OA11493A - Trisubsituted 1,3,5-triazine derivatives for treatment of HIV infections. - Google Patents

Trisubsituted 1,3,5-triazine derivatives for treatment of HIV infections. Download PDF

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Publication number
OA11493A
OA11493A OA1200000266A OA1200000266A OA11493A OA 11493 A OA11493 A OA 11493A OA 1200000266 A OA1200000266 A OA 1200000266A OA 1200000266 A OA1200000266 A OA 1200000266A OA 11493 A OA11493 A OA 11493A
Authority
OA
OAPI
Prior art keywords
amino
phenoxy
anilino
methyl
compound
Prior art date
Application number
OA1200000266A
Other languages
English (en)
Inventor
Frederik Frans Desire Daeyaert
Bart De Corte
Marc Rene De Jonge
Jan Heeres
Chih Yung Ho
Paul Adriaan Jan Janssen
Robert W Kavash
Lucien Maria Henricus Koymans
Michael Joseph Kukla
Donald William Ludovici
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of OA11493A publication Critical patent/OA11493A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/48—Two nitrogen atoms
    • C07D251/50—Two nitrogen atoms with a halogen atom attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/48—Two nitrogen atoms
    • C07D251/52—Two nitrogen atoms with an oxygen or sulfur atom attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/54—Three nitrogen atoms
    • C07D251/66—Derivatives of melamine in which a hetero atom is directly attached to a nitrogen atom of melamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/54—Three nitrogen atoms
    • C07D251/70—Other substituted melamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
OA1200000266A 1998-03-27 2000-09-27 Trisubsituted 1,3,5-triazine derivatives for treatment of HIV infections. OA11493A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7963398P 1998-03-27 1998-03-27
EP98201589A EP0945447A1 (en) 1998-03-27 1998-05-14 Trisubstituted 1,3,5-triazine derivatives for treatment of HIV infections

Publications (1)

Publication Number Publication Date
OA11493A true OA11493A (en) 2004-05-07

Family

ID=22151790

Family Applications (1)

Application Number Title Priority Date Filing Date
OA1200000266A OA11493A (en) 1998-03-27 2000-09-27 Trisubsituted 1,3,5-triazine derivatives for treatment of HIV infections.

Country Status (33)

Country Link
US (3) US6150360A (pt)
EP (2) EP0945447A1 (pt)
JP (1) JP2002511390A (pt)
KR (1) KR100593396B1 (pt)
CN (1) CN1157386C (pt)
AP (1) AP1475A (pt)
AR (1) AR018169A1 (pt)
AT (1) ATE295355T1 (pt)
AU (1) AU758624C (pt)
BG (1) BG64903B1 (pt)
BR (1) BR9909197A (pt)
CA (1) CA2324921C (pt)
DE (1) DE69925256T2 (pt)
DK (1) DK1066269T3 (pt)
EA (1) EA004540B1 (pt)
EE (1) EE200000535A (pt)
ES (1) ES2243056T3 (pt)
HK (1) HK1032394A1 (pt)
HR (1) HRP20000621A2 (pt)
HU (1) HUP0101372A3 (pt)
ID (1) ID26043A (pt)
IL (1) IL138670A (pt)
NO (1) NO317425B1 (pt)
NZ (1) NZ506787A (pt)
OA (1) OA11493A (pt)
PL (1) PL194660B1 (pt)
PT (1) PT1066269E (pt)
SI (1) SI1066269T1 (pt)
SK (1) SK14052000A3 (pt)
TR (1) TR200002761T2 (pt)
TW (1) TW570917B (pt)
WO (1) WO1999050256A1 (pt)
ZA (1) ZA200006042B (pt)

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US20020065270A1 (en) * 1999-12-28 2002-05-30 Moriarty Kevin Joseph N-heterocyclic inhibitors of TNF-alpha expression
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US7034019B2 (en) 2000-05-08 2006-04-25 Janssen Pharmaceutica N.V. Prodrugs of HIV replication inhibiting pyrimidines
US6858608B2 (en) * 2001-01-09 2005-02-22 Aventis Pharma S.A. Chemical derivatives and their application as antitelomerase agents
US6887873B2 (en) * 2001-03-23 2005-05-03 Aventis Pharma S.A. Triazine derivatives and their application as antitelomerase agents
US6958211B2 (en) 2001-08-08 2005-10-25 Tibotech Bvba Methods of assessing HIV integrase inhibitor therapy
JO3429B1 (ar) * 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
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US7163943B2 (en) 2001-09-21 2007-01-16 Reddy Us Therapeutics, Inc. Methods and compositions of novel triazine compounds
US7173032B2 (en) * 2001-09-21 2007-02-06 Reddy Us Therapeutics, Inc. Methods and compositions of novel triazine compounds
US7132423B2 (en) * 2001-09-21 2006-11-07 Reddy Us Therapeutics, Inc. Methods and compositions of novel triazine compounds
JP2005511509A (ja) * 2001-09-21 2005-04-28 レディ ユーエス セラピューティクス インコーポレイテッド 新規トリアジン化合物の方法および組成物
US7169785B2 (en) * 2001-09-21 2007-01-30 Reddy Us Therapeutics, Inc. Methods and compositions of novel triazine compounds
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US7419984B2 (en) * 2002-10-17 2008-09-02 Cell Therapeutics, Inc. Pyrimidines and uses thereof
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US20070232572A1 (en) * 2003-02-07 2007-10-04 Aventis Pharma S.A. Chemical derivatives as antitelomerase agents which bind specifically to the G-quadruplex DNA structures and their application as a specific anticancer agent
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US6875781B2 (en) * 2003-04-04 2005-04-05 Cell Therapeutics, Inc. Pyridines and uses thereof
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US7335770B2 (en) * 2004-03-24 2008-02-26 Reddy U5 Therapeutics, Inc. Triazine compounds and their analogs, compositions, and methods
CA2575002C (en) * 2004-08-10 2015-01-20 Janssen Pharmaceutica N.V. Hiv inhibiting 1,2,4-triazin-6-one derivatives
EP1797048B1 (en) 2004-09-30 2011-08-17 Tibotec Pharmaceuticals Hiv inhibiting 5-carbo- or heterocyclic substituted pyrimidines
MX2007003797A (es) 2004-09-30 2007-04-23 Tibotec Pharm Ltd 5-heterociclil pirimidinas inhibidoras del virus de inmunodeficiencia humana.
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US7592451B2 (en) * 2005-06-23 2009-09-22 New York University Treatment for diabetes and obesity as well as method of screening compounds useful for such treatments
WO2007071199A1 (fr) * 2005-12-22 2007-06-28 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Composes de 2,4-disubstituee amido-6-substituee-[1,3,5]triazine ou de 1,3-pyrimidine, leurs procedes d'elaboration, et preparations pharmaceutiques les contenant et leurs utilisations
CN101405283B (zh) 2006-03-30 2014-06-18 泰博特克药品有限公司 Hiv抑制性5-酰氨基取代的嘧啶类化合物
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Also Published As

Publication number Publication date
ES2243056T3 (es) 2005-11-16
BG104716A (en) 2001-04-30
CN1157386C (zh) 2004-07-14
ID26043A (id) 2000-11-16
BR9909197A (pt) 2000-12-05
EA200000993A1 (ru) 2001-04-23
DK1066269T3 (da) 2005-09-05
AR018169A1 (es) 2001-10-31
AP1475A (en) 2005-10-03
KR100593396B1 (ko) 2006-06-28
PL194660B1 (pl) 2007-06-29
SK14052000A3 (sk) 2001-06-11
WO1999050256A1 (en) 1999-10-07
PL343195A1 (en) 2001-07-30
EE200000535A (et) 2002-04-15
SI1066269T1 (en) 2005-10-31
DE69925256D1 (de) 2005-06-16
HUP0101372A2 (hu) 2001-10-28
AU758624C (en) 2004-03-11
TR200002761T2 (tr) 2001-01-22
NO20004809L (no) 2000-11-24
KR20010034270A (ko) 2001-04-25
NZ506787A (en) 2003-02-28
PT1066269E (pt) 2005-09-30
EA004540B1 (ru) 2004-06-24
IL138670A (en) 2005-12-18
DE69925256T2 (de) 2006-02-23
HUP0101372A3 (en) 2003-02-28
EP1066269B1 (en) 2005-05-11
HRP20000621A2 (en) 2001-04-30
CA2324921A1 (en) 1999-10-07
TW570917B (en) 2004-01-11
NO317425B1 (no) 2004-10-25
US6150360A (en) 2000-11-21
AU3599799A (en) 1999-10-18
EP1066269A1 (en) 2001-01-10
CA2324921C (en) 2009-05-12
ZA200006042B (en) 2001-10-26
BG64903B1 (bg) 2006-08-31
JP2002511390A (ja) 2002-04-16
US20020115668A1 (en) 2002-08-22
CN1295566A (zh) 2001-05-16
ATE295355T1 (de) 2005-05-15
EP0945447A1 (en) 1999-09-29
AP2000001913A0 (en) 2000-09-30
AU758624B2 (en) 2003-03-27
NO20004809D0 (no) 2000-09-26
HK1032394A1 (en) 2001-07-20
US6372729B1 (en) 2002-04-16
US6774235B2 (en) 2004-08-10

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