PE20030042A1 - Derivados de dipeptido como inhibidores de enzima convertidora de angiotensina y endopeptidasa neutra - Google Patents
Derivados de dipeptido como inhibidores de enzima convertidora de angiotensina y endopeptidasa neutraInfo
- Publication number
- PE20030042A1 PE20030042A1 PE2002000407A PE2002000407A PE20030042A1 PE 20030042 A1 PE20030042 A1 PE 20030042A1 PE 2002000407 A PE2002000407 A PE 2002000407A PE 2002000407 A PE2002000407 A PE 2002000407A PE 20030042 A1 PE20030042 A1 PE 20030042A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- carbocyclic
- cycloalkyl
- methylbutanoylamine
- methylpropionyl
- Prior art date
Links
- UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 title abstract 2
- 108010016626 Dipeptides Proteins 0.000 title abstract 2
- 102000003729 Neprilysin Human genes 0.000 title abstract 2
- 108090000028 Neprilysin Proteins 0.000 title abstract 2
- 102000004270 Peptidyl-Dipeptidase A Human genes 0.000 title abstract 2
- 108090000882 Peptidyl-Dipeptidase A Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical class CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 2
- 150000005347 biaryls Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 CARBOXYL Chemical group 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 206010037423 Pulmonary oedema Diseases 0.000 abstract 1
- 208000001647 Renal Insufficiency Diseases 0.000 abstract 1
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 abstract 1
- 201000006370 kidney failure Diseases 0.000 abstract 1
- 208000005333 pulmonary edema Diseases 0.000 abstract 1
- BWHOZHOGCMHOBV-BQYQJAHWSA-N trans-benzylideneacetone Chemical compound CC(=O)\C=C\C1=CC=CC=C1 BWHOZHOGCMHOBV-BQYQJAHWSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29108801P | 2001-05-15 | 2001-05-15 | |
| US33957501P | 2001-12-11 | 2001-12-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030042A1 true PE20030042A1 (es) | 2003-02-28 |
Family
ID=26966569
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002000407A PE20030042A1 (es) | 2001-05-15 | 2002-05-15 | Derivados de dipeptido como inhibidores de enzima convertidora de angiotensina y endopeptidasa neutra |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US6777443B2 (https=) |
| EP (2) | EP1392720A2 (https=) |
| JP (1) | JP4390458B2 (https=) |
| KR (1) | KR100908152B1 (https=) |
| CN (1) | CN1649893A (https=) |
| AR (1) | AR035890A1 (https=) |
| AU (1) | AU2002314067B2 (https=) |
| BR (1) | BR0209652A (https=) |
| CA (1) | CA2449292A1 (https=) |
| CO (1) | CO5540347A2 (https=) |
| CZ (1) | CZ20033077A3 (https=) |
| HU (1) | HUP0304084A3 (https=) |
| IL (1) | IL158772A0 (https=) |
| MX (1) | MXPA03010403A (https=) |
| MY (1) | MY127495A (https=) |
| NO (1) | NO20035084L (https=) |
| NZ (1) | NZ529438A (https=) |
| PE (1) | PE20030042A1 (https=) |
| PL (1) | PL366786A1 (https=) |
| RU (1) | RU2298559C2 (https=) |
| SK (1) | SK14032003A3 (https=) |
| TW (1) | TWI295996B (https=) |
