OA10331A - Condensed-ring thiophene derivatives their production and use - Google Patents

Condensed-ring thiophene derivatives their production and use Download PDF

Info

Publication number
OA10331A
OA10331A OA60907A OA60907A OA10331A OA 10331 A OA10331 A OA 10331A OA 60907 A OA60907 A OA 60907A OA 60907 A OA60907 A OA 60907A OA 10331 A OA10331 A OA 10331A
Authority
OA
OAPI
Prior art keywords
compound
group
benzyl
methyl
phenyl
Prior art date
Application number
OA60907A
Other languages
English (en)
Inventor
Shuichi Furuya
Nobuo Choh
Koichi Kato
Shuji Hinuma
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of OA10331A publication Critical patent/OA10331A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
OA60907A 1994-04-19 1996-10-18 Condensed-ring thiophene derivatives their production and use OA10331A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP8073294 1994-04-19
JP19554194 1994-08-19
JP27101094 1994-11-04
JP2071795 1995-02-08
JP4015195 1995-02-28

Publications (1)

Publication Number Publication Date
OA10331A true OA10331A (en) 1997-10-07

Family

ID=27520246

Family Applications (1)

Application Number Title Priority Date Filing Date
OA60907A OA10331A (en) 1994-04-19 1996-10-18 Condensed-ring thiophene derivatives their production and use

Country Status (17)

Country Link
US (3) US5817819A (zh)
EP (1) EP0756599B1 (zh)
KR (1) KR970702282A (zh)
CN (1) CN1092197C (zh)
AT (1) ATE255113T1 (zh)
AU (2) AU697472B2 (zh)
CA (1) CA2186124A1 (zh)
CZ (1) CZ290713B6 (zh)
DE (1) DE69532194T2 (zh)
FI (2) FI964195A (zh)
HU (1) HUT76320A (zh)
NO (1) NO964434L (zh)
NZ (1) NZ283813A (zh)
OA (1) OA10331A (zh)
PL (1) PL316796A1 (zh)
TW (1) TW449600B (zh)
WO (1) WO1995028405A1 (zh)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69623655T2 (de) * 1995-10-19 2003-04-24 Takeda Chemical Industries, Ltd. Chinolinderivate als gnrh antagonisten
CA2229205A1 (en) * 1995-10-19 1997-04-24 Shuichi Furuya Thienopyridine derivatives, their productions and use
ATE221534T1 (de) * 1995-12-08 2002-08-15 Takeda Chemical Industries Ltd Hemmer der prolaktinsynthese
IL124459A0 (en) * 1995-12-14 1998-12-06 Merck & Co Inc Antagonists of gonadotropin releasing hormone
US5780437A (en) * 1995-12-14 1998-07-14 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
NZ325060A (en) 1995-12-14 2000-02-28 Merck & Co Inc Non peptide indole derivative and their use as antagonists of gonadotropin releasing hormone
US5756507A (en) * 1995-12-14 1998-05-26 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
SK77598A3 (en) * 1995-12-14 1999-01-11 Merck & Co Inc Nonpeptide derivatives, pharmaceutical composition containing them and their use
US5849764A (en) * 1995-12-14 1998-12-15 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US6200957B1 (en) 1995-12-14 2001-03-13 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
WO1997041126A1 (en) * 1996-04-26 1997-11-06 Takeda Chemical Industries, Ltd. Thienopyridine derivatives, their production and use
JP2007302703A (ja) * 1996-04-30 2007-11-22 Takeda Chem Ind Ltd 医薬組成物
EP0906115A1 (en) * 1996-04-30 1999-04-07 Takeda Chemical Industries, Ltd. COMBINED USE OF GnRH AGONIST AND ANTAGONIST
US6150522A (en) * 1996-05-20 2000-11-21 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
WO1997044339A1 (en) * 1996-05-20 1997-11-27 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US6147088A (en) * 1996-05-20 2000-11-14 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
WO1997044037A1 (en) * 1996-05-20 1997-11-27 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
AU729663B2 (en) * 1997-06-05 2001-02-08 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
EP0958297A1 (en) 1997-08-06 1999-11-24 Suntory Limited 1-aryl-1,8-naphthylidin-4-one derivative as type iv phosphodiesterase inhibitor
US6313301B1 (en) * 1997-08-13 2001-11-06 Takeda Chemical Industries, Ltd. Thienopyridine derivatives, their intermediates and production thereof
CA2300479A1 (en) 1997-12-26 1999-07-08 Shuichi Furuya Nitrogen-containing heterocyclic compounds, their production and use
ID26780A (id) 1998-06-26 2001-02-08 Takeda Chemical Industries Ltd Senyawa-senyawa tienopiridina, hasil dan kegunaannya
US6262267B1 (en) 1998-06-26 2001-07-17 Takeda Chemical Industries, Ltd. Thienopyridine compound
US6297255B1 (en) 1998-06-26 2001-10-02 Takeda Chemical Industries, Ltd. Thienopyridine compounds, their production and use
EP1159279B1 (en) * 1999-03-09 2002-10-16 PHARMACIA & UPJOHN COMPANY 4-oxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxamides as antiviral agents
JP2002538208A (ja) * 1999-03-10 2002-11-12 メルク エンド カムパニー インコーポレーテッド 性腺刺激ホルモン放出ホルモン拮抗薬としての６−アザインドール化合物
TWI225863B (en) 1999-03-24 2005-01-01 Takeda Chemical Industries Ltd Thienopyrimidine compounds, their production and use
US6297379B1 (en) 1999-03-24 2001-10-02 Takeda Chemical Industries, Ltd. Thienopyrimidine compounds, their production and use
TW564247B (en) * 1999-04-08 2003-12-01 Akzo Nobel Nv Bicyclic heteraromatic compound
KR20030005205A (ko) 2000-02-29 2003-01-17 다케다 야쿠힌 고교 가부시키가이샤 티에노피리미딘 유도체의 제조 방법
CA2406832A1 (en) * 2000-04-13 2002-10-10 Takeda Chemical Industries, Ltd. Preventives/remedies for alzheimer's disease
WO2002002533A1 (fr) * 2000-07-05 2002-01-10 Yamanouchi Pharmaceutical Co., Ltd. Derives de propane-1,3-dione
CA2423329A1 (en) * 2000-09-22 2003-03-20 Takeda Chemical Industries, Ltd. Solid preparations
AU2002218494A1 (en) * 2000-11-29 2002-06-11 Takeda Chemical Industries Ltd. Medicinal compositions and process for producing the same
US6583153B2 (en) 2000-12-12 2003-06-24 Ortho-Mcneil Pharmaceutical, Inc. 7-heterocyclyl quinoline and thieno[2,3-b]yridine derivatives useful as antagonists of gonadotropin releasing hormone
WO2002047722A1 (fr) * 2000-12-15 2002-06-20 Takeda Chemical Industries, Ltd. Compositions medicinales agoniste ou antagoniste de la gonadoliberine non peptidyl, methode de production et utilisation desdites compositions
US7110936B2 (en) * 2001-02-23 2006-09-19 Complementsoft Llc System and method for generating and maintaining software code
US6620824B2 (en) 2001-04-11 2003-09-16 Merck & Co., Inc. Process for the synthesis of gonadotropin releasing hormone antagonists
BR0211214A (pt) 2001-08-30 2004-07-13 Upjohn Co 4-tioxo-4,7-dihidro-tieno [2,3-b]piridina-5-carboxamidas como agentes antivirais
WO2003020728A1 (en) 2001-08-30 2003-03-13 Pharmacia & Upjohn Company 4-THIOXO-4,7-DIHYDRO-THIENO[2,3-b]PYRIDINE-5-CARBOTHIOAMIDES AS ANTIVIRAL AGENTS
AR038294A1 (es) 2002-01-14 2005-01-12 Upjohn Co Oxotieno(3,2-b)piridincarboxamidas como agentes antivirales
AR038118A1 (es) 2002-01-14 2004-12-29 Upjohn Co Compuestos derivados de la bencinamida del acido 7-oxo-4,7-dihidrotien[2,3-b[piridin-6-carboxilico 3-sustituido que son utiles como antivirales
AR038117A1 (es) 2002-01-14 2004-12-29 Upjohn Co Agentes antivirales derivados de la 4- oxo-4,7 -dihidrofuro [2,3-b]piridin-5-carboxamida
EP1479684A4 (en) 2002-01-30 2006-01-04 Takeda Pharmaceutical THIENOPYRIMIDINES, PROCESS FOR THEIR PRODUCTION AND THEIR USE
AU2003236039A1 (en) * 2002-04-12 2003-10-27 Takeda Pharmaceutical Company Limited Preventives/remedies for hotflash
MXPA05000722A (es) * 2002-07-17 2005-04-08 Warner Lambert Co Combinacion de un inhibidor alosterico carboxilico de la metaloproteinasa-13 de la matriz con un inhibidor selectivo de la ciclooxigenasa-2 que no es celecoxib o valdecoxib.
US6831081B2 (en) 2002-09-04 2004-12-14 Pharmacia & Upjohn 4-Oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides as antiviral agents
US7612078B2 (en) * 2003-03-31 2009-11-03 Epix Delaware, Inc. Piperidinylamino-thieno[2,3-D] pyrimidine compounds
US20050222175A1 (en) * 2004-03-31 2005-10-06 Dhanoa Dale S New piperidinylamino-thieno[2,3-D] pyrimidine compounds
GB0307777D0 (en) 2003-04-04 2003-05-07 Medical Res Council Conjugate compounds
US7488736B2 (en) * 2004-05-17 2009-02-10 Epix Delaware, Inc. Thienopyridinone compounds and methods of treatment
CN1964950A (zh) 2004-06-04 2007-05-16 安斯泰来制药有限公司 丙烷－1,3－二酮衍生物或其盐
DE102004033902A1 (de) 2004-07-14 2006-02-16 Zentaris Gmbh Neue Tetrahydrocarbazolderivate mit verbesserter biologischer Wirkung und verbesserter Löslichkeit als Liganden für G-Protein gekoppelte Rezeptoren (GPCR's)
US7576211B2 (en) * 2004-09-30 2009-08-18 Epix Delaware, Inc. Synthesis of thienopyridinone compounds and related intermediates
US7598265B2 (en) * 2004-09-30 2009-10-06 Epix Delaware, Inc. Compositions and methods for treating CNS disorders
US7407966B2 (en) * 2004-10-07 2008-08-05 Epix Delaware, Inc. Thienopyridinone compounds and methods of treatment
SI1864976T1 (sl) * 2005-03-31 2012-12-31 Astellas Pharma Inc. Propan-1,3-dionski derivat ali njegova sol
JP5352450B2 (ja) * 2007-04-18 2013-11-27 キッセイ薬品工業株式会社 縮合複素環誘導体、それを含有する医薬組成物及びその医薬用途
WO2008133127A1 (ja) * 2007-04-18 2008-11-06 Kissei Pharmaceutical Co., Ltd. 縮合へテロ環誘導体、それを含有する医薬組成物及びその医薬用途
EP2095818A1 (en) 2008-02-29 2009-09-02 AEterna Zentaris GmbH Use of LHRH antagonists at non-castrating doses
US8114894B2 (en) * 2008-12-03 2012-02-14 Nanotherapeutics, Inc. Bicyclic compounds and methods of making and using same
CN102746319B (zh) * 2012-07-25 2015-08-05 中国科学院长春应用化学研究所 一种噻吩并吡啶酮类化合物的制备方法
EP3263110B1 (en) 2015-02-26 2023-05-10 Takeda Pharmaceutical Company Limited A tablet comprising a methoxyurea derivative and mannitol particles
WO2019072478A1 (en) * 2017-10-10 2019-04-18 Galderma Research & Development SPECIFIC ACETYL-COA CARBOXYLASE INHIBITORS FOR USE IN THE TREATMENT AND / OR PREVENTION OF ACNE
CN111943960B (zh) * 2019-07-29 2022-02-15 广东东阳光药业有限公司 取代的嘧啶二酮类化合物及其用途
CN113754679B (zh) * 2020-09-09 2023-04-07 广东东阳光药业有限公司 取代的嘧啶二酮类化合物及其用途
WO2022067566A1 (zh) * 2020-09-29 2022-04-07 广东东阳光药业有限公司 含有饱和含氧杂环基的嘧啶二酮类化合物及其用途
CN114369704B (zh) * 2021-12-20 2023-12-26 无锡鹰贝精密液压有限公司 一种减小内球面变形的低碳合金钢球窝柱塞热处理方法
US20240239807A1 (en) 2022-08-05 2024-07-18 Gilead Sciences, Inc. Sars-cov2 main protease inhibitors

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE293824C (zh) *
DE2006505A1 (de) * 1970-02-13 1971-08-26 Merck Patent Gmbh, 6100 Darmstadt Isoflavanoid ather und Verfahren zu ihrer Herstellung
DE2006550A1 (de) * 1970-02-13 1971-08-26 H Stoll & Co, 7410 Reutlingen Vorrichtung fur Flachstrickmaschinen, insbesondere Jacquard Flachstrickmaschinen zur Vermeidung von Störungen bei fehler hafter Nadel und Stoßerstellung
US4898867A (en) * 1987-09-16 1990-02-06 Taiho Pharmaceutical Company, Limited Thienopyrimidine derivaties as aldose-reductase inhibitors
US5140009A (en) * 1988-02-10 1992-08-18 Tap Pharmaceuticals, Inc. Octapeptide LHRH antagonists
JPH01213284A (ja) * 1988-02-22 1989-08-28 Sankyo Co Ltd チエノピリミジン−２，４−ジオン誘導体
JPH02225485A (ja) * 1989-02-27 1990-09-07 Taiho Yakuhin Kogyo Kk チエノピリミジン―３―酢酸誘導体
CA2036618C (en) * 1990-02-22 2002-10-29 Akira Morimoto Fused thiophene derivatives, their production and use
IL102183A (en) * 1991-06-27 1999-11-30 Takeda Chemical Industries Ltd The heterocyclic compounds are converted into biphenyl groups, their production and the pharmaceutical compositions containing them
WO1994020460A1 (en) * 1993-03-11 1994-09-15 Smithkline Beecham Corporation Chemical compounds
US5677184A (en) * 1994-04-19 1997-10-14 Takeda Chemical Industries, Ltd. CHO cells that express human LH-RH receptor
US5607939A (en) * 1994-04-28 1997-03-04 Takeda Chemical Industries, Ltd. Condensed heterocyclic compounds, their production and use
US6391892B1 (en) * 1995-03-10 2002-05-21 Eli Lilly And Company Naphthyl pharmaceutical compounds

Also Published As

Publication number Publication date
CN1092197C (zh) 2002-10-09
US6514988B1 (en) 2003-02-04
TW449600B (en) 2001-08-11
HUT76320A (en) 1997-08-28
FI964195A0 (fi) 1996-10-18
EP0756599A1 (en) 1997-02-05
NO964434D0 (no) 1996-10-18
US6187788B1 (en) 2001-02-13
ATE255113T1 (de) 2003-12-15
AU2223995A (en) 1995-11-10
FI20012326A (fi) 2001-11-28
US5817819A (en) 1998-10-06
FI964195A (fi) 1996-12-17
HU9602884D0 (en) 1996-12-30
WO1995028405A1 (en) 1995-10-26
CZ302896A3 (en) 1997-05-14
CN1146206A (zh) 1997-03-26
AU713116B2 (en) 1999-11-25
NZ283813A (en) 1998-11-25
CA2186124A1 (en) 1995-10-26
KR970702282A (ko) 1997-05-13
DE69532194D1 (de) 2004-01-08
CZ290713B6 (cs) 2002-09-11
AU697472B2 (en) 1998-10-08
DE69532194T2 (de) 2004-09-09
NO964434L (no) 1996-10-18
PL316796A1 (en) 1997-02-17
EP0756599B1 (en) 2003-11-26
AU8316998A (en) 1998-11-05

Similar Documents

Publication Publication Date Title
OA10331A (en) Condensed-ring thiophene derivatives their production and use
US6015789A (en) Combined use of GnRH agonist and antagonist
JP3789538B2 (ja) チエノピリミジン誘導体、その製造法および用途
US5744479A (en) Thienopyridine compounds which have useful pharmaceutical activity
EP3080085A1 (en) Fused bicyclic heteroaromatic derivatives as modulators of tnf activity
EP0640606A1 (en) Thienopyrimidine derivatives, their production and use
US6048863A (en) Condensed-ring thiophene derivatives and thienopyrimidine derivatives, their production and use
US5977132A (en) Prolactin production inhibitory agent
KR20040029134A (ko) ＬＨ 및 ＦＳＨ의 조합 작용 활성을 갖는티에노[2,3-ｄ]피리미딘
WO1997041126A1 (en) Thienopyridine derivatives, their production and use
JP3854648B2 (ja) 縮合チオフェン誘導体、その製造法及び用途
RU2150470C1 (ru) Бициклические производные тиофена, способ их получения и композиция на их основе
JPH09169766A (ja) チエノピリジン誘導体，その製造法および用途
CZ290723B6 (cs) Kondenzované bicyklické thiofenové deriváty, způsob jejich výroby, farmaceutický prostředek je obsahující a jejich pouľití
RU2158739C2 (ru) Соединения тиенопиримидина, способ их получения, фармацевтическая композиция
JPH09169767A (ja) 複素環化合物、その製造法および用途
JPH09216823A (ja) プロラクチン産生抑制剤
NZ332206A (en) 2,4-Dioxo-thieno[2,3-d]pyrimidine derivatives useful as gonadotropin releasing hormone antagonists