OA06421A - Procédé de préparation de dérivés N-(vinblastinoyl-23) d'acides aminés et de peptides. - Google Patents

Procédé de préparation de dérivés N-(vinblastinoyl-23) d'acides aminés et de peptides.

Info

Publication number
OA06421A
OA06421A OA56972A OA56972A OA06421A OA 06421 A OA06421 A OA 06421A OA 56972 A OA56972 A OA 56972A OA 56972 A OA56972 A OA 56972A OA 06421 A OA06421 A OA 06421A
Authority
OA
OAPI
Prior art keywords
derivatives
preparation
vinblastinoyl
peptides
amino acids
Prior art date
Application number
OA56972A
Other languages
English (en)
French (fr)
Inventor
Andre Benoit Leon Trouet
Kandukuri Sivaprasada Bush Rao
Jean Alfred Alphonse Hannart
Original Assignee
Omnium Chimique Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omnium Chimique Sa filed Critical Omnium Chimique Sa
Priority claimed from LU82514A external-priority patent/LU82514A1/fr
Priority claimed from LU83034A external-priority patent/LU83034A1/fr
Publication of OA06421A publication Critical patent/OA06421A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Distillation Of Fermentation Liquor, Processing Of Alcohols, Vinegar And Beer (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
OA56972A 1980-06-10 1979-12-13 Procédé de préparation de dérivés N-(vinblastinoyl-23) d'acides aminés et de peptides. OA06421A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
LU82514A LU82514A1 (fr) 1980-06-10 1980-06-10 Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique
LU83034A LU83034A1 (fr) 1980-12-23 1980-12-23 Derives n-(vinblastinoyl-23) d'acides amines et de peptides, leur preparation et leur application therapeutique

Publications (1)

Publication Number Publication Date
OA06421A true OA06421A (fr) 1981-09-30

Family

ID=26640267

Family Applications (1)

Application Number Title Priority Date Filing Date
OA56972A OA06421A (fr) 1980-06-10 1979-12-13 Procédé de préparation de dérivés N-(vinblastinoyl-23) d'acides aminés et de peptides.

Country Status (21)

Country Link
US (1) US4388305A (cs)
EP (1) EP0041935B1 (cs)
AT (2) AT390793B (cs)
AU (1) AU541747B2 (cs)
CA (1) CA1196326A (cs)
DD (1) DD160417A5 (cs)
DE (2) DE3122479A1 (cs)
DK (1) DK160614C (cs)
ES (1) ES502644A0 (cs)
FR (1) FR2483926A1 (cs)
GB (1) GB2078730A (cs)
GR (1) GR74565B (cs)
HU (1) HU185261B (cs)
IE (1) IE51403B1 (cs)
IL (1) IL63038A0 (cs)
IT (1) IT1144601B (cs)
NL (1) NL8102802A (cs)
NZ (1) NZ197299A (cs)
OA (1) OA06421A (cs)
PT (1) PT73161B (cs)
SE (1) SE8103594L (cs)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2517680A1 (fr) * 1981-12-08 1983-06-10 Omnichem Sa Derives n-(vinblastinoyl-23) d'acides amines, leur preparation et leur application therapeutique
EP0124502A3 (en) * 1983-04-29 1986-05-07 Omnichem Societe Anonyme Conjugates of vinblastine and its derivatives, process for their preparation and pharmaceutical compositions containing these conjugates