| WO (1) | WO2002092622A2 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6777443B2 (en) * | 2001-05-15 | 2004-08-17 | Novartis Ag | Dipeptide derivatives |
| HUP0401014A2 (hu) * | 2001-07-06 | 2004-08-30 | Teva Pharmaceutical Industries Ltd. | Eljárás 7-amino-szin-3,5-dihidroxi-heptánsavszármazékok előállítására, 6-ciano-szin-3,5-dihidroxi-hexánsav származékokon keresztül |
| CA2456281A1 (en) * | 2001-09-21 | 2003-04-03 | Novartis Ag | Pyrane derivatives as both ace- and nep- inhibitors |
| US7468390B2 (en) | 2002-01-17 | 2008-12-23 | Novartis Ag | Methods of treatment and pharmaceutical composition |
| DK1467728T3 (da) * | 2002-01-17 | 2007-12-27 | Novartis Ag | Farmaceutiske sammensætninger indeholdende valsartan og NEP-inhibitorer |
| WO2003105837A1 (en) * | 2002-06-13 | 2003-12-24 | Novartis Ag | Calcium salts of indole derived statins |
| ES2282062T1 (es) | 2004-06-04 | 2007-10-16 | Teva Pharmaceutical Industries Ltd. | Composicion farmaceutica que contiene irbesartan. |
| RU2410118C2 (ru) * | 2004-12-15 | 2011-01-27 | Зольвай Фармасьютиклз Гмбх | ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ, ВКЛЮЧАЮЩИЕ ИНГИБИТОРЫ НЭП (НЕЙТРАЛЬНОЙ ЭНДОПЕПТИДАЗЫ), ИНГИБИТОРЫ ЭНДОГЕННОЙ ПРОДУЦИРУЮЩЕЙ ЭНДОТЕЛИН СИСТЕМЫ И ИНГИБИТОРЫ ГМГ (ГИДРОКСИМЕТИЛГЛУТАРИЛ)СоА РЕДУКТАЗЫ |
| JP2008533109A (ja) * | 2005-03-14 | 2008-08-21 | オリオン コーポレーション | 利尿を促進するための複合治療 |
| US7390789B2 (en) * | 2005-09-13 | 2008-06-24 | William H Simmons | Thio-containing inhibitors of aminopeptidase P, and compositions thereof |
| US7400236B2 (en) | 2005-10-21 | 2008-07-15 | Gm Global Technology Operations, Inc. | Vehicular lane monitoring system utilizing front and rear cameras |
| AR057882A1 (es) | 2005-11-09 | 2007-12-26 | Novartis Ag | Compuestos de accion doble de bloqueadores del receptor de angiotensina e inhibidores de endopeptidasa neutra |
| US20120157387A1 (en) * | 2006-11-28 | 2012-06-21 | Apotex Technologies Inc. | Orally bioavailable d-gamma-glutamyl-d-tryptophan |
| TW200838501A (en) * | 2007-02-02 | 2008-10-01 | Theravance Inc | Dual-acting antihypertensive agents |
| TWI448284B (zh) | 2007-04-24 | 2014-08-11 | Theravance Inc | 雙效抗高血壓劑 |
| TWI406850B (zh) * | 2007-06-05 | 2013-09-01 | Theravance Inc | 雙效苯并咪唑抗高血壓劑 |
| JP2010538071A (ja) | 2007-09-07 | 2010-12-09 | セラヴァンス， インコーポレーテッド | 二重作用性降圧剤 |
| JP2011506459A (ja) | 2007-12-11 | 2011-03-03 | セラヴァンス， インコーポレーテッド | 抗高血圧剤としての二重作用性ベンゾイミダゾール誘導体およびその使用 |
| EP2297113A1 (en) | 2008-04-29 | 2011-03-23 | Theravance, Inc. | Dual-acting antihypertensive agents |
| WO2010011821A2 (en) * | 2008-07-24 | 2010-01-28 | Theravance, Inc. | Dual-acting antihypertensive agents |
| EP2451782B1 (en) | 2009-07-07 | 2016-11-09 | Theravance Biopharma R&D IP, LLC | Dual-acting pyrazole antihypertensive agents |
| JP2012533626A (ja) | 2009-07-22 | 2012-12-27 | セラヴァンス， インコーポレーテッド | 二重作用オキサゾール降圧剤 |
| WO2011090929A1 (en) | 2010-01-19 | 2011-07-28 | Theravance, Inc. | Dual-acting thiophene, pyrrole, thiazole and furan antihypertensive agents |
| EA201391421A1 (ru) * | 2011-03-31 | 2014-02-28 | Апотекс Текнолоджиз Инк. | Пролекарства d-гамма-глутамил-d-триптофана и d-гамма-глутамил-l-триптофана |
| US9212206B1 (en) * | 2014-11-24 | 2015-12-15 | William H Simmons | 4-Fluoro-Thio-containing inhibitors of APP2, compositions thereof and method of use |
| WO2018002673A1 (en) | 2016-07-01 | 2018-01-04 | N4 Pharma Uk Limited | Novel formulations of angiotensin ii receptor antagonists |
| UY38072A (es) | 2018-02-07 | 2019-10-01 | Novartis Ag | Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos |
| US11396497B2 (en) | 2018-05-04 | 2022-07-26 | New Mexico Tech University Research Park Corporation | Proteasome inhibitors |
| CN113956183B (zh) * | 2021-10-28 | 2023-06-20 | 成都市科隆化学品有限公司 | 一种Boc-Ser(Bzl)-OH及其制备方法 |
| WO2024230583A1 (zh) * | 2023-05-05 | 2024-11-14 | 上海济煜医药科技有限公司 | 一种短肽类化合物及其制备方法和医药应用 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3432307A1 (de) * | 1984-09-03 | 1986-04-10 | Boehringer Ingelheim KG, 6507 Ingelheim | Aminosaeurederivate, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen |
| AU6733190A (en) * | 1989-11-27 | 1991-06-26 | Santen Pharmaceutical Co. Ltd. | Amino acid derivative |
| FR2679564A1 (fr) * | 1991-07-23 | 1993-01-29 | Inst Nat Sante Rech Med | Nouveaux acylmercaptoalcanoldipeptides, leur preparation et les compositions qui les contiennent. |
| EP0580550B1 (en) | 1992-07-21 | 1997-10-22 | Novartis AG | Oxamic acid derivatives as hypocholesteremic agents |
| US5432186A (en) * | 1993-11-16 | 1995-07-11 | Ciba-Geigy Corporation | Cyclic amino acid derivatives |
| US5508266A (en) * | 1994-06-22 | 1996-04-16 | Ciba-Geigy Corporation | Gem-disubstituted amino acid derivatives |
| EP0820464A2 (en) * | 1995-03-31 | 1998-01-28 | Takeda Chemical Industries, Ltd. | Cysteine protease inhibitor |
| DE69632821T2 (de) * | 1995-04-25 | 2005-08-25 | Daiichi Fine Chemical Co., Ltd., Takaoka | In wasser hochlöslicher metalloproteinase-inhibitor |
| US5994293A (en) * | 1995-05-10 | 1999-11-30 | Darwin Discovery Ltd. | Peptidyl compounds and their therapeutic use |
| EP0830368A1 (en) * | 1995-06-07 | 1998-03-25 | Genta Incorporated | Novel carbamate-based cationic lipids |
| US6245809B1 (en) * | 1996-12-09 | 2001-06-12 | Cor Therapeutics Inc. | Integrin antagonists |
| US6492421B1 (en) * | 1997-07-31 | 2002-12-10 | Athena Neurosciences, Inc. | Substituted phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4 |
| DE19745151A1 (de) | 1997-10-14 | 1999-04-15 | Basf Ag | Neue Verbindungen zur Behandlung von Krankheiten, die mit der biologischen Wirkung von Endothelin assoziiert sind |
| FR2770844A1 (fr) | 1997-11-10 | 1999-05-14 | Inst Nat Sante Rech Med | Inhibiteurs de toxines clostridiales et compositions pharmaceutiques les contenant |
| AU1457299A (en) * | 1997-11-12 | 1999-05-31 | Ariad Pharmaceuticals, Inc. | Novel signal transduction inhibitors, compositions containing them |
| EP1080104B1 (en) | 1998-04-23 | 2005-02-09 | Novartis AG | Certain heteroaryl substituted thiol inhibitors of endothelin-converting enzyme |
| JP4350306B2 (ja) | 1998-04-23 | 2009-10-21 | ノバルティス アクチエンゲゼルシャフト | エンドセリン変換酵素のチオール型阻害剤 |
| ES2188277T3 (es) | 1998-12-31 | 2003-06-16 | Aventis Pharma Inc | Inhibidores selectivos de mmp-12. |
| FR2788526B1 (fr) | 1999-01-20 | 2002-07-05 | Inst Nat Sante Rech Med | Composes tripeptidiques utiles a titre d'hinhibiteurs selectifs de l'aminopeptidase a et compositions pharmaceutiques correspondantes |
| CO5160290A1 (es) | 1999-03-29 | 2002-05-30 | Novartis Ag | Derivados de acido fenoxifeniloxamico sustituido . |
| US6503949B1 (en) * | 1999-05-17 | 2003-01-07 | Noro Nordisk A/S | Glucagon antagonists/inverse agonists |
| GB9917909D0 (en) * | 1999-07-31 | 1999-09-29 | Synphar Lab Inc | Cysteine protease inhibitors |
| CN1235875C (zh) * | 1999-08-27 | 2006-01-11 | 西托维亚公司 | 取代的α－羟基酸天冬氨酸特异性半胱氨酸蛋白酶抑制剂及其用途 |
| US6803383B2 (en) * | 2000-03-27 | 2004-10-12 | The Scripps Research Institute | Inhibition of angiogenesis and tumor growth |
| JP2003533440A (ja) | 2000-04-03 | 2003-11-11 | ブリストル−マイヤーズ スクイブ カンパニー | 隔離心収縮期高血圧症を処置するバソペプチダーゼ抑制剤 |
| IL152081A0 (en) | 2000-04-12 | 2003-05-29 | Novartis Ag | Novel medical use of aldosterone synthase inhibitors alone or in combination with at1-receptor antagonists |
| US20020013307A1 (en) | 2000-05-23 | 2002-01-31 | Pablo Lapuerta | Use of vasopeptidase inhibitors to treat or slow the progression of cognitive dysfunction and to treat and/or prevent dementia |
| US6777443B2 (en) * | 2001-05-15 | 2004-08-17 | Novartis Ag | Dipeptide derivatives |
-
2002
- 2002-05-09 US US10/142,693 patent/US6777443B2/en not_active Expired - Fee Related
- 2002-05-13 AR ARP020101736A patent/AR035890A1/es unknown
- 2002-05-14 SK SK1403-2003A patent/SK14032003A3/sk not_active Application Discontinuation
- 2002-05-14 BR BR0209652-8A patent/BR0209652A/pt not_active IP Right Cessation
- 2002-05-14 CZ CZ20033077A patent/CZ20033077A3/cs unknown
- 2002-05-14 TW TW091110028A patent/TWI295996B/zh not_active IP Right Cessation
- 2002-05-14 MY MYPI20021740A patent/MY127495A/en unknown
- 2002-05-14 IL IL15877202A patent/IL158772A0/xx unknown
- 2002-05-14 WO PCT/EP2002/005293 patent/WO2002092622A2/en not_active Ceased
- 2002-05-14 EP EP02740600A patent/EP1392720A2/en not_active Withdrawn
- 2002-05-14 MX MXPA03010403A patent/MXPA03010403A/es active IP Right Grant
- 2002-05-14 RU RU2003134153/04A patent/RU2298559C2/ru not_active IP Right Cessation
- 2002-05-14 HU HU0304084A patent/HUP0304084A3/hu unknown
- 2002-05-14 JP JP2002589505A patent/JP4390458B2/ja not_active Expired - Fee Related
- 2002-05-14 EP EP10164769A patent/EP2239268A1/en not_active Withdrawn
- 2002-05-14 CA CA002449292A patent/CA2449292A1/en not_active Abandoned
- 2002-05-14 AU AU2002314067A patent/AU2002314067B2/en not_active Ceased
- 2002-05-14 NZ NZ529438A patent/NZ529438A/en unknown
- 2002-05-14 CN CNA028118499A patent/CN1649893A/zh active Pending
- 2002-05-14 PL PL02366786A patent/PL366786A1/xx unknown
- 2002-05-14 KR KR1020037014849A patent/KR100908152B1/ko not_active Expired - Fee Related
- 2002-05-15 PE PE2002000407A patent/PE20030042A1/es not_active Application Discontinuation
-
2003
- 2003-11-14 NO NO20035084A patent/NO20035084L/no not_active Application Discontinuation
- 2003-12-02 CO CO03105928A patent/CO5540347A2/es not_active Application Discontinuation
-
2004
- 2004-07-02 US US10/884,150 patent/US6992105B2/en not_active Expired - Fee Related
-
2005
- 2005-10-21 US US11/255,827 patent/US20060058242A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20030042A1 (es) | Derivados de dipeptido como inhibidores de enzima convertidora de angiotensina y endopeptidasa neutra | |
| EA200301094A1 (ru) | Аминопроизводные как ингибиторы протеазы | |
| PE20080404A1 (es) | Derivados bencil-amino-piperidina como inhibidores de cetp | |
| PE20070135A1 (es) | Compuestos heterociclicos como inhibidores de aspartil proteasas | |
| AR035659A1 (es) | Hidroxiamidas de acido (1-oxo-1,2,3,4-tetrahidro-naftalen-2-il)-alcanoico, proceso para la manufactura de estos compuestos, composiciones farmaceuticas que contienen dichos compuestos y los usos de los mismos | |
| TR200201752T2 (tr) | Dipeptid nitril katepsin K inhibitörleri. | |
| RU96120088A (ru) | Антитромботические агенты | |
| EA200602290A1 (ru) | Лиганды crth2 рецептора и их применение | |
| EA200600348A1 (ru) | Новые соединения | |
| EA200300919A1 (ru) | N-замещенные неарильные гетероциклические антагонисты nmda/nr2b | |
| PE20020753A1 (es) | Heteroaromaticos fusionados como activadores de la glucoquinasa | |
| AR016429A1 (es) | Compuesto derivado de acido hidroxamico como inhibidores de metaloproteasa de matriz (mmp), composiciones farmaceuticas y formulaciones veterinarias, usopara la preparacion de composiciones y formulaciones, compuesto intermediario, procedimiento de preparacion del compuesto. | |
| DK0793656T3 (da) | Hidtil ukendte benzyl-pyrimidiner | |
| HUP0301249A2 (hu) | APO B termelődés gátló benzamid-vegyületek ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
| CO4940458A1 (es) | Novedosos inhibidores de urea n-sustituida de transferasa de proteina farnesilo | |
| PE20070115A1 (es) | Derivados de [1,3,5]-triazina como inhibidores de aspartil proteasas | |
| PE20120062A1 (es) | Derivados de 1-bencil-2-amino-tetralina como inhibidores del transportador de glicina glyt1 | |
| KR20010086468A (ko) | 트롬빈 억제제 | |
| PE20060999A1 (es) | Composiciones farmaceuticas que contienen un diuretico y un bloqueador del receptor de angiotensina ii | |
| EA200300777A1 (ru) | N-фенпропилциклопентил-замещенные производные глутарамида в качестве nep ингибиторов для fsad | |
| TR200103067T2 (tr) | Renin inhibitörleri | |
| PE20060823A1 (es) | Compuestos de arilsulfonamida como moduladores de receptores cck1/cck2 | |
| CO4930264A1 (es) | Nuevos derivados de acido piperidin-cetocarboxilico y la obtencion de los mismos | |
| DK0586806T3 (da) | Anvendelse af 2-(N-(2-aminoethyl)-amino)-eddike-syrederivater til behandling af sygdomme, der er betinget af den ikke-enzym | |
| PE20060692A1 (es) | Inhibidores bace |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |