PE20001387A1 - Compuestos empleados en el tratamiento de padecimientos inflamatorios - Google Patents
Compuestos empleados en el tratamiento de padecimientos inflamatoriosInfo
- Publication number
- PE20001387A1 PE20001387A1 PE1999001274A PE00127499A PE20001387A1 PE 20001387 A1 PE20001387 A1 PE 20001387A1 PE 1999001274 A PE1999001274 A PE 1999001274A PE 00127499 A PE00127499 A PE 00127499A PE 20001387 A1 PE20001387 A1 PE 20001387A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- cycloalkyl
- phenyl
- amino
- compound
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 208000027866 inflammatory disease Diseases 0.000 title 1
- -1 PYRROLIDINYL Chemical class 0.000 abstract 5
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 239000000048 adrenergic agonist Substances 0.000 abstract 1
- 229940126157 adrenergic receptor agonist Drugs 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 102000016966 beta-2 Adrenergic Receptors Human genes 0.000 abstract 1
- 108010014499 beta-2 Adrenergic Receptors Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9828074.6A GB9828074D0 (en) | 1998-12-18 | 1998-12-18 | Therapeutically useful compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20001387A1 true PE20001387A1 (es) | 2000-12-22 |
Family
ID=10844608
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1999001274A PE20001387A1 (es) | 1998-12-18 | 1999-12-16 | Compuestos empleados en el tratamiento de padecimientos inflamatorios |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6867192B1 (enExample) |
| EP (1) | EP1140837B1 (enExample) |
| JP (1) | JP4431282B2 (enExample) |
| KR (1) | KR20010101258A (enExample) |
| CN (1) | CN1330637A (enExample) |
| AR (1) | AR023727A1 (enExample) |
| AT (1) | ATE273954T1 (enExample) |
| AU (1) | AU760169B2 (enExample) |
| BR (1) | BR9916282A (enExample) |
| CA (1) | CA2355630A1 (enExample) |
| CO (1) | CO5170533A1 (enExample) |
| CZ (1) | CZ20012209A3 (enExample) |
| DE (1) | DE69919580T2 (enExample) |
| ES (1) | ES2226488T3 (enExample) |
| GB (1) | GB9828074D0 (enExample) |
| GT (1) | GT199900217A (enExample) |
| HK (1) | HK1038744A1 (enExample) |
| HU (1) | HUP0104867A3 (enExample) |
| IL (1) | IL142908A0 (enExample) |
| NO (1) | NO20012995L (enExample) |
| NZ (1) | NZ511478A (enExample) |
| PE (1) | PE20001387A1 (enExample) |
| PL (1) | PL348059A1 (enExample) |
| TR (1) | TR200101709T2 (enExample) |
| WO (1) | WO2000037444A1 (enExample) |
| ZA (1) | ZA200103948B (enExample) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001051487A1 (en) | 1999-12-28 | 2001-07-19 | Pfizer Products Inc. | Non-peptidyl inhibitors of vla-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases |
| GB0014881D0 (en) * | 2000-06-16 | 2000-08-09 | Glaxo Group Ltd | Pharmaceutical aerosol formulation |
| GB0014869D0 (en) * | 2000-06-16 | 2000-08-09 | Glaxo Group Ltd | Novel pharmaceutical formulation |
