PE20001516A1 - Compuestos triciclicos como inhibidores de la farnesil transferasa - Google Patents

Compuestos triciclicos como inhibidores de la farnesil transferasa

Info

Publication number
PE20001516A1
PE20001516A1 PE1999001293A PE00129399A PE20001516A1 PE 20001516 A1 PE20001516 A1 PE 20001516A1 PE 1999001293 A PE1999001293 A PE 1999001293A PE 00129399 A PE00129399 A PE 00129399A PE 20001516 A1 PE20001516 A1 PE 20001516A1
Authority
PE
Peru
Prior art keywords
alkyl
aryl
arylalkyl
halo
farnesil
Prior art date
Application number
PE1999001293A
Other languages
English (en)
Inventor
Jianping Chao
Alan B Cooper
Ronald J Doll
Viyyoor M Girijavallabhan
Arthur G Taveras
Joseph M Kelly
Alan K Mallams
Dinanath F Rane
Corey Strickland
Timothy Guzi
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of PE20001516A1 publication Critical patent/PE20001516A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A UN COMPUESTO TRICICLICO DIBENZOCONDENSADO DE FORMULA I, DONDE: UNO DE a, b, c, d SON N, N+O Y EL RESTO SON CR1, CR2; R1, R2, R3 Y R4 SON H, HALO, CF3, OR10, SR10, S(O)tR11, ENTRE OTROS; t ES 0-2; O R3 Y R4 JUNTOS SON UN ANILLO FUSIONADO C5-C7 CON BENCENO (III); R5, R6 Y R7 SON H, CF3, COR10, ALQUILO, ARILO OPCIONALMENTE SUSTITUIDO CON OR10, S(O)tR11, NR10COOR11, NO2, COR10, ENTRE OTROS; R10 ES H, ALQUILO, ARILO, ARALQUILO; R11 ES ALQUILO, ARILO; X ES N, CH, C; CUANDO X ES CARBONO ESTA PRESENTE EL ENLACE OPCIONAL CON EL CARBONO 11 Y CUANDO X ES CH ESTA AUSENTE EL ENLACE OPCIONAL; A Y B SON H Y HALO, HALO, ALQUILO Y H, OC(O)R10, H Y OR10, =O, ARILO Y H, ENTRE OTROS; R8 ES UN HETEROCICLO SUSTITUIDO CON (CR13R14)n-R12 O Q-R12A; R13 Y R14 SON H, F, ALQUILO, ARILO, ARILALQUILO, HETEROARILO, ENTRE OTROS; Q ES O, N, CUANDO Q NO ES ADYACENTE AL HETEROATOMO EN EL HETEROCICLOALQUILO SUSTITUIDO CON Q-R12; R12 ES DIAZOL O PIRDIDINA; Y ES CH2, NR16, O, S, SO, SO2; n ES 0-6; R9 ES (O=)C-0-R20, (O=C)NR20R21, (O=C)-CH2-R20, (O=C)R22, ENTRE OTROS; R20 ES H, ALQUILO, ARILO, ARILALQUILO, ENTRE OTROS; R21 ES H, ALQUILO, ARILO, ARILALQUILO, ENTRE OTROS; R22 ES CICLOALQUIL, HETEROCICLOALQUILO, ENTRE OTROS. EL COMPUESTO DE FORMULA I INHIBE A LA FARNESIL TRANSFERASA POR LO QUE PUEDE SER UTIL EN EL TRATAMIENTO DE CANCER
PE1999001293A 1998-12-18 1999-12-17 Compuestos triciclicos como inhibidores de la farnesil transferasa PE20001516A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US21656098A 1998-12-18 1998-12-18

Publications (1)

Publication Number Publication Date
PE20001516A1 true PE20001516A1 (es) 2001-01-06

Family

ID=22807539

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999001293A PE20001516A1 (es) 1998-12-18 1999-12-17 Compuestos triciclicos como inhibidores de la farnesil transferasa

Country Status (24)

Country Link
EP (1) EP1140904B1 (es)
JP (1) JP2002533335A (es)
KR (1) KR20010081115A (es)
CN (1) CN1285588C (es)
AR (1) AR021716A1 (es)
AT (1) ATE293622T1 (es)
AU (1) AU2347900A (es)
BR (1) BR9916328A (es)
CA (1) CA2354774C (es)
CO (1) CO5160344A1 (es)
CZ (1) CZ20011900A3 (es)
DE (1) DE69924876T2 (es)
ES (1) ES2237963T3 (es)
HK (1) HK1036279A1 (es)
HU (1) HUP0203054A3 (es)
ID (1) ID29065A (es)
IL (1) IL143409A0 (es)
NO (1) NO20012960L (es)
PE (1) PE20001516A1 (es)
PL (1) PL348294A1 (es)
SK (1) SK7582001A3 (es)
TR (1) TR200101754T2 (es)
WO (1) WO2000037458A1 (es)
ZA (1) ZA200104236B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7361663B2 (en) 1999-11-10 2008-04-22 Aventis Pharmaceuticals Inc. N-acylpyrrolidin-2-ylalkylbenzamidine derivatives as inhibitors of factor Xa
MXPA02003802A (es) * 1999-11-10 2002-09-30 Aventis Pharma Gmbh Derivado de n-acilpirrolidin-2-ilalquilbenzamidina como inhibidores de factor xa.
US6589978B2 (en) * 2000-06-30 2003-07-08 Hoffman-La Roche Inc. 1-sulfonyl pyrrolidine derivatives
US7342016B2 (en) 2000-08-30 2008-03-11 Schering Corporation Farnesyl protein transferase inhibitors as antitumor agents
AR033680A1 (es) * 2000-08-30 2004-01-07 Schering Corp Compuestos triciclicos utiles como inhibidores de la farnesil proteino transferasa y su uso para la manufactura de medicamentos como agentes antitumorales
US6809093B2 (en) 2000-10-17 2004-10-26 H. Lee Moffitt Cancer & Research Institute, Inc. 2-substituted heterocyclic compounds
AU2002236813A1 (en) 2001-01-22 2002-07-30 Schering Corporation Treatment of malaria with farnesyl protein transferase inhibitors
ATE313534T1 (de) 2001-02-16 2006-01-15 Aventis Pharma Inc Heterocyclische substituierte carbonyl derivate und ihre verwendung als dopamin d3 rezeptor liganden
WO2002080895A2 (en) * 2001-04-06 2002-10-17 Schering Corporation Treatment of malaria with farsenyl protein transferase inhibitors
FR2825705B1 (fr) * 2001-06-08 2005-05-20 Aventis Pharma Sa Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens
GB0115862D0 (en) 2001-06-28 2001-08-22 Smithkline Beecham Plc Compounds
US6740757B2 (en) * 2001-08-29 2004-05-25 Pfizer Inc Enantiomers of 6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3h-imidazol-4-yl)-methyl]-4-[3-(3-hydroxy-3-methyl-but-1-ynyl)-phenyl]-1-methyl-1h-quinolin-2-one and salts thereof, useful in the treatment of cancer
FR2835186B1 (fr) 2002-01-28 2006-10-20 Aventis Pharma Sa Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases
FR2844273B1 (fr) 2002-09-05 2008-04-04 Aventis Pharma Sa Nouveaux composes heterocycliques, procede et intermediaires de preparation et utilisation comme medicament, notamment comme inhibiteurs de beta-lactamases et anti-bacteriens.
EP1572299B1 (en) * 2002-12-17 2008-09-24 Schering Corporation 17 beta-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases
CN101115486A (zh) * 2004-12-13 2008-01-30 先灵公司 新的法呢基蛋白转移酶抑制剂及其治疗癌症的用途
WO2006065794A1 (en) * 2004-12-14 2006-06-22 Schering Corporation Farnesyl protein transferase inhibitors and methods for treating proliferative diseases
EP1973882A1 (en) * 2006-01-19 2008-10-01 Schering Corporation Piperazine derivatives as farnesyl protein transferase inhibitors
CN102123999B (zh) * 2008-05-22 2014-06-18 默沙东公司 制备食欲素受体拮抗剂的方法
HU231150B1 (hu) 2017-03-13 2021-03-29 Richter Gedeon Nyrt Eljárás racém 3-alkilpiperidin-3-karbonsav-etil-észterek optikai izomerjeinek elválasztására
TW202220992A (zh) 2020-08-05 2022-06-01 匈牙利商羅特格登公司 具藥理活性之經雜環取代的吡唑并〔１，５－ａ〕嘧啶衍生物
CN114349711B (zh) * 2022-02-28 2023-08-15 四川依维欣医药科技有限公司 一种（R）-1-Boc-3-羟甲基哌嗪的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
GB9420172D0 (en) * 1994-10-06 1994-11-23 Boots Co Plc Therapeutic agents
IL117798A (en) * 1995-04-07 2001-11-25 Schering Plough Corp Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them
AU753658B2 (en) * 1997-06-17 2002-10-24 Pharmacopeia, Inc. Benzpyrido cycloheptane compounds useful for inhibition of farnesyl protein transferase

Also Published As

Publication number Publication date
EP1140904A1 (en) 2001-10-10
DE69924876T2 (de) 2006-03-02
HK1036279A1 (en) 2001-12-28
ZA200104236B (en) 2002-08-23
IL143409A0 (en) 2002-04-21
NO20012960D0 (no) 2001-06-15
DE69924876D1 (de) 2005-05-25
ID29065A (id) 2001-07-26
CZ20011900A3 (cs) 2002-02-13
SK7582001A3 (en) 2002-03-05
BR9916328A (pt) 2001-10-02
JP2002533335A (ja) 2002-10-08
EP1140904B1 (en) 2005-04-20
CN1352642A (zh) 2002-06-05
ES2237963T3 (es) 2005-08-01
CA2354774C (en) 2009-05-26
TR200101754T2 (tr) 2002-05-21
AU2347900A (en) 2000-07-12
AR021716A1 (es) 2002-07-31
CA2354774A1 (en) 2000-06-29
ATE293622T1 (de) 2005-05-15
KR20010081115A (ko) 2001-08-27
HUP0203054A2 (hu) 2003-01-28
CO5160344A1 (es) 2002-05-30
CN1285588C (zh) 2006-11-22
PL348294A1 (en) 2002-05-20
NO20012960L (no) 2001-08-15
WO2000037458A1 (en) 2000-06-29
HUP0203054A3 (en) 2004-01-28

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