OA11901A - Halogenated amidino amino acid derivatives useful as nitric oxide synthase inhibitors. - Google Patents

Halogenated amidino amino acid derivatives useful as nitric oxide synthase inhibitors. Download PDF

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Publication number
OA11901A
OA11901A OA1200000239A OA1200000239A OA11901A OA 11901 A OA11901 A OA 11901A OA 1200000239 A OA1200000239 A OA 1200000239A OA 1200000239 A OA1200000239 A OA 1200000239A OA 11901 A OA11901 A OA 11901A
Authority
OA
OAPI
Prior art keywords
alkyl
dihydrochloride
alkynyl
group
amino
Prior art date
Application number
OA1200000239A
Other languages
English (en)
Inventor
Hallinan E Ann
Barnett S Pitzel
Dale P Spangler
Arija A Bergmanis
Timothy J Hagen
Sofya Tsymbalov
Mihaly V Toth
Webber R Keith
Hansen Donald W Jr
Alik K Awasthi
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of OA11901A publication Critical patent/OA11901A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/14—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
OA1200000239A 1998-03-11 1999-03-04 Halogenated amidino amino acid derivatives useful as nitric oxide synthase inhibitors. OA11901A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3828498A 1998-03-11 1998-03-11

Publications (1)

Publication Number Publication Date
OA11901A true OA11901A (en) 2006-04-10

Family

ID=21899068

Family Applications (1)

Application Number Title Priority Date Filing Date
OA1200000239A OA11901A (en) 1998-03-11 1999-03-04 Halogenated amidino amino acid derivatives useful as nitric oxide synthase inhibitors.

Country Status (35)

Country Link
US (1) US6344483B1 (fr)
EP (2) EP1415982A1 (fr)
JP (1) JP2002506056A (fr)
KR (1) KR20010034598A (fr)
CN (1) CN1171861C (fr)
AP (1) AP2000001900A0 (fr)
AR (1) AR018159A1 (fr)
AT (1) ATE277894T1 (fr)
AU (1) AU746235B2 (fr)
BG (1) BG104766A (fr)
BR (1) BR9908702A (fr)
CA (1) CA2322873A1 (fr)
CU (1) CU23047A3 (fr)
DE (1) DE69920670T2 (fr)
EA (1) EA200000826A1 (fr)
EE (1) EE200000519A (fr)
ES (1) ES2239839T3 (fr)
GE (1) GEP20043179B (fr)
HR (1) HRP20000595A2 (fr)
HU (1) HUP0101467A3 (fr)
ID (1) ID26208A (fr)
IL (1) IL137654A0 (fr)
IS (1) IS5583A (fr)
NO (1) NO20004531L (fr)
NZ (1) NZ506721A (fr)
OA (1) OA11901A (fr)
PL (1) PL343380A1 (fr)
PT (1) PT1062201E (fr)
SI (1) SI1062201T1 (fr)
SK (1) SK13012000A3 (fr)
TR (1) TR200002605T2 (fr)
UA (1) UA67767C2 (fr)
WO (1) WO1999046240A2 (fr)
YU (1) YU52200A (fr)
ZA (1) ZA991894B (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4216502B2 (ja) 2000-03-24 2009-01-28 ファルマシア コーポレーション 酸化窒素シンターゼ阻害剤として有用なアミジノ化合物
US6956131B2 (en) * 2000-04-13 2005-10-18 Pharmacia Corporation 2-amino-3, 4 heptenoic compounds useful as nitric oxide synthase inhibitors
AR034120A1 (es) 2000-04-13 2004-02-04 Pharmacia Corp Compuesto derivado halogenado del acido 2-amino-4,5 heptenoico, composicion farmaceutica que lo comprende y el uso de dicho compuesto y dicha composicion en la fabricacion de un medicamento para inhibir o modular la sintesis de acido nitrico
AR030416A1 (es) 2000-04-13 2003-08-20 Pharmacia Corp COMPUESTO DERIVADO HALOGENADO DEL ACIDO 2-AMINO-3,4 HEPTENOICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE Y SU USO EN LA FABRICACION DE UN MEDICAMENTO uTIL COMO INHIBIDOR DE LA OXIDO NITRICO SINTETASA
US6787668B2 (en) 2000-04-13 2004-09-07 Pharmacia Corporation 2-amino-4,5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
AR032318A1 (es) * 2000-04-13 2003-11-05 Pharmacia Corp Compuesto derivado halogenado del acido 2-amino-5,6 heptenoico; composicion farmaceutica que lo comprende y su uso en la fabricacion de un medicamento util como inhibidor de la oxido nitrico sintetasa
US6545170B2 (en) 2000-04-13 2003-04-08 Pharmacia Corporation 2-amino-5, 6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
AR035585A1 (es) * 2000-09-15 2004-06-16 Pharmacia Corp Derivados del acido 2-amino-2-alquil-4-heptenoico, composicion farmaceutica y su uso en la fabricacion de medicamentos
AR031609A1 (es) * 2000-09-15 2003-09-24 Pharmacia Corp Derivados de acido 2-amino-2-alquil-3 heptenoico y heptinoico utiles como inhibidores de oxido nitrico sintetasa
AR031129A1 (es) 2000-09-15 2003-09-10 Pharmacia Corp Derivados de los acidos 2-amino-2-alquil-4-hexenoico y -hexinoico utiles como inhibidores de oxido nitrico sintetasa
AR031608A1 (es) * 2000-09-15 2003-09-24 Pharmacia Corp Derivados de los acidos 2-amino-2-alquil-3-hexenoico y -hexinoico utiles como inhibidores de oxido nitrico sintetasa
GB0031179D0 (en) 2000-12-21 2001-01-31 Glaxo Group Ltd Nitric oxide synthase inhibitors
US6613280B2 (en) * 2001-03-20 2003-09-02 Therox, Inc. Disposable cartridge for producing gas-enriched fluids
US6582387B2 (en) * 2001-03-20 2003-06-24 Therox, Inc. System for enriching a bodily fluid with a gas
US7012098B2 (en) 2001-03-23 2006-03-14 Pharmacia Corporation Inhibitors of inducible nitric oxide synthase for chemoprevention and treatment of cancers
BR0310061A (pt) * 2002-05-16 2005-03-01 Pharmacia Corp Métodos para o tratamento de doenças e condições respiratórias com um inibidor seletivo da inos e um inibidor da pde e suas composições
SG158148A1 (en) 2004-12-22 2010-01-29 Ambrx Inc Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
KR101280929B1 (ko) * 2005-03-14 2013-07-01 얀센 파마슈티카 엔.브이. 오피오이드 모듈레이터의 제조방법
PL1954710T3 (pl) 2005-11-08 2011-09-30 Ambrx Inc Przyspieszacze do modyfikacji aminokwasów niewystępujących w przyrodzie i polipeptydów zbudowanych z aminokwasów nie występujących w przyrodzie
CA2882445A1 (fr) * 2005-12-14 2007-06-21 Ambrx, Inc. Compositions contenant des acides amines et polypeptides non naturels, procedes mettant en jeu ceux-ci et utilisations de ceux-ci
KR101103720B1 (ko) * 2011-06-02 2012-01-11 한국건설기술연구원 자연환기에 의한 중공층의 온도제어가 가능한 일체형 다중유리 복합창짝
EP3043810B1 (fr) 2013-09-09 2019-10-23 CanImGuide Therapeutics AB Modulateurs du système immunitaire
WO2016144650A1 (fr) 2015-03-06 2016-09-15 Canimguide Therapeutics Ab Modulateurs et compositions du système immunitaire

