MX393138B - Compuestos de microarn y metodos para modular la actividad de mir-21. - Google Patents
Compuestos de microarn y metodos para modular la actividad de mir-21.Info
- Publication number
- MX393138B MX393138B MX2019003090A MX2019003090A MX393138B MX 393138 B MX393138 B MX 393138B MX 2019003090 A MX2019003090 A MX 2019003090A MX 2019003090 A MX2019003090 A MX 2019003090A MX 393138 B MX393138 B MX 393138B
- Authority
- MX
- Mexico
- Prior art keywords
- activity
- mir
- methods
- compositions
- modulating mir
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/343—Spatial arrangement of the modifications having patterns, e.g. ==--==--==--
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161478767P | 2011-04-25 | 2011-04-25 | |
| US201161565779P | 2011-12-01 | 2011-12-01 | |
| PCT/US2012/034880 WO2012148952A1 (en) | 2011-04-25 | 2012-04-25 | Microrna compounds and methods for modulating mir-21 activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2019003090A MX2019003090A (es) | 2019-07-18 |
| MX393138B true MX393138B (es) | 2025-03-24 |
Family
ID=46025979
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019003090A MX393138B (es) | 2011-04-25 | 2012-04-25 | Compuestos de microarn y metodos para modular la actividad de mir-21. |
| MX2013012452A MX2013012452A (es) | 2011-04-25 | 2012-04-25 | Compuestos de microarn y metodos para modular la actividad de mir-21. |
| MX2019003089A MX2019003089A (es) | 2011-04-25 | 2013-10-23 | Compuestos de microarn y metodos para modular la actividad de mir-21. |
| MX2022006595A MX2022006595A (es) | 2011-04-25 | 2013-10-23 | Compuestos de microarn y metodos para modular la actividad de mir-21. |
| MX2022000212A MX2022000212A (es) | 2011-04-25 | 2013-10-23 | Compuestos de microarn y metodos para modular la actividad de mir-21. |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013012452A MX2013012452A (es) | 2011-04-25 | 2012-04-25 | Compuestos de microarn y metodos para modular la actividad de mir-21. |
| MX2019003089A MX2019003089A (es) | 2011-04-25 | 2013-10-23 | Compuestos de microarn y metodos para modular la actividad de mir-21. |
| MX2022006595A MX2022006595A (es) | 2011-04-25 | 2013-10-23 | Compuestos de microarn y metodos para modular la actividad de mir-21. |
| MX2022000212A MX2022000212A (es) | 2011-04-25 | 2013-10-23 | Compuestos de microarn y metodos para modular la actividad de mir-21. |
Country Status (30)
Families Citing this family (22)
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|---|---|---|---|---|
| EP1838852A2 (en) | 2004-11-12 | 2007-10-03 | Asuragen, Inc. | Methods and compositions involving mirna and mirna inhibitor molecules |
| PL2702155T3 (pl) | 2011-04-25 | 2017-09-29 | Regulus Therapeutics Inc. | ZwiÄ zki mikroRNA i sposoby modulowania aktywnoĆci miR-21 |
| EP2836219A1 (en) * | 2012-04-10 | 2015-02-18 | INSERM - Institut National de la Santé et de la Recherche Médicale | Methods for the treatment of nonalcoholic steatohepatitis |
| IN2014DN09134A (cg-RX-API-DMAC7.html) * | 2012-04-25 | 2015-05-22 | Regulus Therapeutics Inc | |
| UA116639C2 (uk) | 2012-10-09 | 2018-04-25 | РДг'ĐźĐ»Đ”Ń ĐąĐ”ŃĐ°Đż'ĐźŃŃĐșŃ ĐĐœĐș. | ĐĄĐżĐŸŃĐŸĐ±Đž Đ»ŃĐșŃĐČĐ°ĐœĐœŃ ŃĐžĐœĐŽŃĐŸĐŒŃ Đ°Đ»ŃĐżĐŸŃŃĐ° |
| WO2014076196A1 (en) | 2012-11-15 | 2014-05-22 | Santaris Pharma A/S | Anti apob antisense conjugate compounds |
| CN105378080A (zh) * | 2013-05-01 | 2016-03-02 | è±ć€è·ŻæŻæČ»çæłèĄä»œæéć Źćž | çšäșè°èmir-122çćŸźć°rnaććç©ćæčæł |
| WO2015061536A1 (en) * | 2013-10-25 | 2015-04-30 | Regulus Therapeutics Inc. | Microrna compounds and methods for modulating mir-21 activity |
| KR101625755B1 (ko) | 2013-11-18 | 2016-05-30 | ìžì°ëíê” ì°ííë „ëš | ïœïœïŒČïŒźïŒĄ ì€í°ì§ ë° ìŽì ì©ë |
| US10358643B2 (en) * | 2014-01-30 | 2019-07-23 | Hoffmann-La Roche, Inc. | Poly oligomer compound with biocleavable conjugates |
| CN105734127A (zh) * | 2016-02-29 | 2016-07-06 | äžæ”·äžć»èŻć€§ćŠ | miR-21-3pćšć¶ć€çšäșæŁæ”æ©ææ„æ§èŸæ䌀çèŻćäžççšé |
| EP3449001B1 (en) * | 2016-04-29 | 2021-12-08 | Aptamir Therapeutics, Inc. | Inhibition of mir-22 mirna by apt-110 |
| EP3548005A4 (en) | 2016-11-29 | 2020-06-17 | Puretech Health LLC | Exosomes for delivery of therapeutic agents |
| AU2018335876B2 (en) | 2017-09-22 | 2024-03-14 | University Of Washington | In situ combinatorial labeling of cellular molecules |
| CN108148911B (zh) * | 2018-03-02 | 2019-11-05 | ćčżć·ć»ç§ć€§ćŠéć±çŹŹäșć»éą | miR-582ćšć¶ć€ććè șçéȘšèœŹç§»çèŻæăéąćèŻćçćèŻç©äžçćșçš |
| WO2019217369A1 (en) | 2018-05-08 | 2019-11-14 | Regulus Therapeutics Inc. | Galnac conjugated modified oligonucleotide as mir-122 inhibitor having hcv antiviral activity with reduced hyperbilirubinemia side-effect |
| CN110747266A (zh) * | 2018-07-23 | 2020-02-04 | æ·±ćłć èżææŻç ç©¶éą | miR-21ćmiR-21æźæććšæć¶éąéČ/æČ»ç1ćçłć°żç äžçćșçš |
| CN109880907A (zh) * | 2019-03-26 | 2019-06-14 | äžćœäșșæ°è§ŁæŸćçŹŹć «äžć»éą | äžç§èçç»è䟔èąèœŹç§»çććæșć¶ç 究æčæł |
| US11965162B2 (en) | 2020-04-16 | 2024-04-23 | The Johns Hopkins University | MicroRNA and inhibitors thereof and methods of treatment |
| WO2022165092A1 (en) * | 2021-01-29 | 2022-08-04 | Angion Biomedica Corp. | Methods for treatment of fibrotic diseases |
| WO2025110217A1 (ja) * | 2023-11-22 | 2025-05-30 | ćœç«ć€§ćŠæłäșșæ±æ”·ćœç«ć€§ćŠæ©æ§ | ćąèæ§è çŸæŁăźäșéČćăłïŒćăŻæČ»çć€ |
| CN120505413A (zh) * | 2025-07-15 | 2025-08-19 | æčćć·„çšćŠéą | äžç§ćșäșćŒç©äș€æąććșćG-ćéŸäœæŁæ”AKIçžć łmiRNAçæąéäœçł»ćæčæł |
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| PL2702155T3 (pl) | 2011-04-25 | 2017-09-29 | Regulus Therapeutics Inc. | ZwiÄ zki mikroRNA i sposoby modulowania aktywnoĆci miR-21 |
| WO2013013165A2 (en) | 2011-07-21 | 2013-01-24 | The Trustees Of The University Of Pennsylvania | Use of lna compounds for therapeutic inhibition of mir-21 in systemic lupus erythematosus |
| IN2014DN09134A (cg-RX-API-DMAC7.html) | 2012-04-25 | 2015-05-22 | Regulus Therapeutics Inc | |
| CN107236735B (zh) | 2012-06-21 | 2019-11-08 | 米ææ čć»çèĄä»œæéć Źćž | ć ć«éæ žé žćșćșçćșäșćŻĄæ žè·é žçæć¶ć |
| US9725721B2 (en) | 2012-09-26 | 2017-08-08 | Mirrx Therapeutics | Oligomers with improved off-target profile |
| UA116639C2 (uk) | 2012-10-09 | 2018-04-25 | РДг'ĐźĐ»Đ”Ń ĐąĐ”ŃĐ°Đż'ĐźŃŃĐșŃ ĐĐœĐș. | ĐĄĐżĐŸŃĐŸĐ±Đž Đ»ŃĐșŃĐČĐ°ĐœĐœŃ ŃĐžĐœĐŽŃĐŸĐŒŃ Đ°Đ»ŃĐżĐŸŃŃĐ° |
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2012
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