PE20061399A1 - N-oxido de piridina fluorados moduladores de la trombina y procesos para la n-oxidacion de heteroarilos nitrogenados - Google Patents
N-oxido de piridina fluorados moduladores de la trombina y procesos para la n-oxidacion de heteroarilos nitrogenadosInfo
- Publication number
- PE20061399A1 PE20061399A1 PE2006000404A PE2006000404A PE20061399A1 PE 20061399 A1 PE20061399 A1 PE 20061399A1 PE 2006000404 A PE2006000404 A PE 2006000404A PE 2006000404 A PE2006000404 A PE 2006000404A PE 20061399 A1 PE20061399 A1 PE 20061399A1
- Authority
- PE
- Peru
- Prior art keywords
- oxide
- fluorates
- nitrogenated
- heteroaryls
- pyridine
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 108090000190 Thrombin Proteins 0.000 title 1
- 238000007254 oxidation reaction Methods 0.000 title 1
- ILVXOBCQQYKLDS-UHFFFAOYSA-N pyridine N-oxide Chemical compound [O-][N+]1=CC=CC=C1 ILVXOBCQQYKLDS-UHFFFAOYSA-N 0.000 title 1
- 229960004072 thrombin Drugs 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 102000009123 Fibrin Human genes 0.000 abstract 1
- 108010073385 Fibrin Proteins 0.000 abstract 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 abstract 1
- 229950003499 fibrin Drugs 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
- C07D215/60—N-oxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67313105P | 2005-04-20 | 2005-04-20 | |
| US11/385,056 US7262210B2 (en) | 2005-04-20 | 2006-03-21 | Fluorinated pyridine N-oxide thrombin modulators and process for N-oxidation of nitrogen containing heteroaryls |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20061399A1 true PE20061399A1 (es) | 2007-02-05 |
Family
ID=36685688
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2006000404A PE20061399A1 (es) | 2005-04-20 | 2006-04-18 | N-oxido de piridina fluorados moduladores de la trombina y procesos para la n-oxidacion de heteroarilos nitrogenados |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7262210B2 (OSRAM) |
| EP (1) | EP1879864A1 (OSRAM) |
| JP (1) | JP2008536918A (OSRAM) |
| KR (1) | KR20080004554A (OSRAM) |
| CN (1) | CN101228129A (OSRAM) |
| AU (1) | AU2006240423A1 (OSRAM) |
| BR (1) | BRPI0610506A2 (OSRAM) |
| CA (1) | CA2605480A1 (OSRAM) |
| MX (1) | MX2007013198A (OSRAM) |
| PE (1) | PE20061399A1 (OSRAM) |
| TW (1) | TW200718688A (OSRAM) |
| WO (1) | WO2006115652A1 (OSRAM) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007109459A2 (en) * | 2006-03-21 | 2007-09-27 | Janssen Pharmaceutica, Nv | Pyridines and pyridine n-oxides as modulators of thrombin |
| ES2566481T3 (es) | 2006-04-12 | 2016-04-13 | Merck Sharp & Dohme Corp. | Antagonistas del canal de calcio de tipo T de piridil amida |
| CA2701594C (en) | 2007-10-24 | 2014-02-18 | Merck Sharp & Dohme Corp. | Heterocycle phenyl amide t-type calcium channel antagonists |
| US9884822B2 (en) | 2012-02-09 | 2018-02-06 | Arch Chemicals, Inc. | Process for the preparation of 1-hydroxy-6-substituted pyridones |
| RU2016150410A (ru) * | 2014-05-28 | 2018-06-28 | Мерк Шарп И Доум Корп. | Ингибиторы фактора xia |