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4639456A (en) * 1980-06-10 1987-01-27 Omnichem S.A. Vinblastin-23-oyl amino acid derivatives
IT1170152B (it) * 1982-07-19 1987-06-03 Lilly Co Eli Miglioramenti a o riguardanti formulazioni di vinca-alcaloidi
ATE57187T1 (de) * 1983-03-30 1990-10-15 Lilly Industries Ltd Vincaleukoblastin-derivate.
US4667030A (en) * 1985-06-17 1987-05-19 Eli Lilly And Company Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
US4675400A (en) * 1985-06-17 1987-06-23 Eli Lilly And Company Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
FI860456A7 (fi) * 1985-07-16 1987-01-17 Huhtamaeki Oy Laeaeketehdas Le Bis-indolalkaloiders proteinkonjugat, bis-indolalkaloider, deras framstaellning och anvaendning.
EP0232693A3 (fr) * 1985-12-16 1988-04-06 La Region Wallonne Conjugués de la vinblastine et de ses dérivés, procédé pour leur préparation et compositions pharmaceutiques les contenant
JPH075608B2 (ja) * 1986-01-13 1995-01-25 イ−ル−セルタ−ク ソシエテ アノニム ビンブラスチン誘導体
EP0316030B1 (en) * 1987-11-11 1991-12-18 Akzo N.V. Vincristine-containing product
FR2623504B1 (fr) * 1987-11-25 1990-03-09 Adir Nouveaux derives n-(vinblastinoyl-23) d'acide amino-1 methylphosphonique, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2626882B1 (fr) * 1988-02-08 1991-11-08 Ire Celltarg Sa Conjugues de derives de vinca comportant une chaine detergente en position c-3
US4980343A (en) * 1988-10-27 1990-12-25 Bayer Aktiengesellschaft Aminooxodihydroisoindoloquinazoline carcinostatic agents
US5043340A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Derivatives of 4-desacetyl VLB C-3 carboxhydrazide
US5043336A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Cyclic imide derivatives of 4-desacetyl VLB c-3 carboxhydrazide
US5866679A (en) * 1994-06-28 1999-02-02 Merck & Co., Inc. Peptides
US5599686A (en) * 1994-06-28 1997-02-04 Merck & Co., Inc. Peptides
US6143864A (en) * 1994-06-28 2000-11-07 Merck & Co., Inc. Peptides
DE69535665T2 (de) * 1994-08-19 2009-04-02 La Region Wallonne Konjugate enthaltend ein antitumorales mittel und deren verwendung
BE1008581A3 (fr) * 1994-08-19 1996-06-04 Wallone Region Prodrogues, composition pharmaceutique les comprenant et leur utilisation.
US5998362A (en) * 1996-09-12 1999-12-07 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US5948750A (en) * 1996-10-30 1999-09-07 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US6127333A (en) * 1997-07-10 2000-10-03 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US6391305B1 (en) 1997-09-10 2002-05-21 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
AU5240999A (en) * 1998-07-31 2000-02-21 Goldsmith Seeds Inc. Trimeric and polymeric alkaloids
DE19842416A1 (de) * 1998-09-16 2000-04-13 Max Planck Gesellschaft Sekundäre Amine zur Prävention und Therapie von Erkrankungen, die durch Oxidationsprozesse verursacht oder verstärkt werden
US7425541B2 (en) 1998-12-11 2008-09-16 Medarex, Inc. Enzyme-cleavable prodrug compounds
AU6685301A (en) 2000-06-14 2001-12-24 Corixa Corp Prodrug compounds with isoleucine
US20030232760A1 (en) * 2001-09-21 2003-12-18 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
JP5448299B2 (ja) * 2003-12-04 2014-03-19 アルバニー モレキュラー リサーチ， インコーポレイテッド ビンカ誘導体
WO2005055943A2 (en) * 2003-12-04 2005-06-23 Amr Technology, Inc. Vinorelbine derivatives
WO2008033930A2 (en) * 2006-09-12 2008-03-20 Amr Technology, Inc. Vinca derivatives
US20080125451A1 (en) * 2006-09-12 2008-05-29 Amr Technology, Inc. Vinorelbine derivatives
AU2021289665A1 (en) 2020-06-10 2022-12-15 Aligos Therapeutics, Inc. Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections
CA3224494A1 (en) 2021-07-09 2023-01-12 Koen Vandyck Anti-viral compounds
WO2023043816A1 (en) 2021-09-17 2023-03-23 Aligos Therapeutics, Inc. Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3387001A (en) * 1964-10-19 1968-06-04 Lilly Co Eli Novel aminoacyl esters of desacetyl vincaleukoblastine
AR204004A1 (es) * 1973-04-02 1975-11-12 Lilly Co Eli Procedimientos para preparar derivados de vinblastina leurosidina y leurocristina
GR69783B (cs) * 1976-09-08 1982-07-07 Lilly Co Eli
US4203898A (en) * 1977-08-29 1980-05-20 Eli Lilly And Company Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2517680A1 (fr) * 1981-12-08 1983-06-10 Omnichem Sa Derives n-(vinblastinoyl-23) d'acides amines, leur preparation et leur application therapeutique
EP0124502A3 (en) * 1983-04-29 1986-05-07 Omnichem Societe Anonyme Conjugates of vinblastine and its derivatives, process for their preparation and pharmaceutical compositions containing these conjugates

Also Published As

Publication number Publication date
ATA253881A (de) 1989-12-15
FR2483926A1 (fr) 1981-12-11
DE3166150D1 (en) 1984-10-25
IE51403B1 (en) 1986-12-24
GB2078730A (en) 1982-01-13
ES8203385A1 (es) 1982-04-01
US4388305A (en) 1983-06-14
DE3122479A1 (de) 1982-06-16
DK250181A (da) 1981-12-11
EP0041935B1 (fr) 1984-09-19
IT8167782A0 (it) 1981-06-08
DK160614B (da) 1991-04-02
SE8103594L (sv) 1981-12-11
ATE9475T1 (de) 1984-10-15
NL8102802A (nl) 1982-01-04
AT390793B (de) 1990-06-25
HU185261B (en) 1984-12-28
EP0041935A1 (fr) 1981-12-16
AU7126281A (en) 1981-12-17
ES502644A0 (es) 1982-04-01
DK160614C (da) 1991-09-23
GR74565B (cs) 1984-06-29
IL63038A0 (en) 1981-09-13
IT1144601B (it) 1986-10-29
AU541747B2 (en) 1985-01-17
NZ197299A (en) 1985-10-11
PT73161B (fr) 1982-07-16
CA1196326A (en) 1985-11-05
IE811275L (en) 1981-12-10
PT73161A (fr) 1981-07-01
DD160417A5 (de) 1983-07-27
FR2483926B1 (cs) 1983-07-29

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