| GB0014892D0 (en) * | 2000-06-16 | 2000-08-09 | Glaxo Group Ltd | Novel pharmaceutical formulation |
| GB0014947D0 (en) * | 2000-06-16 | 2000-08-09 | Glaxo Group Ltd | Novel pharmaceutical formulation |
| GB0014851D0 (en) * | 2000-06-16 | 2000-08-09 | Glaxo Group Ltd | Novel pharmaceutical formulation |
| GB0014849D0 (en) * | 2000-06-16 | 2000-08-09 | Glaxo Group Ltd | Pharmaceutical aerosol formulation |
| GB0014883D0 (en) * | 2000-06-16 | 2000-08-09 | Glaxo Group Ltd | Novel pharmaceutical formulation |
| GB0127423D0 (en) * | 2001-11-15 | 2002-01-09 | Glaxo Group Ltd | Process |
| GB0218630D0 (en) | 2002-08-10 | 2002-09-18 | Tanabe Seiyaku Co | Novel compounds |
| WO2004103967A2 (en) | 2003-05-20 | 2004-12-02 | Genentech, Inc. | Thiocarbamate inhibitors of alpha-4 integrins |
| KR20070029733A (ko) | 2004-06-04 | 2007-03-14 | 제넨테크, 인크. | 다발성 경화증의 치료 방법 |
| US8310442B2 (en) | 2005-02-23 | 2012-11-13 | Pixtronix, Inc. | Circuits for controlling display apparatus |
| US9261694B2 (en) | 2005-02-23 | 2016-02-16 | Pixtronix, Inc. | Display apparatus and methods for manufacture thereof |
| US7999994B2 (en) | 2005-02-23 | 2011-08-16 | Pixtronix, Inc. | Display apparatus and methods for manufacture thereof |
| US8159428B2 (en) | 2005-02-23 | 2012-04-17 | Pixtronix, Inc. | Display methods and apparatus |
| US20070205969A1 (en) | 2005-02-23 | 2007-09-06 | Pixtronix, Incorporated | Direct-view MEMS display devices and methods for generating images thereon |
| US9158106B2 (en) | 2005-02-23 | 2015-10-13 | Pixtronix, Inc. | Display methods and apparatus |
| US8519945B2 (en) | 2006-01-06 | 2013-08-27 | Pixtronix, Inc. | Circuits for controlling display apparatus |
| US9229222B2 (en) | 2005-02-23 | 2016-01-05 | Pixtronix, Inc. | Alignment methods in fluid-filled MEMS displays |
| US8482496B2 (en) | 2006-01-06 | 2013-07-09 | Pixtronix, Inc. | Circuits for controlling MEMS display apparatus on a transparent substrate |
| US7742016B2 (en) | 2005-02-23 | 2010-06-22 | Pixtronix, Incorporated | Display methods and apparatus |
| US9082353B2 (en) | 2010-01-05 | 2015-07-14 | Pixtronix, Inc. | Circuits for controlling display apparatus |
| MY149159A (en) | 2005-11-15 | 2013-07-31 | Hoffmann La Roche | Method for treating joint damage |
| US8526096B2 (en) | 2006-02-23 | 2013-09-03 | Pixtronix, Inc. | Mechanical light modulators with stressed beams |
| US9176318B2 (en) * | 2007-05-18 | 2015-11-03 | Pixtronix, Inc. | Methods for manufacturing fluid-filled MEMS displays |
| TW201438738A (zh) | 2008-09-16 | 2014-10-16 | Genentech Inc | 治療進展型多發性硬化症之方法 |
| US8169679B2 (en) | 2008-10-27 | 2012-05-01 | Pixtronix, Inc. | MEMS anchors |
| WO2010075249A2 (en) | 2008-12-22 | 2010-07-01 | Genentech, Inc. | A method for treating rheumatoid arthritis with b-cell antagonists |
| KR101659642B1 (ko) | 2010-02-02 | 2016-09-26 | 픽스트로닉스 인코포레이티드 | 디스플레이 장치를 제어하기 위한 회로 |
| WO2011097252A2 (en) | 2010-02-02 | 2011-08-11 | Pixtronix, Inc. | Methods for manufacturing cold seal fluid-filled display apparatus |
| WO2013101771A2 (en) | 2011-12-30 | 2013-07-04 | Genentech, Inc. | Compositions and method for treating autoimmune diseases |
| AR091305A1 (es) | 2012-01-31 | 2015-01-28 | Genentech Inc | ANTICUERPOS ANTI-IgE Y SUS METODOS DE USO |
| US9134552B2 (en) | 2013-03-13 | 2015-09-15 | Pixtronix, Inc. | Display apparatus with narrow gap electrostatic actuators |
| WO2015181837A2 (en) * | 2014-05-30 | 2015-12-03 | Sphaera Pharma Pvt. Ltd. | Novel compounds as anti-tubercular agents |
| PL3319639T3 (pl) * | 2015-07-08 | 2021-03-08 | Axerovision, Inc. | Kompozycje farmaceutyczne zawierające antagonistę integryny alfa4 do stosowania w leczeniu stanów zapalnych oka |
| HRP20250052T1 (hr) | 2015-10-06 | 2025-03-14 | F. Hoffmann - La Roche Ag | Postupak liječenja multiple skleroze |
| HRP20220479T1 (hr) * | 2016-06-01 | 2022-05-27 | Athira Pharma, Inc. | Spojevi |
| CN109722455B (zh) * | 2017-10-31 | 2022-03-11 | 中国科学院天津工业生物技术研究所 | 微生物发酵生产谷内酯的方法、工程菌及应用 |
| WO2019246455A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an integrin inhibitor |
| ES3003232T3 (en) | 2018-10-30 | 2025-03-10 | Gilead Sciences Inc | Compounds for inhibition of alpha4beta7 integrin |
| ES2987796T3 (es) | 2018-10-30 | 2024-11-18 | Gilead Sciences Inc | Derivados de N-benzoil-fenilalanina como inhibidores de la integrina alfa4beta7 para el tratamiento de enfermedades inflamatorias |
| CN112969687B (zh) | 2018-10-30 | 2024-08-23 | 吉利德科学公司 | 作为α4β7整合素抑制剂的喹啉衍生物 |
| CA3114240C (en) | 2018-10-30 | 2023-09-05 | Gilead Sciences, Inc. | Imidazopyridine derivatives as alpha4beta7 integrin inhibitors |
| CN114222730B (zh) | 2019-08-14 | 2024-09-10 | 吉利德科学公司 | 用于抑制α4β7整合素的化合物 |
| JP2023546915A (ja) * | 2020-10-21 | 2023-11-08 | アズーラ オフサルミックス エルティーディー． | 眼障害を処置するための化合物および方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1593858A1 (de) | 1967-03-02 | 1970-10-29 | Hoechst Ag | Verfahren zur Herstellung tyrosinhaltiger Peptide und deren Derivaten |
| US4105602A (en) | 1975-02-10 | 1978-08-08 | Armour Pharmaceutical Company | Synthesis of peptides with parathyroid hormone activity |
| US6248713B1 (en) | 1995-07-11 | 2001-06-19 | Biogen, Inc. | Cell adhesion inhibitors |
| AU728435B2 (en) | 1997-05-29 | 2001-01-11 | Merck & Co., Inc. | Sulfonamides as cell adhesion inhibitors |
| ES2257808T3 (es) | 1997-05-29 | 2006-08-01 | MERCK & CO., INC. (A NEW JERSEY CORP.) | Acidos biarilalcanoicos como inhibidores de adhesion celular. |
| CA2291778A1 (en) | 1997-05-29 | 1998-12-03 | Merck & Co., Inc. | Heterocyclic amide compounds as cell adhesion inhibitors |
| ATE256699T1 (de) * | 1997-05-30 | 2004-01-15 | Celltech Therapeutics Ltd | Entzündungshemmende tyrosin-derivate |
-
1998
- 1998-12-18 GB GBGB9828074.6A patent/GB9828074D0/en not_active Ceased
-
1999
- 1999-12-15 AR ARP990106429A patent/AR023727A1/es not_active Application Discontinuation
- 1999-12-15 CO CO99078241A patent/CO5170533A1/es not_active Application Discontinuation
- 1999-12-16 AT AT99964583T patent/ATE273954T1/de not_active IP Right Cessation
- 1999-12-16 PL PL99348059A patent/PL348059A1/xx not_active Application Discontinuation
- 1999-12-16 DE DE69919580T patent/DE69919580T2/de not_active Expired - Lifetime
- 1999-12-16 JP JP2000589516A patent/JP4431282B2/ja not_active Expired - Lifetime
- 1999-12-16 TR TR2001/01709T patent/TR200101709T2/xx unknown
- 1999-12-16 EP EP99964583A patent/EP1140837B1/en not_active Expired - Lifetime
- 1999-12-16 IL IL14290899A patent/IL142908A0/xx unknown
- 1999-12-16 ES ES99964583T patent/ES2226488T3/es not_active Expired - Lifetime
- 1999-12-16 HK HK02100145.2A patent/HK1038744A1/zh unknown
- 1999-12-16 PE PE1999001274A patent/PE20001387A1/es not_active Application Discontinuation
- 1999-12-16 CN CN99814654A patent/CN1330637A/zh active Pending
- 1999-12-16 HU HU0104867A patent/HUP0104867A3/hu unknown
- 1999-12-16 NZ NZ511478A patent/NZ511478A/en unknown
- 1999-12-16 CZ CZ20012209A patent/CZ20012209A3/cs unknown
- 1999-12-16 US US09/868,395 patent/US6867192B1/en not_active Expired - Lifetime
- 1999-12-16 KR KR1020017007579A patent/KR20010101258A/ko not_active Withdrawn
- 1999-12-16 BR BR9916282-2A patent/BR9916282A/pt not_active IP Right Cessation
- 1999-12-16 WO PCT/EP1999/010000 patent/WO2000037444A1/en not_active Ceased
- 1999-12-16 CA CA002355630A patent/CA2355630A1/en not_active Abandoned
- 1999-12-16 AU AU30391/00A patent/AU760169B2/en not_active Ceased
- 1999-12-17 GT GT199900217A patent/GT199900217A/es unknown
-
2001
- 2001-05-15 ZA ZA200103948A patent/ZA200103948B/en unknown
- 2001-06-15 NO NO20012995A patent/NO20012995L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0104867A3 (en) | 2002-06-28 |
| ATE273954T1 (de) | 2004-09-15 |
| US6867192B1 (en) | 2005-03-15 |
| ES2226488T3 (es) | 2005-03-16 |
| PL348059A1 (en) | 2002-05-06 |
| CZ20012209A3 (cs) | 2001-09-12 |
| GT199900217A (es) | 2001-06-09 |
| HUP0104867A2 (hu) | 2002-04-29 |
| GB9828074D0 (en) | 1999-02-17 |
| NO20012995D0 (no) | 2001-06-15 |
| EP1140837B1 (en) | 2004-08-18 |
| BR9916282A (pt) | 2001-10-02 |
| JP4431282B2 (ja) | 2010-03-10 |
| CA2355630A1 (en) | 2000-06-29 |
| AR023727A1 (es) | 2002-09-04 |
| IL142908A0 (en) | 2002-04-21 |
| AU3039100A (en) | 2000-07-12 |
| EP1140837A1 (en) | 2001-10-10 |
| WO2000037444A1 (en) | 2000-06-29 |
| CO5170533A1 (es) | 2002-06-27 |
| NO20012995L (no) | 2001-08-15 |
| TR200101709T2 (tr) | 2001-12-21 |
| JP2002533326A (ja) | 2002-10-08 |
| HK1038744A1 (zh) | 2002-03-28 |
| AU760169B2 (en) | 2003-05-08 |
| CN1330637A (zh) | 2002-01-09 |
| ZA200103948B (en) | 2002-11-15 |
| NZ511478A (en) | 2003-08-29 |
| DE69919580T2 (de) | 2005-09-01 |
| DE69919580D1 (de) | 2004-09-23 |
| KR20010101258A (ko) | 2001-11-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |