PE17298A1 - Procedimiento e intermedios para preparar 3-(1-piperazinil)-1,2-benzoisotiazol - Google Patents

Procedimiento e intermedios para preparar 3-(1-piperazinil)-1,2-benzoisotiazol

Info

Publication number
PE17298A1
PE17298A1 PE1996000766A PE00076696A PE17298A1 PE 17298 A1 PE17298 A1 PE 17298A1 PE 1996000766 A PE1996000766 A PE 1996000766A PE 00076696 A PE00076696 A PE 00076696A PE 17298 A1 PE17298 A1 PE 17298A1
Authority
PE
Peru
Prior art keywords
piperazinyl
formula
piperazine
benzoisotiazol
prepare
Prior art date
Application number
PE1996000766A
Other languages
English (en)
Inventor
Darrell E Fox
John F Lambert
Jr Terry G Sinay
Stanley W Walinsky
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PE17298A1 publication Critical patent/PE17298A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms

Abstract

SE REFIERE AL PROCEDIMIENTO QUE COMPRENDE: HACER REACCIONAR EL COMPUESTO DE FORMULA (II), EN DONDE R1 ES A) 1-PIPERAZINIL, B) 3-IL 1,2-BENZOTIAZOL o C) 1-(2-CIANO FENILTIO) CON PIPERAZINA, A UNA TEMPERATURA DE 80�C A 170�C, EN DONDE: LA RELACION DE EQUIVALENTES MOLARES PIPERAZINA / FORMULA (II) ES 10:1, EN PRESENCIA DE UN AGENTE ACLARADOR DE PIPERAZINA (ISOPROPANOL, PIRIDINA o T-BUTANOL) Y SI R1 FUESE (B) o (C) SE ADICIONA UN AGENTE OXIDANTE DE TIOL (SULFOXIDO DE DIMETILO, SALES DE Cu(II), BISULFITO, METABISULFITO o H2O2); TAMBIEN SE REFIEREN A LOS COMPUESTOS INTERMEDIOS, DE FORMULA (II) EN DONDE: R1 ES (A), (B) o (C), EN LA OBTENCION DEL 3-(1-PIPERAZINIL)-1,2-BENZOISOTIAZOL QUE SE USA PARA PREPARAR EL COMPUESTO FINAL, 5-(2-(4-(1,2-BENZOISOTIAZOL-3-IL)-1-PIPERAZINIL)ETIL)-6-CLORO-1,3-DIHIDRO-2H-INDOL-2-ONA, DE ACCION NEUROLEPTICA
PE1996000766A 1995-11-07 1996-11-04 Procedimiento e intermedios para preparar 3-(1-piperazinil)-1,2-benzoisotiazol PE17298A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US630195P 1995-11-07 1995-11-07

Publications (1)

Publication Number Publication Date
PE17298A1 true PE17298A1 (es) 1998-04-16

Family

ID=21720240

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1996000766A PE17298A1 (es) 1995-11-07 1996-11-04 Procedimiento e intermedios para preparar 3-(1-piperazinil)-1,2-benzoisotiazol

Country Status (29)

Country Link
US (1) US6111105A (es)
EP (1) EP0874834B1 (es)
JP (1) JP3152938B2 (es)
KR (1) KR100315939B1 (es)
CN (1) CN1071324C (es)
AR (2) AR004279A1 (es)
AT (1) ATE198071T1 (es)
AU (1) AU698443B2 (es)
BR (1) BR9611366A (es)
CA (1) CA2236940C (es)
CO (1) CO4480028A1 (es)
CZ (1) CZ290600B6 (es)
DE (1) DE69611253T2 (es)
DK (1) DK0874834T3 (es)
ES (1) ES2152564T3 (es)
GR (1) GR3035215T3 (es)
HU (1) HU225921B1 (es)
MX (1) MX9803599A (es)
MY (1) MY116579A (es)
NO (1) NO309811B1 (es)
NZ (1) NZ318844A (es)
PE (1) PE17298A1 (es)
PL (1) PL185048B1 (es)
PT (1) PT874834E (es)
RU (1) RU2147302C1 (es)
TR (1) TR199800814T2 (es)
TW (1) TW358807B (es)
WO (1) WO1997017336A1 (es)
ZA (1) ZA969315B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY27668A1 (es) 2002-02-20 2003-10-31 Pfizer Prod Inc Composición de ziprasidona y controles sintéticos
US20040048876A1 (en) * 2002-02-20 2004-03-11 Pfizer Inc. Ziprasidone composition and synthetic controls
EP1628973A2 (en) 2003-10-24 2006-03-01 Teva Pharmaceutical Industries Ltd. Processes for preparation of ziprasidone
US7777037B2 (en) * 2004-10-27 2010-08-17 Dr. Reddy's Laboratories Limited Ziprasidone process
CN105891392A (zh) * 2016-03-29 2016-08-24 北京万全德众医药生物技术有限公司 一种用液相色谱法分离测定盐酸鲁拉西酮中间体有关物质的方法
CN107064323A (zh) * 2016-12-05 2017-08-18 北京万全德众医药生物技术有限公司 一种用液相色谱法分离测定盐酸鲁拉西酮及其有关物质的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4590196A (en) * 1984-08-23 1986-05-20 Bristol-Myers Company Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives
JPH06220030A (ja) * 1993-01-22 1994-08-09 Sumitomo Pharmaceut Co Ltd ３−アミノ−１，２−ベンズイソチアゾール誘導体の製造法
JP3701044B2 (ja) * 1995-04-24 2005-09-28 住友精化株式会社 シアノベンゼンスルフェニルハライドおよびそれを用いる３−置換ベンゾイソチアゾールの製造方法
JP3996228B2 (ja) * 1996-10-11 2007-10-24 住友精化株式会社 ３−ピペラジニルベンズイソチアゾール類の製造法

Also Published As

Publication number Publication date
NO309811B1 (no) 2001-04-02
AR004279A1 (es) 1998-11-04
MY116579A (en) 2004-02-28
HU225921B1 (en) 2008-01-28
MX9803599A (es) 1998-09-30
HUP9903765A2 (hu) 2000-03-28
CN1071324C (zh) 2001-09-19
CA2236940A1 (en) 1997-05-15
PT874834E (pt) 2001-04-30
US6111105A (en) 2000-08-29
AU698443B2 (en) 1998-10-29
HUP9903765A3 (en) 2001-12-28
KR100315939B1 (ko) 2002-01-16
CZ137898A3 (cs) 1999-03-17
NZ318844A (en) 1999-04-29
CN1201457A (zh) 1998-12-09
KR19990067381A (ko) 1999-08-16
AR032373A2 (es) 2003-11-05
DE69611253D1 (de) 2001-01-18
GR3035215T3 (en) 2001-04-30
ATE198071T1 (de) 2000-12-15
DE69611253T2 (de) 2001-04-05
ES2152564T3 (es) 2001-02-01
JPH10512595A (ja) 1998-12-02
WO1997017336A1 (en) 1997-05-15
EP0874834B1 (en) 2000-12-13
BR9611366A (pt) 1999-02-23
ZA969315B (en) 1998-05-06
NO982051D0 (no) 1998-05-06
CA2236940C (en) 2001-08-21
PL185048B1 (pl) 2003-02-28
NO982051L (no) 1998-07-03
CZ290600B6 (cs) 2002-08-14
AU7092696A (en) 1997-05-29
TW358807B (en) 1999-05-21
CO4480028A1 (es) 1997-07-09
TR199800814T2 (xx) 1998-07-21
EP0874834A1 (en) 1998-11-04
PL326630A1 (en) 1998-10-12
JP3152938B2 (ja) 2001-04-03
RU2147302C1 (ru) 2000-04-10
DK0874834T3 (da) 2001-02-19

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Legal Events

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FG Grant, registration
FD Application declared void or lapsed