| CN105037280B (zh) * | 2015-06-23 | 2017-09-29 | 西安近代化学研究所 | 一种 2,6‑二氨基‑3,5‑二硝基吡嗪‑1‑氧化物的合成方法 |
| MX387515B (es) * | 2015-10-29 | 2025-03-18 | Merck Sharp & Dohme Llc | Inhibidores de factor xia. |
| EP3500556B1 (en) | 2016-08-22 | 2023-08-02 | Merck Sharp & Dohme LLC | Pyridine-1-oxide derivatives and their use as factor xia inhibitors |
| WO2019060697A1 (en) | 2017-09-22 | 2019-03-28 | Becton, Dickinson And Company | 4% TRISODIC CITRATE SOLUTION FOR USE AS A CATHETER LOCK SOLUTION |
| CN110818629A (zh) * | 2019-12-05 | 2020-02-21 | 杭州勇诚睿生物科技有限公司 | 一种合成氟代异烟酸衍生物的方法 |
| CA3206548A1 (en) * | 2021-01-28 | 2022-08-04 | John S. Debenham | Factor xia inhibitors |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4187379A (en) * | 1978-11-13 | 1980-02-05 | Warner-Lambert Company | 3-Aryloxy-2-pyridinecarbonitrile 1-oxide compounds |
| DE3918834A1 (de) | 1989-01-26 | 1990-08-02 | Bayer Ag | Aryl- und heteroarylethanol-pyridylalkylamine, verfahren zu ihrer herstellung und ihre verwendung als leistungsfoerderer bei tieren und als mittel gegen adipositas |
| DK220890D0 (da) | 1990-09-14 | 1990-09-14 | Ole Buchardt | Fremgangsmaade til fremstilling af c-terminalt amiderede peptider |
| TW204343B (OSRAM) | 1991-05-31 | 1993-04-21 | Sumitomo Pharmaceutics Co Ltd | |
| FR2686084B1 (fr) | 1992-01-10 | 1995-12-22 | Bioprojet Soc Civ | Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques. |
| EP0600317B1 (de) | 1992-11-29 | 1997-03-12 | Hoechst Aktiengesellschaft | Verfahren zur Herstellung von halogenierten Benzoesäuren |
| CN1209060A (zh) | 1995-12-29 | 1999-02-24 | 史密丝克莱恩比彻姆公司 | 玻连蛋白受体拮抗剂 |
| DZ2741A1 (fr) | 1998-03-10 | 2003-09-08 | Smithkline Beecham Corp | Composés nouveaux antagonistes des récepteurs de vitronectine procédé pour leur préparation et compositions. |
| JP2004517074A (ja) | 2000-11-20 | 2004-06-10 | ファルマシア・コーポレーション | 凝血カスケードを選択的に阻害するのに有用な置換された多環アリールおよびヘテロアリールピリジン類 |
| US6610701B2 (en) | 2001-02-09 | 2003-08-26 | Merck & Co., Inc. | Thrombin inhibitors |
| US20030158218A1 (en) * | 2001-12-21 | 2003-08-21 | Nantermet Philippe G. | Thrombin inhibitors |
| DE602004021365D1 (de) * | 2003-04-10 | 2009-07-16 | Ortho Mcneil Pharm Inc | Substituierte phenylacetamide und ihre anwendung als protease inhibitoren |
| US7662987B2 (en) | 2003-07-15 | 2010-02-16 | Xenoport, Inc. | Methods for synthesis of acyloxyalkyl compounds |
-
2006
- 2006-03-21 WO PCT/US2006/010581 patent/WO2006115652A1/en not_active Ceased
- 2006-03-21 CN CNA2006800219864A patent/CN101228129A/zh active Pending
- 2006-03-21 KR KR1020077025219A patent/KR20080004554A/ko not_active Withdrawn
- 2006-03-21 MX MX2007013198A patent/MX2007013198A/es unknown
- 2006-03-21 EP EP06739397A patent/EP1879864A1/en not_active Withdrawn
- 2006-03-21 CA CA002605480A patent/CA2605480A1/en not_active Abandoned
- 2006-03-21 BR BRPI0610506-8A patent/BRPI0610506A2/pt not_active IP Right Cessation
- 2006-03-21 JP JP2008507677A patent/JP2008536918A/ja not_active Withdrawn
- 2006-03-21 AU AU2006240423A patent/AU2006240423A1/en not_active Abandoned
- 2006-03-21 US US11/385,056 patent/US7262210B2/en not_active Expired - Fee Related
- 2006-04-18 PE PE2006000404A patent/PE20061399A1/es not_active Application Discontinuation
- 2006-04-19 TW TW095113865A patent/TW200718688A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1879864A1 (en) | 2008-01-23 |
| MX2007013198A (es) | 2008-03-24 |
| AU2006240423A1 (en) | 2006-11-02 |
| WO2006115652A1 (en) | 2006-11-02 |
| CA2605480A1 (en) | 2006-11-02 |
| TW200718688A (en) | 2007-05-16 |
| US20060241148A1 (en) | 2006-10-26 |
| CN101228129A (zh) | 2008-07-23 |
| BRPI0610506A2 (pt) | 2010-06-29 |
| KR20080004554A (ko) | 2008-01-09 |
| JP2008536918A (ja) | 2008-09-11 |
| US7262210B2 (en) | 2007-08-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20061436A1 (es) | Derivados de amida sustituida como inhibidores de proteina quinasa | |
| NO20081013L (no) | 7-substituerte aza-indazoler, sammensetninger inneholdende disse, produksjonsmetode og anvendelse derav | |
| NO20074666L (no) | Imidazo(1,2-A)pyridinforbindelser som VEGF-R2-inhibitorer | |
| NO20092050L (no) | Nye sulfonamidderivater som bradykininantagonister | |
| NO20073791L (no) | Pyrazolylaminopyridinderivater anvendbare som kinaseinhibitorer | |
| AR066669A1 (es) | Derivados de imidazolona como inhibidores de bencimidazolona quimasa. composiciones farmaceuticas. | |
| EA200500203A1 (ru) | Новый способ синтеза и новая кристаллическая форма агомелатина и фармацевтические композиции, которые её содержат | |
| EA200970156A1 (ru) | Пиридизиноновые производные | |
| NO20092692L (no) | MAPK/ERK kinaseinhibitorer | |
| NO20076306L (no) | Bicykliske derivater som modulatorer av ionekanaler | |
| ECSP045064A (es) | Agonistas receptores de trombina | |
| NO20081001L (no) | Derivater av karboksamid som antagonister for muskarinisk reseptor | |
| ECSP077836A (es) | Compuestos mejorados farmacocinéticamente | |
| AR076435A1 (es) | Compuestos de indazoles sustituidos, composiciones farmaceuticas que los contienen y procesos de obtencion de los mismos | |
| CY1106343T1 (el) | Παραγωγα νικοτιναμιδιου χρησιμα σαν pde4 αναστολεις | |
| EA200800240A1 (ru) | Производные тиазола в качестве активатора амфк | |
| AR055613A1 (es) | Formas cristalinas delta y epsilon de mesilato de imatinib | |
| NO20082209L (no) | Homo- og heterocykliske forbindelser anvendbare som CETP-inhibitorer | |
| MX2010003849A (es) | Antagonistas de cgrp. | |
| NO20085212L (no) | Nye pyridinanaloger | |
| EA200601391A1 (ru) | Производные хинолина для применения в качестве микобактериальных ингибиторов | |
| CY1114354T1 (el) | Νεα παραγωγα βενζαμιδιου ως ανταγωνιστες βραδυκινινης | |
| NO20092341L (no) | Substituerte piperidiner inneholdende et heteroarylamid eller en heteroarylfenyl gruppe | |
| PE20070795A1 (es) | Compuestos pirazol-urea-heterociclicos como inhibidores de cinasa | |
| NO20080468L (no) | Diazepinokinoliner, synteser av disse samt intermediater |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |