OA10189A - Use of indole derivatives as 5htl agonists - Google Patents
Use of indole derivatives as 5htl agonists Download PDFInfo
- Publication number
- OA10189A OA10189A OA60728A OA60728A OA10189A OA 10189 A OA10189 A OA 10189A OA 60728 A OA60728 A OA 60728A OA 60728 A OA60728 A OA 60728A OA 10189 A OA10189 A OA 10189A
- Authority
- OA
- OAPI
- Prior art keywords
- indole
- ylmethyl
- methylaminosulfonylmethyl
- treating
- ranging
- Prior art date
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- 239000000556 agonist Substances 0.000 title description 2
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- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 229940050410 gluconate Drugs 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 238000011597 hartley guinea pig Methods 0.000 description 1
- 210000001308 heart ventricle Anatomy 0.000 description 1
- 150000004678 hydrides Chemical class 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-M hydrogensulfate Chemical compound OS([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-M 0.000 description 1
- 238000005462 in vivo assay Methods 0.000 description 1
- 125000001041 indolyl group Chemical group 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 229960001375 lactose Drugs 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
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- 230000008018 melting Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- WZHJKEUHNJHDLS-QTGUNEKASA-N metergoline Chemical compound C([C@H]1CN([C@H]2[C@@H](C=3C=CC=C4N(C)C=C(C=34)C2)C1)C)NC(=O)OCC1=CC=CC=C1 WZHJKEUHNJHDLS-QTGUNEKASA-N 0.000 description 1
- 229960004650 metergoline Drugs 0.000 description 1
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
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- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- NVFHCOMYGPNDTO-UHFFFAOYSA-N n-[2-bromo-4-(methylsulfamoylmethyl)phenyl]-2,2,2-trifluoroacetamide Chemical compound CNS(=O)(=O)CC1=CC=C(NC(=O)C(F)(F)F)C(Br)=C1 NVFHCOMYGPNDTO-UHFFFAOYSA-N 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- KDLHZDBZIXYQEI-UHFFFAOYSA-N palladium Substances [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- LXNAVEXFUKBNMK-UHFFFAOYSA-N palladium(II) acetate Substances [Pd].CC(O)=O.CC(O)=O LXNAVEXFUKBNMK-UHFFFAOYSA-N 0.000 description 1
- YJVFFLUZDVXJQI-UHFFFAOYSA-L palladium(ii) acetate Chemical compound [Pd+2].CC([O-])=O.CC([O-])=O YJVFFLUZDVXJQI-UHFFFAOYSA-L 0.000 description 1
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- 229920001592 potato starch Polymers 0.000 description 1
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- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical class CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 210000003752 saphenous vein Anatomy 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 201000009032 substance abuse Diseases 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- 239000002511 suppository base Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
- 229940029284 trichlorofluoromethane Drugs 0.000 description 1
- IIHPVYJPDKJYOU-UHFFFAOYSA-N triphenylcarbethoxymethylenephosphorane Chemical compound C=1C=CC=CC=1P(C=1C=CC=CC=1)(=CC(=O)OCC)C1=CC=CC=C1 IIHPVYJPDKJYOU-UHFFFAOYSA-N 0.000 description 1
- 238000012762 unpaired Student’s t-test Methods 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 239000005526 vasoconstrictor agent Substances 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5393093A | 1993-04-27 | 1993-04-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| OA10189A true OA10189A (en) | 1996-12-18 |
Family
ID=21987528
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| OA60728A OA10189A (en) | 1993-04-27 | 1995-10-27 | Use of indole derivatives as 5htl agonists |
Country Status (29)
| Country | Link |
|---|---|
| EP (1) | EP0696194B1 (cs) |
| JP (1) | JP2922307B2 (cs) |
| KR (1) | KR960701636A (cs) |
| CN (3) | CN1515252A (cs) |
| AP (1) | AP486A (cs) |
| AT (1) | ATE222492T1 (cs) |
| AU (1) | AU689469B2 (cs) |
| BG (1) | BG61898B1 (cs) |
| BR (1) | BR9406435A (cs) |
| CA (1) | CA2161533C (cs) |
| CO (1) | CO4230093A1 (cs) |
| CZ (1) | CZ290416B6 (cs) |
| DE (1) | DE69431201T2 (cs) |
| DK (1) | DK0696194T3 (cs) |
| ES (1) | ES2180573T3 (cs) |
| HU (1) | HU222488B1 (cs) |
| IL (1) | IL109376A (cs) |
| MX (1) | MX9403088A (cs) |
| NO (1) | NO308236B1 (cs) |
| NZ (1) | NZ263614A (cs) |
| OA (1) | OA10189A (cs) |
| PL (1) | PL175156B1 (cs) |
| PT (1) | PT696194E (cs) |
