de difracción de polvo por rayos X que posee picos expresados como 20 a alrededor 9.9, 11.1, 16.3, 17.3, 18.1, 19.1, 19.6, 20.3, 21.1, 21.9, 23.2, 23.6, 24.2, 24.9, 25.6, 26.0, 27.3, 27.9, 28.9, 29.4, 30.4 y 30.5 grados. Reivindicación 13: Un procedimiento para preparar hidrato de mesilato de imatinib de acuerdo con la reivindicación 9, que comprende los pasos de: a) Disolvente mesilato de imatinib en una mezcla de un solvente adecuado y agua; b) Retirar los solventes de la solución formada en (a) ya seas por secado al vacío o por secado por aspersión; en donde el solvente adecuado es seleccionado entre alcoholes, cetonas, acetonitrilo y una mezcla de los mismos.
ARP030103826A 2003-06-02 2003-10-21 Compuestos polimorfos de mesilato de imatinib AR041679A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IN2003/000206 WO2004106326A1 (en) 2003-06-02 2003-06-02 Novel polymorphs of imatinib mesylate

Publications (1)

Publication Number Publication Date
AR041679A1 true AR041679A1 (es) 2005-05-26

Family

ID=33485465

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP030103826A AR041679A1 (es) 2003-06-02 2003-10-21 Compuestos polimorfos de mesilato de imatinib

Country Status (5)

