NZ777930A - Multivalent and multispecific dr5-binding fusion proteins - Google Patents

Multivalent and multispecific dr5-binding fusion proteins

Info

Publication number
NZ777930A
NZ777930A NZ777930A NZ77793016A NZ777930A NZ 777930 A NZ777930 A NZ 777930A NZ 777930 A NZ777930 A NZ 777930A NZ 77793016 A NZ77793016 A NZ 77793016A NZ 777930 A NZ777930 A NZ 777930A
Authority
NZ
New Zealand
Prior art keywords
multivalent
multispecific
fusion proteins
binding fusion
dr5bd
Prior art date
Application number
NZ777930A
Other languages
English (en)
Inventor
John Timmer
Kyle Jones
Amir Razai
Abrahim Hussain
Quinn Deveraux
Katelyn Willis
Brendan Eckelman
Original Assignee
Inhibrx Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inhibrx Biosciences Inc filed Critical Inhibrx Biosciences Inc
Priority claimed from NZ738850A external-priority patent/NZ738850B2/en
Publication of NZ777930A publication Critical patent/NZ777930A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001136—Cytokines
    • A61K39/001138—Tumor necrosis factors [TNF] or CD70
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
NZ777930A 2015-07-16 2016-07-18 Multivalent and multispecific dr5-binding fusion proteins NZ777930A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562193309P 2015-07-16 2015-07-16
NZ738850A NZ738850B2 (en) 2016-07-18 Multivalent and multispecific dr5-binding fusion proteins

Publications (1)

Publication Number Publication Date
NZ777930A true NZ777930A (en) 2025-05-02

Family

ID=57757772

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ777930A NZ777930A (en) 2015-07-16 2016-07-18 Multivalent and multispecific dr5-binding fusion proteins

Country Status (25)

Country Link
US (4) US10308720B2 (OSRAM)
EP (2) EP3322734B1 (OSRAM)
JP (4) JP6807606B2 (OSRAM)
KR (2) KR20250017305A (OSRAM)
CN (2) CN107922491B (OSRAM)
AU (2) AU2016291701B2 (OSRAM)
CA (1) CA2991634A1 (OSRAM)
CY (1) CY1123615T1 (OSRAM)
DK (1) DK3322734T3 (OSRAM)
ES (1) ES2833773T3 (OSRAM)
HR (1) HRP20201785T1 (OSRAM)
HU (1) HUE051896T2 (OSRAM)
IL (3) IL307994A (OSRAM)
LT (1) LT3322734T (OSRAM)
MX (2) MX2018000523A (OSRAM)
NZ (1) NZ777930A (OSRAM)
PL (1) PL3322734T3 (OSRAM)
PT (1) PT3322734T (OSRAM)
RS (1) RS61062B1 (OSRAM)
RU (2) RU2748620C2 (OSRAM)
SG (1) SG10201912410TA (OSRAM)
SI (1) SI3322734T1 (OSRAM)
SM (1) SMT202100066T1 (OSRAM)
WO (1) WO2017011837A2 (OSRAM)
ZA (1) ZA201800238B (OSRAM)

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CN110305210B (zh) * 2018-03-27 2023-02-28 信达生物制药(苏州)有限公司 新型抗体分子、其制备方法及其用途
JP7724061B2 (ja) 2018-04-11 2025-08-15 インヒブルクス バイオサイエンシズ インコーポレイテッド 制約されたｃｄ３結合を有する多重特異性ポリペプチド構築物ならびに関連する方法および使用
WO2020047705A1 (zh) * 2018-09-03 2020-03-12 安菲尼生命科技有限公司 Dr5单域抗体及其用途
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EP4294842A1 (en) * 2021-02-19 2023-12-27 Inhibrx, Inc. Formulations of dr5 binding polypeptides
IL316085A (en) * 2022-04-08 2024-12-01 Inhibrx Biosciences Inc Dr5 agonist and plk1 inhibitor or cdk inhibitor combination therapy
US20250302948A1 (en) * 2022-05-23 2025-10-02 Inhibrx Biosciences, Inc. DR5 Agonist and IAP Antagonist Combination Therapy
CN117285644A (zh) * 2022-06-16 2023-12-26 清华大学 一种相变调节元件及其用途
KR20250131767A (ko) 2022-09-28 2025-09-03 발린크 테라퓨틱스 리미티드 다가 단백질 및 스크리닝 방법
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Also Published As

Publication number Publication date
JP2023022214A (ja) 2023-02-14
US20240376220A1 (en) 2024-11-14
AU2016291701B2 (en) 2022-09-29
AU2016291701A1 (en) 2018-01-25
PT3322734T (pt) 2020-11-30
EP3322734A2 (en) 2018-05-23
ES2833773T3 (es) 2021-06-15
IL307994A (en) 2023-12-01
JP2025084923A (ja) 2025-06-03
MX2018000523A (es) 2018-04-13
US11976126B2 (en) 2024-05-07
CN114106178A (zh) 2022-03-01
KR20250017305A (ko) 2025-02-04
CA2991634A1 (en) 2017-01-19
MX2023002379A (es) 2023-03-21
CN107922491B (zh) 2021-09-28
KR102760380B1 (ko) 2025-01-31
HK1254433A1 (en) 2019-07-19
RU2018102803A3 (OSRAM) 2019-12-27
JP6807606B2 (ja) 2021-01-06
DK3322734T3 (da) 2020-10-26
US20220064318A1 (en) 2022-03-03
IL256772A (en) 2018-03-29
PL3322734T3 (pl) 2021-05-04
RU2748620C2 (ru) 2021-05-28
HRP20201785T1 (hr) 2021-01-22
CN107922491A (zh) 2018-04-17
RU2021111382A (ru) 2021-05-21
KR20180030518A (ko) 2018-03-23
LT3322734T (lt) 2021-02-10
US11117973B2 (en) 2021-09-14
WO2017011837A2 (en) 2017-01-19
US20190309083A1 (en) 2019-10-10
ZA201800238B (en) 2021-07-28
EP3322734A4 (en) 2019-04-17
SMT202100066T1 (it) 2021-03-15
SG10201912410TA (en) 2020-02-27
SI3322734T1 (sl) 2021-02-26
US20170015753A1 (en) 2017-01-19
EP3322734B1 (en) 2020-09-09
HUE051896T2 (hu) 2021-03-29
US10308720B2 (en) 2019-06-04
JP2018522888A (ja) 2018-08-16
BR112018000584A2 (pt) 2018-09-11
IL292037A (en) 2022-06-01
WO2017011837A3 (en) 2017-03-02
JP7244938B2 (ja) 2023-03-23
RU2018102803A (ru) 2019-08-19
RS61062B1 (sr) 2020-12-31
AU2022291498A1 (en) 2023-02-02
EP3798232A1 (en) 2021-03-31
NZ738850A (en) 2024-11-29
CY1123615T1 (el) 2022-03-24
IL256772B (en) 2022-05-01
JP2021046414A (ja) 2021-03-25

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Effective date: 20240704