OA13029A - Triazole compounds useful in therapy. - Google Patents

Triazole compounds useful in therapy. Download PDF

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Publication number
OA13029A
OA13029A OA1200500229A OA1200500229A OA13029A OA 13029 A OA13029 A OA 13029A OA 1200500229 A OA1200500229 A OA 1200500229A OA 1200500229 A OA1200500229 A OA 1200500229A OA 13029 A OA13029 A OA 13029A
Authority
OA
OAPI
Prior art keywords
compound
chloro
mmol
tetrahydro
préparation
Prior art date
Application number
OA1200500229A
Other languages
English (en)
Inventor
Justin Stephen Bryans
Patrick Stephen Johnson
Rachel Jane Russell
Thomas Ryckmans
Alan Stobie
Christopher Peter Wayman
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0303852.8A external-priority patent/GB0303852D0/en
Priority claimed from GBGB0317227.7A external-priority patent/GB0317227D0/en
Application filed by Pfizer filed Critical Pfizer
Publication of OA13029A publication Critical patent/OA13029A/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Reproductive Health (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pregnancy & Childbirth (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
OA1200500229A 2003-02-19 2004-02-09 Triazole compounds useful in therapy. OA13029A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0303852.8A GB0303852D0 (en) 2003-02-19 2003-02-19 Triazole compounds useful in therapy
GBGB0317227.7A GB0317227D0 (en) 2003-07-23 2003-07-23 Treatment of male sexual dysfunction

Publications (1)

Publication Number Publication Date
OA13029A true OA13029A (en) 2006-11-10

Family

ID=34889119

Family Applications (1)

Application Number Title Priority Date Filing Date
OA1200500229A OA13029A (en) 2003-02-19 2004-02-09 Triazole compounds useful in therapy.

Country Status (25)

Country Link
EP (1) EP1597260B1 (es)
JP (2) JP4033886B2 (es)
KR (1) KR100750028B1 (es)
AP (1) AP2005003376A0 (es)
AT (1) ATE349449T1 (es)
AU (1) AU2004213242B2 (es)
BR (1) BRPI0407676A (es)
CA (1) CA2516557C (es)
DE (1) DE602004003914T2 (es)
DK (1) DK1597260T3 (es)
EA (1) EA009460B1 (es)
EC (1) ECSP055973A (es)
ES (1) ES2277237T3 (es)
GE (1) GEP20074089B (es)
HR (1) HRP20050681A2 (es)
IS (1) IS2450B (es)
MA (1) MA27712A1 (es)
MX (1) MXPA05008923A (es)
NO (1) NO20054053L (es)
OA (1) OA13029A (es)
PL (1) PL378747A1 (es)
PT (1) PT1597260E (es)
RS (1) RS20050638A (es)
SI (1) SI1597260T1 (es)
TN (1) TNSN05200A1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012001107A1 (en) * 2010-07-01 2012-01-05 Boehringer Ingelheim International Gmbh Piperidine derivatives and their use for the treatment of metabolic disorders

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200904403A (en) * 2007-04-25 2009-02-01 Daiichi Sankyo Co Ltd Tricyclic aryl compounds
US8765728B2 (en) * 2009-11-16 2014-07-01 Mellitech [1,5]-diazocin derivatives
US8420633B2 (en) * 2010-03-31 2013-04-16 Hoffmann-La Roche Inc. Aryl-cyclohexyl-tetraazabenzo[e]azulenes
US8461151B2 (en) * 2010-04-13 2013-06-11 Hoffmann-La Roche Inc. Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes
US8492376B2 (en) * 2010-04-21 2013-07-23 Hoffmann-La Roche Inc. Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes
US8481528B2 (en) * 2010-04-26 2013-07-09 Hoffmann-La Roche Inc. Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes
JP6454707B2 (ja) * 2013-12-05 2019-01-16 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ｔｒａｎｓ−８−クロロ−５−メチル−１−［４−（ピリジン−２−イルオキシ）−シクロヘキシル］−５，６−ジヒドロ−４Ｈ−２，３，５，１０ｂ−テトラアザ−ベンゾ［ｅ］アズレン及びその結晶形態の合成
HU231206B1 (hu) * 2017-12-15 2021-10-28 Richter Gedeon Nyrt. Triazolobenzazepinek

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8823475D0 (en) * 1988-10-06 1988-11-16 Merck Sharp & Dohme Chemical compounds
US5438035A (en) * 1994-06-24 1995-08-01 American Cyanamid Company Methods for controlling undesirable plant species with benzodiazepine compounds
US5753648A (en) * 1995-01-17 1998-05-19 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
JP2001503759A (ja) * 1996-11-01 2001-03-21 アメリカン・ホーム・プロダクツ・コーポレイション ５Ｈ―ピロロ［２，１―ｃ］［１，４］ベンゾジアゼピンの３―カルボキサミド誘導体
DE69911259T4 (de) * 1999-01-19 2009-07-09 Ortho-Mcneil Pharmaceutical, Inc. Tricyclische benzodiazepine als vasopressin antagonisten
US7109193B2 (en) * 2001-04-12 2006-09-19 Wyeth Tricyclic diazepines tocolytic oxytocin receptor antagonists
GB0224919D0 (en) * 2002-10-25 2002-12-04 Pfizer Ltd Triazole compounds useful in therapy

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012001107A1 (en) * 2010-07-01 2012-01-05 Boehringer Ingelheim International Gmbh Piperidine derivatives and their use for the treatment of metabolic disorders
US9006450B2 (en) 2010-07-01 2015-04-14 Boehringer Ingelheim International Gmbh Compounds, pharmaceutical compositions and uses thereof

Also Published As

Publication number Publication date
GEP20074089B (en) 2007-04-10
MA27712A1 (fr) 2006-01-02
KR100750028B1 (ko) 2007-08-16
KR20050106443A (ko) 2005-11-09
MXPA05008923A (es) 2006-03-09
BRPI0407676A (pt) 2006-03-01
EA200501136A1 (ru) 2006-06-30
ATE349449T1 (de) 2007-01-15
RS20050638A (en) 2007-12-31
SI1597260T1 (sl) 2007-04-30
JP4033886B2 (ja) 2008-01-16
EP1597260B1 (en) 2006-12-27
IS7957A (is) 2005-07-25
DE602004003914T2 (de) 2007-05-31
IS2450B (is) 2008-11-15
AU2004213242B2 (en) 2007-04-19
HRP20050681A2 (en) 2005-12-31
JP2007045838A (ja) 2007-02-22
CA2516557C (en) 2008-11-18
AU2004213242A1 (en) 2004-09-02
TNSN05200A1 (fr) 2007-06-11
ES2277237T3 (es) 2007-07-01
PL378747A1 (pl) 2006-05-15
AP2005003376A0 (en) 2005-09-30
EP1597260A1 (en) 2005-11-23
PT1597260E (pt) 2007-01-31
DK1597260T3 (da) 2007-04-02
ECSP055973A (es) 2006-01-16
NO20054053D0 (no) 2005-08-31
DE602004003914D1 (de) 2007-02-08
CA2516557A1 (en) 2004-09-02
EA009460B1 (ru) 2007-12-28
NO20054053L (no) 2005-10-31
JP2006517921A (ja) 2006-08-03

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