Country Link
US (1) US7300938B2 (es)
AR (1) AR041679A1 (es)
AU (1) AU2003237596A1 (es)
TR (1) TR200504337T1 (es)
WO (1) WO2004106326A1 (es)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1720853T1 (sl) * 2004-02-11 2016-04-29 Natco Pharma Limited "Natco House Nova polimorfna oblika imatinibijevega mesilata in postopek za njeno pripravo
US8269003B2 (en) 2004-09-02 2012-09-18 Cipla Limited Stable crystal form of imatinib mesylate and process for the preparation thereof
WO2006054314A1 (en) * 2004-11-17 2006-05-26 Natco Pharma Limited Polymorphic forms of imatinib mesylate
UY29766A1 (es) * 2005-08-26 2007-03-30 Novartis Ag Formas cristalinas delta y épsilon de mesilato de imatinib
CN102351842B (zh) * 2005-11-25 2014-07-23 诺华股份有限公司 甲磺酸伊马替尼的f、g、h、i 和k晶形
US7977348B2 (en) 2006-04-27 2011-07-12 Sicor Inc. Polymorphic forms of imatinib mesylate and processes for preparation of novel crystalline forms as well as amorphous and form α
WO2007136510A2 (en) * 2006-04-27 2007-11-29 Sicor Inc. Polymorphic forms of imatinib mesylate and processes for their preparation as well as of amorphous imatinib mesylate and form alpha
US8067421B2 (en) 2006-04-27 2011-11-29 Sicor Inc. Polymorphic forms of imatinib mesylate and processes for preparation of novel crystalline forms as well as amorphous and form α
US20060223816A1 (en) * 2006-05-08 2006-10-05 Chemagis Ltd. Imatinib mesylate alpha form and production process therefor
US20060223817A1 (en) * 2006-05-15 2006-10-05 Chemagis Ltd. Crystalline imatinib base and production process therefor
US20080207904A1 (en) * 2006-10-26 2008-08-28 Macdonald Peter Imatinib base, and imatinib mesylate and processes for preparation thereof
EP2009008A1 (en) 2006-10-26 2008-12-31 Sicor, Inc. Imatinib base, and imatinib mesylate and processes for preparation thereof
US20100087444A1 (en) * 2007-03-12 2010-04-08 Dr. Reddy's Laboratories Ltd. Imatinib mesylate
US20080234286A1 (en) * 2007-03-20 2008-09-25 Chemagis Ltd. Stable amorphous imatinib mesylate and production process therefor
US7550591B2 (en) 2007-05-02 2009-06-23 Chemagis Ltd. Imatinib production process
ES2391625T3 (es) * 2007-06-07 2012-11-28 Novartis Ag Formas amorfas estabilizadas de mestilato de imatinib
AU2012201613B2 (en) * 2007-06-07 2014-12-04 Novartis Ag Stabilized amorphous forms of Imatinib mesylate
CA2700844A1 (en) 2007-09-25 2009-04-02 Teva Pharmaceutical Industries Ltd. Stable imatinib compositions
US7947699B2 (en) * 2008-01-10 2011-05-24 Actavis Group Ptc Ehf Anhydrous amorphous imatinib mesylate
WO2009151899A2 (en) * 2008-05-26 2009-12-17 Dr. Reddy's Laboratories Ltd. Preparation of imatinib mesylate
US20100330130A1 (en) 2009-05-22 2010-12-30 Actavis Group Ptc Ehf Substantially pure imatinib or a pharmaceutically acceptable salt thereof
CZ2009570A3 (cs) 2009-08-26 2011-03-09 Zentiva, K. S. Príprava, stabilizace a využití polymorfu imatinib mesylátu pro vývoj lékových forem
PL389357A1 (pl) 2009-10-22 2011-04-26 Tomasz Koźluk Sole imatinibu z pochodnymi kwasów winowych i sposób ich wytwarzania
WO2011095835A1 (en) 2010-02-02 2011-08-11 Actavis Group Ptc Ehf Highly pure imatinib or a pharmaceutically acceptable salt thereof
WO2011100282A2 (en) * 2010-02-09 2011-08-18 Dr. Reddy's Laboratories Ltd. Imatinib mesylate polymorphs
CA2789989A1 (en) 2010-02-15 2011-08-18 Reliance Life Sciences Pvt. Ltd. Process for the preparation of alpha form of imatinib mesylate
PL390611A1 (pl) 2010-03-04 2011-09-12 Tomasz Koźluk Sposób otrzymywania polimorficznej formy alfa i nowa forma polimorficzna mesylanu imatinibu
WO2011114337A1 (en) 2010-03-15 2011-09-22 Natco Pharma Limited Process for the preparation of highly pure crystalline imatinib base
EP2582689B1 (en) 2010-06-18 2017-03-01 KRKA, D.D., Novo Mesto New polymorphic form of imatinib base and preparation of salts thereof
CN102477031B (zh) 2010-11-30 2015-07-15 浙江九洲药业股份有限公司 一种甲磺酸伊马替尼α晶型的制备方法
WO2012090221A1 (en) 2010-12-29 2012-07-05 Cadila Healthcare Limited Novel salts of imatinib
PL394169A1 (pl) 2011-03-09 2012-09-10 Adamed Spółka Z Ograniczoną Odpowiedzialnością Kompozycja farmaceutyczna metanosulfonianu imatinibu do napełniania jednostkowych postaci dawkowania oraz sposób jej wytwarzania
EP2604596A1 (en) 2011-12-16 2013-06-19 Deva Holding Anonim Sirketi Polymorphs of imatinib
CA2877030A1 (en) 2012-06-22 2013-12-27 Basf Se Multicomponent crystals comprising imatinib mesilate and selected co-crystal formers
KR101242955B1 (ko) * 2012-06-25 2013-03-12 제일약품주식회사 이마티닙 메실레이트 결정형 α의 제조 방법
CN103570673B (zh) * 2012-08-04 2018-04-06 浙江九洲药业股份有限公司 一种甲磺酸伊马替尼α晶型的制备方法
US9439903B2 (en) 2012-10-25 2016-09-13 Cadila Healthcare Limited Process for the preparation of amorphous imatinib mesylate
WO2014100113A2 (en) * 2012-12-18 2014-06-26 Hulow, Llc Syk kinase inhibitors as treatment for malaria
EP2749557A1 (en) 2012-12-31 2014-07-02 Deva Holding Anonim Sirketi Process for preparation of alpha polymorph of imatinib mesylate from IPA and THF solvate forms of imatinib mesylate
ES2683361T3 (es) 2013-05-14 2018-09-26 Hetero Research Foundation Composiciones de Imatinib
WO2017078647A1 (en) 2015-11-05 2017-05-11 Koçak Farma Ilaç Ve Kimya Sanayi Anonim Şirketi Pharmaceutical compositions of imatinib
EA035891B1 (ru) 2016-01-25 2020-08-27 КРКА, д.д., НОВО МЕСТО Быстродиспергируемая фармацевтическая композиция, включающая ингибитор тирозинкиназы
CN107778291A (zh) * 2016-08-31 2018-03-09 亚宝药业集团股份有限公司 一种甲磺酸达比加群酯晶型ⅱ的制备方法

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US5521184A (en) * 1992-04-03 1996-05-28 Ciba-Geigy Corporation Pyrimidine derivatives and processes for the preparation thereof
CO4940418A1 (es) 1997-07-18 2000-07-24 Novartis Ag Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso

Also Published As

Publication number Publication date
US20050234069A1 (en) 2005-10-20
WO2004106326A1 (en) 2004-12-09
US7300938B2 (en) 2007-11-27
TR200504337T1 (tr) 2006-12-21
AU2003237596A1 (en) 2005-01-21

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