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9127376D0 (en) * 1991-12-24 1992-02-19 Wellcome Found Amidino derivatives
GB9312761D0 (en) * 1993-06-21 1993-08-04 Wellcome Found Amino acid derivatives
ES2145282T3 (es) 1994-06-15 2000-07-01 Wellcome Found Inhibidores de enzimas.
GB9425701D0 (en) * 1994-12-20 1995-02-22 Wellcome Found Enzyme inhibitors
US5981511A (en) * 1996-03-06 1999-11-09 G.D. Searle & Co. Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors
US5945408A (en) * 1996-03-06 1999-08-31 G.D. Searle & Co. Hydroxyanidino derivatives useful as nitric oxide synthase inhibitors

Also Published As

Publication number Publication date
AU746235B2 (en) 2002-04-18
AR018159A1 (es) 2001-10-31
AP2000001900A0 (en) 2000-09-30
UA67767C2 (uk) 2004-07-15
CN1292779A (zh) 2001-04-25
EP1415982A1 (fr) 2004-05-06
JP2002506056A (ja) 2002-02-26
HRP20000595A2 (en) 2001-04-30
YU52200A (sh) 2002-09-19
GEP20043179B (en) 2004-02-25
PL343380A1 (en) 2001-08-13
CU23047A3 (es) 2005-04-26
EP1062201B1 (fr) 2004-09-29
ATE277894T1 (de) 2004-10-15
SK13012000A3 (sk) 2001-06-11
NO20004531D0 (no) 2000-09-11
DE69920670T2 (de) 2006-02-16
EA200000826A1 (ru) 2001-04-23
CN1171861C (zh) 2004-10-20
DE69920670D1 (de) 2004-11-04
CA2322873A1 (fr) 1999-09-16
NZ506721A (en) 2003-07-25
NO20004531L (no) 2000-10-30
PT1062201E (pt) 2005-02-28
WO1999046240A2 (fr) 1999-09-16
TR200002605T2 (tr) 2000-12-21
EP1062201A2 (fr) 2000-12-27
AU2778699A (en) 1999-09-27
IL137654A0 (en) 2001-10-31
IS5583A (is) 2000-08-04
US6344483B1 (en) 2002-02-05
ID26208A (id) 2000-11-07
KR20010034598A (ko) 2001-04-25
HUP0101467A2 (hu) 2001-08-28
WO1999046240A3 (fr) 1999-11-11
SI1062201T1 (en) 2005-10-31
BR9908702A (pt) 2000-11-21
EE200000519A (et) 2002-02-15
ES2239839T3 (es) 2005-10-01
ZA991894B (en) 1999-09-27
BG104766A (bg) 2001-03-30
HUP0101467A3 (en) 2003-03-28

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