| RO (1) | RO117760B1 (cs) |
| RU (1) | RU2132683C1 (cs) |
| SG (1) | SG43951A1 (cs) |
| SK (1) | SK283353B6 (cs) |
| WO (1) | WO1994025023A1 (cs) |
| ZA (1) | ZA942805B (cs) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5578612A (en) * | 1990-10-15 | 1996-11-26 | Pfizer Inc. | Indole derivatives |
| US5559246A (en) * | 1990-10-15 | 1996-09-24 | Pfizer Inc. | Indole derivatives |
| US5559129A (en) * | 1990-10-15 | 1996-09-24 | Pfizer Inc | Indole derivatives |
| US5545644A (en) * | 1990-10-15 | 1996-08-13 | Pfizer Inc. | Indole derivatives |
| US5607951A (en) * | 1990-10-15 | 1997-03-04 | Pfizer Inc | Indole derivatives |
| WO1995006636A1 (en) * | 1993-08-31 | 1995-03-09 | Pfizer Inc. | 5-arylindole derivatives |
| GB9417310D0 (en) | 1994-08-27 | 1994-10-19 | Pfizer Ltd | Therapeutic agents |
| DK0804433T3 (da) * | 1994-10-12 | 2002-10-14 | Pfizer Res & Dev | Indolderivat til behandling af migræne |
| GB9424471D0 (en) * | 1994-12-03 | 1995-01-18 | Pfizer Ltd | Treatment of emesis |
| GB9510223D0 (en) | 1995-05-20 | 1995-07-19 | Pfizer Ltd | Therapeutic agent |
| US5945118A (en) * | 1995-09-29 | 1999-08-31 | Pfizer Inc | Indole derivative for the treatment of migraine |
| US5773015A (en) * | 1996-11-27 | 1998-06-30 | Elizabeth Arden Co., Division Of Conopco, Inc. | Method for controlling skin oils and grease |
| GB9706089D0 (en) * | 1997-03-24 | 1997-05-14 | Scherer Ltd R P | Pharmaceutical composition |
| US5994352A (en) * | 1998-11-13 | 1999-11-30 | Pfizer Inc. | 5-arylindole derivatives |
| ES2199086B1 (es) * | 2002-07-31 | 2005-06-01 | Cepa Schwarz Pharma Sl | Nuevos derivados de cicloalcanodionas, procedimiento para su preparacion y sus aplicaciones farmacologicas. |
| MX2022009528A (es) * | 2020-02-04 | 2022-11-14 | Mindset Pharma Inc | Derivados de 3-pirrolidina-indol como agentes psicodélicos serotoninérgicos para el tratamiento de trastornos del snc. |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU225055B1 (en) * | 1990-10-15 | 2006-05-29 | Pfizer | Indole derivatives, their intermediates, process for production them and pharmaceutical compositions containing the compounds |
| GB9102579D0 (en) * | 1991-01-24 | 1991-03-27 | Glaxo Group Ltd | Compositions |
| GB9103770D0 (en) * | 1991-02-22 | 1991-04-10 | Glaxo Group Ltd | Chemical compounds |
-
1994
- 1994-04-07 AP APAP/P/1994/000633A patent/AP486A/en active
- 1994-04-21 IL IL10937694A patent/IL109376A/xx not_active IP Right Cessation
- 1994-04-22 ZA ZA942805A patent/ZA942805B/xx unknown
- 1994-04-25 CO CO94016790A patent/CO4230093A1/es unknown
- 1994-04-26 EP EP94912048A patent/EP0696194B1/en not_active Expired - Lifetime
- 1994-04-26 CA CA002161533A patent/CA2161533C/en not_active Expired - Fee Related
- 1994-04-26 BR BR9406435A patent/BR9406435A/pt not_active Application Discontinuation
- 1994-04-26 CN CNA021506892A patent/CN1515252A/zh active Pending
- 1994-04-26 NZ NZ263614A patent/NZ263614A/en unknown
- 1994-04-26 HU HU9503089A patent/HU222488B1/hu not_active IP Right Cessation
- 1994-04-26 KR KR1019950704678A patent/KR960701636A/ko not_active Ceased
- 1994-04-26 PT PT94912048T patent/PT696194E/pt unknown
- 1994-04-26 PL PL94311266A patent/PL175156B1/pl unknown
- 1994-04-26 AU AU64360/94A patent/AU689469B2/en not_active Ceased
- 1994-04-26 AT AT94912048T patent/ATE222492T1/de not_active IP Right Cessation
- 1994-04-26 DE DE69431201T patent/DE69431201T2/de not_active Expired - Fee Related
- 1994-04-26 CZ CZ19952802A patent/CZ290416B6/cs not_active IP Right Cessation
- 1994-04-26 RO RO95-01860A patent/RO117760B1/ro unknown
- 1994-04-26 SK SK1332-95A patent/SK283353B6/sk unknown
- 1994-04-26 ES ES94912048T patent/ES2180573T3/es not_active Expired - Lifetime
- 1994-04-26 SG SG1996006766A patent/SG43951A1/en unknown
- 1994-04-26 CN CN94191935A patent/CN1121689A/zh active Pending
- 1994-04-26 DK DK94912048T patent/DK0696194T3/da active
- 1994-04-26 CN CNA011046600A patent/CN1509713A/zh active Pending
- 1994-04-26 JP JP6524076A patent/JP2922307B2/ja not_active Expired - Fee Related
- 1994-04-26 RU RU95120093/14A patent/RU2132683C1/ru not_active IP Right Cessation
- 1994-04-26 WO PCT/IB1994/000079 patent/WO1994025023A1/en active IP Right Grant
- 1994-04-27 MX MX9403088A patent/MX9403088A/es unknown
-
1995
- 1995-10-25 BG BG100093A patent/BG61898B1/bg unknown
- 1995-10-26 NO NO954287A patent/NO308236B1/no not_active IP Right Cessation
- 1995-10-27 OA OA60728A patent/OA10189A/en unknown
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