PE20001342A1 - Compuestos triciclicos como inhibidores de farnesil transferasa - Google Patents
Compuestos triciclicos como inhibidores de farnesil transferasaInfo
- Publication number
- PE20001342A1 PE20001342A1 PE1999001295A PE00129599A PE20001342A1 PE 20001342 A1 PE20001342 A1 PE 20001342A1 PE 1999001295 A PE1999001295 A PE 1999001295A PE 00129599 A PE00129599 A PE 00129599A PE 20001342 A1 PE20001342 A1 PE 20001342A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- aryl
- arylalkyl
- tumors
- carcinoma
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 229950008696 farnesil Drugs 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 5
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- 201000009030 Carcinoma Diseases 0.000 abstract 3
- -1 IMIDAZOLYL Chemical group 0.000 abstract 1
- 102000004357 Transferases Human genes 0.000 abstract 1
- 108090000992 Transferases Proteins 0.000 abstract 1
- 230000003325 follicular Effects 0.000 abstract 1
- 210000004072 lung Anatomy 0.000 abstract 1
- 208000025113 myeloid leukemia Diseases 0.000 abstract 1
- 210000001685 thyroid gland Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Electroluminescent Light Sources (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21639898A | 1998-12-18 | 1998-12-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20001342A1 true PE20001342A1 (es) | 2000-12-09 |
Family
ID=22806914
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1999001295A PE20001342A1 (es) | 1998-12-18 | 1999-12-17 | Compuestos triciclicos como inhibidores de farnesil transferasa |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1140902A1 (enExample) |
| JP (1) | JP2002533336A (enExample) |
| KR (1) | KR20010081116A (enExample) |
| CN (1) | CN1326850C (enExample) |
| AR (1) | AR021718A1 (enExample) |
| AU (1) | AU776558B2 (enExample) |
| BR (1) | BR9916314A (enExample) |
| CA (1) | CA2354779A1 (enExample) |
| CO (1) | CO5160350A1 (enExample) |
| CZ (1) | CZ20011950A3 (enExample) |
| HU (1) | HUP0202152A2 (enExample) |
| IL (1) | IL143408A0 (enExample) |
| NO (1) | NO20012961L (enExample) |
| NZ (1) | NZ511878A (enExample) |
| PE (1) | PE20001342A1 (enExample) |
| PL (1) | PL348293A1 (enExample) |
| SK (1) | SK7592001A3 (enExample) |
| TR (1) | TR200101755T2 (enExample) |
| WO (1) | WO2000037459A1 (enExample) |
| ZA (1) | ZA200104233B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR200101755T2 (tr) | 1998-12-18 | 2001-09-21 | Schering Corporation | Trisiklik farnezil protein transferaz inhibitörleri. |
| US7342016B2 (en) | 2000-08-30 | 2008-03-11 | Schering Corporation | Farnesyl protein transferase inhibitors as antitumor agents |
| US6645966B2 (en) | 2001-01-22 | 2003-11-11 | Schering Corporation | Treatment of malaria with farnesyl protein transferase inhibitors |
| WO2002080895A2 (en) * | 2001-04-06 | 2002-10-17 | Schering Corporation | Treatment of malaria with farsenyl protein transferase inhibitors |
| JP2008523104A (ja) * | 2004-12-13 | 2008-07-03 | シェーリング コーポレイション | 癌を治療するための新規なファルネシルタンパク質トランスフェラーゼ阻害剤およびその使用 |
| CA2591123A1 (en) * | 2004-12-14 | 2006-06-22 | Schering Corporation | Farnesyl protein transferase inhibitors and methods for treating proliferative diseases |
| EP1973882A1 (en) * | 2006-01-19 | 2008-10-01 | Schering Corporation | Piperazine derivatives as farnesyl protein transferase inhibitors |
| BR112016021257B1 (pt) * | 2014-03-19 | 2021-03-02 | Viamet Pharmaceuticals (NC), Inc. | 2-(2,4- difluorofenil-1,1-diflúor-1-(5-substituído-piridin-2-il)-3- (1h-tetrazol-1-il)propan-2-óis e processos para preparação e uso dos mesmos |
| EP3119756B9 (en) | 2014-03-19 | 2021-08-25 | Dow AgroSciences LLC | 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL111235A (en) * | 1993-10-15 | 2001-03-19 | Schering Plough Corp | Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them |
| US5801175A (en) * | 1995-04-07 | 1998-09-01 | Schering Corporation | Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
| IL117798A (en) * | 1995-04-07 | 2001-11-25 | Schering Plough Corp | Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them |
| US5712280A (en) | 1995-04-07 | 1998-01-27 | Schering Corporation | Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
| PE92098A1 (es) * | 1996-07-31 | 1998-12-31 | Schering Corp | N-cianoiminas triciclicas utiles como inhibidores de transferasa de proteina farnesilo |
| AU753658B2 (en) * | 1997-06-17 | 2002-10-24 | Pharmacopeia, Inc. | Benzpyrido cycloheptane compounds useful for inhibition of farnesyl protein transferase |
| TR200101755T2 (tr) | 1998-12-18 | 2001-09-21 | Schering Corporation | Trisiklik farnezil protein transferaz inhibitörleri. |
-
1999
- 1999-12-16 TR TR2001/01755T patent/TR200101755T2/xx unknown
- 1999-12-16 SK SK759-2001A patent/SK7592001A3/sk unknown
- 1999-12-16 KR KR1020017007632A patent/KR20010081116A/ko not_active Abandoned
- 1999-12-16 AU AU20307/00A patent/AU776558B2/en not_active Ceased
- 1999-12-16 CO CO99078843A patent/CO5160350A1/es unknown
- 1999-12-16 BR BR9916314-4A patent/BR9916314A/pt not_active IP Right Cessation
- 1999-12-16 WO PCT/US1999/027939 patent/WO2000037459A1/en not_active Ceased
- 1999-12-16 AR ARP990106461A patent/AR021718A1/es unknown
- 1999-12-16 JP JP2000589531A patent/JP2002533336A/ja active Pending
- 1999-12-16 CN CNB99816206XA patent/CN1326850C/zh not_active Expired - Fee Related
- 1999-12-16 HU HU0202152A patent/HUP0202152A2/hu unknown
- 1999-12-16 EP EP99963980A patent/EP1140902A1/en not_active Withdrawn
- 1999-12-16 CA CA002354779A patent/CA2354779A1/en not_active Abandoned
- 1999-12-16 NZ NZ511878A patent/NZ511878A/en unknown
- 1999-12-16 PL PL99348293A patent/PL348293A1/xx not_active Application Discontinuation
- 1999-12-16 CZ CZ20011950A patent/CZ20011950A3/cs unknown
- 1999-12-16 IL IL14340899A patent/IL143408A0/xx unknown
- 1999-12-17 PE PE1999001295A patent/PE20001342A1/es not_active Application Discontinuation
-
2001
- 2001-05-23 ZA ZA200104233A patent/ZA200104233B/en unknown
- 2001-06-15 NO NO20012961A patent/NO20012961L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1334811A (zh) | 2002-02-06 |
| NO20012961L (no) | 2001-08-16 |
| SK7592001A3 (en) | 2002-03-05 |
| EP1140902A1 (en) | 2001-10-10 |
| NO20012961D0 (no) | 2001-06-15 |
| IL143408A0 (en) | 2002-04-21 |
| AU776558B2 (en) | 2004-09-16 |
| NZ511878A (en) | 2003-10-31 |
| KR20010081116A (ko) | 2001-08-27 |
| PL348293A1 (en) | 2002-05-20 |
| AR021718A1 (es) | 2002-07-31 |
| AU2030700A (en) | 2000-07-12 |
| WO2000037459A1 (en) | 2000-06-29 |
| CO5160350A1 (es) | 2002-05-30 |
| HUP0202152A2 (en) | 2002-10-28 |
| CN1326850C (zh) | 2007-07-18 |
| BR9916314A (pt) | 2001-10-02 |
| ZA200104233B (en) | 2002-08-22 |
| JP2002533336A (ja) | 2002-10-08 |
| TR200101755T2 (tr) | 2001-09-21 |
| CA2354779A1 (en) | 2000-06-29 |
| CZ20011950A3 (cs) | 2001-12-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20001516A1 (es) | Compuestos triciclicos como inhibidores de la farnesil transferasa | |
| ES2188016T3 (es) | Derivaqdo de benzamidoxima, productos intermedios y procedimiento para su obtencion y su empleo como fungicidas. | |
| PE20001342A1 (es) | Compuestos triciclicos como inhibidores de farnesil transferasa | |
| ATE137805T1 (de) | Verfahren zur erhöhung von chemilumineszenz | |
| AR061492A2 (es) | Procedimiento para la preparacion de compuestos intermediarios para la preparacion de 5-amino-1-aril-3-ciano pirazoles | |
| SE432253B (sv) | Analogiforfarande for framstellning av 8alfa-ergolin-i-derivat | |
| DE69925472D1 (de) | Benzoheterocyclische distamycinderivate, verfahren zu ihrer herstellung und ihre verwendung als antitumormittel | |
| ES305661A1 (es) | Procedimiento para la produccion de derivados de fenilciclopropano. | |
| ES440426A1 (es) | Un procedimiento para la preparacion de derivados de tieno- tiacina. | |
| KR850003719A (ko) | 시아노피라졸 제초제에 대한 개량 | |
| PT90912A (pt) | Processo para a preparacao de derivados de tiofenol | |
| GB1098806A (en) | Novel benzoxazinethiones | |
| ES288448A1 (es) | Procedimiento de obtención de nuevos tintes monoazoicos | |
| PE20020687A1 (es) | Imidazoles y tiazoles sustituidos como inhibidores de la farnesil transferasa | |
| GB1477957A (en) | Heterocyclic substituted styrenes and their use as optical brighteners | |
| ES2035919T3 (es) | Composiciones fungicidas. | |
| GB1076747A (en) | Substituted quinazolones | |
| ES438757A1 (es) | Un procedimiento de obtencion de las meta-trifluormetilben- cilaminas sustituidas al nitrogeno. | |
| ES448849A1 (es) | Procedimiento para preparar derivados de hexahidroacepina. | |
| ES382883A1 (es) | Procedimiento para la obtencion de colorantes monoazoicos insolubles en agua. | |
| PE20040711A1 (es) | Compuestos de haloalqueno, proceso para su produccion y pesticidas que los contienen | |
| ES399022A1 (es) | Procedimiento para la preparacion de cetonas derivadas de la dihidro-10,11 dibenzo (b,f) azepina. | |
| ES428525A1 (es) | Procedimiento para la produccion de derivados de bromopro- panol. | |
| GB1010998A (en) | Pyrimidine derivatives | |
| ES272262A2 (es) | Procedimiento de fabricación de nuevos tintes monoazoicos |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |