OA13079A - Pre-organized tricyclic integrase inhibitor compounds. - Google Patents
Pre-organized tricyclic integrase inhibitor compounds. Download PDFInfo
- Publication number
- OA13079A OA13079A OA1200500108A OA1200500108A OA13079A OA 13079 A OA13079 A OA 13079A OA 1200500108 A OA1200500108 A OA 1200500108A OA 1200500108 A OA1200500108 A OA 1200500108A OA 13079 A OA13079 A OA 13079A
- Authority
- OA
- OAPI
- Prior art keywords
- compound
- phosphonate
- substituted
- aryl
- heteroaryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/20—Spiro-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41896302P | 2002-10-16 | 2002-10-16 | |
US47878303P | 2003-06-16 | 2003-06-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
OA13079A true OA13079A (en) | 2006-11-10 |
Family
ID=32110203
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
OA1200500108A OA13079A (en) | 2002-10-16 | 2003-10-16 | Pre-organized tricyclic integrase inhibitor compounds. |
Country Status (19)
Country | Link |
---|---|
US (3) | US20040157804A1 (no) |
EP (1) | EP1558613A2 (no) |
JP (1) | JP2006514099A (no) |
KR (1) | KR20050087787A (no) |
CN (1) | CN100374438C (no) |
AP (1) | AP1858A (no) |
AU (2) | AU2003301439A1 (no) |
BR (1) | BR0315405A (no) |
CA (1) | CA2501881A1 (no) |
EA (1) | EA011399B1 (no) |
HR (1) | HRP20050431A2 (no) |
IS (1) | IS7845A (no) |
MX (1) | MXPA05003950A (no) |
NO (1) | NO20052378L (no) |
NZ (1) | NZ539264A (no) |
OA (1) | OA13079A (no) |
PL (1) | PL377966A1 (no) |
UA (1) | UA79830C2 (no) |
WO (2) | WO2004035577A2 (no) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000071102A2 (en) * | 1999-05-19 | 2000-11-30 | Neurosearch A/S | Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders |
AU2004234087A1 (en) * | 2003-04-28 | 2004-11-11 | Tibotec Pharmaceuticals Ltd. | HIV integrase inhibitors |
AU2004274493A1 (en) | 2003-09-19 | 2005-03-31 | Gilead Sciences, Inc. | Aza-quinolinol phosphonate integrase inhibitor compounds |
CA2547418A1 (en) * | 2003-12-08 | 2005-06-23 | The Research Foundation Of State University Of New York | Site selectively tagged and templated molecularly imprinted polymers for sensor applications |
JP2007514759A (ja) | 2003-12-19 | 2007-06-07 | タケダ サン ディエゴ インコーポレイテッド | キナーゼ阻害剤 |
US7598087B2 (en) * | 2004-01-07 | 2009-10-06 | The Research Foundation Of State University Of New York | Protein imprinted polymers with integrated emission sites |
DK1742642T3 (da) * | 2004-04-14 | 2009-02-16 | Gilead Sciences Inc | Phosphonatanaloge af HIV-integraseinhibitorforbindelser |
JP4824673B2 (ja) * | 2004-05-07 | 2011-11-30 | メルク・シャープ・エンド・ドーム・コーポレイション | Hivインテグラーゼ阻害剤 |
AU2005251820A1 (en) * | 2004-06-09 | 2005-12-22 | Merck & Co., Inc. | HIV integrase inhibitors |
US7745459B2 (en) | 2004-09-21 | 2010-06-29 | Japan Tobacco Inc. | Quinolizinone compound and use thereof as HIV integrase inhibitor |
JP2008516973A (ja) | 2004-10-15 | 2008-05-22 | タケダ サン ディエゴ インコーポレイテッド | キナーゼ阻害剤 |
US20070072831A1 (en) * | 2005-05-16 | 2007-03-29 | Gilead Sciences, Inc. | Integrase inhibitor compounds |
US8013159B2 (en) * | 2005-05-19 | 2011-09-06 | Merck Canada Inc. | Quinoline derivatives as EP4 antagonists |
AU2006272521A1 (en) * | 2005-07-27 | 2007-02-01 | Gilead Sciences, Inc. | Antiviral phosphonate conjugates for inhibition of HIV |
EP1909578A4 (en) * | 2005-08-04 | 2010-07-14 | Glaxosmithkline Llc | INHIBITORS OF HIV INTEGRASE |
US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
WO2007076005A2 (en) * | 2005-12-21 | 2007-07-05 | Gilead Sciences, Inc. | Processes and intermediates useful for preparing integrase inhibitor compounds |
US20090233964A1 (en) * | 2005-12-30 | 2009-09-17 | Gilead Sciences, Inc. | Methods for improving the pharmacokinetics of hiv integrase inhibitors |
KR20160074018A (ko) | 2005-12-30 | 2016-06-27 | 길리애드 사이언시즈, 인코포레이티드 | Hiv 인테그라제 억제제의 약동학을 개선하기 위한 방법 |
CA2651579A1 (en) | 2006-05-16 | 2007-11-29 | Gilead Sciences, Inc. | Integrase inhibitors |
SG175609A1 (en) | 2006-10-09 | 2011-11-28 | Takeda Pharmaceutical | Kinase inhibitors |
WO2009067541A2 (en) * | 2007-11-20 | 2009-05-28 | Gilead Sciences, Inc. | Integrase inhibitors |
EP2254582B1 (en) | 2008-01-25 | 2016-01-20 | Chimerix, Inc. | Methods of treating viral infections |
KR101772610B1 (ko) | 2008-07-25 | 2017-09-12 | 비이브 헬쓰케어 컴퍼니 | 화합물 |
KR20110063435A (ko) * | 2008-07-28 | 2011-06-10 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 항말라리아 화합물 |
MX351942B (es) | 2008-12-11 | 2017-11-03 | Shionogi & Co | Sintesis de inhibidores de integrasa de vih de carbamoil-piridona e intermediarios. |
WO2010068262A1 (en) | 2008-12-11 | 2010-06-17 | Glaxosmithkline Llc | Processes and intermediates for carbamoylpyridone hiv integrase inhibitors |
TWI518084B (zh) | 2009-03-26 | 2016-01-21 | 鹽野義製藥股份有限公司 | 哌喃酮與吡啶酮衍生物之製造方法 |
EP2270021A1 (en) * | 2009-06-18 | 2011-01-05 | Centre National de la Recherche Scientifique | Phosphonates synthons for the synthesis of phosphonates derivatives showing better bioavailability |
WO2011011483A1 (en) * | 2009-07-22 | 2011-01-27 | Glaxosmithkline Llc | Chemical compounds |
JP5624148B2 (ja) | 2009-10-13 | 2014-11-12 | エランコ・アニマル・ヘルス・アイルランド・リミテッド | 大環状インテグラーゼ阻害剤 |
JP5745869B2 (ja) * | 2010-01-22 | 2015-07-08 | 富山化学工業株式会社 | アルアルキル基を有する複素環化合物 |
US8283366B2 (en) | 2010-01-22 | 2012-10-09 | Ambrilia Biopharma, Inc. | Derivatives of pyridoxine for inhibiting HIV integrase |
CA2789443C (en) | 2010-02-12 | 2016-09-13 | Chimerix, Inc. | Nucleoside phosphonate salts |
TWI582097B (zh) | 2010-03-23 | 2017-05-11 | Viiv醫療保健公司 | 製備胺甲醯吡啶酮衍生物及中間體之方法 |
TWI503323B (zh) * | 2010-03-29 | 2015-10-11 | Oncotherapy Science Inc | 三環化合物以及含此化合物之pbk抑制劑 |
US8716293B2 (en) | 2010-04-02 | 2014-05-06 | Janssen R&D Ireland | Macrocyclic integrase inhibitors |
ES2602794T3 (es) | 2011-03-31 | 2017-02-22 | Pfizer Inc | Piridinonas bicíclicas novedosas |
US9089574B2 (en) | 2011-11-30 | 2015-07-28 | Emory University | Antiviral JAK inhibitors useful in treating or preventing retroviral and other viral infections |
KR101365849B1 (ko) * | 2012-03-28 | 2014-02-24 | 경동제약 주식회사 | 솔리페나신 또는 그의 염의 제조방법 및 이에 사용되는 신규 중간체 |
UA110688C2 (uk) | 2012-09-21 | 2016-01-25 | Пфайзер Інк. | Біциклічні піридинони |
US10260089B2 (en) | 2012-10-29 | 2019-04-16 | The Research Foundation Of The State University Of New York | Compositions and methods for recognition of RNA using triple helical peptide nucleic acids |
PT3236972T (pt) | 2014-12-26 | 2021-09-24 | Univ Emory | Derivados antivirais n4-hidroxicitidina |
JP6628805B2 (ja) | 2015-02-03 | 2020-01-15 | ファイザー・インク | 新規シクロプロパベンゾフラニルピリドピラジンジオン |
CN104803905B (zh) * | 2015-04-17 | 2017-10-10 | 复旦大学 | 一种合成异吲哚啉‑1‑酮衍生物的方法 |
WO2017133517A1 (zh) * | 2016-02-03 | 2017-08-10 | 四川海思科制药有限公司 | 一种磷酰胺衍生物及制备方法和用途 |
CN109305989B (zh) * | 2017-07-28 | 2021-02-26 | 四川海思科制药有限公司 | 一种磷酰胺衍生物及制备方法和用途 |
CN109305990B (zh) * | 2017-07-28 | 2021-02-26 | 四川海思科制药有限公司 | 一种磷酸衍生物及制备方法和用途 |
EP3706762A4 (en) | 2017-12-07 | 2021-09-01 | Emory University | N4-HYDROXYCYTIDINE AND DERIVATIVES AND ANTIVIRAL USES IN RELATION TO IT |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH385846A (de) * | 1960-03-31 | 1964-12-31 | Geigy Ag J R | Verfahren zur Herstellung von neuen 7-Acyl-8-hydroxy-chinolinen und ihre Verwendung als Fungizide und Bakterizide im Pflanzen- und Materialschutz |
US4816570A (en) * | 1982-11-30 | 1989-03-28 | The Board Of Regents Of The University Of Texas System | Biologically reversible phosphate and phosphonate protective groups |
US4968788A (en) * | 1986-04-04 | 1990-11-06 | Board Of Regents, The University Of Texas System | Biologically reversible phosphate and phosphonate protective gruops |
DE69115694T2 (de) | 1990-06-13 | 1996-10-17 | Arnold Newton Mass. Glazier | Phosphorylierte prodrugs |
ES2118069T3 (es) * | 1990-09-14 | 1998-09-16 | Acad Of Science Czech Republic | Profarmacos de fosfonatos. |
ES2104862T3 (es) * | 1991-02-07 | 1997-10-16 | Roussel Uclaf | Derivados biciclicos nitrogenados, su procedimiento de preparacion, sus productos intermedios obtenidos, su aplicacion como medicamentos y composiciones farmaceuticas que los contienen. |
EP0520573A1 (en) * | 1991-06-27 | 1992-12-30 | Glaxo Inc. | Cyclic imide derivatives |
US5639881A (en) * | 1991-11-08 | 1997-06-17 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Synthesis and elucidation of pyrimido (4,5-Q) quinazoline derivatives |
TW304945B (no) * | 1992-06-27 | 1997-05-11 | Hoechst Ag | |
US5798340A (en) * | 1993-09-17 | 1998-08-25 | Gilead Sciences, Inc. | Nucleotide analogs |
US5538988A (en) * | 1994-04-26 | 1996-07-23 | Martinez; Gregory R. | Benzocycloalkylazolethione derivatives |
US5854275A (en) * | 1996-05-16 | 1998-12-29 | Pfizer Inc. | Cyclic imide derivatives |
AU4172197A (en) * | 1996-09-10 | 1998-04-02 | Pharmacia & Upjohn Company | 8-hydroxy-7-substituted quinolines as anti-viral agents |
US6329375B1 (en) * | 1997-08-05 | 2001-12-11 | Sugen, Inc. | Tricyclic quinoxaline derivatives as protein tyrosine kinase inhibitors |
US6312662B1 (en) * | 1998-03-06 | 2001-11-06 | Metabasis Therapeutics, Inc. | Prodrugs phosphorus-containing compounds |
EP1083897A4 (en) | 1998-06-03 | 2003-01-02 | Merck & Co Inc | HIV INTEGRASE INHIBITORS |
AU4225499A (en) | 1998-06-03 | 1999-12-20 | Merck & Co., Inc. | Hiv integrase inhibitors |
AU751590B2 (en) * | 1998-06-10 | 2002-08-22 | Arena Pharmaceuticals, Inc. | Acetylcholine enhancers |
US6187907B1 (en) * | 1998-08-31 | 2001-02-13 | James Chen | Triple helix coil template having a biologically active ligand |
AU3118200A (en) | 1998-12-14 | 2000-07-03 | Merck & Co., Inc. | Hiv integrase inhibitors |
CZ20012160A3 (cs) | 1998-12-25 | 2001-10-17 | Shionogi & Co., Ltd. | Heteroaromatické deriváty s inhibiční aktivitou proti HIV integráze |
CA2376043A1 (en) | 1999-06-02 | 2000-12-14 | Shionogi & Co., Ltd. | Novel processes for the preparation of substituted propenone derivatives |
CA2370500A1 (en) | 1999-06-25 | 2001-01-04 | Lekhanh O. Tran | 1-(aromatic- or heteroaromatic-substituted)-3-(heteroaromatic substituted)-1,3-propanediones and uses thereof |
US6245806B1 (en) | 1999-08-03 | 2001-06-12 | Merck & Co., Inc. | HIV integrase inhibitors |
AU8009900A (en) * | 1999-10-13 | 2001-04-23 | Merck & Co., Inc. | Hiv integrase inhibitors |
DE60124577T2 (de) | 2000-10-12 | 2007-09-27 | Merck & Co., Inc. | Aza- und polyaza-naphthalenylcarbonsäureamide als hiv-integrase-hemmer |
CA2425067A1 (en) | 2000-10-12 | 2002-05-10 | Merck & Co., Inc. | Aza-and polyaza-naphthalenyl ketones useful as hiv integrase inhibitors |
