PE20000169A1 - Comprimido de mesilato de trovafloxacino - Google Patents
Comprimido de mesilato de trovafloxacinoInfo
- Publication number
- PE20000169A1 PE20000169A1 PE1999000036A PE00003699A PE20000169A1 PE 20000169 A1 PE20000169 A1 PE 20000169A1 PE 1999000036 A PE1999000036 A PE 1999000036A PE 00003699 A PE00003699 A PE 00003699A PE 20000169 A1 PE20000169 A1 PE 20000169A1
- Authority
- PE
- Peru
- Prior art keywords
- composition
- weight
- less
- degradation
- microcrystalline cellulose
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
SE REFIERE A UNA COMPOSICION GRANULADA EN SECO, QUE COMPRENDE LA FORMA POLIMORFO II DEL MESILATO DE TROVAFLOXACINO, UN LUBRICANTE Y AL MENOS 5% DE CELULOSA MICROCRISTALINA. LA COMPOSICION SE PUEDE PRESENTAR EN FORMA DE COMPRIMIDO QUE PUEDE ESTAR OPCIONALMENTE ENVUELTO EN UNA PELICULA QUE COMPRENDE HIDROXIPROPILCELULOSA. LA COMPOSICION COMPRENDE ADEMAS UN DESINTEGRANTE; Y SE CARACTERIZA POR TENER UNA DUREZA DE 8kP Y PRESENTA UNA ESTABILIDAD DESPUES DE ALMACENAMIENTO DE 12 SEMANAS EN UN RECIPIENTE ABIERTO A CONDICIONES CONSTANTES DE 40°C Y A UNA HUMEDAD RELATIVA DEL 75%; PRESENTANDO LOS SIGUIENTES NIVELES DE DEGRADACION a)MENOS DE 0,5% EN PESO DE N-ESTEAROILTROVAFLOXACINO Y N-PALMITOILTROVAFLOXACINO, b)MENOS DE 0,2% EN PESO DE CUALQUIER OTRO PRODUCTO DE DEGRADACION; c)EL TOTAL DE LOS PRODUCTOS DE DEGRADACION ES MENOR DE 1% EN PESO. UNA COMPOSICION PREFERIDA ES MESILATO DE TROVAFLOXACINO (FORMA II) 52,7% p/p; CELULOSA MICROCRISTALINA 36,8% p/p; CROSCARMELOSA SODICA 4,8% p/p; ESTEARATO DE MAGNESIO 1,9% p/p; RECUBRIMIENTO DE PELICULA 3,8% p/p
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7201398P | 1998-01-21 | 1998-01-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20000169A1 true PE20000169A1 (es) | 2000-03-10 |
Family
ID=22105016
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1999000036A PE20000169A1 (es) | 1998-01-21 | 1999-01-15 | Comprimido de mesilato de trovafloxacino |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US6187341B1 (es) |
| EP (1) | EP0930068A3 (es) |
| JP (1) | JPH11269072A (es) |
| KR (1) | KR100314977B1 (es) |
| CN (1) | CN1227743A (es) |
| AP (1) | AP1094A (es) |
| AR (1) | AR012780A1 (es) |
| AU (1) | AU758381B2 (es) |
| BG (1) | BG103106A (es) |
| BR (1) | BR9900116A (es) |
| CA (1) | CA2259698C (es) |
| CO (1) | CO4810225A1 (es) |
| DZ (1) | DZ2712A1 (es) |
| EA (1) | EA003247B1 (es) |
| GT (1) | GT199900004A (es) |
| HR (1) | HRP990023A2 (es) |
| HU (1) | HUP9900154A3 (es) |
| ID (1) | ID23735A (es) |
| IL (1) | IL128051A0 (es) |
| IS (1) | IS4947A (es) |
| MA (1) | MA24747A1 (es) |
| NO (1) | NO990243L (es) |
| NZ (1) | NZ333838A (es) |
| OA (1) | OA10958A (es) |
| PA (1) | PA8466701A1 (es) |
| PE (1) | PE20000169A1 (es) |
| PL (1) | PL330981A1 (es) |
| SG (1) | SG70666A1 (es) |
| SK (1) | SK4299A3 (es) |
| TN (1) | TNSN99007A1 (es) |
| TR (1) | TR199900089A3 (es) |
| TW (1) | TW518224B (es) |
| YU (1) | YU2399A (es) |
| ZA (1) | ZA99393B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ID29089A (id) * | 1998-11-10 | 2001-07-26 | Bayer Ag | Sediaan farmasi moksifloksasin |
| AU1188601A (en) * | 1999-09-20 | 2001-04-24 | Alza Corporation | Process for lessening polymorphic conversion of a drug |
| UY26380A1 (es) * | 1999-10-08 | 2001-04-30 | Smithkline Beecham Corp | Inhibidores de fab i |
| FR2808441B1 (fr) * | 2000-05-04 | 2004-06-18 | Oreal | Utilisation de fibres dans une composition de soin ou de maquillage pour matifier la peau |
| DE10031043A1 (de) * | 2000-06-26 | 2002-02-14 | Bayer Ag | Retardzubereitungen von Chinolonantibiotika und Verfahren zu ihrer Herstellung |
| DK1560584T3 (da) * | 2001-04-06 | 2009-05-18 | Affinium Pharm Inc | Fab I inhibitorer |
| EP1396263A1 (en) * | 2002-08-09 | 2004-03-10 | Warner-Lambert Company | Film coating for tablets and caplets |
| PT1575951E (pt) | 2002-12-06 | 2014-09-15 | Debiopharm Int Sa | Compostos heterocíclicos, métodos para os preparar e sua utilização em terapia |
| CN100415284C (zh) * | 2002-12-30 | 2008-09-03 | 毛友昌 | 六味木香片的制备方法 |
| CA2519429C (en) | 2003-03-17 | 2013-08-06 | Affinium Pharmaceuticals, Inc. | Pharmaceutical compositions comprising inhibitors of fab i and further antibiotics |
| ES2297067T3 (es) * | 2003-03-19 | 2008-05-01 | The Jordanian Pharmaceutical Manufacturing Co. Ltd. | Composiciones farmaceuticas no higroscopicas que contienen acidos quinolinacarboxilicos de hidratados. |
| US8906413B2 (en) * | 2003-05-12 | 2014-12-09 | Supernus Pharmaceuticals, Inc. | Drug formulations having reduced abuse potential |
| CA2531637A1 (en) * | 2003-07-23 | 2005-02-03 | L. Perrigo Company | Cellulosic fiber containing composition |
| EP1828167B1 (en) | 2004-06-04 | 2014-08-06 | Debiopharm International SA | Acrylamide derivatives as antibiotic agents |
| AU2005295482B2 (en) * | 2004-10-15 | 2011-03-31 | Supernus Pharmaceuticals Inc. | Less abusable pharmaceutical preparations |
| KR20080075027A (ko) * | 2005-12-05 | 2008-08-13 | 아피늄 파마슈티컬스, 인크. | Ｆａｂｉ 억제제 및 항박테리아제로서의헤테로시클릴아크릴아미드 화합물 |
| WO2008009122A1 (en) | 2006-07-20 | 2008-01-24 | Affinium Pharmaceuticals, Inc. | Acrylamide derivatives as fab i inhibitors |
| EP2125802A4 (en) * | 2007-02-16 | 2014-08-20 | Debiopharm Int Sa | SALTS, PRODRUGS AND POLYMORPHES OF FAB I INHIBITORS |
| EA028136B1 (ru) | 2012-06-19 | 2017-10-31 | Дибиофарм Интернешнл Са | Пролекарственные производные (е)-n-метил-n-((3-метилбензофуран-2-ил)метил)-3-(7-оксо-5,6,7,8-тетрагидро-1,8-нафтиридин-3-ил)акриламида |
| BR122023021456A2 (pt) | 2016-02-26 | 2024-02-20 | Debiopharm International S.A. | Uso de di-hidrogeno fosfato de {6- [(e)-3-{metil[(3-metil-1-benfofuran-2- iol)metil]amino)-3- oxopro-1-en-1-il]-2-oxo-3,4-di-hidro-1,8-naftiridin-1(2h)- il}metila para tratamento de osteomielite do pé diabético e composição farmacêutica |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5286754A (en) | 1986-01-21 | 1994-02-15 | Bayer Aktiengesellschaft | Pharmaceutical formulations of ciprofloxacin |
| DE3601566A1 (de) * | 1986-01-21 | 1987-07-23 | Bayer Ag | Pharmazeutische zubereitungen von ciprofloxacin |
| US4957554A (en) | 1989-08-16 | 1990-09-18 | Minnesota Mining And Manufacturing Company | Dimensionally-controlled ceramics |
| DE4120646A1 (de) | 1991-06-22 | 1992-12-24 | Bayer Ag | 7-isoindolinyl-chinolon- und naphthyridoncarbonsaeure-derivate |
| NZ312199A (en) * | 1995-08-29 | 1999-06-29 | Pfizer | Zwitterionic forms of trovafloxacin |
-
1999
- 1999-01-11 PA PA19998466701A patent/PA8466701A1/es unknown
- 1999-01-13 EP EP99300258A patent/EP0930068A3/en not_active Withdrawn
- 1999-01-14 IL IL12805199A patent/IL128051A0/xx unknown
- 1999-01-14 TR TR1999/00089A patent/TR199900089A3/tr unknown
- 1999-01-14 AP APAP/P/1999/001443A patent/AP1094A/en active
- 1999-01-14 SK SK42-99A patent/SK4299A3/sk unknown
- 1999-01-15 MA MA25433A patent/MA24747A1/fr unknown
- 1999-01-15 OA OA9900009A patent/OA10958A/en unknown
- 1999-01-15 PE PE1999000036A patent/PE20000169A1/es not_active Application Discontinuation
- 1999-01-15 GT GT199900004A patent/GT199900004A/es unknown
- 1999-01-15 ID IDP990036D patent/ID23735A/id unknown
- 1999-01-19 JP JP11010298A patent/JPH11269072A/ja active Pending
- 1999-01-19 AR ARP990100191A patent/AR012780A1/es not_active Application Discontinuation
- 1999-01-19 BR BR9900116-0A patent/BR9900116A/pt not_active IP Right Cessation
- 1999-01-19 CA CA002259698A patent/CA2259698C/en not_active Expired - Fee Related
- 1999-01-19 IS IS4947A patent/IS4947A/is unknown
- 1999-01-20 YU YU2399A patent/YU2399A/sh unknown
- 1999-01-20 NZ NZ333838A patent/NZ333838A/xx unknown
- 1999-01-20 CN CN99101232A patent/CN1227743A/zh active Pending
- 1999-01-20 US US09/233,823 patent/US6187341B1/en not_active Expired - Fee Related
- 1999-01-20 NO NO990243A patent/NO990243L/no not_active Application Discontinuation
- 1999-01-20 SG SG1999000117A patent/SG70666A1/en unknown
- 1999-01-20 TN TNTNSN99007A patent/TNSN99007A1/fr unknown
- 1999-01-20 ZA ZA9900393A patent/ZA99393B/xx unknown
- 1999-01-20 AU AU12173/99A patent/AU758381B2/en not_active Ceased
- 1999-01-20 PL PL99330981A patent/PL330981A1/xx unknown
- 1999-01-20 DZ DZ990013A patent/DZ2712A1/xx active
- 1999-01-20 KR KR1019990001589A patent/KR100314977B1/ko not_active IP Right Cessation
- 1999-01-20 HU HU9900154A patent/HUP9900154A3/hu unknown
- 1999-01-21 TW TW088100897A patent/TW518224B/zh not_active IP Right Cessation
- 1999-01-21 CO CO99003190A patent/CO4810225A1/es unknown
- 1999-01-21 EA EA199900046A patent/EA003247B1/ru not_active IP Right Cessation
- 1999-01-21 HR HR60/072,013A patent/HRP990023A2/hr not_active Application Discontinuation
- 1999-01-21 BG BG103106A patent/BG103106A/xx unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |