NZ706354A - 1,2,4-triazine derivatives for the treatment of viral infections. - Google Patents

1,2,4-triazine derivatives for the treatment of viral infections.

Info

Publication number
NZ706354A
NZ706354A NZ706354A NZ70635413A NZ706354A NZ 706354 A NZ706354 A NZ 706354A NZ 706354 A NZ706354 A NZ 706354A NZ 70635413 A NZ70635413 A NZ 70635413A NZ 706354 A NZ706354 A NZ 706354A
Authority
NZ
New Zealand
Prior art keywords
viral infections
treatment
triazine derivatives
triazine
derivatives
Prior art date
Application number
NZ706354A
Other languages
English (en)
Inventor
Vincent Gembus
Philippe Jubault
Christophe Hoarau
Vincent Levacher
Jean-François Bonfanti
Gowan David Mc
Jérôme Guillemont
Original Assignee
Centre Nat Rech Scient
Univ Rouen
Institut Nat Des Sciences Appliquees De Rouen Insa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Nat Rech Scient, Univ Rouen, Institut Nat Des Sciences Appliquees De Rouen Insa filed Critical Centre Nat Rech Scient
Publication of NZ706354A publication Critical patent/NZ706354A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D253/00Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/061,2,4-Triazines
    • C07D253/0651,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/071,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075Two hetero atoms, in positions 3 and 5
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D253/00Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/061,2,4-Triazines
    • C07D253/0651,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/071,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Plural Heterocyclic Compounds (AREA)
NZ706354A 2012-10-01 2013-10-01 1,2,4-triazine derivatives for the treatment of viral infections. NZ706354A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12306196.2A EP2712866A1 (en) 2012-10-01 2012-10-01 1,2,4-triazine derivatives for the treatment of viral infections
PCT/EP2013/070488 WO2014053516A1 (en) 2012-10-01 2013-10-01 1,2,4-triazine derivatives for the treatment of viral infections.

Publications (1)

Publication Number Publication Date
NZ706354A true NZ706354A (en) 2018-08-31

Family

ID=46982496

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ706354A NZ706354A (en) 2012-10-01 2013-10-01 1,2,4-triazine derivatives for the treatment of viral infections.

Country Status (21)

Country Link
US (1) US9416114B2 (en:Method)
EP (2) EP2712866A1 (en:Method)
JP (1) JP6298998B2 (en:Method)
KR (1) KR102138393B1 (en:Method)
CN (1) CN104812747B (en:Method)
AU (1) AU2013326579B2 (en:Method)
BR (1) BR112015007310B1 (en:Method)
CA (1) CA2886630C (en:Method)
CL (1) CL2015000787A1 (en:Method)
EA (1) EA026236B1 (en:Method)
ES (1) ES2616496T3 (en:Method)
IL (1) IL237871A (en:Method)
IN (1) IN2015DN03327A (en:Method)
MX (1) MX348229B (en:Method)
MY (1) MY182558A (en:Method)
NZ (1) NZ706354A (en:Method)
PH (1) PH12015500724B1 (en:Method)
SG (1) SG11201502522WA (en:Method)
UA (1) UA114644C2 (en:Method)
WO (1) WO2014053516A1 (en:Method)
ZA (1) ZA201502240B (en:Method)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SMT201800527T1 (it) 2011-04-08 2018-11-09 Janssen Sciences Ireland Uc Derivati della pirimidina per il trattamento di infezioni virali
HRP20181497T1 (hr) 2011-11-09 2018-11-30 Janssen Sciences Ireland Uc Derivati purina za liječenje virusnih infekcija
PL2872515T3 (pl) 2012-07-13 2017-05-31 Janssen Sciences Ireland Uc Puryny makrocykliczne do leczenia infekcji wirusowych
BR112015007586B1 (pt) 2012-10-10 2021-02-09 Janssen Sciences Ireland Uc derivados de pirrolo[3,2-d]pirimidina, seu uso e composição farmacêutica que os compreende
MY171115A (en) 2012-11-16 2019-09-26 Janssen Sciences Ireland Uc Heterocyclic substituted 2-amino-quinazoline derivatives for the treatment of viral infections
EP2958900B1 (en) 2013-02-21 2019-04-10 Janssen Sciences Ireland Unlimited Company 2-aminopyrimidine derivatives for the treatment of viral infections
WO2014154859A1 (en) 2013-03-29 2014-10-02 Janssen R&D Ireland Macrocyclic deaza-purinones for the treatment of viral infections
ES2657283T3 (es) 2013-05-24 2018-03-02 Janssen Sciences Ireland Uc Derivados de piridona para el tratamiento de infecciones virales y enfermedades adicionales
SG11201510637UA (en) 2013-06-27 2016-01-28 Janssen Sciences Ireland Uc Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases
MY179503A (en) 2013-07-30 2020-11-09 Janssen Sciences Ireland Uc Thieno[3,2-d]pyrimidines derivatives for the treatment of viral infections
AU2017289418B2 (en) 2016-07-01 2021-06-03 Janssen Sciences Ireland Unlimited Company Dihydropyranopyrimidines for the treatment of viral infections
MA46340A (fr) * 2016-09-29 2019-08-07 Janssen Sciences Ireland Unlimited Co Promédicaments de pyrimidine pour le traitement d'infections virales et d'autres maladies
TW201945003A (zh) 2018-03-01 2019-12-01 愛爾蘭商健生科學愛爾蘭無限公司 2,4-二胺基喹唑啉衍生物及其醫學用途
JP7287708B2 (ja) 2019-02-08 2023-06-06 プロジェニア インコーポレイテッド Toll-like受容体7または8アゴニストとコレステロールの結合体およびその用途
CA3170551A1 (en) 2020-03-02 2021-09-10 Yong Taik Lim Live-pathogen-mimetic nanoparticles based on pathogen cell wall skeleton, and production method thereof
EP4194006A4 (en) 2020-08-04 2024-12-04 Progeneer Inc. mRNA VACCINE WITH AN ADJUVANT CAPABLE OF KINETIC CONTROL
EP4194008A4 (en) 2020-08-04 2025-01-08 Progeneer Inc. Kinetically acting adjuvant ensemble
JP2023536954A (ja) 2020-08-04 2023-08-30 プロジェニア インコーポレイテッド 活性化部位が一時的に不活性化したトール様受容体7または8作用薬と機能性薬物の結合体およびその用途
WO2024151953A1 (en) * 2023-01-15 2024-07-18 Viradem Inc. Compounds and methods for treating diseases caused by sars-cov-2 and other coronaviruses

