WO2008081901A1 - アルキルガレート薬剤組成物 - Google Patents

アルキルガレート薬剤組成物 Download PDF

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Publication number
WO2008081901A1
WO2008081901A1 PCT/JP2007/075197 JP2007075197W WO2008081901A1 WO 2008081901 A1 WO2008081901 A1 WO 2008081901A1 JP 2007075197 W JP2007075197 W JP 2007075197W WO 2008081901 A1 WO2008081901 A1 WO 2008081901A1
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WO
WIPO (PCT)
Prior art keywords
alkyl
alkyl gallate
gallate
pharmaceutical
composition
Prior art date
Application number
PCT/JP2007/075197
Other languages
English (en)
French (fr)
Inventor
Tomihiko Higuchi
Hirofumi Shibata
Masanori Higuchi
Original Assignee
Microbiotech Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbiotech Inc. filed Critical Microbiotech Inc.
Priority to US12/448,595 priority Critical patent/US20100056627A1/en
Priority to JP2008552165A priority patent/JP5232656B2/ja
Priority to CN2007800484296A priority patent/CN101636156B/zh
Priority to MX2009007090A priority patent/MX2009007090A/es
Priority to CA002672538A priority patent/CA2672538A1/en
Priority to BRPI0720982-7A priority patent/BRPI0720982A2/pt
Publication of WO2008081901A1 publication Critical patent/WO2008081901A1/ja

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Birds (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Pulmonology (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

　アルキルガレートの抗真菌・抗ウイルス・抗バクテリア活性の増強を図ることと、水への可溶化を可能とする新しい技術手段を提供する。 　本発明のアルキルガレート薬剤組成物は、（Ａ）アルキル基の炭素数が５～１６の範囲のアルキルガレート、および（Ｂ）アルキル基の炭素数が前記（Ａ）のものより小さいアルキルガレートを含有することを特徴とする。好ましくは、アルキルガレート（Ｂ）のアルキル基の炭素数は２～７の範囲であり、（Ｃ）アルカリ金属塩、ホウ酸、ホウ酸ナトリウム、および有機塩から選ばれる少なくとも１種を含有する。
PCT/JP2007/075197 2006-12-28 2007-12-27 アルキルガレート薬剤組成物 WO2008081901A1 (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US12/448,595 US20100056627A1 (en) 2006-12-28 2007-12-27 Pharmaceutical compositions of alkyl gallates
JP2008552165A JP5232656B2 (ja) 2006-12-28 2007-12-27 アルキルガレート薬剤組成物
CN2007800484296A CN101636156B (zh) 2006-12-28 2007-12-27 没食子酸烷基酯的药物组合物
MX2009007090A MX2009007090A (es) 2006-12-28 2007-12-27 Composiciones farmaceuticas de galatos de alquilo.
CA002672538A CA2672538A1 (en) 2006-12-28 2007-12-27 Pharmaceutical compositions of alkyl gallates
BRPI0720982-7A BRPI0720982A2 (pt) 2006-12-28 2007-12-27 Composições farmacêuticas de galatos de alquila

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2006-356662 2006-12-28
JP2006356662 2006-12-28
JP2007-267254 2007-10-12
JP2007267254 2007-10-12
JP2007323964 2007-12-14
JP2007-323964 2007-12-14

Publications (1)

Publication Number Publication Date
WO2008081901A1 true WO2008081901A1 (ja) 2008-07-10

Family

ID=39588583

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2007/075197 WO2008081901A1 (ja) 2006-12-28 2007-12-27 アルキルガレート薬剤組成物

Country Status (7)

Country Link
US (1) US20100056627A1 (ja)
JP (1) JP5232656B2 (ja)
CN (1) CN101636156B (ja)
BR (1) BRPI0720982A2 (ja)
CA (1) CA2672538A1 (ja)
TW (1) TWI344841B (ja)
WO (1) WO2008081901A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017061630A1 (ja) * 2015-10-09 2017-04-13 日清食品ホールディングス株式会社 抗菌剤および海洋生物の腸炎ビブリオの感染による疾病を抑制する方法

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4786285B2 (ja) * 2005-10-07 2011-10-05 浜松ホトニクス株式会社 Ｘ線管
CN102892293A (zh) * 2010-02-16 2013-01-23 凯敏工业公司 改善水生生态系统中的水质的方法
EP2949331A1 (en) 2012-10-17 2015-12-02 Methylation Sciences International SRL Compositions comprising s-adenosylmethionine and a gallic acid ester
KR102024947B1 (ko) * 2013-10-31 2019-09-24 주식회사 엘지생활건강 옥틸 갈레이트를 포함하는 조성물
CN112273385B (zh) * 2020-11-25 2021-07-23 宿迁市产品质量监督检验所 没食子酸辛酯与丙烯醛的加合产物在制备抑菌剂中的应用
CN113456655B (zh) * 2021-06-29 2022-12-06 中国农业大学 没食子酸丙酯增效抗猪链球菌抗生素的新用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09194358A (ja) * 1996-01-23 1997-07-29 Alps Yakuhin Kogyo Kk 多価フェノール誘導体含有抗ｍｒｓａ活性医薬組成物
WO2004066992A1 (ja) * 2003-01-29 2004-08-12 Alps Pharmaceutical Ind. Co., Ltd. 薬剤耐性黄色ブドウ球菌感染症治療のための医薬組成物
JP2006306836A (ja) * 2005-01-11 2006-11-09 Microbiotech:Kk 抗ウイルス・抗炎症作用薬剤組成物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0959151A (ja) * 1995-08-24 1997-03-04 Kao Corp ＮＦ−κＢ活性化抑制剤

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09194358A (ja) * 1996-01-23 1997-07-29 Alps Yakuhin Kogyo Kk 多価フェノール誘導体含有抗ｍｒｓａ活性医薬組成物
WO2004066992A1 (ja) * 2003-01-29 2004-08-12 Alps Pharmaceutical Ind. Co., Ltd. 薬剤耐性黄色ブドウ球菌感染症治療のための医薬組成物
JP2006306836A (ja) * 2005-01-11 2006-11-09 Microbiotech:Kk 抗ウイルス・抗炎症作用薬剤組成物

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017061630A1 (ja) * 2015-10-09 2017-04-13 日清食品ホールディングス株式会社 抗菌剤および海洋生物の腸炎ビブリオの感染による疾病を抑制する方法

Also Published As

Publication number Publication date
US20100056627A1 (en) 2010-03-04
CA2672538A1 (en) 2008-07-10
CN101636156B (zh) 2012-05-02
TWI344841B (en) 2011-07-11
JP5232656B2 (ja) 2013-07-10
CN101636156A (zh) 2010-01-27
TW200835478A (en) 2008-09-01
BRPI0720982A2 (pt) 2014-03-11
JPWO2008081901A1 (ja) 2010-04-30

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