EE200300145A (et) | 2000-10-12 | 2003-06-16 | Merck & Co., Inc. | Asa- ja polüasanaftalenüülkarboksamiidid ja farmatseutiline kompositsioon |
CA2425395C (en) * | 2000-10-12 | 2009-06-02 | Merck & Co., Inc. | Aza- and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors |
WO2002030970A2 (en) * | 2000-10-13 | 2002-04-18 | Bayer Aktiengesellschaft | Human histone deacetylase gene |
US6518767B1 (en) * | 2000-10-19 | 2003-02-11 | Schweitzer Engineering Laboratories, Inc. | Line differential protection system for a power transmission line |
DK1742642T3 (da) * | 2004-04-14 | 2009-02-16 | Gilead Sciences Inc | Phosphonatanaloge af HIV-integraseinhibitorforbindelser |
-
2003
- 2003-10-15 AU AU2003301439A patent/AU2003301439A1/en not_active Abandoned
- 2003-10-15 WO PCT/US2003/032866 patent/WO2004035577A2/en not_active Application Discontinuation
- 2003-10-15 US US10/687,374 patent/US20040157804A1/en not_active Abandoned
- 2003-10-16 US US10/687,373 patent/US7253180B2/en not_active Expired - Fee Related
- 2003-10-16 NZ NZ539264A patent/NZ539264A/en not_active IP Right Cessation
- 2003-10-16 MX MXPA05003950A patent/MXPA05003950A/es active IP Right Grant
- 2003-10-16 UA UAA200504480A patent/UA79830C2/uk unknown
- 2003-10-16 OA OA1200500108A patent/OA13079A/en unknown
- 2003-10-16 CN CNB2003801061816A patent/CN100374438C/zh not_active Expired - Fee Related
- 2003-10-16 PL PL377966A patent/PL377966A1/pl not_active Application Discontinuation
- 2003-10-16 EA EA200500660A patent/EA011399B1/ru not_active IP Right Cessation
- 2003-10-16 AP AP2005003279A patent/AP1858A/xx active
- 2003-10-16 EP EP03809030A patent/EP1558613A2/en not_active Withdrawn
- 2003-10-16 WO PCT/US2003/032666 patent/WO2004035576A2/en active Application Filing
- 2003-10-16 CA CA002501881A patent/CA2501881A1/en not_active Abandoned
- 2003-10-16 BR BR0315405-0A patent/BR0315405A/pt not_active IP Right Cessation
- 2003-10-16 JP JP2005501423A patent/JP2006514099A/ja active Pending
- 2003-10-16 KR KR1020057006668A patent/KR20050087787A/ko not_active Application Discontinuation
- 2003-10-16 AU AU2003301306A patent/AU2003301306A1/en not_active Abandoned
-
2005
- 2005-05-13 IS IS7845A patent/IS7845A/is unknown
- 2005-05-13 NO NO20052378A patent/NO20052378L/no not_active Application Discontinuation
- 2005-05-13 HR HR20050431A patent/HRP20050431A2/hr not_active Application Discontinuation
-
2007
- 2007-05-25 US US11/807,303 patent/US20090029939A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EA011399B1 (ru) | 2009-02-27 |
CA2501881A1 (en) | 2004-04-29 |
KR20050087787A (ko) | 2005-08-31 |
AU2003301439A8 (en) | 2004-05-04 |
WO2004035576A3 (en) | 2004-06-24 |
AU2003301306A1 (en) | 2004-05-04 |
EP1558613A2 (en) | 2005-08-03 |
NZ539264A (en) | 2007-08-31 |
AU2003301439A1 (en) | 2004-05-04 |
WO2004035577A3 (en) | 2004-07-29 |
HRP20050431A2 (en) | 2005-10-31 |
MXPA05003950A (es) | 2005-06-17 |
AP1858A (en) | 2008-06-30 |
BR0315405A (pt) | 2005-08-09 |
WO2004035576A2 (en) | 2004-04-29 |
NO20052378L (no) | 2005-07-18 |
US20090029939A1 (en) | 2009-01-29 |
JP2006514099A (ja) | 2006-04-27 |
IS7845A (is) | 2005-05-13 |
US7253180B2 (en) | 2007-08-07 |
UA79830C2 (en) | 2007-07-25 |
US20040167124A1 (en) | 2004-08-26 |
NO20052378D0 (no) | 2005-05-13 |
AP2005003279A0 (en) | 2005-06-30 |
US20040157804A1 (en) | 2004-08-12 |
CN100374438C (zh) | 2008-03-12 |
PL377966A1 (pl) | 2006-02-20 |
EA200500660A1 (ru) | 2005-10-27 |
WO2004035577A2 (en) | 2004-04-29 |
CN1726212A (zh) | 2006-01-25 |
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