NZ717921A - Microrna compounds and methods for modulating mir-21 activity - Google Patents

Microrna compounds and methods for modulating mir-21 activity Download PDF

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Publication number
NZ717921A
NZ717921A NZ717921A NZ71792112A NZ717921A NZ 717921 A NZ717921 A NZ 717921A NZ 717921 A NZ717921 A NZ 717921A NZ 71792112 A NZ71792112 A NZ 71792112A NZ 717921 A NZ717921 A NZ 717921A
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NZ
New Zealand
Prior art keywords
nucleoside
activity
methods
modified
modulating mir
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NZ717921A
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English (en)
Inventor
Balkrishen Bhat
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Regulus Therapeutics Inc
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Publication date
Application filed by Regulus Therapeutics Inc filed Critical Regulus Therapeutics Inc
Priority claimed from NZ616748A external-priority patent/NZ616748B2/en
Publication of NZ717921A publication Critical patent/NZ717921A/en

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
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    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/11—Antisense
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/343—Spatial arrangement of the modifications having patterns, e.g. ==--==--==--
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification

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  • Wood Science & Technology (AREA)
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NZ717921A 2011-04-25 2012-04-25 Microrna compounds and methods for modulating mir-21 activity NZ717921A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161478767P 2011-04-25 2011-04-25
US201161565779P 2011-12-01 2011-12-01
NZ616748A NZ616748B2 (en) 2011-04-25 2012-04-25 Microrna compounds and methods for modulating mir-21 activity

Publications (1)

Publication Number Publication Date
NZ717921A true NZ717921A (en) 2017-09-29

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NZ717921A NZ717921A (en) 2011-04-25 2012-04-25 Microrna compounds and methods for modulating mir-21 activity

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EP (3) EP2702155B9 (cg-RX-API-DMAC7.html)
JP (2) JP6320292B2 (cg-RX-API-DMAC7.html)
KR (2) KR102055172B1 (cg-RX-API-DMAC7.html)
CN (3) CN103620035B (cg-RX-API-DMAC7.html)
AU (4) AU2012249851B2 (cg-RX-API-DMAC7.html)
BR (1) BR112013027187A2 (cg-RX-API-DMAC7.html)
CA (2) CA3165397A1 (cg-RX-API-DMAC7.html)
CL (1) CL2013003105A1 (cg-RX-API-DMAC7.html)
CO (1) CO6821889A2 (cg-RX-API-DMAC7.html)
CY (1) CY1120304T1 (cg-RX-API-DMAC7.html)
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HR (2) HRP20170557T2 (cg-RX-API-DMAC7.html)
HU (2) HUE031595T2 (cg-RX-API-DMAC7.html)
IL (3) IL229032B (cg-RX-API-DMAC7.html)
LT (2) LT3211082T (cg-RX-API-DMAC7.html)
MX (5) MX393138B (cg-RX-API-DMAC7.html)
MY (2) MY187685A (cg-RX-API-DMAC7.html)
NZ (1) NZ717921A (cg-RX-API-DMAC7.html)
PH (1) PH12013502199A1 (cg-RX-API-DMAC7.html)
PL (2) PL2702155T3 (cg-RX-API-DMAC7.html)
PT (2) PT3211082T (cg-RX-API-DMAC7.html)
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UA (1) UA115652C2 (cg-RX-API-DMAC7.html)
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CN103620035A (zh) 2014-03-05
EP3211082A1 (en) 2017-08-30
AU2020201403A1 (en) 2020-03-12
US20200291400A1 (en) 2020-09-17
MX393138B (es) 2025-03-24
PT3211082T (pt) 2021-04-28
MX2013012452A (es) 2014-11-21
HK1243130A1 (en) 2018-07-06
AU2012249851A1 (en) 2013-10-31
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