PE20020468A1 - Compuestos macrolidos como agentes antibacterianos y antiprotozoarios - Google Patents

Compuestos macrolidos como agentes antibacterianos y antiprotozoarios

Info

Publication number
PE20020468A1
PE20020468A1 PE2001000778A PE2001000778A PE20020468A1 PE 20020468 A1 PE20020468 A1 PE 20020468A1 PE 2001000778 A PE2001000778 A PE 2001000778A PE 2001000778 A PE2001000778 A PE 2001000778A PE 20020468 A1 PE20020468 A1 PE 20020468A1
Authority
PE
Peru
Prior art keywords
alkyl
antibacterial
compounds
clarithromycin
carbamate
Prior art date
Application number
PE2001000778A
Other languages
English (en)
Inventor
Yan Chen
Wei-Guo Su
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20020468A1 publication Critical patent/PE20020468A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

SE REFIERE COMPUESTOS MACROLIDOS DE FORMULA I DONDE X ES CR9R10, O, NR11, S CUANDO X ES NR11 PUEDE FORMA JUNTO CON R2 UN GRUPO CARBOCICLICO DE 4-10 MIEMBROS O UN GRUPO HETEROCICLICO DE 4 A 10 MIEMBROS; Z ES -C(=O), -C(=NOR13)-, -CH(NR11R12)-, -N(Me)CH2-; R1 ES H, OR16, ALQUILO C1-C6, (HETEROCICLO DE 4-10 MIEMBROS)(ALQUILO C0-C6), ENTRE OTROS; R2 ES H, ALQUILO C1-C16, ENTRE OTROS; R3 ES ALQUILO C1-C16, ALQUENILO C2-C16, ENTRE OTROS; R1 Y R3 JUNTOS FORMAN =O, =NOR13; R4 ES H, OR19; Z Y R4 JUNTOS FORMAN EL GRUPO (C10)(C6)CH2-V-C(=O)(O); V ES O, NR17; R5 Y R7 JUNTOS SON OH, ENTRE OTROS; R6 ES H, -C(O)-ALQUILO C1-C6), BENCILO, BENCILOXICARBONILO, ENTRE OTROS; R8 ES ALQUILO C1-C10, ALQUENILO C2-C6, ALQUINILO C2-C6, ENTRE OTROS; R13 ES H, ALQUILO C1-C6, ENTRE OTROS; R9 Y 10 SON H, ALQUILO C1-C6; R11 Y R12 SON H, ALQUILO C1-C6; R16 ES H, ALQUILO C1-C6, ENTRE OTROS; R19 ES H, ALQUILO C1-C6, ENTRE OTROS; R17 ES H, OR16 ENTRE OTROS. SON COMPUESTOS PREFERIDOS CLARITROMICINA-11,12-CARBAMATO-3-DESCLADINOSA-3-ESTER DEL ACIDO (O-O-METOXIMETIL)FENILACETICO, CLARITROMICINA-11,12-CARBAMATO-3-DESCLADINOSA-3-ESTER DEL ACIDO (O-O-ALIL)FENILACETICO, CLARITROMICINA-11,12-CARBAMATO-3-DESCLADINOSA-3-ESTER DEL ACIDO (O-O-METILOMETIL)FENILACETICO, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO PARA LA PREPARACION Y UNA COMPOSICION FARMACEUTICA. LOS COMPUESTOS MENCIONADOS SON AGENTES ANTIBACTERIANOS Y ANTIPROTOZOARIOS
PE2001000778A 2000-08-07 2001-08-06 Compuestos macrolidos como agentes antibacterianos y antiprotozoarios PE20020468A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22359100P 2000-08-07 2000-08-07

Publications (1)

Publication Number Publication Date
PE20020468A1 true PE20020468A1 (es) 2002-06-14

Family

ID=22837162

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001000778A PE20020468A1 (es) 2000-08-07 2001-08-06 Compuestos macrolidos como agentes antibacterianos y antiprotozoarios

Country Status (17)

Country Link
US (2) US20020115621A1 (es)
EP (1) EP1307468A1 (es)
JP (1) JP2004505987A (es)
AP (1) AP2001002236A0 (es)
AR (1) AR034695A1 (es)
AU (1) AU2001272719A1 (es)
BR (1) BR0112863A (es)
CA (1) CA2419044A1 (es)
DO (1) DOP2001000228A (es)
GT (1) GT200100159A (es)
HN (1) HN2001000176A (es)
MX (1) MXPA03001148A (es)
PA (1) PA8524501A1 (es)
PE (1) PE20020468A1 (es)
TN (1) TNSN01121A1 (es)
UY (1) UY26870A1 (es)
WO (1) WO2002012260A1 (es)

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US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
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US7271155B2 (en) 2005-01-07 2007-09-18 Enanta Pharmaceuticals, Inc. 9A, 11-2C-bicyclic 9a-azalide derivatives
DE602006004555D1 (de) 2005-01-13 2009-02-12 Glaxosmithkline Zagreb Decladinosyl-macrolide mit entzündungshemmender wirkung
US20090130225A1 (en) * 2005-11-23 2009-05-21 Anjan Chakrabarti Macrolides derivatives as antibacterial agents
WO2007060518A2 (en) * 2005-11-23 2007-05-31 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
WO2007143507A2 (en) * 2006-06-05 2007-12-13 Auspex Pharmaceuticals, Inc. Preparation and utility of substituted erythromycin analogs
WO2009055557A1 (en) 2007-10-25 2009-04-30 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
US8796232B2 (en) 2008-10-24 2014-08-05 Cempra Pharmaceuticals, Inc. Methods for treating resistant diseases using triazole containing macrolides
US9937194B1 (en) * 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
JP5914335B2 (ja) 2009-09-10 2016-05-11 センプラ ファーマシューティカルズ，インコーポレイテッド マラリア、結核、及びｍａｃ病の治療方法
WO2011119604A1 (en) 2010-03-22 2011-09-29 Cempra Pharmaceuticals, Inc. Crystalline forms of a macrolide, and uses therefor
BR112012029586A2 (pt) 2010-05-20 2016-08-02 Cempra Pharmaceuticals Inc processos para preparar macrolídeos e cetolídeos e intermediários dos mesmos
KR20180110181A (ko) 2010-09-10 2018-10-08 셈프라 파마슈티컬스, 인크. 질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드
CA2868262A1 (en) 2012-03-27 2013-10-03 Cempra Pharmaceuticals, Inc. Parenteral formulations for administering macrolide antibiotics
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Also Published As

Publication number Publication date
BR0112863A (pt) 2003-07-01
GT200100159A (es) 2002-03-22
DOP2001000228A (es) 2002-09-30
CA2419044A1 (en) 2002-02-14
HN2001000176A (es) 2001-10-08
TNSN01121A1 (fr) 2005-11-10
US6849608B2 (en) 2005-02-01
AP2001002236A0 (en) 2001-09-30
AU2001272719A1 (en) 2002-02-18
PA8524501A1 (es) 2002-08-29
JP2004505987A (ja) 2004-02-26
EP1307468A1 (en) 2003-05-07
MXPA03001148A (es) 2003-06-09
US20020115621A1 (en) 2002-08-22
US20040009930A1 (en) 2004-01-15
AR034695A1 (es) 2004-03-17
UY26870A1 (es) 2002-03-22
WO2002012260A1 (en) 2002-02-14

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