NZ783034A - Compositions and methods for decreasing tau expression - Google Patents

Compositions and methods for decreasing tau expression

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Publication number
NZ783034A
NZ783034A NZ783034A NZ78303416A NZ783034A NZ 783034 A NZ783034 A NZ 783034A NZ 783034 A NZ783034 A NZ 783034A NZ 78303416 A NZ78303416 A NZ 78303416A NZ 783034 A NZ783034 A NZ 783034A
Authority
NZ
New Zealand
Prior art keywords
compositions
methods
tau expression
decreasing tau
decreasing
Prior art date
Application number
NZ783034A
Other languages
English (en)
Inventor
Ofengeim Manuela Polydoro
Jan Weiler
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NZ783034A publication Critical patent/NZ783034A/en

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
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    • C12N2320/00—Applications; Uses
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NZ783034A 2015-12-21 2016-12-19 Compositions and methods for decreasing tau expression NZ783034A (en)

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US201562270165P 2015-12-21 2015-12-21
NZ743231A NZ743231A (en) 2015-12-21 2016-12-19 Compositions and methods for decreasing tau expression

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NZ783034A true NZ783034A (en) 2025-07-25

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