CN1326850C - 三环类法尼基蛋白转移酶抑制剂 - Google Patents
三环类法尼基蛋白转移酶抑制剂 Download PDFInfo
- Publication number
- CN1326850C CN1326850C CNB99816206XA CN99816206A CN1326850C CN 1326850 C CN1326850 C CN 1326850C CN B99816206X A CNB99816206X A CN B99816206XA CN 99816206 A CN99816206 A CN 99816206A CN 1326850 C CN1326850 C CN 1326850C
- Authority
- CN
- China
- Prior art keywords
- dichloromethane
- title compound
- stirred
- methanol
- mmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Electroluminescent Light Sources (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21639898A | 1998-12-18 | 1998-12-18 | |
| US09/216,398 | 1998-12-18 | ||
| US09/216398 | 1998-12-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1334811A CN1334811A (zh) | 2002-02-06 |
| CN1326850C true CN1326850C (zh) | 2007-07-18 |
Family
ID=22806914
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB99816206XA Expired - Fee Related CN1326850C (zh) | 1998-12-18 | 1999-12-16 | 三环类法尼基蛋白转移酶抑制剂 |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1140902A1 (enExample) |
| JP (1) | JP2002533336A (enExample) |
| KR (1) | KR20010081116A (enExample) |
| CN (1) | CN1326850C (enExample) |
| AR (1) | AR021718A1 (enExample) |
| AU (1) | AU776558B2 (enExample) |
| BR (1) | BR9916314A (enExample) |
| CA (1) | CA2354779A1 (enExample) |
| CO (1) | CO5160350A1 (enExample) |
| CZ (1) | CZ20011950A3 (enExample) |
| HU (1) | HUP0202152A2 (enExample) |
| IL (1) | IL143408A0 (enExample) |
| NO (1) | NO20012961L (enExample) |
| NZ (1) | NZ511878A (enExample) |
| PE (1) | PE20001342A1 (enExample) |
| PL (1) | PL348293A1 (enExample) |
| SK (1) | SK7592001A3 (enExample) |
| TR (1) | TR200101755T2 (enExample) |
| WO (1) | WO2000037459A1 (enExample) |
| ZA (1) | ZA200104233B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0202152A2 (en) | 1998-12-18 | 2002-10-28 | Schering Corp | Tricyclyc farnesyl protein transferase inhibitors |
| US7342016B2 (en) | 2000-08-30 | 2008-03-11 | Schering Corporation | Farnesyl protein transferase inhibitors as antitumor agents |
| US6645966B2 (en) | 2001-01-22 | 2003-11-11 | Schering Corporation | Treatment of malaria with farnesyl protein transferase inhibitors |
| AU2002257114A1 (en) * | 2001-04-06 | 2002-10-21 | Schering Corporation | Treatment of malaria with farsenyl protein transferase inhibitors |
| CA2590979A1 (en) | 2004-12-13 | 2006-06-22 | Schering Corporation | Novel farnesyl protein transferase inhibitors and their use to treat cancer |
| JP2008523148A (ja) * | 2004-12-14 | 2008-07-03 | シェーリング コーポレイション | ファルネシルプロテイントランスフェラーゼインヒビターおよび増殖性疾患を処置するための方法 |
| CA2637572A1 (en) * | 2006-01-19 | 2007-07-26 | Schering Corporation | Piperazine derivatives as farnesyl protein transferase inhibitors |
| MX2016012060A (es) | 2014-03-19 | 2017-01-19 | Viamet Pharmaceuticals Inc | 2-(2,4-difluorofenil)-1,1-difluoro-1-(5-sustituido-piridin-2-il)- 3-(1h-tetrazol-1-il)propan-2-oles y procesos para su preparacion. |
| BR112016021257B1 (pt) * | 2014-03-19 | 2021-03-02 | Viamet Pharmaceuticals (NC), Inc. | 2-(2,4- difluorofenil-1,1-diflúor-1-(5-substituído-piridin-2-il)-3- (1h-tetrazol-1-il)propan-2-óis e processos para preparação e uso dos mesmos |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998004545A1 (en) * | 1996-07-31 | 1998-02-05 | Schering Corporation | Novel tricyclic n-cyanoimines useful as inhibitors of farnesyl-protein transferase |
| US5801175A (en) * | 1995-04-07 | 1998-09-01 | Schering Corporation | Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL111235A (en) | 1993-10-15 | 2001-03-19 | Schering Plough Corp | Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them |
| IL117798A (en) | 1995-04-07 | 2001-11-25 | Schering Plough Corp | Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them |
| US5712280A (en) * | 1995-04-07 | 1998-01-27 | Schering Corporation | Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
| ZA985203B (en) * | 1997-06-17 | 1999-01-05 | Schering Corp | Compounds useful for inhibition of farnesyl protein transferase |
| HUP0202152A2 (en) | 1998-12-18 | 2002-10-28 | Schering Corp | Tricyclyc farnesyl protein transferase inhibitors |
-
1999
- 1999-12-16 HU HU0202152A patent/HUP0202152A2/hu unknown
- 1999-12-16 CZ CZ20011950A patent/CZ20011950A3/cs unknown
- 1999-12-16 AU AU20307/00A patent/AU776558B2/en not_active Ceased
- 1999-12-16 EP EP99963980A patent/EP1140902A1/en not_active Withdrawn
- 1999-12-16 PL PL99348293A patent/PL348293A1/xx not_active Application Discontinuation
- 1999-12-16 WO PCT/US1999/027939 patent/WO2000037459A1/en not_active Ceased
- 1999-12-16 NZ NZ511878A patent/NZ511878A/en unknown
- 1999-12-16 CA CA002354779A patent/CA2354779A1/en not_active Abandoned
- 1999-12-16 SK SK759-2001A patent/SK7592001A3/sk unknown
- 1999-12-16 BR BR9916314-4A patent/BR9916314A/pt not_active IP Right Cessation
- 1999-12-16 IL IL14340899A patent/IL143408A0/xx unknown
- 1999-12-16 TR TR2001/01755T patent/TR200101755T2/xx unknown
- 1999-12-16 AR ARP990106461A patent/AR021718A1/es unknown
- 1999-12-16 KR KR1020017007632A patent/KR20010081116A/ko not_active Abandoned
- 1999-12-16 JP JP2000589531A patent/JP2002533336A/ja active Pending
- 1999-12-16 CO CO99078843A patent/CO5160350A1/es unknown
- 1999-12-16 CN CNB99816206XA patent/CN1326850C/zh not_active Expired - Fee Related
- 1999-12-17 PE PE1999001295A patent/PE20001342A1/es not_active Application Discontinuation
-
2001
- 2001-05-23 ZA ZA200104233A patent/ZA200104233B/en unknown
- 2001-06-15 NO NO20012961A patent/NO20012961L/no not_active Application Discontinuation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5801175A (en) * | 1995-04-07 | 1998-09-01 | Schering Corporation | Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
| WO1998004545A1 (en) * | 1996-07-31 | 1998-02-05 | Schering Corporation | Novel tricyclic n-cyanoimines useful as inhibitors of farnesyl-protein transferase |
Also Published As
| Publication number | Publication date |
|---|---|
| PL348293A1 (en) | 2002-05-20 |
| IL143408A0 (en) | 2002-04-21 |
| SK7592001A3 (en) | 2002-03-05 |
| ZA200104233B (en) | 2002-08-22 |
| NZ511878A (en) | 2003-10-31 |
| CZ20011950A3 (cs) | 2001-12-12 |
| KR20010081116A (ko) | 2001-08-27 |
| AR021718A1 (es) | 2002-07-31 |
| JP2002533336A (ja) | 2002-10-08 |
| AU776558B2 (en) | 2004-09-16 |
| HUP0202152A2 (en) | 2002-10-28 |
| CA2354779A1 (en) | 2000-06-29 |
| WO2000037459A1 (en) | 2000-06-29 |
| TR200101755T2 (tr) | 2001-09-21 |
| EP1140902A1 (en) | 2001-10-10 |
| BR9916314A (pt) | 2001-10-02 |
| PE20001342A1 (es) | 2000-12-09 |
| CO5160350A1 (es) | 2002-05-30 |
| AU2030700A (en) | 2000-07-12 |
| NO20012961D0 (no) | 2001-06-15 |
| NO20012961L (no) | 2001-08-16 |
| CN1334811A (zh) | 2002-02-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| C10 | Entry into substantive examination | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20070718 Termination date: 20111216 |