PE20020918A1 - Diclorhidrato del acido 3-(3-amidinofenil)-5-[({[1-iminoetil)-4-piperidil]metil}amino)metil] benzoico y proceso para prepararlo - Google Patents
Diclorhidrato del acido 3-(3-amidinofenil)-5-[({[1-iminoetil)-4-piperidil]metil}amino)metil] benzoico y proceso para prepararloInfo
- Publication number
- PE20020918A1 PE20020918A1 PE2002000069A PE2002000069A PE20020918A1 PE 20020918 A1 PE20020918 A1 PE 20020918A1 PE 2002000069 A PE2002000069 A PE 2002000069A PE 2002000069 A PE2002000069 A PE 2002000069A PE 20020918 A1 PE20020918 A1 PE 20020918A1
- Authority
- PE
- Peru
- Prior art keywords
- methyl
- amidinophenyl
- piperidyl
- amino
- iminoethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
SE REFIERE AL CRISTAL HIDRATADO O TRIHIDRATADO DEL DICLORHIDRATO DEL ACIDO 3-(3-AMIDINOFENIL)-5-[({[1-IMINOETIL)-4-PIPERIDIL]METIL}}AMINO)METIL]BENZOICO DE FORMULA I QUE SE CARATERIZA POR SU PATRON DE DIFRACCION DE RAYOS X; TAMBIEN SE REFIERE A UN PROCESO PARA PREPARAR EL HIDRATO DEL DICLORHIDRATO DEL COMPUESTO QUE COMPRENDE REACCIONAR 3-(3-AMIDINOFENIL)-5-({[(4-PIPERIDIL]METIL}}AMINO)METIL]BENZOATO DE METILO CON CLORHIDRATO DE ETILACETOIMIDATO PARA FORMAR 3-(3-AMIDINOFENIL)-5-[({[1-(1-IMINOETIL)-4-PIPERIDIL]METIL}}AMINO)METIL]BENZOATO DE METILO.XHCL; X ES 0-3 O SU SAL HIDROLIZANDO EL ESTER METILICO CON UN ACIDO Y SOMETIENDO AL HIDROSALISADO RESULTANTE A NEUTRALIZACION, PURIFICACION POR RECRISTALIZACION Y ACONDICIONAMIENTO POR HUMEDAD. EL COMPUESTO ES INHIBIDOR DEL FACTOR X DE COAGULACION, PRESENTA UNA FORMA CRISTALINA ESTABLE
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001021475 | 2001-01-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20020918A1 true PE20020918A1 (es) | 2002-10-21 |
Family
ID=18887035
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2002000069A PE20020918A1 (es) | 2001-01-30 | 2002-01-29 | Diclorhidrato del acido 3-(3-amidinofenil)-5-[({[1-iminoetil)-4-piperidil]metil}amino)metil] benzoico y proceso para prepararlo |
Country Status (11)
Country | Link |
---|---|
US (1) | US20040053967A1 (es) |
EP (1) | EP1363882A4 (es) |
JP (1) | JP2004518683A (es) |
KR (1) | KR20040016837A (es) |
CN (1) | CN1489578A (es) |
AR (1) | AR035425A1 (es) |
CA (1) | CA2436265A1 (es) |
HU (1) | HUP0302866A3 (es) |
NZ (1) | NZ527138A (es) |
PE (1) | PE20020918A1 (es) |
WO (1) | WO2002060873A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003235236A1 (en) * | 2002-05-13 | 2003-11-11 | Daiichi Pharmaceutical Co., Ltd. | Lyophilization product |
JPWO2010041569A1 (ja) | 2008-10-09 | 2012-03-08 | 旭化成ファーマ株式会社 | インダゾール化合物 |
CN102171191A (zh) * | 2008-10-09 | 2011-08-31 | 旭化成制药株式会社 | 吲唑衍生物 |
US20100222404A1 (en) * | 2008-11-04 | 2010-09-02 | Asahi Kasei Pharma Corporation | Indazole derivative dihydrochloride |
EP3307725A1 (en) | 2015-06-11 | 2018-04-18 | Basilea Pharmaceutica International AG | Efflux-pump inhibitors and therapeutic uses thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4102024A1 (de) * | 1991-01-24 | 1992-07-30 | Thomae Gmbh Dr K | Biphenylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
US5463116A (en) * | 1991-07-30 | 1995-10-31 | Ajinomoto Co., Inc. | Crystals of N- (trans-4-isopropylcyclohexlycarbonyl)-D-phenylalanine and methods for preparing them |
EP0526171B1 (en) * | 1991-07-30 | 1997-03-05 | Ajinomoto Co., Inc. | Crystals of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine and methods for preparing them |
JPH101467A (ja) * | 1996-06-13 | 1998-01-06 | Banyu Pharmaceut Co Ltd | ビフェニルアミジン誘導体 |
EE04564B1 (et) * | 1997-11-20 | 2005-12-15 | Teijin Limited | Bifenlamidiini derivaadid, eelravim, vere koagulatsiooniinhibiitor ning proflaktiline ja terapeutiline toimeaine tromboosi v?i emboolia vastu |
CA2360686A1 (en) * | 1999-01-28 | 2000-08-03 | Teijin Limited | Release-regulating preparations |
-
2002
- 2002-01-25 AR ARP020100278A patent/AR035425A1/es unknown
- 2002-01-28 CA CA002436265A patent/CA2436265A1/en not_active Abandoned
- 2002-01-28 NZ NZ527138A patent/NZ527138A/en unknown
- 2002-01-28 CN CNA028043162A patent/CN1489578A/zh active Pending
- 2002-01-28 KR KR10-2003-7010019A patent/KR20040016837A/ko not_active Application Discontinuation
- 2002-01-28 EP EP02716418A patent/EP1363882A4/en not_active Withdrawn
- 2002-01-28 WO PCT/JP2002/000606 patent/WO2002060873A1/en not_active Application Discontinuation
- 2002-01-28 US US10/470,383 patent/US20040053967A1/en not_active Abandoned
- 2002-01-28 JP JP2002561024A patent/JP2004518683A/ja not_active Withdrawn
- 2002-01-28 HU HU0302866A patent/HUP0302866A3/hu unknown
- 2002-01-29 PE PE2002000069A patent/PE20020918A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
HUP0302866A3 (en) | 2007-05-02 |
EP1363882A4 (en) | 2005-11-30 |
EP1363882A1 (en) | 2003-11-26 |
CN1489578A (zh) | 2004-04-14 |
CA2436265A1 (en) | 2002-08-08 |
JP2004518683A (ja) | 2004-06-24 |
AR035425A1 (es) | 2004-05-26 |
KR20040016837A (ko) | 2004-02-25 |
NZ527138A (en) | 2005-01-28 |
HUP0302866A2 (hu) | 2003-12-29 |
US20040053967A1 (en) | 2004-03-18 |
WO2002060873A1 (en) | 2002-08-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2501252B2 (ja) | 酢酸誘導体、その製造法、それを含む製薬調製剤、及びその製薬調製剤製造への利用 | |
BR0213570A (pt) | Cristal na forma alfa ou forma beta de derivado de acetanilida | |
US5747522A (en) | Amino acid derivatives | |
CA2445145A1 (en) | Carboxylic acid substituted oxazole derivatives for use as ppar-alpha and -gamma activators in the treatment of diabetes | |
EA021537B1 (ru) | Аминозамещенные производные бисфенилпентановой кислоты в качестве ингибиторов nep | |
ATE151418T1 (de) | Heterocyclische carbonsäure-derivate, die an rar rezeptoren binden können | |
UY25843A1 (es) | Compuestos orgánicos inhibidores de peptidasa de dipeptidilo-iv | |
CA2296604A1 (en) | Crystal modification of a n-phenyl-2-pyrimidineamine derivative, processes for its manufacture and its use | |
NO20062905L (no) | Nye hydroksaminsyreestere og farmasoytisk anvendelse derav | |
NO20055568L (no) | Substituerte 1,4-diazepiner og anvendelser derav | |
JP2011509261A (ja) | 炎症および免疫関連用途向けの化合物 | |
JP2010506852A (ja) | 二環式ヘテロ芳香族化合物 | |
PE20020918A1 (es) | Diclorhidrato del acido 3-(3-amidinofenil)-5-[({[1-iminoetil)-4-piperidil]metil}amino)metil] benzoico y proceso para prepararlo | |
SMAP200900080A (it) | Sali di addizione acida, idrati e polimorfi di acido 5-(2,4-diidrossi-5-isopropil-fenil)-isossazolo-3-carbossilico etilammide e formulazioni comprendenti queste forme | |
BR9804753A (pt) | Compostos de ácido picolìnico 5-substituìdo e processos para a sua produção. | |
DK0624586T3 (da) | Substituerede pyrroler | |
WO2007047893A3 (en) | Use of dasatinib for the treatment of bone metastasis | |
WO2014104272A1 (ja) | ケイ皮酸アミド誘導体 | |
JP2016028061A (ja) | アルコキシイミダゾール−1−イルメチルビフェニルカルボン酸の結晶性形態 | |
RS20050514A (en) | Compounds having prolyl oligopeptidase inhibitory activity | |
CA2434829A1 (en) | New benzoylguanidine salt | |
KR970707118A (ko) | 의약용 수화물(Hydrate for medicinal use) | |
ATE257702T1 (de) | Verwendung von 2-imidazolyl-substituierten carbinolen zur herstellung eines medikaments zur behandlung oder prophylaxe von durch ischämischen zuständen bewirkten krankheiten | |
MY133525A (en) | Ethyl(2s)-2-(naphthalene-1-sulfonylamino)-3-(4-(2-(1,4,5,6-tetrahydropyrimidin-2-ylcarbamoyl)ethyl)benzoylamino)propionate hemifumarate, a process and intermediates for its preparation, and its use asa pharmaceutical | |
YU89903A (sh) | Derivati oksazola koji su supstituisani karboksilnom kiselinom za primenu kao ppar-alfa i -gama aktivatori u lečenju dijabetesa |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Refusal |