CA2605480A1 - Fluorinated pyridine n-oxide thrombin modulators and process for n-oxidation of nitrogen containing heteroaryls - Google Patents
Fluorinated pyridine n-oxide thrombin modulators and process for n-oxidation of nitrogen containing heteroaryls Download PDFInfo
- Publication number
- CA2605480A1 CA2605480A1 CA002605480A CA2605480A CA2605480A1 CA 2605480 A1 CA2605480 A1 CA 2605480A1 CA 002605480 A CA002605480 A CA 002605480A CA 2605480 A CA2605480 A CA 2605480A CA 2605480 A1 CA2605480 A1 CA 2605480A1
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- Prior art keywords
- compound
- mammal
- pyridin
- oxide
- temperature
- Prior art date
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- 108090000190 Thrombin Proteins 0.000 title claims abstract description 17
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- 238000007254 oxidation reaction Methods 0.000 title abstract description 10
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
- C07D215/60—N-oxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
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- Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
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- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67313105P | 2005-04-20 | 2005-04-20 | |
| US60/673,131 | 2005-04-20 | ||
| PCT/US2006/010581 WO2006115652A1 (en) | 2005-04-20 | 2006-03-21 | Fluorinated pyridine n-oxide thrombin modulators and process for n-oxidation of nitrogen containing heteroaryls |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2605480A1 true CA2605480A1 (en) | 2006-11-02 |
Family
ID=36685688
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002605480A Abandoned CA2605480A1 (en) | 2005-04-20 | 2006-03-21 | Fluorinated pyridine n-oxide thrombin modulators and process for n-oxidation of nitrogen containing heteroaryls |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7262210B2 (OSRAM) |
| EP (1) | EP1879864A1 (OSRAM) |
| JP (1) | JP2008536918A (OSRAM) |
| KR (1) | KR20080004554A (OSRAM) |
| CN (1) | CN101228129A (OSRAM) |
| AU (1) | AU2006240423A1 (OSRAM) |
| BR (1) | BRPI0610506A2 (OSRAM) |
| CA (1) | CA2605480A1 (OSRAM) |
| MX (1) | MX2007013198A (OSRAM) |
| PE (1) | PE20061399A1 (OSRAM) |
| TW (1) | TW200718688A (OSRAM) |
| WO (1) | WO2006115652A1 (OSRAM) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007109459A2 (en) * | 2006-03-21 | 2007-09-27 | Janssen Pharmaceutica, Nv | Pyridines and pyridine n-oxides as modulators of thrombin |
| ES2566481T3 (es) | 2006-04-12 | 2016-04-13 | Merck Sharp & Dohme Corp. | Antagonistas del canal de calcio de tipo T de piridil amida |
| CA2701594C (en) | 2007-10-24 | 2014-02-18 | Merck Sharp & Dohme Corp. | Heterocycle phenyl amide t-type calcium channel antagonists |
| US9884822B2 (en) | 2012-02-09 | 2018-02-06 | Arch Chemicals, Inc. | Process for the preparation of 1-hydroxy-6-substituted pyridones |
| RU2016150410A (ru) * | 2014-05-28 | 2018-06-28 | Мерк Шарп И Доум Корп. | Ингибиторы фактора xia |
| CN105037280B (zh) * | 2015-06-23 | 2017-09-29 | 西安近代化学研究所 | 一种 2,6‑二氨基‑3,5‑二硝基吡嗪‑1‑氧化物的合成方法 |
| MX387515B (es) * | 2015-10-29 | 2025-03-18 | Merck Sharp & Dohme Llc | Inhibidores de factor xia. |
| EP3500556B1 (en) | 2016-08-22 | 2023-08-02 | Merck Sharp & Dohme LLC | Pyridine-1-oxide derivatives and their use as factor xia inhibitors |
| WO2019060697A1 (en) | 2017-09-22 | 2019-03-28 | Becton, Dickinson And Company | 4% TRISODIC CITRATE SOLUTION FOR USE AS A CATHETER LOCK SOLUTION |
| CN110818629A (zh) * | 2019-12-05 | 2020-02-21 | 杭州勇诚睿生物科技有限公司 | 一种合成氟代异烟酸衍生物的方法 |
| CA3206548A1 (en) * | 2021-01-28 | 2022-08-04 | John S. Debenham | Factor xia inhibitors |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4187379A (en) * | 1978-11-13 | 1980-02-05 | Warner-Lambert Company | 3-Aryloxy-2-pyridinecarbonitrile 1-oxide compounds |
| DE3918834A1 (de) | 1989-01-26 | 1990-08-02 | Bayer Ag | Aryl- und heteroarylethanol-pyridylalkylamine, verfahren zu ihrer herstellung und ihre verwendung als leistungsfoerderer bei tieren und als mittel gegen adipositas |
| DK220890D0 (da) | 1990-09-14 | 1990-09-14 | Ole Buchardt | Fremgangsmaade til fremstilling af c-terminalt amiderede peptider |
| TW204343B (OSRAM) | 1991-05-31 | 1993-04-21 | Sumitomo Pharmaceutics Co Ltd | |
| FR2686084B1 (fr) | 1992-01-10 | 1995-12-22 | Bioprojet Soc Civ | Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques. |
| EP0600317B1 (de) | 1992-11-29 | 1997-03-12 | Hoechst Aktiengesellschaft | Verfahren zur Herstellung von halogenierten Benzoesäuren |
| CN1209060A (zh) | 1995-12-29 | 1999-02-24 | 史密丝克莱恩比彻姆公司 | 玻连蛋白受体拮抗剂 |
| DZ2741A1 (fr) | 1998-03-10 | 2003-09-08 | Smithkline Beecham Corp | Composés nouveaux antagonistes des récepteurs de vitronectine procédé pour leur préparation et compositions. |
| JP2004517074A (ja) | 2000-11-20 | 2004-06-10 | ファルマシア・コーポレーション | 凝血カスケードを選択的に阻害するのに有用な置換された多環アリールおよびヘテロアリールピリジン類 |
| US6610701B2 (en) | 2001-02-09 | 2003-08-26 | Merck & Co., Inc. | Thrombin inhibitors |
| US20030158218A1 (en) * | 2001-12-21 | 2003-08-21 | Nantermet Philippe G. | Thrombin inhibitors |
| DE602004021365D1 (de) * | 2003-04-10 | 2009-07-16 | Ortho Mcneil Pharm Inc | Substituierte phenylacetamide und ihre anwendung als protease inhibitoren |
| US7662987B2 (en) | 2003-07-15 | 2010-02-16 | Xenoport, Inc. | Methods for synthesis of acyloxyalkyl compounds |
-
2006
- 2006-03-21 WO PCT/US2006/010581 patent/WO2006115652A1/en not_active Ceased
- 2006-03-21 CN CNA2006800219864A patent/CN101228129A/zh active Pending
- 2006-03-21 KR KR1020077025219A patent/KR20080004554A/ko not_active Withdrawn
- 2006-03-21 MX MX2007013198A patent/MX2007013198A/es unknown
- 2006-03-21 EP EP06739397A patent/EP1879864A1/en not_active Withdrawn
- 2006-03-21 CA CA002605480A patent/CA2605480A1/en not_active Abandoned
- 2006-03-21 BR BRPI0610506-8A patent/BRPI0610506A2/pt not_active IP Right Cessation
- 2006-03-21 JP JP2008507677A patent/JP2008536918A/ja not_active Withdrawn
- 2006-03-21 AU AU2006240423A patent/AU2006240423A1/en not_active Abandoned
- 2006-03-21 US US11/385,056 patent/US7262210B2/en not_active Expired - Fee Related
- 2006-04-18 PE PE2006000404A patent/PE20061399A1/es not_active Application Discontinuation
- 2006-04-19 TW TW095113865A patent/TW200718688A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1879864A1 (en) | 2008-01-23 |
| MX2007013198A (es) | 2008-03-24 |
| AU2006240423A1 (en) | 2006-11-02 |
| WO2006115652A1 (en) | 2006-11-02 |
| TW200718688A (en) | 2007-05-16 |
| US20060241148A1 (en) | 2006-10-26 |
| CN101228129A (zh) | 2008-07-23 |
| BRPI0610506A2 (pt) | 2010-06-29 |
| KR20080004554A (ko) | 2008-01-09 |
| JP2008536918A (ja) | 2008-09-11 |
| PE20061399A1 (es) | 2007-02-05 |
| US7262210B2 (en) | 2007-08-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |