PA8848901A1 - Derivados de carbamatos de alquil-heterociclos, su preparación y su aplicación en terapéutica - Google Patents

Derivados de carbamatos de alquil-heterociclos, su preparación y su aplicación en terapéutica

Info

Publication number
PA8848901A1
PA8848901A1 PA20098848901A PA8848901A PA8848901A1 PA 8848901 A1 PA8848901 A1 PA 8848901A1 PA 20098848901 A PA20098848901 A PA 20098848901A PA 8848901 A PA8848901 A PA 8848901A PA 8848901 A1 PA8848901 A1 PA 8848901A1
Authority
PA
Panama
Prior art keywords
group
rent
therapeutics
application
trifluorometilo
Prior art date
Application number
PA20098848901A
Other languages
English (en)
Inventor
Ahmed Abouabdellah
Nathalie Chereze
Aude Fayol
Mourad Saady
Julien Vache
Corinne Veronique
Philippe Yaiche
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40852115&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PA8848901(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of PA8848901A1 publication Critical patent/PA8848901A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4709Non-condensed quinolines and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Diabetes (AREA)
  • Anesthesiology (AREA)
  • Obesity (AREA)
  • Otolaryngology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)

Abstract

COMPUESTO QUE RESPONDE A LA FÓRMULA GENERAL (1): EN LA QUE R2 REPRESENTA UN ÁTOMO DE HIDRÓGENO, DE FLÚOR O UN GRUPO HIDROXILO, CIANO, TRIFLUOROMETILO, ALQUILO-C1-6, ALCOXI-C1-6, NR8R9 ; N REPRESENTA UN NÚMERO ENTERO IGUAL A 1, 2 Ó 3 Y M REPRESENTA UN NÚMERO ENTERO IGUAL A 1 Ó 2; A REPRESENTA UN ENLACE COVALENTE O UN GRUPO ALQUILENO-C1-8 ; R1 REPRESENTA UN GRUPO FENILO, PIRIDINILO, PIRIDACINILO, PIRIMIDINILO, PIRACINILO, TRIACINILO, NAFTALENILO, QUINOLINILO, ISOQUINOLINILO, FTALACINILO, QUINAZOLINILO, QUINOXALINILO, CINOLINILO, NAFTIRIDINILO, ESTANDO ESTE GRUPO SUSTITUIDO OPCIONALMENT ; R3 REPRESENTA UN ÁTOMO DE HIDRÓGENO, DE FLÚOR, UN GRUPO ALQUILO-C1-6 O UN GRUPO TRIFLUOROMETILO ; R4 REPRESENTA UN GRUPO ELEGIDO ENTRE UN FURANILO, PIRROLILO, TIENILO, ISOTIAZOLILO, OXAZOLILO, ISOXAZOLILO, PIRAZOLILO, OXADIAZOLILO, TIADIAZOLILO, IMIDAZOL, TRIAZOLILO, TETRAZOLILO, OXAZOLONA, OXAZOLIDINONA, ISOXAZOLONA, ISOXAZOLIDINONA, ISOTIAZOLONA, ISOTIAZOLIDINONA, IMIDAZOLONA, IMIDAZOLIDINONA, PIRAZOLONA, PIRAZOLIDINONA, OXADIAZOLONA, TIADIAZOLONA, TRIAZOLONA, ESTANDO ESTE GRUPO SUSTITUIDO OPCIONALMENTE; EN EL ESTADO DE BASE O DE SAL DE ADICIÓN A UN ÁCIDO. APLICACIÓN EN TERAPÉUTICA.
PA20098848901A 2008-11-14 2009-11-12 Derivados de carbamatos de alquil-heterociclos, su preparación y su aplicación en terapéutica PA8848901A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0806371A FR2938537B1 (fr) 2008-11-14 2008-11-14 Derives de carbamates d'alkyl-heterocycles, leur preparation et leur application en therapeutique.

