OA13079A - Pre-organized tricyclic integrase inhibitor compounds. - Google Patents

Pre-organized tricyclic integrase inhibitor compounds. Download PDF

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Publication number
OA13079A
OA13079A OA1200500108A OA1200500108A OA13079A OA 13079 A OA13079 A OA 13079A OA 1200500108 A OA1200500108 A OA 1200500108A OA 1200500108 A OA1200500108 A OA 1200500108A OA 13079 A OA13079 A OA 13079A
Authority
OA
OAPI
Prior art keywords
compound
phosphonate
substituted
aryl
heteroaryl
Prior art date
Application number
OA1200500108A
Other languages
English (en)
Inventor
James M Chen
Xiaowu Chen
Maria Fardis
Haolun Jin
Choung U Kim
Laura N Schacherer
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of OA13079A publication Critical patent/OA13079A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
OA1200500108A 2002-10-16 2003-10-16 Pre-organized tricyclic integrase inhibitor compounds. OA13079A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41896302P 2002-10-16 2002-10-16
US47878303P 2003-06-16 2003-06-16

Publications (1)

Publication Number Publication Date
OA13079A true OA13079A (en) 2006-11-10

Family

ID=32110203

Family Applications (1)

Application Number Title Priority Date Filing Date
OA1200500108A OA13079A (en) 2002-10-16 2003-10-16 Pre-organized tricyclic integrase inhibitor compounds.

Country Status (19)

Country Link
US (3) US20040157804A1 (no)
EP (1) EP1558613A2 (no)
JP (1) JP2006514099A (no)
KR (1) KR20050087787A (no)
CN (1) CN100374438C (no)
AP (1) AP1858A (no)
AU (2) AU2003301439A1 (no)
BR (1) BR0315405A (no)
CA (1) CA2501881A1 (no)
EA (1) EA011399B1 (no)
HR (1) HRP20050431A2 (no)
IS (1) IS7845A (no)
MX (1) MXPA05003950A (no)
NO (1) NO20052378L (no)
NZ (1) NZ539264A (no)
OA (1) OA13079A (no)
PL (1) PL377966A1 (no)
UA (1) UA79830C2 (no)
WO (2) WO2004035577A2 (no)

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Also Published As

Publication number Publication date
EA011399B1 (ru) 2009-02-27
CA2501881A1 (en) 2004-04-29
KR20050087787A (ko) 2005-08-31
AU2003301439A8 (en) 2004-05-04
WO2004035576A3 (en) 2004-06-24
AU2003301306A1 (en) 2004-05-04
EP1558613A2 (en) 2005-08-03
NZ539264A (en) 2007-08-31
AU2003301439A1 (en) 2004-05-04
WO2004035577A3 (en) 2004-07-29
HRP20050431A2 (en) 2005-10-31
MXPA05003950A (es) 2005-06-17
AP1858A (en) 2008-06-30
BR0315405A (pt) 2005-08-09
WO2004035576A2 (en) 2004-04-29
NO20052378L (no) 2005-07-18
US20090029939A1 (en) 2009-01-29
JP2006514099A (ja) 2006-04-27
IS7845A (is) 2005-05-13
US7253180B2 (en) 2007-08-07
UA79830C2 (en) 2007-07-25
US20040167124A1 (en) 2004-08-26
NO20052378D0 (no) 2005-05-13
AP2005003279A0 (en) 2005-06-30
US20040157804A1 (en) 2004-08-12
CN100374438C (zh) 2008-03-12
PL377966A1 (pl) 2006-02-20
EA200500660A1 (ru) 2005-10-27
WO2004035577A2 (en) 2004-04-29
CN1726212A (zh) 2006-01-25

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