PE20061393A1 - Base libre de lercanidipina - Google Patents

Base libre de lercanidipina

Info

Publication number
PE20061393A1
PE20061393A1 PE2006000225A PE2006000225A PE20061393A1 PE 20061393 A1 PE20061393 A1 PE 20061393A1 PE 2006000225 A PE2006000225 A PE 2006000225A PE 2006000225 A PE2006000225 A PE 2006000225A PE 20061393 A1 PE20061393 A1 PE 20061393A1
Authority
PE
Peru
Prior art keywords
base
lercanidipine
free base
solution
free
Prior art date
Application number
PE2006000225A
Other languages
English (en)
Inventor
Amedeo Leonardi
Gianni Motta
Ilaria Candiani
Francesco Corcella
Fabio Berlati
Original Assignee
Recordati Ireland Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recordati Ireland Ltd filed Critical Recordati Ireland Ltd
Publication of PE20061393A1 publication Critical patent/PE20061393A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
  • Pyridine Compounds (AREA)

Abstract

REFERIDA A UNA BASE LIBRE DE LERCANIDIPINA QUE TIENE UNA PUREZA DE 95%, PREFERENTEMENTE DE POR LO MENOS 99,8%. QUE SE PREPARA DISOLVIENDO UNA SAL DE LERCANIDIPINA EN UN SOLVENTE ORGANICO PARA FORMAR UNA SOLUCION, SE MEZCLA LA SOLUCION Y UN MEDIO ACUOSO QUE TIENE UN PH DE ENTRE 9 Y 14 Y SE AISLA LA BASE LIBRE DE LERCANIDIPINA. EL MEDIO ACUOSO ES UNA SOLUCION BASICA QUE COMPRENDE UNA BASE ORGANICA, UNA BASE INORGANICA O UNA RESINA DE INTERCAMBIO DE IONES ANIONICOS; DONDE LA BASE ORGANICA ES TRIETILAMINA, PIPERAZINA, ETILENDIAMINA, ENTRE OTRAS, LA BASE INORGANICA ES HIDROXIDO DE SODIO, HIDROXIDO DE LITIO, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHA BASE LIBRE DE LERCANIDIPINA SE FORMA COMO UN SOLIDO AMORFO SE MANIPULA FACILMENTE Y ES ADECUADO PARA LA FORMULACION DE COMPOSICIONES FARMACEUTICAS
PE2006000225A 2005-02-25 2006-02-24 Base libre de lercanidipina PE20061393A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65674105P 2005-02-25 2005-02-25

Publications (1)

Publication Number Publication Date
PE20061393A1 true PE20061393A1 (es) 2007-01-16

Family

ID=36587241

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000225A PE20061393A1 (es) 2005-02-25 2006-02-24 Base libre de lercanidipina

Country Status (18)

Country Link
US (1) US20060199849A1 (es)
EP (1) EP1853562A1 (es)
JP (1) JP2008531516A (es)
KR (1) KR20070105978A (es)
CN (1) CN101142186A (es)
AR (1) AR053023A1 (es)
AU (1) AU2006218027A1 (es)
BR (1) BRPI0608136A2 (es)
CA (1) CA2597992A1 (es)
EA (1) EA200701686A1 (es)
IL (1) IL184348A0 (es)
MX (1) MX2007010362A (es)
NO (1) NO20074873L (es)
PE (1) PE20061393A1 (es)
TW (1) TW200640860A (es)
UY (1) UY29400A1 (es)
WO (1) WO2006089788A1 (es)
ZA (1) ZA200708126B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100651212B1 (ko) * 2004-10-27 2006-12-01 제일약품주식회사 무정형 레르카니디핀의 제조방법
WO2008040367A1 (en) * 2006-08-01 2008-04-10 Union Quimico-Farmaceutica S.A. Lercanidipine hydrobromide, a process for its preparation, crystalline forms and compositions thereof
DE102010005124A1 (de) * 2010-01-19 2012-03-01 Stada Arzneimittel Ag Feste pharmazeutische Zusammensetzung umfassend Lercanidipin
CN102531999B (zh) * 2011-12-16 2014-02-26 华润赛科药业有限责任公司 无定形盐酸乐卡地平及其制备方法
CN102558032B (zh) * 2011-12-16 2014-02-26 华润赛科药业有限责任公司 一种无定形盐酸乐卡地平及其制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8403866D0 (en) * 1984-02-14 1984-03-21 Recordati Chem Pharm Diphenylalkylaminoalkyl esters
US5912351A (en) * 1995-05-12 1999-06-15 Recordati, S.A. Chemical And Pharmaceutical Company Anhydrous 1,4-Dihydropyridines and salts thereof
IT1275532B (it) * 1995-07-14 1997-08-07 Recordati Chem Pharm Uso di derivati 1,4-diidropiridinici per la prevenzione e la terapia della degenerazione aterosclerotica della parete arteriosa
US5696139A (en) * 1995-05-12 1997-12-09 Recordati S.A., Chemical And Pharmaceutical Company Use of S-enantiomers of 1,4-dihydropyridine derivatives for treating heart failure
IT1298732B1 (it) * 1998-03-13 2000-02-02 Recordati Chem Pharm Composizioni farmaceutiche orali assumibili senza liquidi,contenenti complessi di inclusione
US6852737B2 (en) * 2001-08-06 2005-02-08 Recordati Ireland Limited Crude and crystalline forms of lercanidipine hydrochloride
US20030069285A1 (en) * 2001-08-06 2003-04-10 Recordati Ireland Limited Novel solvate and crystalline forms of lercanidipine hydrochloride
US20030180355A1 (en) * 2001-10-16 2003-09-25 Amedeo Leonardi Combination therapy for hypertension
US20040147566A1 (en) * 2002-10-16 2004-07-29 Amedeo Leonardi Lisinopril/lercanidipine combination therapy
WO2004035051A1 (en) * 2002-10-16 2004-04-29 Recordati Ireland Limited Lisinopril/lercanidipine combination therapy
US20040198789A1 (en) * 2003-02-28 2004-10-07 Recordati Ireland Limited Lercanidipine/ARB/diuretic therapeutic combinations
CA2547657A1 (en) * 2003-12-01 2005-06-16 Lifecycle Pharma A/S Pharmaceutical compositions comprising lercanidipine
TW200613275A (en) * 2004-08-24 2006-05-01 Recordati Ireland Ltd Lercanidipine salts
TW200616681A (en) * 2004-10-05 2006-06-01 Recordati Ireland Ltd Lercanidipine capsules

Also Published As

Publication number Publication date
CN101142186A (zh) 2008-03-12
EA200701686A1 (ru) 2008-02-28
WO2006089788A1 (en) 2006-08-31
NO20074873L (no) 2007-11-22
ZA200708126B (en) 2008-11-26
UY29400A1 (es) 2006-06-30
US20060199849A1 (en) 2006-09-07
MX2007010362A (es) 2007-10-17
IL184348A0 (en) 2007-10-31
TW200640860A (en) 2006-12-01
BRPI0608136A2 (pt) 2009-11-17
EP1853562A1 (en) 2007-11-14
JP2008531516A (ja) 2008-08-14
CA2597992A1 (en) 2006-08-31
AU2006218027A1 (en) 2006-08-31
AR053023A1 (es) 2007-04-18
KR20070105978A (ko) 2007-10-31

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