PE20020918A1 - Diclorhidrato del acido 3-(3-amidinofenil)-5-[({[1-iminoetil)-4-piperidil]metil}amino)metil] benzoico y proceso para prepararlo - Google Patents

Diclorhidrato del acido 3-(3-amidinofenil)-5-[({[1-iminoetil)-4-piperidil]metil}amino)metil] benzoico y proceso para prepararlo

Info

Publication number
PE20020918A1
PE20020918A1 PE2002000069A PE2002000069A PE20020918A1 PE 20020918 A1 PE20020918 A1 PE 20020918A1 PE 2002000069 A PE2002000069 A PE 2002000069A PE 2002000069 A PE2002000069 A PE 2002000069A PE 20020918 A1 PE20020918 A1 PE 20020918A1
Authority
PE
Peru
Prior art keywords
methyl
amidinophenyl
piperidyl
amino
iminoethyl
Prior art date
Application number
PE2002000069A
Other languages
English (en)
Inventor
Takayuki Hara
Midori Kamimura
Yasunobu Takano
Masayasu Tabe
Toru Minoshima
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Publication of PE20020918A1 publication Critical patent/PE20020918A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE REFIERE AL CRISTAL HIDRATADO O TRIHIDRATADO DEL DICLORHIDRATO DEL ACIDO 3-(3-AMIDINOFENIL)-5-[({[1-IMINOETIL)-4-PIPERIDIL]METIL}}AMINO)METIL]BENZOICO DE FORMULA I QUE SE CARATERIZA POR SU PATRON DE DIFRACCION DE RAYOS X; TAMBIEN SE REFIERE A UN PROCESO PARA PREPARAR EL HIDRATO DEL DICLORHIDRATO DEL COMPUESTO QUE COMPRENDE REACCIONAR 3-(3-AMIDINOFENIL)-5-({[(4-PIPERIDIL]METIL}}AMINO)METIL]BENZOATO DE METILO CON CLORHIDRATO DE ETILACETOIMIDATO PARA FORMAR 3-(3-AMIDINOFENIL)-5-[({[1-(1-IMINOETIL)-4-PIPERIDIL]METIL}}AMINO)METIL]BENZOATO DE METILO.XHCL; X ES 0-3 O SU SAL HIDROLIZANDO EL ESTER METILICO CON UN ACIDO Y SOMETIENDO AL HIDROSALISADO RESULTANTE A NEUTRALIZACION, PURIFICACION POR RECRISTALIZACION Y ACONDICIONAMIENTO POR HUMEDAD. EL COMPUESTO ES INHIBIDOR DEL FACTOR X DE COAGULACION, PRESENTA UNA FORMA CRISTALINA ESTABLE
PE2002000069A 2001-01-30 2002-01-29 Diclorhidrato del acido 3-(3-amidinofenil)-5-[({[1-iminoetil)-4-piperidil]metil}amino)metil] benzoico y proceso para prepararlo PE20020918A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2001021475 2001-01-30

Publications (1)

Publication Number Publication Date
PE20020918A1 true PE20020918A1 (es) 2002-10-21

Family

ID=18887035

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002000069A PE20020918A1 (es) 2001-01-30 2002-01-29 Diclorhidrato del acido 3-(3-amidinofenil)-5-[({[1-iminoetil)-4-piperidil]metil}amino)metil] benzoico y proceso para prepararlo

Country Status (11)

Country Link
US (1) US20040053967A1 (es)
EP (1) EP1363882A4 (es)
JP (1) JP2004518683A (es)
KR (1) KR20040016837A (es)
CN (1) CN1489578A (es)
AR (1) AR035425A1 (es)
CA (1) CA2436265A1 (es)
HU (1) HUP0302866A3 (es)
NZ (1) NZ527138A (es)
PE (1) PE20020918A1 (es)
WO (1) WO2002060873A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050187249A1 (en) * 2002-05-13 2005-08-25 Daiichi Pharmaceutical Co., Ltd. Lypohilization product
JPWO2010041568A1 (ja) * 2008-10-09 2012-03-08 旭化成ファーマ株式会社 インダゾール誘導体
AU2009301798B2 (en) 2008-10-09 2012-03-01 Asahi Kasei Pharma Corporation Indazole compound
US20100222404A1 (en) * 2008-11-04 2010-09-02 Asahi Kasei Pharma Corporation Indazole derivative dihydrochloride
WO2016198691A1 (en) 2015-06-11 2016-12-15 Basilea Pharmaceutica Ag Efflux-pump inhibitors and therapeutic uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4102024A1 (de) * 1991-01-24 1992-07-30 Thomae Gmbh Dr K Biphenylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
ES2100291T3 (es) * 1991-07-30 1997-06-16 Ajinomoto Kk Cristales de n-(trans-4-isopropilciclohexilcarbonil)-d-fenilalanina y metodos para prepararlos.
US5463116A (en) * 1991-07-30 1995-10-31 Ajinomoto Co., Inc. Crystals of N- (trans-4-isopropylcyclohexlycarbonyl)-D-phenylalanine and methods for preparing them
JPH101467A (ja) * 1996-06-13 1998-01-06 Banyu Pharmaceut Co Ltd ビフェニルアミジン誘導体
NZ504407A (en) * 1997-11-20 2002-02-01 Teijin Ltd Biphenylamidine derivatives substituted by nitrogen containing heterocyclic ring useful as a Factor Xa inhibitor
US6676968B1 (en) * 1999-01-28 2004-01-13 Teijin Limited Release-regulating preparations comprising biphenyldiamine derivatives

Also Published As

Publication number Publication date
HUP0302866A2 (hu) 2003-12-29
CN1489578A (zh) 2004-04-14
CA2436265A1 (en) 2002-08-08
AR035425A1 (es) 2004-05-26
NZ527138A (en) 2005-01-28
KR20040016837A (ko) 2004-02-25
WO2002060873A1 (en) 2002-08-08
US20040053967A1 (en) 2004-03-18
EP1363882A4 (en) 2005-11-30
JP2004518683A (ja) 2004-06-24
HUP0302866A3 (en) 2007-05-02
EP1363882A1 (en) 2003-11-26

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