Publications (1)

Publication Number Publication Date
PA8848901A1 true PA8848901A1 (es) 2010-06-28

Family

ID=40852115

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20098848901A PA8848901A1 (es) 2008-11-14 2009-11-12 Derivados de carbamatos de alquil-heterociclos, su preparación y su aplicación en terapéutica

Country Status (27)

Country Link
US (1) US8716289B2 (es)
EP (1) EP2356108B1 (es)
JP (1) JP5560287B2 (es)
KR (1) KR20110083743A (es)
CN (1) CN102216291B (es)
AR (1) AR074119A1 (es)
AU (1) AU2009315448B2 (es)
BR (1) BRPI0921057A2 (es)
CA (1) CA2743558C (es)
CL (1) CL2011001122A1 (es)
CO (1) CO6331472A2 (es)
CR (1) CR20110246A (es)
EA (1) EA019742B1 (es)
EC (1) ECSP11011040A (es)
FR (1) FR2938537B1 (es)
IL (1) IL212830A (es)
MA (1) MA32884B1 (es)
MX (1) MX2011005124A (es)
NI (1) NI201100095A (es)
NZ (1) NZ592740A (es)
PA (1) PA8848901A1 (es)
PE (1) PE20120217A1 (es)
SV (1) SV2011003895A (es)
TW (1) TWI462919B (es)
UY (1) UY32246A (es)
WO (1) WO2010055267A1 (es)
ZA (1) ZA201103516B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2934265B1 (fr) * 2008-07-23 2010-07-30 Sanofi Aventis Derives de carbamates d'alkylthiazoles, leur preparation et leur application en therapeutique
WO2011085216A2 (en) 2010-01-08 2011-07-14 Ironwood Pharmaceuticals, Inc. Use of faah inhibitors for treating parkinson's disease and restless legs syndrome
US20130224151A1 (en) 2010-03-31 2013-08-29 United States Of America Use of FAAH Inhibitors for Treating Abdominal, Visceral and Pelvic Pain
FR2960875B1 (fr) 2010-06-04 2012-12-28 Sanofi Aventis Derives de carbamates d'hexafluoroisopropyle, leur preparation et leur application en therapeutique
GB201309508D0 (en) * 2013-05-28 2013-07-10 Redx Pharma Ltd Compounds
ITMI20131180A1 (it) 2013-07-15 2015-01-16 Fond Istituto Italiano Di Tecnologia O-alchil triazolil carbammati come inibitori di idrolasi delle ammidi degli acidi grassi (faah)
JP6428778B2 (ja) * 2014-07-28 2018-11-28 住友化学株式会社 アミド化合物及びその有害節足動物防除用途
CN111171315B (zh) * 2020-02-25 2021-08-17 常熟理工学院 一种结晶性n-取代聚硫代氨基甲酸酯及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA80841C2 (en) * 2002-10-07 2007-11-12 Univ California Fatty acid amide hydrolase inhibitors, pharmaceutical composition (variants) and method to treat appetite disorders, glaucoma, pain, and related neurological disorders (variants)
FR2854633B1 (fr) * 2003-05-07 2005-06-24 Sanofi Synthelabo Derives de piperidinyl-et piperazinyl-alkylcarbamates, leur preparation et leur application en therapeutique
DK1732892T3 (da) 2004-03-26 2009-01-05 Hoffmann La Roche Tetrahydrocarbazoler og derivater
SE0401656D0 (sv) 2004-06-24 2004-06-24 Astrazeneca Ab Chemical compounds
BRPI0515015A (pt) * 2004-08-11 2008-07-01 Kyorin Seiyaku Kk derivado cìclico de ácido aminobenzóico; medicamento; agonista ppar(alpha); agonista duplo ppar(alpha), y; agonista duplo ppar(alpha), (delta); modulador ppar; agente lipìdeo; agente profilático ou terapêutico compreendendo pelo menos um dos derivados cìclicos de ácido aminobenzóico ou sal do mesmo farmacêuticamente aceitável
AU2006236387A1 (en) * 2005-04-18 2006-10-26 Neurogen Corporation Subtituted heteroaryl CB1 antagonists
GB0510140D0 (en) 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds B2
WO2007146761A2 (en) * 2006-06-12 2007-12-21 Neurogen Corporation Diaryl pyrimidinones and related compounds
AU2008321046B2 (en) 2007-11-16 2013-10-24 Incyte Holdings Corporation 4-pyrazolyl-N-arylpyrimidin-2-amines and 4-pyrazolyl-N-heteroarylpyrimidin-2-amines as janus kinase inhibitors
FR2934265B1 (fr) * 2008-07-23 2010-07-30 Sanofi Aventis Derives de carbamates d'alkylthiazoles, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
IL212830A (en) 2014-11-30
FR2938537B1 (fr) 2012-10-26
CL2011001122A1 (es) 2011-09-16
AU2009315448B2 (en) 2015-07-16
US8716289B2 (en) 2014-05-06
CO6331472A2 (es) 2011-10-20
CA2743558C (fr) 2017-02-14
CN102216291A (zh) 2011-10-12
SV2011003895A (es) 2011-08-15
IL212830A0 (en) 2011-07-31
FR2938537A1 (fr) 2010-05-21
KR20110083743A (ko) 2011-07-20
UY32246A (es) 2010-06-30
CR20110246A (es) 2012-06-15
ZA201103516B (en) 2012-07-25
MA32884B1 (fr) 2011-12-01
EA019742B1 (ru) 2014-05-30
EA201170686A1 (ru) 2011-12-30
EP2356108A1 (fr) 2011-08-17
NZ592740A (en) 2013-03-28
CA2743558A1 (fr) 2010-05-20
MX2011005124A (es) 2011-05-30
PE20120217A1 (es) 2012-03-12
TWI462919B (zh) 2014-12-01
AR074119A1 (es) 2010-12-22
JP2012508785A (ja) 2012-04-12
TW201026692A (en) 2010-07-16
US20120015950A1 (en) 2012-01-19
WO2010055267A1 (fr) 2010-05-20
ECSP11011040A (es) 2011-06-30
CN102216291B (zh) 2016-08-03
JP5560287B2 (ja) 2014-07-23
BRPI0921057A2 (pt) 2018-10-16
EP2356108B1 (fr) 2014-10-15
AU2009315448A1 (en) 2010-05-20
NI201100095A (es) 2011-12-14

Similar Documents

Publication Publication Date Title
PA8848901A1 (es) Derivados de carbamatos de alquil-heterociclos, su preparación y su aplicación en terapéutica
HRP20120830T1 (hr) Imidazolkarboksamidi
ATE439349T1 (de) Cyclische anilinopyridinotriazine als gsk-3- inhibitoren
AR076563A1 (es) Derivados de ciclopenta[c]pirrol-2-carboxilatos, su preparacion y su apli-cacion en terapeutica
RS50553B (sr) Derivati imidazola kao tafia-inhibitori
BR112012003592B8 (pt) composição farmacêutica contendo derivado de quinolina
RS53275B (en) ARYL-PYRIDINE AS AN ALDOSTERON SYNTHASE INHIBITOR
UY30603A1 (es) Derivados de 2-aril-6-fenil-imidazo[1, 2-a]piridinas, su preparacion y su aplicacion en terapéutica
RS53839B1 (en) SPIROCYCLES AS INHIBITORS OF 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE 1
HN2010001460A (es) Derivados biciclicos de carboxamidas aza-biciclicas, su preparacion y su aplicacion terapeutica
AR073380A1 (es) Composicion farmaceutica solida. comprimido multicapa
AR074801A1 (es) Monocarbamas y composiciones farmaceuticas que los contienen
AR070485A1 (es) Compuestos derivados de azetidinas, su preparacion y su aplicacion en terapeutica
PE20120732A1 (es) Agonistas del receptor de esfingosina-1-fosfato
MX2010006446A (es) Nuevos derivados de diazeniodiolato, procedimiento para la preparacion de los mismos y composiciones farmaceuticas que los contienen.
RS52810B (en) 3-AMINOCYCLOPENTANKARBOXAMIDES AS MODULATORS OF CHEMOKINE RECEPTORS
MX2010010471A (es) Derivado de tetrahidroisoquinolina novedoso.
NO20080628L (no) Aktiverer av peroksisomproliferator aktivert reseptor &dgr
ES2541401T3 (es) Nuevos derivados de isoquinolina disustituidos en 6,7 y su uso
WO2009021957A3 (en) Tricyclic heterocyclic compounds as gaba a modulators
EA201070272A1 (ru) 5-членное гетероциклическое соединение
CO5690555A2 (es) Preparacion farmaceutica solida
ES2565087T3 (es) Procedimiento de preparación de derivados de 1-alquiltetrazolil oxima 5-sustituidos
TH90875A (th) อนุพันธ์เบนซิมิดาโซลที่ถูกแทนที่ด้วยโครเมน
TH114427A (th) สารประกอบ 1,2,4,5-เตตราไฮโดร-3h-เบนซาซีพีน, กระบวนการสำหรับการเตรียมของมันและองค์ประกอบทางเภสัชกรรมที่มีสารนี้