PE20001342A1 - Compuestos triciclicos como inhibidores de farnesil transferasa - Google Patents

Compuestos triciclicos como inhibidores de farnesil transferasa

Info

Publication number
PE20001342A1
PE20001342A1 PE1999001295A PE00129599A PE20001342A1 PE 20001342 A1 PE20001342 A1 PE 20001342A1 PE 1999001295 A PE1999001295 A PE 1999001295A PE 00129599 A PE00129599 A PE 00129599A PE 20001342 A1 PE20001342 A1 PE 20001342A1
Authority
PE
Peru
Prior art keywords
alkyl
aryl
arylalkyl
tumors
carcinoma
Prior art date
Application number
PE1999001295A
Other languages
English (en)
Inventor
Adriano Afonso
Jay Weinstein
Carmen Alvarez
Jianping Chao
Alan B Cooper
Jagdish A Desai
Ronald J Doll
Johan A Ferreira
Viyyoor M Girijavallabhan
Timothy Guzi
Joseph M Kelly
Tarik Lalwani
Alan K Mallams
Dinanath F Rane
Arthur G Taveras
James J-S Wang
Cynthia J Aki
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of PE20001342A1 publication Critical patent/PE20001342A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Electroluminescent Light Sources (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

SE REFIERE A UN COMPUESTO TRICICLICO DE FORMULA I, DONDE: UNO DE a, b, c, d ES N, NO Y LOS OTROS SON CR1, CR2; X ES N, CH CUANDO EL ENLACE ES SIMPLE; C CUANDO ES UN DOBLE ENLACE; R1 Y R2 SON H, HALO, CF3, OR15, COR15, S(O)tR16, ENTRE OTROS; R3 Y R4 SON H; LOS SUSTITUYENTES DE R1 Y R2 O R3 Y R4 JUNTOS SON UN ANILLO FUSIONADO C5-C7 CON BENCENO III; R5, R6 Y R7 SON H, CF3, ALQUILO, ARILO; R8 ES H, ALQUILO C3-C4, ARILO, ARILALQUILO, HETEROARILO, ENTRE OTROS; R9 Y R10 SON H, ALQUILO ARILO, ARILALQUILO, HETEROARILO, ENTRE OTROS o JUNTOS FORMAN UN ANILLO C3-C6; R11 Y R12 SON H, ALQUILO, ARILO, ARILALQUILO O JUNTOS FORMAN UN CICLOALQUILO C3-C6, ENTRE OTROS; R13 ES UN IMIDAZOLILO; R14 ES COOR20, CONR20R21, COCH2R20, ENTRE OTROS; R15 ES H, ALQUILO, ARILO, ARILALQUILO; R2O ES H, ALQUILO, ALCOXI, ARILO, ENTRE OTROS; R21 ES H, ALQUILO, ARILO, ARILALQUILO; n ES 0-5; R32 Y R33 PARA CADA n SON H, ALQUILO, ARILO, ARILALQUILO, ENTRE OTROS; CUANDO R14 ES COOR20, CONR20, R20-SO2 Y X ES N ENTONCES R8 ES ALQUILO C3-C10, ARILAQUILO, HETEROARILALQUILO, ENTRE OTROS. EL COMPUESTO I ES UN INHIBIDOR DE LA FARNESIL TRANSFERASA Y PUEDE SER UTIL PARA EL TRATAMIENTO DE TUMORES PANCREATICOS, PULMON, LEUCEMIA MIELOIDE, TUMORES FOLICULARES DE TIROIDES, TUMORES MIELODISPLASCICOS, TUMORES DE CARCINOMA EPIDERMICO, TUMORES DE CARCINOMA DE VESICULA
PE1999001295A 1998-12-18 1999-12-17 Compuestos triciclicos como inhibidores de farnesil transferasa PE20001342A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US21639898A 1998-12-18 1998-12-18

Publications (1)

Publication Number Publication Date
PE20001342A1 true PE20001342A1 (es) 2000-12-09

Family

ID=22806914

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999001295A PE20001342A1 (es) 1998-12-18 1999-12-17 Compuestos triciclicos como inhibidores de farnesil transferasa

Country Status (20)

Country Link
EP (1) EP1140902A1 (es)
JP (1) JP2002533336A (es)
KR (1) KR20010081116A (es)
CN (1) CN1326850C (es)
AR (1) AR021718A1 (es)
AU (1) AU776558B2 (es)
BR (1) BR9916314A (es)
CA (1) CA2354779A1 (es)
CO (1) CO5160350A1 (es)
CZ (1) CZ20011950A3 (es)
HU (1) HUP0202152A2 (es)
IL (1) IL143408A0 (es)
NO (1) NO20012961L (es)
NZ (1) NZ511878A (es)
PE (1) PE20001342A1 (es)
PL (1) PL348293A1 (es)
SK (1) SK7592001A3 (es)
TR (1) TR200101755T2 (es)
WO (1) WO2000037459A1 (es)
ZA (1) ZA200104233B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010081116A (ko) 1998-12-18 2001-08-27 둘락 노먼 씨. 트리사이클릭 파르네실 단백질 트랜스퍼라제 억제제
US7342016B2 (en) 2000-08-30 2008-03-11 Schering Corporation Farnesyl protein transferase inhibitors as antitumor agents
US6645966B2 (en) 2001-01-22 2003-11-11 Schering Corporation Treatment of malaria with farnesyl protein transferase inhibitors
WO2002080895A2 (en) * 2001-04-06 2002-10-17 Schering Corporation Treatment of malaria with farsenyl protein transferase inhibitors
CA2590979A1 (en) 2004-12-13 2006-06-22 Schering Corporation Novel farnesyl protein transferase inhibitors and their use to treat cancer
MX2007007078A (es) 2004-12-14 2007-09-04 Schering Corp Inhibidores de farnesil-transferasa de proteina y metodos para tratar las enfermedades proliferativas.
CN101400656A (zh) * 2006-01-19 2009-04-01 先灵公司 作为法呢基蛋白转移酶抑制剂的哌嗪衍生物
MX371291B (es) * 2014-03-19 2020-01-24 Viamet Pharmaceuticals Nc Inc 2-(2,4-difluorofenil)-1,1-difluoro-1-(5-sustituido-piridin-2-il)- 3-(1h-tetrazol-1-il)propan-2-oles y procedimientos para su preparacion.
KR102441243B1 (ko) 2014-03-19 2022-09-07 브이피에스-3, 엘엘씨 2-(2,4-디플루오르페닐)-1,1-디플루오르-1-(5-치환된-피리딘-2-일)-3-(1h-테트라졸-1-일)프로판-2-올 및 이의 제조방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL111235A (en) 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
IL117798A (en) * 1995-04-07 2001-11-25 Schering Plough Corp Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them
US5712280A (en) * 1995-04-07 1998-01-27 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US5801175A (en) * 1995-04-07 1998-09-01 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
PE92098A1 (es) * 1996-07-31 1998-12-31 Schering Corp N-cianoiminas triciclicas utiles como inhibidores de transferasa de proteina farnesilo
IL133386A0 (en) 1997-06-17 2001-04-30 Schering Corp Benzpyrido cycloheptane compounds useful for inhibition of a farnesyl protein transferase
KR20010081116A (ko) 1998-12-18 2001-08-27 둘락 노먼 씨. 트리사이클릭 파르네실 단백질 트랜스퍼라제 억제제

Also Published As

Publication number Publication date
IL143408A0 (en) 2002-04-21
CN1326850C (zh) 2007-07-18
CO5160350A1 (es) 2002-05-30
EP1140902A1 (en) 2001-10-10
AR021718A1 (es) 2002-07-31
HUP0202152A2 (en) 2002-10-28
AU776558B2 (en) 2004-09-16
CN1334811A (zh) 2002-02-06
PL348293A1 (en) 2002-05-20
ZA200104233B (en) 2002-08-22
TR200101755T2 (tr) 2001-09-21
NO20012961D0 (no) 2001-06-15
NZ511878A (en) 2003-10-31
WO2000037459A1 (en) 2000-06-29
CZ20011950A3 (cs) 2001-12-12
NO20012961L (no) 2001-08-16
KR20010081116A (ko) 2001-08-27
BR9916314A (pt) 2001-10-02
SK7592001A3 (en) 2002-03-05
JP2002533336A (ja) 2002-10-08
CA2354779A1 (en) 2000-06-29
AU2030700A (en) 2000-07-12

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