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2485531A1 (fr) * 1980-06-25 1981-12-31 Fabre Sa Pierre Nouveaux n-oxydes de diaryl-5,6 as triazines 1-2-4, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
AU698419B2 (en) 1996-07-03 1998-10-29 Dainippon Sumitomo Pharma Co., Ltd. A novel purine derivative
ATE247654T1 (de) 1997-11-28 2003-09-15 Sumitomo Pharma Neue heterozyklische verbindungen
CN101035773B (zh) * 2004-08-10 2012-06-06 詹森药业有限公司 抑制hiv的1,2,4-三嗪-6-酮衍生物
KR20080006004A (ko) 2005-05-04 2008-01-15 화이자 리미티드 암 및 c형 간염과 같은 바이러스 감염의 치료를 위한톨-유사 수용체 조절제인 2-아미도-6-아미노-8-옥소퓨린유도체
CN101296907B (zh) * 2005-09-01 2013-03-27 弗·哈夫曼-拉罗切有限公司 作为p2x3和p2x2/3调节剂的二氨基嘧啶类
RU2352565C1 (ru) * 2007-10-08 2009-04-20 Государственное образовательное учреждение высшего профессионального образования "Пермский государственный университет" 3-амино-6-ароилметил-5-гидрокси-1,2,4-триазины и способ их получения
PE20091236A1 (es) * 2007-11-22 2009-09-16 Astrazeneca Ab Derivados de pirimidina como immunomoduladores de tlr7
WO2012067269A1 (en) * 2010-11-19 2012-05-24 Dainippon Sumitomo Pharma Co., Ltd. Aminoalkoxyphenyl compounds and their use in the treatment of disease

Also Published As

Publication number Publication date
AU2013326579B2 (en) 2017-04-27
IL237871A (en) 2017-04-30
IN2015DN03327A (en:Method) 2015-10-09
WO2014053516A1 (en) 2014-04-10
EA026236B1 (ru) 2017-03-31
US20150336907A1 (en) 2015-11-26
BR112015007310A2 (pt) 2017-08-08
ES2616496T3 (es) 2017-06-13
EP2903976A1 (en) 2015-08-12
MX2015004160A (es) 2016-02-05
SG11201502522WA (en) 2015-05-28
UA114644C2 (uk) 2017-07-10
HK1208223A1 (en) 2016-02-26
CA2886630C (en) 2021-01-26
EP2903976B1 (en) 2016-12-07
EP2712866A1 (en) 2014-04-02
CN104812747B (zh) 2017-03-08
ZA201502240B (en) 2016-05-25
KR20150084791A (ko) 2015-07-22
US9416114B2 (en) 2016-08-16
PH12015500724A1 (en) 2015-06-01
PH12015500724B1 (en) 2015-06-01
JP6298998B2 (ja) 2018-03-28
CA2886630A1 (en) 2014-04-10
AU2013326579A1 (en) 2015-04-09
MY182558A (en) 2021-01-25
EA201500383A1 (ru) 2015-07-30
CL2015000787A1 (es) 2015-10-02
CN104812747A (zh) 2015-07-29
MX348229B (es) 2017-05-31
KR102138393B1 (ko) 2020-08-14
BR112015007310B1 (pt) 2022-07-19
JP2015535839A (ja) 2015-12-17

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